[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"coronary-artery-bypass-graft\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:coronary-artery-bypass-graft":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100593988","phase-2-nicotinamide-mononucleotide-in-patients-undergoing-cabg-surgery-100593988",false,"NCT07013591","Nicotinamide Mononucleotide in Patients Undergoing CABG Surgery","Randomized Clinical Trial of β Nicotinamide Mononucleotide in Patients Undergoing CABG Surgery","Inclusion Criteria:\n\n1. Age ≥18 years\n2. Scheduled to undergo elective isolated CABG surgery with cardiopulmonary bypass (CPB)\n3. At increased risk of postoperative complications based on ≥1 of the following:\n\n   1. Age ≥65 years\n   2. eGFR \\\u003C45 ml\u002Fmin\u002F1.73m2\n   3. Documented history of congestive heart failure or left ventricular ejection fraction (LVEF) ≤40% within 6 months before surgery\n   4. Diabetes mellitus and urine albumin-to-creatinine ratio \\>30 mg\u002Fg creatinine\n   5. Peripheral arterial disease\n   6. Anemia, defined as hemoglobin \\\u003C10 g\u002Fdl\n   7. Prior cardiac surgery\n\nExclusion Criteria:\n\n1. Any of the following laboratory abnormalities at the time of screening:\n\n   1. ALT \\>3-fold the upper limit of normal\n   2. eGFR \\\u003C30 ml\u002Fmin\u002F1.73m2 or ESKD on dialysis\n   3. Hemoglobin \\\u003C8 g\u002Fdl\n2. History of gastric bypass or malabsorption\n3. Active alcohol or illicit substance use in the prior 6 months\n4. Participation in an investigational trial to evaluate pharmaceuticals or biologics within the past 3 months or 5 half-lives, whichever is shorter\n5. Pregnant or breast-feeding\n6. Unwillingness to use contraception while taking study drug and for 8 weeks after the last dose for women of reproductive age or non-sterilized male participants who are sexually active with a female partner of childbearing potential\n7. Current use of niacin \\>100 mg\u002Fday or NMN, nicotinamide, or nicotinamide riboside at any dose\n8. Conflict with other research studies\n9. Any condition which, in the judgement of the investigator, might increase the risk to the participant","ALL","18 Years",{"count":19,"type":20},90,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","The investigators will perform a phase 2a, randomized, double-blind, placebo-controlled clinical trial in adult patients undergoing elective coronary artery bypass grafting (CABG) surgery to investigate the effects of oral nicotinamide mononucleotide (NMN) administration on myocardial NAD+ concentrations and on postoperative markers of myocardial and kidney injury.",[26],"Coronary Artery Bypass Graft",[28,29,30,31,32,33],"coronary artery bypass graft","cardiac surgery","cardiopulmonary bypass","nicotinamide","NMN","acute kidney injury","RECRUITING","2026-06-24",{"date":37,"type":38},"2026-06-26","ACTUAL",{"date":40,"type":38},"2026-06-10",{"date":42,"type":20},"2029-01-01",{"name":44,"class":45},"Brigham and Women's Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":46},"100577602","graft-failure-and-consequences-of-coronary-artery-bypass-graft-surgery-100577602","NCT06800430","Graft Failure and Consequences of Coronary Artery Bypass Graft Surgery","Vein Graft Failure and Cardiovascular Consequences of Coronary Artery Bypass Graft Surgery","INCLUSION CRITERIA:\n\nCohort 1: Patients undergoing CABG surgery\n\n* Males and females over 18 years of age\n* Patients undergoing CABG surgery for multivessel coronary artery disease, who receive at least one saphenous vein graft\n\nCohort 2: Patients with symptomatic saphenous vein graft vasculopathy\n\n* Males and females over 18 years of age\n* Patients who underwent CABG surgery ≥ 5 years prior to recruitment for multivessel disease and received 2 or more saphenous vein grafts\n* Referred for invasive coronary angiography due to recurrent symptoms and with a high suspicion of graft vasculopathy\n\nEXCLUSION CRITERIA:\n\n* Patients with a life expectancy of \\\u003C 2 years\n* Renal failure (estimated glomerular filtration rate \\\u003C30 mL\u002Fmin\u002F1.73 m2)\n* Patients on immunosuppressive therapies\n* Females of child-bearing age who are pregnant or breastfeeding,\n* Known allergy or contraindications to iodinated contrast or radiotracer\n* Patients who are unable to tolerate the supine position\n* Patients who are unable to provide informed consent",{"count":55,"type":20},70,"OBSERVATIONAL","Coronary artery bypass graft (CABG) surgery is the commonest type of heart operation performed. During this, arteries or veins (termed 'grafts') are used to supply blood around blockages within the blood vessels that supply the heart. Unfortunately, these grafts can sometimes fail, and patients can also experience complications like heart attacks and strokes, after surgery. It is known that vein grafts are more likely to narrow over time. Additionally, treating vein graft failure is very challenging, as repeat surgery is riskier and procedures to stent open the veins can also fail. However, it is not fully understood why these complications occur.\n\nIn this study, the investigators will use an imaging technique called a total-body Positron Emission Tomography (PET) scan. This uses special radioactive dyes (radiotracers) to look at what is happening inside vein grafts. With this technique, the investigators will also be able to see what is happening to the heart, brain and wider parts of the body after CABG surgery.\n\nThis study will aim to recruit 70 participants in total (maximum 150). 40 (maximum of 120) of these participants will have recently undergone CABG surgery and received ≥1 vein graft. The remaining 30 will have undergone CABG surgery ≥5 years ago and will have symptoms suggestive of vein graft failure.\n\nThe study will last a total of 36 months and will involve participants undertaking the following assessments:\n\n1. Total-body Positron Emission Tomography and Computed Tomography (PET-CT) scan\n2. Ultrasound scan of the heart (echocardiogram)\n3. A blood test - up to four tablespoons (60 mL) of blood will be taken for immediate testing and the remainder will be stored for future ethically approved studies.",[59,60,26,61],"Coronary Artery Bypass","Graft Failure","Coronary Artery Bypass Graft Surgery (CABG)",[63,64,65,66,67,29,28,68,69,70],"CABG","graft failure","coronary artery bypass","cardiovascular","heart surgery","cardiovascular disease","heart disease","positron emission tomography","2026-04-15",{"date":73,"type":38},"2026-04-20",{"date":75,"type":38},"2025-03-28",{"date":77,"type":20},"2027-08-06",{"name":79,"class":45},"University of Edinburgh",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":21,"phases":91,"briefSummary":93,"conditions":94,"keywords":104,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":118},"100562499","prevention-of-edema-after-coronary-artery-bypass-graft-by-customized-pressure-guided-elastic-bandages-100562499","NCT06603961","Prevention of Edema After Coronary Artery Bypass Graft by Customized Pressure-guided Elastic Bandages","Efficacy of Customized Pressure-Guided Elastic Bandages in Preventing Postoperative Edema and Complications in Coronary Artery Bypass Graft (CABG) Patients: A Comparative Study of Compression Therapy and Standard Post-CABG Care.","PEACCE","Inclusion Criteria:\n\n1. All patients scheduled for elective coronary artery bypass grafting (CABG) surgery with saphenous vein harvesting from the leg at Siriraj Hospital.\n2. Patients aged 18 years and older undergoing CABG surgery with saphenous vein harvesting from the leg at Siriraj Hospital, who willingly consent to participate in the study.\n\nExclusion Criteria:\n\n1. Patients with an Ankle-brachial pressure index (ABI) \\\u003C 0.8\n2. Patients with severe leg swelling (pitting edema of grade 3 or higher) or with pre-existing or post-operative heart failure that remains uncontrolled despite diuretic therapy.\n3. Patients with occlusive peripheral arterial disease (PAD) or chronic venous insufficiency (CEAP 2s), characterized by significant venous stasis, leg pain, varicose veins, or lymphadenopathy.",true,{"count":90,"type":20},106,[92],"NA","The study aimed to assess the efficacy of customized pressure-guided elastic bandages (CPG-EB) in preventing postoperative edema and complications in Coronary Artery Bypass Graft (CABG) patients. While compression therapy, like compressive stockings, has benefits in preventing edema, concerns about affordability persist. CPG-EB provides optimal sub-bandage pressure, proven effective in venous leg ulcers. Implementing CPG-EB post-CABG could enhance venous blood flow, reducing complications and improving outcomes. Patients were divided into two groups: one with CPG-EB and the other standard post-CABG care. Data collected at 1, 2, and 6 weeks post-surgery assessed swelling and wound complications. Comparative analysis used standardized criteria.",[95,96,97,98,26,63,99,100,101,102,103],"Limb Edema","Surgical Site Infections","Leg Swelling","Compression Bandages","Saphenectomy","Saphenous Vein","Delayed Wound Healing","Post Operative Complications","Post Operative Surgical Site Infection",[105,106,107,63,108],"compression bandages","compression therapy","customized pressure-guided elastic bandages","coronary arterial bypass graft","2026-02-06",{"date":111,"type":38},"2026-02-09",{"date":113,"type":38},"2025-01-19",{"date":115,"type":20},"2026-05-31",{"name":117,"class":45},"Siriraj Hospital",2]