[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"coronary-artery-bypass-off-pump\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:coronary-artery-bypass-off-pump":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100334058","targeted-blood-pressure-management-and-acute-kidney-injury-after-coronary-artery-bypass-surgery-100334058",false,"NCT03629418","Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery","Impact of Targeted Blood-pressure Management on Incidence of Acute Kidney Injury After Off-pump Coronary Artery Bypass Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 50 years;\n* Scheduled to undergo off-pump CABG surgery.\n\nExclusion Criteria:\n\n* Refuse to participate;\n* Untreated or uncontrolled severe hypertension (systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg);\n* Chronic kidney disease with a glomerular filtration rate \\\u003C 30 ml\u002Fmin\u002F1.73 m2 or end-stage renal disease requiring renal-replacement therapy;\n* Inability to communicate during the preoperative period because of coma, profound dementia, language barrier, or end-stage disease;\n* Requirement of vasopressors\u002Finotropics to maintain blood pressure before surgery;\n* Second or emergency surgery;\n* Expected survival of less than 24 hours.","ALL","50 Years",{"count":19,"type":20},612,"ESTIMATED","INTERVENTIONAL",[23],"NA","Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. It is now realized that intraoperative hypotension is an important risk factor for the development of AKI. In a recent randomized controlled trial of patients undergoing major noncardiac surgery, intraoperative individualized blood-pressure management reduced the incidence of postoperative organ dysfunction. The investigators hypothesize that, for patients undergoing off-pump CABG, targeted blood-pressure management during surgery may also reduce the incidence of postoperative AKI.",[26,27,28,29,30],"Coronary Artery Bypass, Off-Pump","Intraoperative Hypotension","Acute Kidney Injury","Preventive Medicine","Intraoperative Care",[26,27,28,29,30],"RECRUITING","2025-07-29",{"date":35,"type":36},"2025-07-30","ACTUAL",{"date":38,"type":36},"2018-08-14",{"date":40,"type":20},"2026-07",{"name":42,"class":43},"Peking University First Hospital","OTHER"]