[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"corneal-ectasia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:corneal-ectasia":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,68],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100629453","phase-4-outcomes-of-ctak-surgery-100629453",false,"NCT07474870","Outcomes of CTAK Surgery","Outcomes of Corneal Tissue Addition for Keratoplasty (CTAK) in Patients With Ectatic Corneas","CTAK","Inclusion Criteria:\n\n* Corneal Ectasia and Keratoconus\n\nExclusion Criteria:\n\n* Excessively thin cornea\n* Significant corneal scarring","ALL","18 Years","85 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","Measuring quality of vision and quality of life outcomes using a validated questionnaire in participants undergoing CTAK surgery for corneal ectasia",[28,29],"Keratoconus","Corneal Ectasia",[15,29],"NOT_YET_RECRUITING","2026-04-21",{"date":34,"type":35},"2026-04-24","ACTUAL",{"date":37,"type":22},"2026-05",{"date":39,"type":22},"2031-01",{"name":41,"class":42},"Stanford University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":43},"100369726","phase-2-safety-and-effectiveness-of-the-pxl-platinum-330-system-for-corneal-cross-linking-in-eyes-with-corneal-ectasia-100369726","NCT04094090","Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia","Inclusion Criteria:\n\nSubjects who have one or both eyes that meet criteria 1 and 1 or more of the following criteria will be considered candidates for this study:\n\n1.10 years of age or older 2. Presence of central or inferior steepening 3. Axial topography consistent with keratoconus, post-surgical ectasia, or pellucid marginal degeneration 4. Presence of one or more findings associated with keratoconus or pellucid marginal degeneration, such as:\n\n1. Fleischer ring\n2. Vogt's striae\n3. Decentered corneal apex\n4. Munson's sign\n5. Apical Corneal scarring consistent with Bowman's breaks\n6. Scissoring of the retinoscopic reflex\n7. Crab-claw appearance on topography 5. Steepest keratometry (Kmax) value ≥ 47.20 D 6. I-S keratometry difference \\> 1.5 D on the Pentacam map or topography map 7. Posterior corneal elevation \\>16 microns 8. Thinnest corneal point \\>300 microns 9. Contact Lens Wearers Only:\n\na. Removal of contact lenses for the required period of time prior to the screening refraction: Contact Lens Type Minimum Discontinuation Time Soft or Scleral 3 days Rigid gas permeable 2 weeks\n\nExclusion Criteria:\n\nAll subjects meeting any of the following criteria will be excluded from this study:\n\n1. Eyes classified as either normal or atypical normal on the severity grading scheme.\n2. Corneal pachymetry at the screening exam that is \\\u003C300 microns at the thinnest point in the eye(s) to be treated.\n3. Previous ocular condition (other than refractive error) in the eye(s) to be treated that may predispose the eye for future complications, for example:\n\n   1. History of or active corneal disease (e.g., herpes simplex, herpes zoster keratitis, recurrent erosion syndrome, acanthomeoeba, etc.)\n   2. Clinically significant corneal scarring in the CXL treatment zone that is not related to keratoconus or, in the investigator's opinion, will interfere with the cross-linking procedure.\n4. Pregnancy (including plan to become pregnant) or lactation during the course of the study\n5. A known sensitivity to study medications\n6. Patients with nystagmus or any other condition that would prevent a steady gaze during the CXL treatment or other diagnostic tests.\n7. Patients with a current condition that, in the physician's opinion, would interfere with or prolong epithelial healing.","10 Years",{"count":52,"type":22},500,[54],"PHASE2","To evaluate the safety and effectiveness of the PXL Platinum 330 system for performing corneal cross-linking (CXL) for the treatment of ectatic disorders.",[28,57,29],"Pellucid Marginal Corneal Degeneration","RECRUITING","2025-10-15",{"date":61,"type":35},"2025-10-20",{"date":63,"type":35},"2019-10-19",{"date":65,"type":22},"2029-10-19",{"name":67,"class":42},"Goodman Eye Center",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":78,"phases":4,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":43},"100381786","dresden-corneal-disease-and-treatment-study-100381786","NCT04251143","Dresden Corneal Disease and Treatment Study","Dresden Corneal Disease and Treatment Study - Analysis for Quality Inspection of Follow-up and Treatment Procedures of Corneal Diseases of the Department of Ophthalmology (University Hospital Carl Gustav Carus Dresden)","Inclusion Criteria:\n\n* corneal disease\n* corneal ectasia\n\nExclusion Criteria:\n\n* pregnancy\n* age under 18 years","65 Years",{"count":77,"type":22},700,"OBSERVATIONAL","The purpose of this study is long-term follow up of patients with corneal diseases to analyze the quality of surgical interventions and diagnosis. Corneal ectasia, especially keratoconus, is a corneal disease that leads to an irreversible loss of visual acuity while the cornea becomes steeper, thinner and irregular. For these patients, surgical intervention (e.g. corneal cross-linking) is performed, in case of disease progression. Overall, a long-term follow up is needed to evaluate an early disease progression as well as corneal stability after surgical intervention.",[29,81,82,28,83],"Corneal Disease","Corneal Astigmatism","Keratopathy",[85,86,28,87,88],"Cornea","Ectasia","Cross-Linking","Keratoplasty","2023-02-27",{"date":91,"type":35},"2023-02-28",{"date":93,"type":35},"2018-03-12",{"date":95,"type":22},"2030-12-31",{"name":97,"class":42},"Technische Universität Dresden"]