[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"coronary-artery-bypass\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:coronary-artery-bypass":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,53,77,111,143,171,198,222,256,287,314,341,372],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":39,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":49,"locationsCount":52},"100642312","risk-factors-of-atrial-fibrillation-after-cardiac-surgery-100642312",false,"NCT07625033","Risk Factors of Atrial Fibrillation After Cardiac Surgery","PFAS","Inclusion Criteria:\n\n* age \\>18\n* having undergone a scheduled cardiac surgery in the study center\n* having agreed to the reuse of their hospital care data\n\nExclusion Criteria:\n\n* Atrial fibrillation at the admission in hospital.","ALL","18 Years",{"count":19,"type":20},918,"ESTIMATED","OBSERVATIONAL","Supraventricular arrhythmias complicate more than 40% of cardiac surgeries and are associated with an increased risk of bleeding, stroke, heart failure, and death. Preventing the occurrence of these arrhythmias is a major challenge. This study aims to investigate risk factors and protective factors regarding atrial fibrillation and other iatrogenic cardiac arrhythmias after cardiac surgery, particularly innovative anesthetic strategies such as stellar ganglion blockade which have been recently implemented in our center.",[24,25,26,27,28,29,30,31,32,33,34,35,36,37,38],"Cardiac Surgery","Peri Operative Medicine","Thoracic Surgery","Cardiopulmonary Bypass","Coronary Artery Bypass","Heart Valve Prosthesis Implantation","Aortic Valve Replacement","Perioperative Medicine","Preoperative Care","Intraoperative Care","Postoperative Care","Enhanced Recovery After Surgery","Anesthesia","Cardiac Anesthesia","Intensive Care Unit",[40],"Stellar Ganglion Blockade, SGB, cardiac surgery","NOT_YET_RECRUITING","2026-06-23",{"date":44,"type":45},"2026-06-25","ACTUAL",{"date":47,"type":20},"2026-07-01",{"date":47,"type":20},{"name":50,"class":51},"Centre Hospitalier Régional Metz-Thionville","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":63,"conditions":64,"keywords":65,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":52},"100589955","prospective-cohort-study-on-fuzheng-yangxin-prescription-for-rapid-rehabilitation-of-patients-with-qi-yin-deficiency-syndrome-after-coronary-artery-bypass-grafting-100589955","NCT06961136","Prospective Cohort Study on Fuzheng Yangxin Prescription For Rapid Rehabilitation of Patients With Qi-Yin Deficiency Syndrome After Coronary Artery Bypass Grafting","Inclusion Criteria:\n\n* Patients who received coronary artery bypass surgery with syndrome differentiation of Qi-Yin deficiency after operation\n\nExclusion Criteria:\n\n* ① Patients allergic to Fuzheng Yangxin Fang granules\n\n  * Patients with postoperative cold and fever ③ Patients with severe postoperative hepatic and renal insufficiency ④ Other circumstances: Concurrent valvular surgery or other cardiac surgery, end-stage malignant tumor, uncontrolled infection, bleeding, progressive degenerative systemic disease, severe brain injury, multiple organ failure, other vital organ dysfunction such as severe liver impairment, severe heart failure or cardiogenic shock, inability to tolerate surgery, etc.","25 Years","85 Years",{"count":62,"type":20},300,"Data from the Global Burden of Disease Study 2021, recently published in the Lancet, show that ischaemic heart disease remains the first most common cause of death worldwide. Ischemic heart disease mainly refers to coronary artery stenosis or obstruction caused by coronary artery atherosclerosis leading to myocardial ischemia heart disease, called coronary heart disease. \"China Cardiovascular Health and Disease Report 2022\" mentioned that coronary heart disease is an important cardiovascular disease affecting the health of Chinese residents, and its prevalence and mortality are on the rise. Coronary artery bypass grafting (CABG) and interventional therapy (PCI) are commonly used in the treatment of coronary heart disease. CABG surgery can significantly reduce the recurrence of angina pectoris, the incidence of acute myocardial infarction and improve the survival rate of patients, the patency rate of 5 years after mammary arterial bridge can reach more than 90%. Current guidelines and various RCT studies have shown that CABG is the gold standard for revascularization in patients with complex coronary artery disease. With the increasing aging of Chinese population, there are more and more cases of complex coronary artery diseases, and CABG, as the first choice for complex coronary artery diseases, will be more and more widely used in the foreseeable future. At present, the number of coronary artery bypass surgery is on the rise, about 50,000 cases per year. Traditional Chinese medicine can play a role in preventing complications, improving the quality of life and long-term curative effect of patients after CABG. It is particularly important to actively seek the treatment of integrated Chinese and Western medicine for patients after CABG. This study aims to explore the effectiveness and safety of Fuzheng Yangxin prescription in the treatment of Qi-Yin deficiency after CABG by means of a prospective cohort study, so as to determine the efficacy of Fuzheng Yangxin prescription on the recovery after CABG. To formulate a routine program of Chinese and Western combined therapy for postoperative rehabilitation of cardiac surgery, and actively promote the technology and program, promote the transformation of intellectual property rights, etc., and contribute to the formulation of relevant guidelines.",[28],[28,66],"Chinese herbal medicine","RECRUITING","2026-05-06",{"date":70,"type":45},"2026-05-08",{"date":72,"type":45},"2025-05-10",{"date":74,"type":20},"2026-06-30",{"name":76,"class":51},"Peking University Third Hospital",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":52},"100577602","graft-failure-and-consequences-of-coronary-artery-bypass-graft-surgery-100577602","NCT06800430","Graft Failure and Consequences of Coronary Artery Bypass Graft Surgery","Vein Graft Failure and Cardiovascular Consequences of Coronary Artery Bypass Graft Surgery","INCLUSION CRITERIA:\n\nCohort 1: Patients undergoing CABG surgery\n\n* Males and females over 18 years of age\n* Patients undergoing CABG surgery for multivessel coronary artery disease, who receive at least one saphenous vein graft\n\nCohort 2: Patients with symptomatic saphenous vein graft vasculopathy\n\n* Males and females over 18 years of age\n* Patients who underwent CABG surgery ≥ 5 years prior to recruitment for multivessel disease and received 2 or more saphenous vein grafts\n* Referred for invasive coronary angiography due to recurrent symptoms and with a high suspicion of graft vasculopathy\n\nEXCLUSION CRITERIA:\n\n* Patients with a life expectancy of \\\u003C 2 years\n* Renal failure (estimated glomerular filtration rate \\\u003C30 mL\u002Fmin\u002F1.73 m2)\n* Patients on immunosuppressive therapies\n* Females of child-bearing age who are pregnant or breastfeeding,\n* Known allergy or contraindications to iodinated contrast or radiotracer\n* Patients who are unable to tolerate the supine position\n* Patients who are unable to provide informed consent",{"count":85,"type":20},70,"Coronary artery bypass graft (CABG) surgery is the commonest type of heart operation performed. During this, arteries or veins (termed 'grafts') are used to supply blood around blockages within the blood vessels that supply the heart. Unfortunately, these grafts can sometimes fail, and patients can also experience complications like heart attacks and strokes, after surgery. It is known that vein grafts are more likely to narrow over time. Additionally, treating vein graft failure is very challenging, as repeat surgery is riskier and procedures to stent open the veins can also fail. However, it is not fully understood why these complications occur.\n\nIn this study, the investigators will use an imaging technique called a total-body Positron Emission Tomography (PET) scan. This uses special radioactive dyes (radiotracers) to look at what is happening inside vein grafts. With this technique, the investigators will also be able to see what is happening to the heart, brain and wider parts of the body after CABG surgery.\n\nThis study will aim to recruit 70 participants in total (maximum 150). 40 (maximum of 120) of these participants will have recently undergone CABG surgery and received ≥1 vein graft. The remaining 30 will have undergone CABG surgery ≥5 years ago and will have symptoms suggestive of vein graft failure.\n\nThe study will last a total of 36 months and will involve participants undertaking the following assessments:\n\n1. Total-body Positron Emission Tomography and Computed Tomography (PET-CT) scan\n2. Ultrasound scan of the heart (echocardiogram)\n3. A blood test - up to four tablespoons (60 mL) of blood will be taken for immediate testing and the remainder will be stored for future ethically approved studies.",[28,88,89,90],"Graft Failure","Coronary Artery Bypass Graft","Coronary Artery Bypass Graft Surgery (CABG)",[92,93,94,95,96,97,98,99,100,101],"CABG","graft failure","coronary artery bypass","cardiovascular","heart surgery","cardiac surgery","coronary artery bypass graft","cardiovascular disease","heart disease","positron emission tomography","2026-04-15",{"date":104,"type":45},"2026-04-20",{"date":106,"type":45},"2025-03-28",{"date":108,"type":20},"2027-08-06",{"name":110,"class":51},"University of Edinburgh",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":120,"phases":121,"briefSummary":123,"conditions":124,"keywords":128,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":52},"100633576","effects-of-reflexology-and-cold-application-before-chest-tube-removal-in-cabg-patients-100633576","NCT07528482","Effects of Reflexology and Cold Application Before Chest Tube Removal in CABG Patients","Determining the Effects of Reflexology and Cold Application Before Chest Tube Removal on Pain, Anxiety, and Physiological Parameters in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Controlled Study","Inclusion Criteria:\n\n* Being 18 years of age or older\n* Not having undergone previous open heart surgery\n* Not having received analgesics within 4 hours prior to the procedure\n* Having a VAS pain score of 3 or higher\n* Voluntary participation in the study\n\nExclusion Criteria:\n\n* Being under 18 years of age\n* Using inotropic drugs\n* Having a history of chronic pain\n* Having a history of alcohol or drug use\n* Having a psychiatric illness\n* Having skin lesions, burns, or wounds on the feet that would prevent massage application",{"count":119,"type":20},108,"INTERVENTIONAL",[122],"NA","This study aims to evaluate the effects of combined reflexology and cold application on pain, anxiety, and physiological parameters in patients undergoing chest tube removal (CTR) after coronary artery bypass grafting (CABG) surgery. Chest tube removal is an invasive procedure that often causes significant pain and anxiety, which can negatively impact the recovery process. In this randomized controlled trial, patients will be assigned to a combined intervention group (reflexology and cold application) or a control group. The study seeks to provide evidence-based recommendations for non-pharmacological nursing interventions to improve patient comfort and reduce complications during the post-operative period.",[125,126,127,28],"Pain, Acute Post-Operative","Anxiety","Chest Tube Removal",[129,130,131,132,133],"Reflexology","Cold Application","Chest Tube Removal Pain","Non-pharmacological Interventions","Nursing Care","2026-04-10",{"date":136,"type":45},"2026-04-14",{"date":138,"type":45},"2025-12-15",{"date":140,"type":20},"2026-05-04",{"name":142,"class":51},"Ankara University",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":150,"targetDuration":152,"studyType":21,"phases":4,"briefSummary":153,"conditions":154,"keywords":156,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":52},"100632067","sustainable-anesthesia-in-myocardial-revascularization-surgery-100632067","NCT07508865","Sustainable Anesthesia in Myocardial Revascularization Surgery.","Sustainable Anesthesia in Myocardial Revascularization Surgery: a Non-randomized Interventional Study","Inclusion Criteria:\n\n1. Patients with coronary artery disease scheduled for coronary artery bypass graft surgery at Dr. Hernán Henríquez Aravena Hospital in Temuco.\n2. Competent patients over 18 years of age, meaning they can easily understand the informed consent process and the characteristics of the study.\n3. Elective interventions.\n\nExclusion Criteria:\n\n1. Interventions combined with other procedures or surgeries.\n2. Reoperations or second cardiac or thoracic surgical interventions.",{"count":151,"type":20},116,"1 Day","* Introduction: Greenhouse gases threaten the health and safety of humanity. The Declaration of Helsinki seeks to protect human health and emphasizes the urgency of implementing sustainable strategies. Sustainability is defined by three pillars: economic (costs), social (clinical effectiveness), and environmental (environmental impact). Clinical effectiveness in cardiac surgery has a new paradigm: \"optimized recovery,\" which translates into fewer complications, earlier extubation, shorter ICU stays, and potential cost reductions. The objective of this study is to compare the sustainability of the optimized recovery anesthetic technique with standard anesthetic practice in coronary artery bypass graft surgery, using a non-randomized interventional study design.\n* Methods: Patients aged 18 years or older with coronary artery disease scheduled for elective coronary artery bypass graft surgery will be recruited. Combined procedures and reinterventions will be excluded. Sample size: The optimized recovery group is expected to reduce postoperative mechanical ventilation by two hours. With a 95% confidence interval, 80% power, and a 1:3 ratio between the groups, a sample size of 29 and 87 patients was estimated for the optimized recovery and standard anesthesia groups, respectively.\n* The optimized recovery technique includes, preoperatively, oral pregabalin 75 mg, fasting, no benzodiazepines, total intravenous anesthesia, low-dose intravenous fentanyl, methadone 0.1-0.2 mg\u002Fkg IV, erector spinae plane block with 0.25% bupivacaine (20 mL per side), and postoperative nausea and vomiting prophylaxis with dexamethasone. Postoperatively, administer paracetamol 1 g IV every 6 hours, NSAIDs, and methadone 1 mg IV as needed. The standard anesthetic technique involves the anesthesiologist administering anesthesia as they have routinely done prior to the study, without changes.\n* Four anesthesiologists will participate in the study. Only one anesthesiologist will perform the OR technique, and their results will be compared with those of the other three, who will use their standard anesthetic technique. Patient assignment is independent, based on the hospital's schedule.\n* Analysis: The clinical effectiveness of each technique will be evaluated based on ICU extubation time. An economic analysis will be conducted based on average costs, and critical environmental impacts will be estimated through a life-cycle assessment.\n* Outcome: The performance of the indicator \"Costs in Euros\u002FCO2e\u002FExtubation Time\" will be studied. These will contribute to the estimation of an anesthetic strategy that addresses the challenges of sustainable medicine, reduces emissions, and enables the rational use of resources and their associated costs, offering environmentally friendly and clinically effective health solutions.",[28,36,155],"Sustainability",[157,158,159,160,161],"sustainability","myocardial revascularization surgery","Enhanced recovery after surgery","life cycle assessment","cost effectiveness","2026-03-30",{"date":164,"type":45},"2026-04-02",{"date":166,"type":45},"2024-07-02",{"date":168,"type":20},"2026-05-30",{"name":170,"class":51},"Universidad de La Frontera",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":120,"phases":181,"briefSummary":182,"conditions":183,"keywords":184,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":52},"100623483","oropharyngeal-humidification-after-extubation-on-thirst-100623483","NCT07397221","Oropharyngeal Humidification After Extubation on Thirst","The Effect of Oropharyngeal Humidification After Extubation on Thirst, Pain, and Anxiety in Patients Undergoing Coronary Artery Bypass Surgery: A Randomized Controlled Study","Inclusion Criteria:\n\n* Age 18-65\n* Undergoing coronary artery bypass surgery\n* Postoperative mechanical ventilation and extubation\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Neuromuscular diseases (e.g., stroke, Parkinson's disease)\n* Head\u002Fneck deformities\n* Pre-existing dysphagia\n* Tracheostomy\n* Inability to participate in assessments","65 Years",{"count":180,"type":20},42,[122],"In patients who have undergone endotracheal intubation following cardiac surgery, symptoms such as thirst, dysphagia (difficulty swallowing), restlessness, nausea, and vomiting are frequently observed, and these conditions negatively affect the patients' overall comfort. Especially in the post-intubation period, dryness in the mouth and throat, an intense feeling of thirst, and difficulty swallowing can lead to feelings of suffocation, helplessness, fear, and anxiety in patients. Effective management of these symptoms is critically important both for accelerating the recovery process and for increasing patient satisfaction.\n\nTraditionally, methods such as moistening the mouth with a cotton swab have been used to relieve complaints like thirst and dry mouth. However, these practices are often insufficient and have limited effectiveness in increasing patients' comfort. In recent years, the use of oropharyngeal sprays has emerged as an innovative and effective approach to alleviate symptoms such as thirst and dry mouth. In a randomized controlled trial conduct, it was shown that a spray-based oropharyngeal moisturizing program significantly reduced the severity of thirst and discomfort in patients who underwent intubation after cardiac surgery. Thirst and discomfort scores were found to be significantly lower in the spray-applied groups compared to the control group, and no significant difference was observed between the groups in terms of dysphagia frequency or adverse events. Similarly, studies conducted in different surgical and intensive care populations have shown that applications of cold water or cold saline sprays significantly reduce complaints of thirst and dry mouth, increase patient comfort, and are safe to use.\n\nAdditionally, it has been reported that alternative approaches such as menthol lozenges or aromatherapy also have positive effects on thirst, nausea, and comfort after cardiac surgery. Examining the effects of oropharyngeal sprays and similar practices on parameters such as thirst, dysphagia, discomfort, nausea, vomiting, and overall comfort in patients who are intubated after cardiac surgery may contribute to the development of innovative and effective approaches in patient care. Integrating such practices into postoperative care protocols carries significant potential for increasing patient comfort and supporting the recovery process.\n\nThis randomized controlled study aims to investigate the effects of oropharyngeal humidification after extubation on thirst, pain, and anxiety in patients undergoing coronary artery bypass surgery.",[28],[185,186,187,188],"Oropharyngeal Humidification","Thirst","Pain","Coronary Artery Bypass Surgery","2026-02-09",{"date":191,"type":45},"2026-02-11",{"date":193,"type":20},"2026-02-01",{"date":195,"type":20},"2026-08-01",{"name":197,"class":51},"Muş Alparslan University",{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":205,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":207,"conditions":208,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":216,"leadSponsor":218,"locationsCount":221},"100622998","gls-in-difficult-cpb-weaning-100622998","NCT07390903","GLS in Difficult CPB Weaning","Global Longitudinal Strain as a Predictor of Difficult Separating From Cardiopulmonary Bypass","Inclusion Criteria\n\n* Age \\> 18 years.\n* Scheduled for elective cardiac surgery requiring cardiopulmonary bypass (CPB).\n* Provided written informed consent to participate.\n* Eligible surgical procedures include:\n\n  * Isolated mitral valve replacement or repair.\n  * Isolated aortic valve replacement or repair.\n  * Isolated coronary artery bypass grafting (CABG).\n  * Combined valve and CABG surgery.\n  * Multiple valve replacement or repair.\n  * Surgery involving the ascending aorta or aortic arch.\n\nExclusion Criteria\n\n* Emergency cardiac surgery.\n* Redo cardiac surgery.\n* Contraindications to transesophageal echocardiography (TEE).\n* Critical preoperative conditions, including:\n\n  * Ongoing inotropic drug therapy.\n  * Preoperative mechanical circulatory support (e.g., IABP, ECMO, VAD).\n  * Requirement for mechanical ventilation.\n  * Preoperative atrial fibrillation.",{"count":206,"type":20},213,"The goal of this observational study is to learn whether global longitudinal strain (GLS), measured by echocardiography, can predict difficulty separating from cardiopulmonary bypass (CPB) in adults undergoing elective cardiac surgery.\n\nThe main questions it aims to answer are:\n\n* Can preoperative GLS measurement predict difficult separation from CPB?\n* Are GLS values associated with outcomes such as intensive care unit (ICU) stay, hospital stay, cardiac biomarkers, or 30-day mortality?\n\nParticipants will:\n\n* Undergo standard cardiac surgery requiring CPB\n* Have echocardiographic assessments (TTE before and after surgery)\n* Have their recovery and outcomes monitored, including ICU and hospital stay, postoperative labs, and survival within 30 days",[27,28,209,210,211,212],"Heart Valve Diseases","Echocardiography","Intraoperative Complications","Postoperative Complications (Cardiopulmonary)",{"date":214,"type":45},"2026-02-05",{"date":214,"type":20},{"date":217,"type":20},"2026-08-30",{"name":219,"class":220},"Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital","OTHER_GOV",2,{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":228,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":230,"targetDuration":4,"studyType":120,"phases":232,"briefSummary":233,"conditions":234,"keywords":242,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":52},"100605541","postural-mobilization-compared-to-noradrenaline-only-in-off-pump-cabg-surgery-100605541","NCT07163858","Postural Mobilization Compared to Noradrenaline Only in Off-Pump CABG Surgery","Comparison of Hemodynamic Management by Postural Mobilization Versus Chemical Vasoconstriction Using Noradrenaline Exclusively in Off-pump Coronary Artery Bypass Graft Surgery: A Prospective, Randomized, Comparative, Single-center Study.","OPTICAB","Inclusion Criteria:\n\n* Adult patient\n* patient requiring isolated coronary bypass surgery\n* Elective procedure or medical emergency\n* First cardiac surgery\n* Patient with an EF ≥30%\n* Mandatory affiliation to a social security system\n* Signed informed consent form\n* Suspension of renin-angiotensin system inhibitors and angiontensn-neprilysin receptor blockers and sartans the day before surgical procedure\n\nExclusion Criteria:\n\n* Contraindication to an inotropic substance (only NA will be used)\n* Contraindication to passive leg raising\n* Patient in a life-threatening emergency\n* History of cardiac surgery\n* Bilateral iliac or common femoral artery occlusion\n* EF \\\u003C 30%\n* Pregnancy and breastfeeding\n* Renal failure (GFR \\\u003C 40 ml\u002Fmin\u002F1.73 m²)\n* Patient with bilateral thigh amputation\n* Class III obesity BMI \\> 40 kg\u002Fm²",{"count":231,"type":20},50,[122],"This interventional prospective randomized study is designed to compare hemodynamic management using postural mobilization (+\u002F- noradrenaline) versus noradrenaline only in patients undergoing open-heart coronary artery bypass graft (CABG) surgery.",[235,236,28,237,238,239,240,241],"Coronary Artery Disease With Need for Bypass Surgery","Coronary Artery Disease(CAD)","Off Pump Coronary Artery Bypass Graft","Off Pump Coronary Artery Bypass Surgery","Hemodynamic Management","Hemodynamic Optimization","Noradrenaline",[243,244,245,246],"open-heart coronary bypass","passive leg raising","hemodynamic management","off-pump CABG surgery","2025-11-25",{"date":249,"type":45},"2025-12-03",{"date":251,"type":45},"2025-10-06",{"date":253,"type":20},"2027-08",{"name":255,"class":51},"Infirmerie Protestante de Lyon",{"id":257,"slug":258,"hasResults":11,"nctId":259,"briefTitle":260,"officialTitle":260,"acronym":4,"eligibilityCriteria":261,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":262,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":264,"conditions":265,"keywords":273,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":52},"100513945","integration-of-telemedicine-and-home-based-cardiac-rehabilitation-feasibility-efficacy-and-adherence-100513945","NCT05972070","Integration of Telemedicine and Home-Based Cardiac Rehabilitation: Feasibility, Efficacy, and Adherence","Inclusion Criteria:\n\n1. Over the age of 18\n2. NYHA Functional Class I, II,\n3. Recent (within 60 days) status post coronary artery revascularization for atherosclerotic coronary artery disease (coronary artery bypass grafting or percutaneous coronary revascularization with stent implantation)\n4. Candidate for traditional center-based cardiac rehabilitation\n\nExclusion Criteria:\n\n1. Under the age of 18\n2. Adults lacking capacity to consent.\n3. NYHA Functional Class III, IV\n4. Acute coronary syndrome\n5. Systolic heart failure (LV EF \\\u003C40%)\n6. Status post cardiac surgery for structural heart disease or heart transplant\n7. Percutaneous coronary angioplasty\n8. Adults lacking capacity to consent.\n9. Pregnant women",{"count":263,"type":20},500,"The aim of this study is to evaluate feasibility, efficacy, and adherence of home-based cardiac rehabilitation with the integration of telemedicine. Several components will be assessed such as quality-of-life, nutritional counseling, maximum metabolic activity (MET's), diabetic management, tobacco cessation, lipid, blood pressure, and psychosocial management. These tasks will be accomplished through concurrent conversations between patients and their therapist's utilizing telemedicine with observed exercise training.",[266,267,28,268,269,270,271,272],"Myocardial Infarction","Percutaneous Transluminal Coronary Angioplasty","Stable Angina","Heart Failure","Valve Disease, Heart","Cardiac Rehabilitation","Stent",[274,275,276],"Cardiac rehabilitation","Home based cardiac rehabilitation","Telemedicine and Home-Based Cardiac Rehabilitation","2025-07-21",{"date":279,"type":45},"2025-07-24",{"date":281,"type":45},"2023-06-01",{"date":283,"type":20},"2025-12-31",{"name":285,"class":286},"ROM Technologies, INC","INDUSTRY",{"id":288,"slug":289,"hasResults":11,"nctId":290,"briefTitle":291,"officialTitle":292,"acronym":293,"eligibilityCriteria":294,"healthyVolunteers":11,"sex":16,"minAge":295,"maxAge":296,"enrollmentInfo":297,"targetDuration":4,"studyType":120,"phases":299,"briefSummary":301,"conditions":302,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":221},"100510376","phase-2-improving-cardiac-rehabilitation-exercise-using-target-heart-rate-trial-100510376","NCT05925634","Improving Cardiac Rehabilitation Exercise Using Target Heart Rate Trial","Improving Outcomes From Cardiac Rehabilitation Among Older Adults Through Exercise Testing and Individualized Exercise Intensity Prescriptions","PACE SETTER","Inclusion Criteria:\n\n* Patients who are eligible for cardiac rehabilitation by having had a cardiac event such as a myocardial infarction (heart attack), heart failure, percutaneous coronary intervention or angioplasty with stent, coronary artery bypass graft, or heart valve surgery in the past 6 months.\n* Lives in, or plans to reside in, the Springfield, MA, or greater Detroit, MI, area for the next year.\n* Recruited from a Phase 2 Cardiac Rehabilitation Center at either Baystate Medical Center or Henry Ford Health System.\n* Age ≥ 60 years\n* Agrees to attend at least 18 sessions of cardiac rehabilitation after randomization\n* Agrees to attend cardiac rehabilitation at least twice a week\n\nExclusion Criteria: These include conditions that alter the physiology and monitoring of resting and exercise heart rate. These also include conditions that might limit an individual's ability to exercise.\n\n* Permanent atrial fibrillation\n* Heart transplant\n* Left-ventricular assist devices\n* Stable angina\n* High-risk un-revascularized coronary artery disease\n* Symptomatic peripheral artery disease\n* Aortic and\u002For mitral stenosis\n* Any condition where exercise testing or training might be unsafe or limited","60 Years","99 Years",{"count":298,"type":20},320,[300],"PHASE2","The goal of this clinical trial is to compare two types of exercise prescriptions in cardiac rehabilitation eligible older adults (60 years or older) with heart disease. The investigators found in a single site pilot trial (insert NCTxxx) that one exercise prescription was better and are now repeating this study in a larger population at two sites (Baystate Medical Center, Springfield MA and Henry Ford Health System, Detroit MI). The main questions the investigators aim to answer are:\n\n1. Compare two different exercise prescriptions in cardiac rehabilitation on exercise outcomes\n\n   1. Graded exercise test +Target heart rate range prescription \\[GXT-THRR\\]\n   2. Rating of perceived exertion (RPE)\n2. What is the role of psychological feedback on fitness outcomes during cardiac rehabilitation and physical activity outside of cardiac rehabilitation.\n3. What are the long-term clinical outcomes between the two exercise prescriptions\n\nParticipants will be asked to:\n\n* Complete surveys about physical activity, exercise anxiety, exercise efficacy, and fears about exercising\n* Perform fitness measures (6-minute walk test, balance tests, stand to sit tests, a 400 meter walk, and handgrip strength)\n* Attend at least 18 sessions of cardiac rehabilitation after they are randomized to their exercise prescription group\n* Wear a heart rate monitor and a physical activity monitor per study protocol\n\nParticipants will be randomized (flip of a coin) to either receive a graded exercise test and psychoeducational feedback or lifestyle education (nutrition for cardiac). The graded exercise test will be used to create a personalized exercise prescription with the target heart rate range calculated from the test and the lifestyle education group will use their ratings of perceived exertion for their exercise prescription.",[266,28,303,269,304],"Percutaneous Coronary Intervention","Cardiac Valve Surgery","2025-07-04",{"date":307,"type":45},"2025-07-09",{"date":309,"type":45},"2023-08-10",{"date":311,"type":20},"2027-06-30",{"name":313,"class":51},"Baystate Medical Center",{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":321,"targetDuration":4,"studyType":120,"phases":322,"briefSummary":323,"conditions":324,"keywords":330,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":52},"100595647","cabgprehab---a-feasibility-study-protocol-100595647","NCT07035171","CABGpreHAB - a Feasibility Study Protocol","CABGpreHAB- Home-based Multimodal Prehabilitation (CABGpreHAB) for Elective Patients Awaiting CABG-surgery - a Feasibility Study Protocol","Inclusion Criteria:\n\n* Planned to have elective isolated first-time CABG surgery.\n* 18 years or older\n* Two weeks or more before surgery\n* Speaks and understands Danish.\n* Gives written informed consent.\n\nExclusion Criteria:\n\n* Patient with unstable angina pectoris and\u002F or MI during the last two weeks.\n* Left main stem stenosis \\>50%\n* Left ventricular ejection fraction \\\u003C 35%\n* Significant ventricular arrhythmia\n* Orthopedic or neurologic preconditions precluding exercise training.\n* Inability to attend the prehabilitation program due to physical limitations.\n* Patients who have cognitive deficits that would disqualify prehabilitation.\n* Severe heart failure, NYHA Class IV\n* Lack of capacity to consent",{"count":231,"type":20},[122],"Patients with ischemic heart disease (IHD) awaiting coronary artery bypass graft (CABG) surgery often face challenges like advanced age, frailty, comorbidities, and physical inactivity. These factors, combined with the physiological and psychological stress of surgery, can hinder postoperative recovery. Traditionally, strategies to improve surgical outcomes focus on the intra- and postoperative periods. However, the pre-surgery waiting period offers a \"window of opportunity\" for prehabilitation, which aims to enhance patients' functional capacity through exercise, nutrition, and psychological support.\n\nThe CABGpreHAB feasibility study evaluates the feasibility of a home-based multimodal prehabilitation intervention for patients awaiting elective CABG surgery. This randomized pilot study compares the intervention plus usual care to usual care alone, assessing feasibility outcomes like recruitment, retention, attrition, fidelity, and adherence. The study aims to optimize a subsequent full-scale randomized controlled trial (RCT) and improve patient outcomes by leveraging the pre-surgery period for prehabilitation.",[325,326,28,327,328,329],"Ischaemic Heart Disease","Prehabilitation","Feasibility Studies","Multimodal Intervention","Adult",[331],"Prehabilitation, CABG surgery, adult, preoperative,homebased","2025-06-25",{"date":334,"type":45},"2025-06-29",{"date":336,"type":45},"2025-06-24",{"date":338,"type":20},"2026-07-18",{"name":340,"class":51},"Rigshospitalet, Denmark",{"id":342,"slug":343,"hasResults":11,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":11,"sex":16,"minAge":348,"maxAge":60,"enrollmentInfo":349,"targetDuration":4,"studyType":120,"phases":351,"briefSummary":352,"conditions":353,"keywords":356,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":221},"100591192","remote-ischemic-preconditioning-in-type-2-diabetic-patients-undergoing-cabg-100591192","NCT06977230","Remote Ischemic Preconditioning in Type 2 Diabetic Patients Undergoing CABG","The Effect of Remote Ischemic Preconditioning on Myocardial Protection in Patients With Type 2 Diabetes Mellitus Undergoing Coronary Artery Bypass Graft Surgery: A Randomized Controlled Double-Blind Study","Inclusion Criteria:\n\n* Diagnosed with type 2 diabetes mellitus and receiving medical treatment\n* Scheduled for isolated elective coronary artery bypass graft (CABG) surgery\n* American Society of Anesthesiologists (ASA) physical status class III or IV\n* Age between 40 and 85 years\n\nExclusion Criteria:\n\nEmergency CABG surgery Reoperation (revision surgery) Left ventricular ejection fraction (LVEF) \\\u003C 40% History of cardiac arrest or cardiogenic shock Pregnancy Clinically significant peripheral arterial disease affecting the upper limbs Hepatic dysfunction (bilirubin \\> 20 μmol\u002FL or INR \\> 2.0) Renal failure (eGFR \\\u003C 20 mL\u002Fmin\u002F1.73 m²) Ongoing treatment with glibenclamide or nicorandil (agents known to interfere with ischemic preconditioning mechanisms) Asthma","45 Years",{"count":350,"type":20},60,[122],"This randomized, double-blind, prospective clinical trial aims to investigate the effect of remote ischemic preconditioning (RIPC) on myocardial protection in patients with type 2 diabetes mellitus undergoing elective coronary artery bypass graft (CABG) surgery. Perioperative myocardial injury remains a significant concern during CABG, particularly in high-risk patients such as those with diabetes. RIPC is a low-cost, non-invasive intervention that may reduce myocardial damage by enhancing ischemic tolerance through intermittent limb ischemia.\n\nSixty patients aged 40-85 years with type 2 diabetes scheduled for isolated CABG will be randomized to either receive RIPC or standard care. RIPC will be applied through five cycles of upper limb cuff inflation and deflation prior to sternotomy. High-sensitivity troponin T levels will be measured at 24, 48, and 72 hours postoperatively to assess myocardial injury. Secondary outcomes include acute kidney injury (KDIGO classification), maximum vasoactive-inotropic score (VIS) during the first 72 postoperative hours, ICU and hospital length of stay. This study will provide insight into the cardioprotective role of RIPC in diabetic patients undergoing cardiac surgery.",[354,28,355],"Diabetes Mellitus","Remote Ischaemic Conditioning",[357,358,28,359,360,361,362],"High sensitive Troponin T","Diabetes mellitus Type 2","Myocardial Ischemia","Remote Ischemic Conditioning","Acute Kidney Injury","Cardioprotection","2025-06-15",{"date":365,"type":45},"2025-06-18",{"date":367,"type":45},"2025-05-26",{"date":369,"type":20},"2025-09-15",{"name":371,"class":51},"Muğla Sıtkı Koçman University",{"id":373,"slug":374,"hasResults":11,"nctId":375,"briefTitle":376,"officialTitle":377,"acronym":378,"eligibilityCriteria":379,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":380,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":382,"conditions":383,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":390,"locationsCount":52},"100553612","enhancing-care-study-in-patients-after-cabg-100553612","NCT06488352","Enhancing Care Study in Patients After CABG","Enhancing Care in Patients After Coronary Artery Bypass Graft Surgery (CABG)： OptiCABG Study","OptiCABG","Inclusion Criteria:\n\n* patients accepted CABG enrolled from January 2013 to June 2023\n\nExclusion Criteria:\n\n* patients discharged within 72 hours of admission\n* patients with an admission diagnosis of atrial fibrillation\n* patients underwent CABG as emergency surgery\n* patients underwent concurrent surgical treatments\n* patients with repeat admissions",{"count":381,"type":20},40000,"Review the data of patients who underwent coronary artery bypass grafting (CABG) at the National Center for Cardiovascular Disease, Fuwai Hospital from January 2013 to June 2023 including medical history, head CT scan, and postoperative, including 30-day mortality, arrhythmia, cerebrovascular disease and intracerebral haemorrhage, etc. Case-control and retrospective cohort studies were conducted to explore the risk factors associated with early postoperative complications, examine their relationship with postoperative management, explore independent risk factors of compound complications, and build predictive models.",[28],"2024-06-28",{"date":386,"type":45},"2024-07-05",{"date":388,"type":45},"2013-01-01",{"date":74,"type":20},{"name":391,"class":51},"Chinese Academy of Medical Sciences, Fuwai Hospital"]