[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"control-subjects\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:control-subjects":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,55,82,110],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100600716","socio-cognitive-and-biological-responses-to-maltreatment-100600716",false,"NCT07101107","Socio-cognitive and Biological Responses to Maltreatment","Socio-cognitive and Biological Responses to Childhood Maltreatment in Individuals With Bipolar Disorder and Control Subjects","Inclusion Criteria for individuals diagnosed with bipolar disorder (BD):\n\n* diagnosis of a moderate to severe depressive episode without psychotic features in the context of BD-I according to the Diagnostic and Statistical Manual of Mental Disorders (DSM)-5: 296.52 BD-I, most recent episode depressed, moderate; 296.53 BD-I, most recent episode depressed, severe without psychotic features;\n* Montgomery-Åsberg Depression Rating Scale (MADRS) score≥20;\n* age between 18 and 65 years; and\n* able to provide written informed consent for magnetic resonance imaging (MRI) and study participation.\n\nExclusion Criteria for individuals diagnosed with BD:\n\n* a history of one or more diagnoses of the following DSM-5 categories: past or current moderate or severe substance dependence (303.x, 304.x, 305.x) with the exclusion of tobacco use disorder (305.1), neurodevelopmental disorders (299.x, 307.x, 314.x, 315.x, 319.x), schizophrenia spectrum and other psychotic disorders (293.x, 295.x, 297.x, 298.x), neurocognitive disorders (290.x, 292.x, 294.x, 331.x), BD-I Single Manic (296.0x), BD-I Manic (296.4x), BD-I Mixed (296.6, 296.7, 296.8, 296.9), BD-II (296.89), or comorbid Borderline Personality Disorder (BPD) as assessed by Structured Clinical Interview for DSM-5 Personality Disorders (SCID-5-PD);\n* a current episode of illness with psychotic features (296.54);\n* a recent history of central nervous system (CNS) trauma or significant CNS trauma;\n* physical illness that might interfere with the participant's cognitive performance;\n* an autoimmune disorder or inflammatory diseases;\n* currently on anti-inflammatory drugs, cortisol or cortisol derivates;\n* cardiovascular impairment with life-threatening issues;\n* electroconvulsive therapy in the last 12 months;\n* current substance abuse (except caffeine and nicotine) as assessed by DSM-5 or positive urine drug screen;\n* IQ≤70 as assessed by the Mehrfachwahl-Wortschatztest\" version B (MWT-B);\n* MRI contraindications (e.g. claustrophobia, metal, electric, magnetic or mechanically driven implants); or\n* other ethical considerations (e.g. pregnancy, lactation, participants not fluent in the language of the cognitive batteries and questionnaires).\n\nInclusion Criteria for healthy volunteers:\n\n* absence of any axis I disorder according to DSM-5 and physical illness that might interfere with participant's cognitive performance;\n* age between 18 and 65 years according to clinical group; and\n* ability to give written informed consent for MRI and study participation.\n\nExclusion Criteria for healthy volunteers:\n\n* first degree relatives with BD, schizophrenia, or known genetically-based mitochondriopathies;\n* a history of any axis I disorder, neurological, developmental disorders, CNS trauma, or comorbid BPD.\n* physical illness that might interfere with the participants' cognitive performance;\n* an autoimmune disorder or inflammatory diseases;\n* currently on anti-inflammatory drugs, cortisol or cortisol-derivates;\n* cardiovascular impairments with life-threatening issues;\n* current substance abuse;\n* IQ≤70;\n* MRI contraindications; or\n* other ethical considerations.",true,"ALL","18 Years","65 Years",{"count":21,"type":22},160,"ESTIMATED","OBSERVATIONAL","The study will investigate how a history of emotional childhood maltreatment (CM) is associated with different aspects of psychological (social behaviour, empathy) and biological (brain function and structure, inflammation) health. In fact, CM is a risk factor for many mental disorders, such as schizophrenia and autism. However, it is unclear how a history of emotional CM affects psychological and biological outcomes in bipolar disorder (BD). Therefore, this study focuses on understanding how a possible history of CM affects BD compared to control participants (CP) with no known psychiatric illness.\n\nThe aim of the project is to investigate how a history of emotional CM is associated with social cognition. The investigators will recruit 80 CP and 80 people diagnosed with BD, some of whom will have a history of CM. The investigators will assess psychological well-being (social behaviour, empathy) at two points in time at the Department of Psychiatry, Psychotherapy, Psychosomatics and Medical Psychology at the Medical University of Innsbruck (MUI). Additionally, as they want to understand how emotional CM affects brain function and structure, the investigators will perform magnetic resonance imaging (MRI) of the brain at the Neuroimaging Core Facility (Medical University of Innsbruck). The investigators also want to understand how biological markers in the blood (such as telomere length, inflammation) might be affected, assessed in collaboration with the Department of Psychology (Leopold-Franzens University of Innsbruck). Finally, the investigators will look at a combination of the psychological and biological tests to see if there is a link between emotional CM and health outcomes.",[26,27],"Bipolar 1 Disorder","Control Subjects",[29,30,31,32,33,34,35,36,37,38,39,40,41],"childhood maltreatment","Social Cognition","empathy","Bipolar Disorder","Biomolecules","Magnetic Resonance Imaging","Theory Of Mind","telomere length","mitochondria","benevolent childhood experiences","trauma","positive childhood experiences","inflammatory markers","NOT_YET_RECRUITING","2026-06-24",{"date":45,"type":46},"2026-06-29","ACTUAL",{"date":48,"type":22},"2026-07-01",{"date":50,"type":22},"2030-02-28",{"name":52,"class":53},"Medical University Innsbruck","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":54},"100593876","deciphering-preserved-autonomic-function-after-multiple-sclerosis-100593876","NCT07012135","Deciphering Preserved Autonomic Function After Multiple Sclerosis","DPAF-MS","Inclusion Criteria:\n\n* 18-50 years old\n* clinically confirmed diagnosis of multiple sclerosis -OR- uninjured control\n\nExclusion Criteria:\n\n* symptoms of cardiovascular (including, but not limited to: hypertension, stroke, chest pain, etc.), respiratory, peripheral neurological or autonomic disease (particularly diabetes mellitus requiring treatment)\n* women who are pregnant or lactating\n* having a body mass index (BMI) ≥ 35 kg\u002Fm2\n* taking or being administered a medication known to potentially have adverse interactions with phenylephrine\n* in the judgement of the principal investigator or clinical collaborator, any illness or condition that will interfere with the patient's ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of the study results","50 Years",{"count":64,"type":22},13,"INTERVENTIONAL",[67],"NA","This study looks to characterize gradients of dysfunction in the autonomic nervous system in patients with clinically diagnosed multiple sclerosis. The autonomic nervous system plays key roles in regulation of blood pressure, skin blood flow, and bladder health- all issues that individuals with multiple sclerosis typically suffer. Focusing on blood pressure regulation, the most precise metric with broad clinical applicability, the investigators will perform laboratory-based tests to probe the body's ability to generate autonomic responses. For both individuals with multiple sclerosis and uninjured controls, laboratory-based experiments will utilize multiple parallel recordings to identify how the autonomic nervous system is able to inhibit and activate signals. The investigators anticipate that those with autonomic dysfunction with multiple sclerosis will exhibit abnormalities in these precise metrics. The investigators will look to see if any substantial connections exist between different degrees of preserved autonomic function and secondary autonomic complications from multiple sclerosis. In accomplishing this, the investigators hope to give scientists important insights to how the autonomic nervous system works after multiple sclerosis and give physicians better tools to manage these secondary autonomic complications.",[70,27,71],"Multiple Sclerosis","Autonomic Dysreflexia","RECRUITING","2026-05-26",{"date":75,"type":46},"2026-05-28",{"date":77,"type":46},"2025-09-17",{"date":79,"type":22},"2026-12-31",{"name":81,"class":53},"Mayo Clinic",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":89,"targetDuration":4,"studyType":65,"phases":91,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":54},"100573376","decision-making-in-schizophrenia-a-combined-neuroimaging-and-experience-sampling-study-100573376","NCT06745479","Decision-Making in Schizophrenia: A Combined Neuroimaging and Experience Sampling Study","Promoting Adaptive Decision-Making in Schizophrenia Through Improved Evidence Integration: A Combined Neuroimaging and Experience Sampling Study","Inclusion Criteria\n\nThe following criteria apply to all subjects:\n\n1. Between ages of 18-50.\n2. Have capacity to provide informed consent\n3. Fluent communication in English\n4. Willingness and ability to follow study requirements, as evidenced by an ability to provide written or virtual informed consent and read, and complete, study procedures.\n5. Cognitive ability to understand tasks and estimated IQ greater than 70.\n\nThe following criteria apply to subjects with schizophrenia:\n\n1\\. Primary diagnosis of schizophrenia or schizoaffective disorder\n\nThe following additional criteria apply to subjects without schizophrenia:\n\n1\\. Inclusion based on subject matched to psychiatric group based on age, sex, race\u002Fethnicity, and education level.\n\nExclusion Criteria\n\nThe following criteria apply to all subjects:\n\n1. Self-disclosed or noticeable intoxication from alcohol or illicit drugs (e.g., arriving to participate in the study drunk\u002Fhigh)\n2. Self-disclosure of consistent current substance use other than nicotine, alcohol, or cannabis (e.g. cocaine, heroin).\n3. Many-year history of severely disordered substance use other than nicotine\u002Ftobacco (determined via interview)\n4. Significant physical health disorder, robust physical health conditions, neurological disease\u002Fdisorder (e.g., Parkinson's, history of strokes).\n5. History of traumatic brain injury, head injury resulting in loss of consciousness for an extended duration or with noted neurobehavioral consequences.\n6. Electroconvulsive therapy within one month of participation.\n7. History of seizures or epilepsy.\n8. Currently untreated or unstable psychiatric and medical conditions.\n9. Intellectual disability\n10. Contra indications for MR imaging (detailed below)\n\nThe following additional criteria apply to subjects without schizophrenia:\n\n1. Pervasive history of problematic substance use (other than nicotine, alcohol, and mild-moderate cannabis use) as defined by meeting DSM-5 criteria for a substance use disorder.\n2. Diagnosis of, or first-degree relative with, significant psychiatric disorder (e.g., bipolar disorder, psychotic disorder, or Cluster A personality disorder).",{"count":90,"type":22},74,[67],"The goal of this clinical trial is to learn if attention and ways of thinking impact decision-making and brain processes related to decision-making in people with schizophrenia or schizoaffective disorder relative to people without either condition. It will also learn how brain functioning during decision-making relates to real-world decisions made during daily life. The main questions it aims to answer are:\n\n* Does paying attention to specific information impact decision-making and brain processes?\n* Does thinking in a certain way according to specific 'thinking strategies' improve brain processes related to decision-making?\n* Does brain functioning during decision-making relate to real-world choices to engage in activities?\n\nResearchers will compare brain functioning and decision-making on computer tasks of gambling after participants have been trained to use a positive thinking strategy. They will compare what is different in the brain and behavior when participants use this strategy and when they do not. Participants will also answer brief surveys about activities and feelings for a week in their daily lives.\n\nParticipants will:\n\n* Complete several hours of clinical interviewing, cognitive tests, and surveys of about symptoms, experiences, and personality\n* Complete computer tasks about gambling decisions during MRI brain scanning and while having their visual attention measured using eye-tracking\n* Complete brief surveys about their activities and feelings 5 times a day for 1 week using a cell phone. Each survey only take several minutes.",[94,95,27],"Schizophrenia","Schizoaffective Disorder",[97,98,99,94,100],"Cognitive Strategy","Emotion Regulation","Psychosis","functional MRI","2026-03-09",{"date":103,"type":46},"2026-03-11",{"date":105,"type":46},"2025-01-07",{"date":107,"type":22},"2027-06-30",{"name":109,"class":53},"Rutgers, The State University of New Jersey",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":65,"phases":121,"briefSummary":122,"conditions":123,"keywords":126,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":54},"100562862","timing-and-facilitation-effects-of-theta-burst-stimulation-in-the-reading-and-language-networks-100562862","NCT06608680","Timing and Facilitation Effects of Theta-Burst Stimulation in the Reading and Language Networks","Timing and Facilitation Effects of Theta-Burst Stimulation in the Reading and Language Systems","TAFE","Inclusion Criteria:\n\n* Subjects must have a minimum of low average intellectual functioning (\\>=80) on at least one subscale on the Wechsler Abbreviated Scale of Intelligence-2 (WASI-2; Wechsler, 2011) to be included.\n* Within a normal range of reading skills as \\>85 on the Test of Word Reading Efficiency - Second Edition (TOWRE-2; Torgesen et al., 2012) and the Woodcock-Johnson IV Tests of Achievement (WJ-IV; Schrank et al., 2014)\n* Individuals with a documented history of learning disability will not be included. This will be determined via demographics questionnaire.\n* Subjects must be between the ages of 18 and 30 to be included. This will be determined via demographics questionnaire.\n* Because reading is critically linked to language, only individuals who are native speakers of English will be included in the study. This will be determined via demographics questionnaire.\n* The reading network is typically localized to the left side of the brain. However, left-handed individuals may have different brain lateralization, introducing an important confound to the study. Therefore, only right-handed individuals will be included in the study. This will be determined via demographics questionnaire.\n* Individuals who have hearing deficits (\\>25dB at 500+ Hz), visual deficits (\\>20\u002F40), serious emotional problems, certain neurological conditions (e.g., uncontrolled seizure disorders) will not be included. This will be determined via CABI Screening Forms and Demographics Questionnaire.\n* Individuals with certain metals in their bodies or with certain health conditions will not be included. If an individual has braces on their teeth, a cardiac pacemaker; hearing aid; other metal in their body or eyes (which may include certain metallic-embedded tattoos), including but not limited to pins, screws, shrapnel, plates, dentures or other metal objects they will not be included. This will be determined via CABI Screening forms.\n* Individuals with MRI Screening and Contraindication Forms which do not pass MRI Tech review will not be included.\n* Individuals with TMS Screening Forms which do not pass TMS Tech review will not be included.","30 Years",{"count":120,"type":22},50,[67],"The purpose of this study is to understand how transcranial magnetic stimulation affects how quickly, easily, and accurately a person read. Transcranial magnetic stimulation is a technique that uses magnetic fields to briefly affect how well certain brain regions function. The investigators would like to better understand how long the effects of transcranial magnetic stimulation occur in the reading system and at what point the effect is strongest in this system. The main questions it aims to answer are:\n\n1. At what point after stimulation are the greatest effects on behavior seen\n2. How excitatory and inhibitory stimulation affect behavior\n\nResearchers will compare stimulation types against a sham condition to see effects on reading and language behavior.\n\nParticipants will be asked to\n\n* undergo reading, language, and cognitive testing\n* receive an MRI\n* receive TMS stimulation\n* perform language, reading, and motor tasks",[124,125,27],"Reading","Language",[127,128,129,124,125],"transcranial magnetic stimulation","TMS","MRI","2024-09-19",{"date":132,"type":46},"2024-09-23",{"date":134,"type":46},"2023-05-01",{"date":136,"type":22},"2028-12-31",{"name":138,"class":53},"Georgia State University"]