[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"corneal-endothelial-cell-loss\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:corneal-endothelial-cell-loss":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100504367","the-viability-control-of-human-endothelial-cells-before-keratoplasty-v-check-study-100504367",false,"NCT05847387","The Viability Control of Human Endothelial Cells Before Keratoplasty (V-CHECK) Study","Preoperative Surgeon Evaluation of Corneal Endothelial Status: the Viability Control of Human Endothelial Cells Before Keratoplasty (V-CHECK) Study","V-CHECK","Inclusion Criteria:\n\n* Age older than 18 years old\n* Planned corneal transplantation: perforating keratoplasty (PK), Descemet stripping automated endothelial keratoplasty (DSAEK), ultra-thin DSAEK (UT-DSAEK) or Descemet membrane endothelial keratoplasty (DMEK)\n* Indication for corneal transplantation (low-moderate risk of rejection): keratoconus, Fuchs endothelial dystrophy\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Prior corneal transplantation\n* Planned preloaded DSAEK or preloaded DMEK\n* Planned keratoplasty not involving corneal endothelium transplantation (i.e., superficial\u002Fdeep anterior lamellar keratoplasty)\n* Evidence of concurrent microbial keratitis\n* Evidence of non-infectious or autoimmune keratitis\n* Impending or frank corneal perforation\n* Uncontrolled, elevated intraocular pressure (IOP)- Previous glaucoma surgery\n* Acute or chronic inflammatory\u002Finfectious anterior segment uveitis\n* Presence of an anterior chamber intraocular lens (IOL) for phakic or aphakic purposes","ALL","18 Years",{"count":20,"type":21},135,"ESTIMATED","OBSERVATIONAL","The purpose of this international cohort study is to validate a new method for preoperative assessment of endothelial viability in donor corneal tissues for transplantation, and to correlate endothelial health as assessed by the surgical team to functional and structural long-term outcomes in the cohort of patients receiving them.",[25,26],"Corneal Transplant Failure","Corneal Endothelial Cell Loss",[28,29,30],"Keratoplasty","Corneal endothelium","Eye Banking","RECRUITING","2025-09-29",{"date":34,"type":35},"2025-10-02","ACTUAL",{"date":37,"type":35},"2023-12-01",{"date":39,"type":21},"2026-09-30",{"name":41,"class":42},"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","OTHER",12]