[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"copper\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:copper":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100590523","correlation-and-predictive-research-of-metal-elements-in-radiation-induced-oral-mucositis-100590523",false,"NCT06968520","Correlation and Predictive Research of Metal Elements in Radiation-Induced Oral Mucositis","Correlation and Predictive Study of Metal Elements in Radiation-Induced Oral Mucositis: A Prospective, Longitudinal Cohort Study","Inclusion Criteria:\n\n1）Sign the informed consent form; 2) Confirmed by pathological biopsy as nasopharyngeal carcinoma or head and neck tumors; 3) Have indications for radiotherapy and voluntarily accept radiotherapy; 4) ECOG PS: 0\u002F1; 5) Age: 18-75 years old; 6) Laboratory tests confirm good organ function.\n\nExclusion Criteria:\n\n1. There are contraindications for radiotherapy;\n2. Combined with other tumors;\n3. Pathological sections could not be obtained;\n4. The patient has any serious concurrent diseases that may pose unacceptable risks or have a negative impact on trial compliance. For instance, unstable heart diseases requiring treatment, chronic hepatitis, kidney diseases with poor conditions, uncontrolled diabetes (fasting blood glucose greater than 1.5 × ULN), and mental disorders;\n5. The researcher judged that it was not suitable to participate in this study.","ALL","18 Years","75 Years",{"count":20,"type":21},383,"ESTIMATED","OBSERVATIONAL","Radiotherapy is the main treatment method for head and neck tumors. However, almost all patients with head and neck tumors will develop acute inflammatory reactions such as Radiotherapy-Induced Oral Mucositis (RIOM) after receiving Radiotherapy, resulting in a decline in the quality of life of patients, hindering the smooth implementation of the treatment plan, reducing the therapeutic effect, and increasing the economic burden of patients. However, the current treatment strategies for RIOM focus on symptomatic treatment and have little impact on the course, severity and related complications of mucositis. Therefore, exploring effective strategies, predicting the incidence and severity of RIOM in patients, and providing prevention and treatment are the clinical bottlenecks and cutting-edge issues that urgently need to be solved in the current clinical practice of radiotherapy for head and neck tumors. Previous studies have shown that the steady-state of metallic elements may be closely related to the occurrence and development of RIOM. Therefore, we plan to conduct a prospective, single-center, observational study to further explore the correlation between metal elements and severe RIOM, analyze its predictive efficacy, and observe the dynamic changes of metal elements in radiotherapy.",[25,26,27,28],"Head and Neck Tumors","Metal","Copper","Radiotherapy-Induced Oral Mucositis","RECRUITING","2025-05-05",{"date":32,"type":33},"2025-05-13","ACTUAL",{"date":35,"type":33},"2025-04-24",{"date":37,"type":21},"2026-02-28",{"name":39,"class":40},"Nanfang Hospital, Southern Medical University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":50,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":41},"100523521","the-correlation-between-ovarian-function-and-serum-biomarkers-100523521","NCT06096766","The Correlation Between Ovarian Function and Serum Biomarkers","Study on the Correlation Between Ovarian Function and Serum Biomarkers","Inclusion Criteria:\n\n1. The selection criteria for healthy individuals are follows.\n\n   * women aged 18-45.\n\n     * Basic FSH\\\u003C10IU\u002FL, and AMH is within the normal range.\n\n       * Regular menstruation.\n\n         * Agree and sign an informed consent form.\n2. The selection criteria for DOR patients are follows.\n\n   * women aged 18-45.\n\n     * For two consecutive menstrual cycles, 25 ≥ basal FSH ≥ 10IU\u002FL or AMH\\\u003C1.1ng\u002Fml.\n\n       * Agree and sign an informed consent form.\n3. Selection criteria for POI patients are follows.\n\n   * 18 ≤ females aged \\\u003C40 years old.\n\n     * Two consecutive menstrual cycles with basal FSH\\>25IU\u002FL or AMH\\\u003C1.1ng\u002Fml.\n\n       * Agree and sign an informed consent form.\n\nExclusion Criteria:\n\n1. Patients with congenital gonadal developmental abnormalities or a family history similar to \"early menopause\".\n2. Patients with acquired organic lesions or decreased ovarian function caused by ovarian surgery.\n3. Patients who have undergone artificial cycle therapy with Western medicine or other endocrine treatments within the past three months.\n4. Patients with severe primary diseases and mental disorders such as crdiovascular, cerebrovascular, liver, kidney, and hematopoietic system.\n5. Patients during lactation or pregnancy.\n6. Patients who are allergic to the drugs used in this study or have a history of allergic reactions to traditional Chinese medicine.\n\nThose who meet any of the above 5 criteria for DOR and POI will be excluded and not included in this study. The exclusion criteria for healthy subjects are as (1), (3), (4), and (5).",true,"FEMALE","45 Years",{"count":53,"type":21},35,"The goal of this observational study is to find differences in serum biomarkers between ovarian function and normal individuals.",[56,57,58,27,59,60],"Premature Ovarian Insufficiency","Diminished Ovarian Reserve","Biomarker","Ceruloplasmin","Aging","2024-12-04",{"date":63,"type":33},"2024-12-09",{"date":65,"type":33},"2023-10-25",{"date":67,"type":21},"2025-11-11",{"name":69,"class":40},"Shi Yun"]