[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"conversion-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:conversion-disorder":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100511762","observational-study-on-functional-overlay-in-patients-with-movement-disorders-100511762",false,"NCT05943652","Observational Study on \"Functional Overlay\" in Patients With Movement Disorders","Prevalence and Clinical Presentation of Functional Neurological Disorders in Patients With Movement Disorders - A Cross-sectional Study in the Movement Disorders Clinic of the Department of Neurology, Medical University of Graz","Inclusion Criteria:\n\n* Functional or non-functional movement disorder\n* 18 to 80 years\n\nExclusion Criteria:\n\n* Patient is not able to consent\n* Patient is not able to understand \u002F speak German fluently (questionnaires are available only in German)","ALL","18 Years",{"count":19,"type":20},216,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn about functional neurological disorders in patients with common non-functional movement disorders (\"functional overlay\"). The main questions it aims to answer are:\n\n* What is the frequency of functional neurological disorders in patients with non-functional movement disorders (functional overlay)?\n* What are the characteristics of functional neurological disorders in patients with non-functional movement disorders?\n\nParticipants will be examined clinically and electrophysiologically, the examinations consist of:\n\n* a neurological examination\n* neuropsychological testing\n* electrophysiological tremor diagnostic\n* questionnaires about psychological, biological and social risk factors\n\nResearchers will compare patients with functional motor disorders to patients wit non-functional movement disorders to see if they differ from each other regarding the functional symptoms.",[24,25,26,27],"Conversion Disorder","Parkinson Disease","Tremor","Dystonia",[29,30,31],"Accelerometry","Patient Health Questionnaire","Neuropsychology","RECRUITING","2025-09-23",{"date":35,"type":36},"2025-09-29","ACTUAL",{"date":38,"type":36},"2023-01-01",{"date":40,"type":20},"2026-06-30",{"name":42,"class":43},"Medical University of Graz","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100593436","brain-computer-interface-rehabilitation-and-virtual-environments-in-functional-neurological-disorder-brave-fnd-100593436","NCT07006415","Brain-computer Interface Rehabilitation And Virtual Environments in Functional Neurological Disorder (BRAVE-FND)","BRAVE-FND","Inclusion Criteria:\n\n* DSM5 diagnosis of motor FND (limb weakness, gait disorder, tremor or dystonia) from a neurologist and\u002For neuropsychiatrist.\n* Moderate or severe symptoms (≥4 on Clinical Global Impression Severity (CGI-S) scale).\n* Able to tolerate VR and BCI use.\n* Age 18 - 60 years.\n* English speaking.\n\nExclusion Criteria:\n\n* Current diagnosis of epilepsy, severe depression, bipolar disorder, psychotic disorder, personality disorder, or drug\u002Falcohol dependence\u002Fharmful use (defined as meeting DSM-5 criteria) (Mini International Neuropsychiatric Interview \\[MINI\\] 7.0). Positive diagnoses on the MINI will be subject to confirmation at clinical interview by a psychiatrist.\n* Current diagnosis of epilepsy, autistic spectrum disorder, dementia, learning disability (defined as meeting DSM-5 criteria) based on clinical interview by a psychiatrist.\n* A pacemaker, implantable cardioverter-defibrillator or any other implanted electronic or metallic device.\n* Current pregnancy.\n* Non-registration with a GP or failure to consent to sharing of the GP summary care record and any psychiatric assessments held.\n* Those enrolled in another clinical or research study.\n* Those unable to give informed consent.","60 Years",{"count":54,"type":20},24,"INTERVENTIONAL",[57],"NA","The purpose of this study is to determine whether a course of rehabilitation using a device called a brain-computer interface can change the level of control people feel over bodily movements, in functional neurological disorder.",[60,24,61,62],"Functional Neurological Disorder","Functional Neurological Disorders","Conversion Disorder With Weakness\u002FParalysis",[64,65],"brain-computer interface","rehabilitation","NOT_YET_RECRUITING","2025-05-27",{"date":69,"type":36},"2025-06-05",{"date":71,"type":20},"2025-10-01",{"date":73,"type":20},"2028-01-31",{"name":75,"class":43},"King's College London",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":55,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":99},"100369964","efficacy-of-dorso-lateral-prefrontal-cortex-stimulation-by-tdcs-in-motor-conversion-disorder-patients-100369964","NCT04097184","Efficacy of Dorso-lateral Prefrontal Cortex Stimulation by tDCS in Motor Conversion Disorder Patients","Efficacy of Dorso-lateral Prefrontal Cortex Stimulation by tDCS in Patients With Motor Conversion Disorder - Multicentre Randomized Double Blind Assay","CONVERSTIM","Inclusion Criteria:\n\n* The patient must have given his\u002Fher informed and signed consent.\n* The patient is at least (≥) 18 years old and 65 years old at the most (≤). The risk of an increased frequency of somatic comorbidity, drug co-prescription, and cognitive impairment prompts us to limit recruitment to age 65 in this study.\n* The patient is hospitalized or followed in consultation.\n* Patient is available for a follow-up of 6 months.\n* With current DSM-5 criteria for conversion disorder during more than 10 days, motor type (i.e. with paralysis or motor weakness) and initial EDSS score ≥ 3 or initial WHO Score is ≥ 2\n\nExclusion Criteria:\n\n* The patient is participating in another interventional trial.\n* The patient refuses to sign the consent.\n* It is impossible to correctly inform the patient.\n* The patient is pregnant or breastfeeding.\n* Specialized neurological clinical examination and the performing of brain and medullary MRI reveal an organic neurological involvement.\n* Current episode of mania, hypomania, diagnosis of substance abuse\u002Fdependence (excluding smoking), diagnosis of schizophrenia over lifetime, severe neurological pathology (epilepsy, stroke, brain tumor).\n* Patient with a contraindication to MRI (for patients enrolled in Nîmes).\n* Acute eczema at the electrodes loci.","65 Years",{"count":86,"type":20},96,[57],"Conversion disorder refers to impaired voluntary motor or sensory functions that are not compatible with a well-known neurological condition. This disorder affects up to 30% of hospitalized patients in neurology departments and symptoms persist in 35% of patients after 12 years of evolution. Despite a poor prognosis, no treatments have been validated to date.\n\nThe development of non-invasive brain stimulation techniques has allowed the creation of treatments focused on dysfunctional brain regions associated with motor conversion disorder. Hypoactivation of prefrontal dorso-lateral cortex underlies the course of functional motor symptoms. Results of the HYCORE study conducted at Nîmes University Hospital (including 20 patients, clinicaltrial.gov NCT02329626) confirmed these results and related hypoactivation of PFDLC to persistent motor disability at 3 months and 6 months follow-up. Activation of the PFDLC could restore executive control and thus promote the recovery of motor symptoms.\n\nHowever, in most repeated Transcranial Magnetic Stimulation (rTMS) the primary motor areas were targeted and the clinical improvement was related to self-suggestion induced by the motor response produced.\n\nAmong the different techniques, transcranial Direct Current Stimulation (tDCS) is a medical neuromodulation device that delivers a direct, low-intensity electric current to cortical areas, facilitating neuronal activity. Recently, PFDLC stimulation via tDCS has been used to treat several neuropsychiatric disorders and shown to be effective in depression. In addition, this technique has several advantages compared to rTMS: its use is simpler and costs 5 to 8 times less, the device is portable and there is no titration procedure. The tolerance of the tDCS is also better with no risk of epileptic seizure, neuronal depolarization being absent.",[24],"2025-02-11",{"date":92,"type":36},"2025-02-13",{"date":94,"type":36},"2021-03-05",{"date":96,"type":20},"2025-09",{"name":98,"class":43},"Centre Hospitalier Universitaire de Nīmes",8]