[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"copd---chronic-obstructive-pulmonary-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:copd---chronic-obstructive-pulmonary-disease":37},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,57,87,116,145],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":39,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100634739","enhanced-copd-management-in-suspected-lung-cancer-patients-100634739",false,"NCT07543601","Enhanced COPD Management in Suspected Lung Cancer Patients","Enhanced COPD Management in Suspected Lung Cancer Patients - Improving Outcomes Through Timely Intervention","ECHELON","Inclusion Criteria:\n\n* Undergoing diagnostic evaluation for suspected lung cancer\n* Spirometry showing obstructive airflow limitation (FEV₁\u002FFVC \\\u003C 75 % or FEV₁ \\\u003C 80 %, and no reversibility) at the first outpatient visit at the lung cancer evaluation\n\nExclusion Criteria:\n\n* Presence of significant comorbidities that may interfere with diagnostic procedures or spirometry\n* Pregnant or breastfeeding women","ALL","18 Years",{"count":20,"type":21},280,"ESTIMATED","INTERVENTIONAL",[24],"NA","Identifying and treating COPD in patients undergoing lung cancer evaluation is crucial. Early intervention could lead to better management of both diseases, improving health status, reducing healthcare costs, and potentially increasing survival rates.\n\nThis study aims to assess the impact of early diagnosis and optimal treatment of COPD on clinical outcomes in patients under evaluation for lung cancer. The study will combine information through an open-label RCT at the Lung Cancer Investigation Unit at Lillebaelt Hospital Vejle.\n\nThe findings could inform clinical practice by emphasizing the importance of integrated care approaches for patients with coexisting COPD and lung cancer, ultimately leading to better health outcomes.",[27,28,29,30,31,32,33,34,35,36,37,38],"COPD (Chronic Obstructive Pulmonary Disease)","Lung Cancer (Diagnosis)","Lung Neoplasm Malignant","Lung Carcinoma","Pulmonary Neoplasms","Pulmonary Neoplasm","Pulmonary Cancers","Pulmonary Cancer","Pulmonary Carcinoma","COPD","COPD - Chronic Obstructive Pulmonary Disease","Airflow Obstruction, Chronic",[40,41,42,43],"Invesigation","Evaluation","Diagnostic Work-up","Diagnostic Pathway","RECRUITING","2026-04-15",{"date":47,"type":48},"2026-04-22","ACTUAL",{"date":50,"type":48},"2026-03-06",{"date":52,"type":21},"2027-06-30",{"name":54,"class":55},"Ditte Krag-Hansen","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":17,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":22,"phases":68,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":86},"100623290","comprehensive-maintenance-program-a-health-haven-for-copd-in-lleidathe-napoleon-project-100623290","NCT07394712","Comprehensive Maintenance Program: a Health Haven for COPD in Lleida.The NAPOLEON Project.","NAPOLEON","Inclusion Criteria:\n\n* Adults aged 40 to 75 years.\n* Confirmed medical diagnosis of chronic obstructive pulmonary disease (COPD) of moderate to severe severity, based on clinical evaluation and pulmonary function testing.\n* Clinically stable for at least 4 weeks following the last severe exacerbation, as confirmed by the treating pulmonologist.\n* Referred to an outpatient pulmonary rehabilitation program due to persistent symptoms and a history of exacerbations, with moderate to severe dyspnea (Medical Research Council \\[MRC\\] dyspnea scale score \\> 2), according to physician assessment.\n* Completed at least 6 out of 8 sessions of a standard 8-week initial pulmonary rehabilitation program.\n\nExclusion Criteria:\n\n* Presence of medical contraindications to physical exercise, including unstable cardiovascular conditions (e.g., recent myocardial infarction, uncontrolled arrhythmias), severe musculoskeletal or neurological disorders, recent surgery, or acute medical conditions (e.g., recent stroke) that impair participation.\n* Severe cognitive impairment that limits the ability to understand instructions or participate actively in the program.\n* Unstable psychiatric disorders that may compromise adherence to or continuity with the exercise regimen.\n* Lack of availability or refusal to attend the scheduled sessions of the community-based exercise program.\n* Participation in another pulmonary rehabilitation program within the 6 months prior to study enrollment.","40 Years","75 Years",{"count":67,"type":21},86,[24],"Introduction:\n\nPulmonary rehabilitation programs (PRPs) are known to reduce symptoms such as dyspnea and fatigue, while improving functional capacity and quality of life in individuals with chronic obstructive pulmonary disease (COPD). However, the benefits of an initial pulmonary rehabilitation program (PRP) tend to diminish rapidly over time, prompting the development of strategies to maintain these effects. Such strategies include supervised exercise programs, telephone follow-ups, and home-based exercise regimens. Nevertheless, the optimal maintenance strategy remains uncertain.\n\nObjectives:\n\nThe primary objective is to evaluate the impact of a supervised, multidimensional maintenance PRP on symptoms and quality of life in individuals with COPD. Additionally, the study aims to compare exercise capacity, healthcare resource utilization, economic benefits, and participant perceptions between the intervention and control groups.\n\nMethodology:\n\nA 12-month randomized controlled trial (RCT) with two parallel groups will be conducted in adults with COPD who have completed an initial 8-week PRP. Participants will be randomly assigned in a 1:1 ratio to either the intervention or control group. The intervention group will undergo a maintenance PRP consisting of two weekly supervised exercise sessions and monthly educational sessions on COPD in a comprehensive health center over a 3-month period. The control group will receive standard clinical care recommendations regarding physical activity. Clinical evaluations will be conducted at four time points throughout the study: baseline (T0), 3 months (T1), 6 months (T2), and 12 months (T3). Full pulmonary function tests and anthropometric assessments will be performed at T0 and T3. Other variables, including symptom burden, quality of life, functional capacity, mental health, physical activity, sleep-wake pattern, and healthcare utilization, will be systematically collected at all four time points.",[37,71,72],"Pulmonary Rehabilitation","Randomised Controlled Trial",[74,75,76],"Pulmonary rehabilitation","chronic obstructive pulmonary disease (COPD)","Randomised controlled trial","2026-02-05",{"date":79,"type":48},"2026-02-06",{"date":81,"type":48},"2025-10-01",{"date":83,"type":21},"2026-10",{"name":85,"class":55},"Institut de Recerca Biomèdica de Lleida",2,{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":94,"sex":17,"minAge":64,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":22,"phases":98,"briefSummary":99,"conditions":100,"keywords":102,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":56},"100615501","combined-posture-correction-and-resistive-respiratory-muscles-training-in-copd-with-fhp-100615501","NCT07293429","Combined Posture Correction and Resistive Respiratory Muscles Training in COPD With FHP","Effects of Combined Posture Correction Exercise and Resistive Respiratory Muscle Training on Dyspnea, Chest Expansion, Craniovertebral Angle and Pulmonary Function Test, in COPD Patients With Forward Head Posture","Inclusion Criteria:\n\n* • Patients of COPD at stage 1 and 2\n\n  * COPD with forward head posture.\n  * Craniovertebral angle \\\u003C 53 degrees (20)\n  * Age 40-60\n  * Both genders\n  * Spirometric evidence of significant chronic air-flow limitation (ie, FEV1 of 50% of predicted and FEV1\u002FFVC ratio of 70% of predicted) in whom COPD had been diagnosed (21)\n  * Persistent dyspnea with a self-rated intensity of ⩾6 (out of 10) on a visual analogue\n  * Having muscular tightness (pectoralis major and minor, upper trapezius, sternocleidomastoid)\n\nExclusion Criteria:\n\n* • COPD with severe complications (respiratory infections, acute exacerbations, pulmonary hypertension)\n\n  * COPD with cardiovascular complications (Cor Pulmonale, atherosclerosis, risk of venous thromboembolism)\n  * Unstable respiratory, neurological, and cardiovascular conditions\n  * Congenital Cervical\u002Fspinal deformity\n  * Patients with frozen shoulder, shoulder, cervical radiculopathy)\n  * Uncontrolled underlying conditions(22)",true,"60 Years",{"count":97,"type":21},72,[24],"Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation, often exacerbated by postural abnormalities such as forward head posture (FHP). FHP can lead to significant alterations in breathing patterns, reducing the efficiency of respiratory muscles and impairing lung function. Patients with COPD and FHP frequently exhibit muscular imbalances, where overactive accessory muscles compensate for weakened primary respiratory muscles Resistive Inspiratory Muscle Training strengthens inhalation muscles using resistance devices to enhance respiratory function in COPD patients. Resistive Expiratory Muscle Training focuses on strengthening exhalation muscles through resistance during exhalation, improving breathing efficiency. Posture Correction Exercises address forward head posture by stretching tight muscles and strengthening weak ones to optimize breathing mechanics. Combined Resistive Inspiratory and Expiratory Muscle Training integrates both inspiratory and expiratory muscle training, using resistance for both inhalation and exhalation, to maximize respiratory efficiency and overall lung function in COPD patients. The objective of the study is to determine the effects of combined exercise and resistive respiratory muscles training on dyspnea, chest expansion, craniovertebral angle and pulmonary function test, in COPD patients with forward head posture.\n\nPatients of COPD with forward head posture will be recruited by convenient sampling technique using seal opaque method. 72 patients will be equally divided into three groups with 24 patients each. Posture correction exercises will be added as baseline treatment for all three groups session. GROUP A will be treated with resistive inspiratory muscles training (RIMT). GROUP B will be treated with resistive expiratory muscles training (REMT). GROUP C will be treated with combined resistive inspiratory and expiratory muscles technique (RIMT+REMT).treatment session will be of 8 weeks and will include three reading (pre, post treatment and one follow-up). Outcomes measurement will include; dyspnea by dyspnea 12 questionnaires, chest expansion by measuring tape, craniovertebral angle by radiograph and pulmonary function test by spirometer. Data will be analyzed by SPSS software version 21.",[37,101],"Forward Head Posture",[103,104,105,106],"craniovertebral angle","resistive training","posture correction","dyspnea","2025-12-29",{"date":109,"type":48},"2026-01-05",{"date":111,"type":48},"2025-12-02",{"date":113,"type":21},"2026-02-25",{"name":115,"class":55},"Riphah International University",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":94,"sex":17,"minAge":64,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":135,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":56},"100590978","hemodynamic-responses-and-brain-activity-during-dual-tasks-in-copd-patients-versus-healthy-individuals-100590978","NCT06974448","Hemodynamic Responses and Brain Activity During Dual Tasks in COPD Patients Versus Healthy Individuals","Comparison of Frontal Hemodynamic Responses and Electrical Brain Activity During Dual Tasks in COPD Patients Versus Healthy Individuals","Inclusion Criteria for the COPD Group:\n\n* Being diagnosed with COPD\n* Being between the ages of 40-65\n* Not having a history of exacerbations in the last 4 week\n* Being willing to participate in the study\n\nInclusion criteria for the Control Group\n\n* Being between the ages of 40-65\n* Being willing to participate in the study\n\nExclusion Criteria for COPD Group :\n\n* Known alpha-1 anti-trypsin deficiency\n* Presence of ischemic heart disease, uncontrolled hypertension, and diabetes mellitus\n* Presence of obstructive sleep apnea syndrome\n* Untreated tumors\n* Known history of dementia\n* Existing musculoskeletal, neuromuscular, or neurological diseases that may prevent participation in the tests\n* Not being willing to participate in the study\n\nExclusion criteria for the Control Group:\n\n* Having a known chronic health problem\n* Not being willing to participate in the study","65 Years",{"count":125,"type":21},32,"OBSERVATIONAL","Abstract\n\nCognitive dysfunction is joint in patients with chronic obstructive pulmonary disease (COPD).\n\nIn particular, there are effects in tasks that require attention, executive functions, and working memory related to the prefrontal cortex. These effects make it difficult to perform two tasks simultaneously and cause performance errors. The number of studies investigating the effects of cognitive impairments on dual-task performance in COPD is limited. In these studies, no tests were applied specifically for attention and working memory areas; therefore, the brain's neural activity was not investigated during these tests. Multimodal approaches are recommended for a comprehensive assessment of the functional activity of the brain. Multimodal approaches provide more accurate results than single-modality approaches. In the integrated electroencephalography (EEG)-functional near-infrared spectroscopy (fNIRS) approach, EEG provides adequate temporal resolution, while fNIRS offers better spatial resolution and is robust to noise. There is no study in COPD where simultaneous fNIRS-EEG measurements were made during both cognitive tests and dual tasks. In our study, the simultaneous measurement of frontal hemodynamic responses and electrical brain activity in both cognitive tests and dual-task conditions and the examination of the relationship between the results and arterial stiffness, balance, exercise capacity, anxiety, depression, and quality of life scores, which are reported to be related to cognitive function in COPD, constitute the original aspect of our study. The study will include 16 COPD and 16 healthy individuals. The same assessments will be made in both groups, and the results will be compared. General and task-specific cognitive tests, prefrontal cortex oxygenation (fNIRS), electrical brain activity (EEG), exercise capacity, muscle oxygenation, arterial stiffness, balance, respiratory function, dyspnea, depression, anxiety, and quality of life will be evaluated. As a result of this study is expected to determine the effects of cognitive function and dual-task on frontal hemodynamic responses and electrical brain activity in COPD.",[37,129],"Healty Controls",[37,131,132,133,134],"dual task","cognitive function","electroencephalogram","Functional Near-Infrared Spectroscopy","NOT_YET_RECRUITING","2025-05-07",{"date":138,"type":48},"2025-05-16",{"date":140,"type":21},"2025-05-15",{"date":142,"type":21},"2026-10-09",{"name":144,"class":55},"Hacettepe University",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":151,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":17,"minAge":153,"maxAge":4,"enrollmentInfo":154,"targetDuration":4,"studyType":22,"phases":156,"briefSummary":157,"conditions":158,"keywords":159,"overallStatus":135,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":56},"100583267","respiratory-oxygen-adherence-monitor-for-chronic-obstructive-pulmonary-disease-patients-100583267","NCT06874101","Respiratory Oxygen Adherence Monitor for Chronic Obstructive Pulmonary Disease Patients","Evaluating a Respiratory Oxygen Adherence Monitor for COPD Patients With Long-term Oxygen Therapy","ROAM","Inclusion Criteria:\n\n* Post-Bronchodilator FEV1\u002FFVC\\\u003C.80\n* Participants with medical history of COPD\n* Prescription for oxygen use via nasal cannula or mask at home\n* At baseline of health with no hospitalization\u002Fexacerbation within the past 6 weeks\n* Use of Continuous oxygen at baseline\n\nExclusion Criteria:\n\n* Post -Bronchodilator FEV1\u002FFVC ≤25%\n* Intermittent oxygen use at home\n* Inability to understand simple instructions\n* Respiratory exacerbation or infections within 6 weeks prior to screen visit\n* Not at baseline of medical health prior to screen visit","21 Years",{"count":155,"type":21},100,[24],"The goal of this clinical trial is to test a device called \"ROAM\" that is being developed to see how patients with chronic obstructive pulmonary disease (COPD) use oxygen therapy over a long period of time. This study will focus on evaluating the ROAM device, which will be attached to your oxygen source. The question that the study aims to answer is: will patients who receive daily adherence feedback from the ROAM have increased adherence to their prescribed long term oxygen therapy regimens?\n\nResearchers will compare the amount of time using oxygen and attitudes about oxygen therapy observed in a group that receives feedback from ROAM, and a control group that does not receive feedback.\n\nParticipants will have their oxygen supplies fitted with the ROAM device and then use their oxygen as usual for the 5-week study duration. Participants in the study group will have access to information about their oxygen usage and pulse oximetry levels. All participants will attend two in-clinic sessions of about an hour each, and will complete questionnaires at the beginning and end of the study.",[36,37],[160,36],"oxygen therapy","2025-03-07",{"date":163,"type":48},"2025-03-13",{"date":165,"type":21},"2025-05-01",{"date":167,"type":21},"2026-04-30",{"name":169,"class":170},"Barron Associates, Inc.","INDUSTRY"]