[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"convulsion-non-epileptic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:convulsion-non-epileptic":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,42,64,89,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100559962","retraining-and-control-therapy-react--adults-100559962",false,"NCT06570954","Retraining and Control Therapy (ReACT)- Adults","Retraining and Control Therapy (ReACT): Sense of Control and Catastrophic Symptom Expectations as Targets of a Cognitive Behavioral Treatment for Adult Functional Seizures (FS)","ReACT","Inclusion Criteria:\n\n* 19 years and older.\n* Diagnosis of psychogenic non-epileptic seizures by a medical doctor using video-EEG.\n\nExclusion Criteria:\n\n* Comorbid Epilepsy\n* Less than 4 PNES per month\n* Other paroxysmal nonepileptic events (e.g. episodes related to hypoxic-ischemic phenomena, sleep disorders or migraine-associated disorders)\n* Participation in other therapy during the study\n* Severe intellectual disability\n* Severe mental illness (delusions\u002Fhallucinations)\n\nExclusion for CPT:\n\n• Blood pressure \\>130\u002F80 mmHg","ALL","19 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of adult psychogenic non-epileptic seizures (PNES, episodes resembling epileptic seizures but with no correlated epileptiform activity). 19 years and older participants diagnosed with PNES who are treated at UAB FND clinic will engage in twelve sessions of ReACT. Participants will be randomly assigned to one of three conditions: no wait, 3-month waiting period, 6-month waiting period. Sense of control over actions will be measured by the magic and turbulence task, a well-validated measure of sense of control. Participants will complete the cold pressor test (CPT) in which participants hold their hand in cool water for as long as possible up to 3 minutes. Catastrophic symptom expectations in response to the CPT will be measured by Pain Catastrophizing Scale (PCS), pain tolerance (time with hand in water) and cortisol response. Target assessments occur 7 days before treatment and 7 days after the 12th treatment session. Participants randomized to the 3-month and 6-month waiting period will also complete these measures one additional time immediately before the beginning of their waiting period. Long term follow-up assessments will occur at 2 months, 6 months and 12 months after the 12th treatment session. PNES frequency will be measured from 30 days before to 12 months after treatment. Participants randomized to the 3-month or 6-month waiting period conditions will log weekly PNES episodes until the start of therapy.",[27],"Convulsion, Non-Epileptic",[15],"RECRUITING","2026-06-08",{"date":32,"type":33},"2026-06-11","ACTUAL",{"date":35,"type":33},"2025-04-10",{"date":37,"type":21},"2027-12-31",{"name":39,"class":40},"University of Alabama at Birmingham","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":52,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":58,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":41},"100543921","establishment-of-an-interdisciplinary-functional-neurological-disorder-fnd-treatment-program-and-development-of-a-clinical-care-pathway-for-fnd-100543921","NCT06362161","Establishment of an Interdisciplinary Functional Neurological Disorder (FND) Treatment Program and Development of a Clinical Care Pathway for FND","Inclusion Criteria:\n\n* Diagnosis of FND\n* Can read and write English fluently\n* Referred to UAB outpatient treatment for FND in physical, occupational, or speech therapy\n* Referred to UAB outpatient treatment for FND in psychiatry\n* Referred to inpatient consult for FND at Children's of Alabama or UAB Hospital\n* Parent\u002Fguardian willing to participate in the study with a pediatric patient\n\nExclusion Criteria:\n\n* Unable to read or write English fluently","8 Years","89 Years",{"count":51,"type":21},1100,"4 Months","OBSERVATIONAL","The purpose of this study is to help providers develop an interdisciplinary treatment pathway for functional neurological disorder (FND) at University of Alabama at Birmingham (UAB), and will involve psychiatry, speech therapy, physical therapy, and occupational therapy. The study will also help providers to evaluate the treatment pathway and publish results regarding the process and outcomes.",[56,27,57],"Functional Neurological Disorder","Functional Seizure",{"date":32,"type":33},{"date":60,"type":33},"2025-07-18",{"date":62,"type":21},"2028-12-31",{"name":39,"class":40},{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":15,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":17,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":22,"phases":76,"briefSummary":77,"conditions":78,"keywords":79,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":41},"100516633","retraining-and-control-therapy-react-r33-phase-100516633","NCT06007053","Retraining and Control Therapy (ReACT) R33 Phase","Retraining and Control Therapy (ReACT): Sense of Control and Catastrophic Symptom Expectations as Targets of a Cognitive Behavioral Treatment for Pediatric Psychogenic Non-epileptic Seizures (PNES) - R33 Phase","Inclusion Criteria:\n\n* 11-18 years old.\n* Diagnosis of psychogenic non-epileptic seizures by a medical doctor using video-EEG.\n* Family member (parent\u002Fguardian if a minor) willing to participate and that the subject with PNES chooses.\n\nExclusion Criteria:\n\n* Comorbid Epilepsy\n* Less than 4 PNES per month\n* Other paroxysmal nonepileptic events (e.g. episodes related to hypoxic-ischemic phenomena, sleep disorders or migraine-associated disorders)\n* Participation in other therapy during the study\n* Severe intellectual disability\n* Severe mental illness (delusions\u002Fhallucinations)\n\nExclusion for CPT:\n\n* Blood pressure \\>130\u002F80 mmHg for adolescents greater than or equal to 13 years old\n* Either systolic and\u002For diastolic blood pressure greater than or equal to 95% based on sex and age for children less than 13 years old",true,"11 Years","18 Years",{"count":75,"type":21},160,[24],"The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of pediatric psychogenic non-epileptic seizures (PNES, episodes resembling epileptic seizures but with no correlated epileptiform activity). 11-18-year-olds diagnosed with PNES will engage in twelve sessions of either ReACT or supportive therapy. Sense of control over actions will be measured by the magic and turbulence task, a well-validated measure of sense of control. Participants will complete the cold pressor test (CPT) in which participants hold their hand in cool water for as long as possible up to 3 minutes. Catastrophic symptom expectations in response to the CPT will be measured by Pain Catastrophizing Scale for Children (PCS-C), pain tolerance (time with hand in water) and cortisol response. Target assessments occur 7 days before treatment, 7 days after 12th treatment session, and 2 months after the 12th treatment session. Long term follow-up assessments will occur 6 months and 12 months after the 12th treatment session. PNES frequency will be measured from 30 days before to 12 months after treatment.",[27],[80,15],"Supportive therapy","2026-03-16",{"date":83,"type":33},"2026-03-17",{"date":85,"type":33},"2024-03-09",{"date":87,"type":21},"2026-12-31",{"name":39,"class":40},{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":17,"minAge":72,"maxAge":73,"enrollmentInfo":95,"targetDuration":4,"studyType":22,"phases":97,"briefSummary":98,"conditions":99,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":101,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":41},"100502208","a-multi-site-feasibility-clinical-trial-of-retraining-and-control-therapy-react-a-mind-and-body-treatment-for-pediatric-functional-seizures-100502208","NCT05819268","A Multi-site Feasibility Clinical Trial of Retraining and Control Therapy (ReACT), a Mind and Body Treatment for Pediatric Functional Seizures","Inclusion Criteria:\n\n* Males and females ages 11-18\n* Diagnosis of functional seizures\n* Internet access for telehealth sessions and CATCH-IT\n\nExclusion Criteria:\n\n* Comorbid epilepsy\n* Less than 4 functional seizures per month\n* Other paroxysmal nonepileptic events (e.g. hypoxic-ischemic phenomena, sleep disorders or migraine-associated disorders)\n* Participation in other therapy\n* Severe intellectual disability\n* Severe mental illness (active delusions\u002Fhallucinations)",{"count":96,"type":21},108,[24],"The purpose of this study is to assess the feasibility of conducting a future fully powered multi-site efficacy Randomized Controlled Trial (RCT) comparing two treatments for pediatric functional seizures (FS). In this study, 11-18-year-olds diagnosed with FS will be randomized to 12 sessions of Retraining and Control Therapy (ReACT) or Competent Adulthood Transition with Cognitive Behavioral, Humanistic, and Interpersonal Training (CATCH-IT) at 3 sites: University of Alabama at Birmingham, Yale School of Medicine\u002FYale New Haven Children's Hospital and Baylor College of Medicine\u002FTexas Children's Hospital.\n\nFeasibility of recruitment will be measured by the percentage of planned participant enrollment target obtained at each site and overall during the 18 months of planned enrollment. Acceptability will be assessed using the Acceptability Questionnaire. Participant retention will be measured by the percent of enrolled participants that complete the 2-month follow-up visit at each site and overall. For treatment fidelity assessment, 20% of each therapist's sessions will be randomly chosen and assessed for fidelity. Patient adherence will be measured in two ways: 1) the percent of ReACT or CATCH-IT sessions completed at each site and overall and 2) for ReACT, the percent of times participants report using the treatment plan during FS episodes (measured by FS diary) and for CATCH-IT, the number of times parents and children spend using CATCH-IT each week (measured by the CATCH-IT platform). These data will be used to support a future fully-powered multi-site RCT assessing the efficacy of ReACT for pediatric FS.",[100,27],"Functional Seizures",{"date":83,"type":33},{"date":103,"type":33},"2024-03-18",{"date":105,"type":21},"2027-08",{"name":39,"class":40},{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":71,"sex":17,"minAge":72,"maxAge":73,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":125,"locationsCount":41},"100446656","retraining-and-control-therapy-react-sense-of-control-and-symptom-expectations-as-targets-of-a-treatment-for-pnes-100446656","NCT05096273","Retraining and Control Therapy (ReACT): Sense of Control and Symptom Expectations as Targets of a Treatment for PNES","Retraining and Control Therapy (ReACT): Sense of Control and Catastrophic Symptom Expectations as Targets of a Cognitive Behavioral Treatment for Pediatric Psychogenic Non-epileptic Seizures (PNES)","Inclusion Criteria:\n\n* 9-18 years old.\n* Diagnosis of psychogenic non-epileptic seizures by a medical doctor using video-EEG.\n* Family member (parent if a minor) willing to participate and that the subject with PNES chooses.\n\nExclusion Criteria:\n\n* Comorbid Epilepsy\n* Less than 4 PNES per month\n* Other paroxysmal nonepileptic events (e.g. episodes related to hypoxic-ischemic phenomena, sleep disorders or migraine-associated disorders)\n* Participation in other therapy\n* Severe intellectual disability\n* Severe mental illness (delusions\u002Fhallucinations)\n\nExclusion for CPT:\n\n* Blood pressure \\>130\u002F80 mmHg for adolescents greater than or equal to 13 years old\n* Either systolic and\u002For diastolic blood pressure greater than or equal to 95% based on sex and age for children less than 13 years old",{"count":115,"type":21},68,[24],"The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of pediatric psychogenic non-epileptic seizures (PNES, episodes resembling epileptic seizures but with no medical explanation). 11-18-year-olds diagnosed with PNES will engage in twelve sessions of ReACT. Sense of control over actions will be measured by the magic and turbulence task, a well-validated measure of sense of control. Participants will complete the cold pressor test (CPT) in which participants hold their hand in cool water for as long as possible up to 3 minutes. Catastrophic symptom expectations in response to the CPT will be measured by Pain Catastrophizing Scale for Children (PCS-C) pain tolerance (time with hand in water) and cortisol response. Target assessments will occur 7 days before treatment, 7 days after 8th treatment session and 7 days after 12th treatment session. Participants will also complete long term follow-up visits via HIPAA-compliant Zoom at 6 months and 12 months after the 12th treatment session where participants will complete questionnaires. PNES frequency will be measured from 30 days before to 12 months after treatment.",[27],"2025-08-26",{"date":121,"type":33},"2025-09-03",{"date":123,"type":33},"2021-10-28",{"date":87,"type":21},{"name":39,"class":40}]