[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"coronary-artery-disease-left-main\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:coronary-artery-disease-left-main":59},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100503025","fractional-flow-reserve-versus-angiography-for-treatment-decision-and-evaluation-of-significant-left-main-coronary-artery-disease-100503025",false,"NCT05829889","Fractional Flow Reserve Versus Angiography for Treatment-Decision and Evaluation of Significant Left MAIN Coronary Artery Disease","A Comparison of Fractional Flow Reserve- Versus Angiography-Guided Percutaneous Coronary Intervention in Patients With Left Main Coronary Artery Disease","FATE-MAIN","Inclusion Criteria:\n\n1. The subject must be ≥20 years of age with angina and\u002For evidence of myocardial ischemia.\n2. Significant de novo LMCA disease, defined as ≥ 50% diameter stenosis by visual estimation with or without concomitant non-left main major epicardial coronary artery disease, amenable to PCI with drug-eluting stent(DES) implantation.\n3. The patient or guardian agrees to the study protocol and the schedule of clinical follow-up, and provides informed, written consent, as approved by the appropriate Institutional Review Board\u002FEthical Committee of the respective clinical site.\n\nExclusion Criteria:\n\n1. left anterior descending coronary artery (LAD) or left circumflex coronary artery (LCx) chronic total occlusion (CTO)\n2. Extremely calcified or tortuous vessels precluding FFR measurement.\n3. The presence of complex coronary disease anatomy or lesion characteristics or other cardiac condition(s) which leads the participating interventional cardiologist to believe that PCI is not suitable (i.e. the subject should be managed with coronary artery bypass graft or medical therapy alone).\n4. Recent ST Elevation Myocardial Infarction(\\\u003C7 days prior to randomization).\n5. Cardiogenic shock and\u002For need for mechanical\u002Fpharmacologic hemodynamic support.\n6. Severe left ventricular dysfunction (ejection fraction \\\u003C30%).\n7. Requirement for other cardiac surgical procedure (e.g., valve replacement or aorta surgery).\n8. Contraindication or inability to take aspirin or P2Y12 inhibitors (clopidogrel, ticagrelor, or clopidogrel).\n9. Prior PCI of the left main trunk.\n10. Prior coronary artery bypass graft surgery.\n11. Subjects requiring or who may require additional surgery (cardiac or noncardiac) within 1 year.\n12. End-stage renal disease requiring renal replacement therapy.\n13. Liver cirrhosis.\n14. Pregnant and\u002For lactating women.\n15. Concurrent medical condition with a limited life expectancy of less than 2 years.\n16. Subjects who are actively participating in another drug or device investigational study, which have not completed the primary endpoint follow-up period. However, where at least one or more conditions are satisfied, it could be an exception according to an investigator's discretion;\n\n1\\) Participated in the observational study expected no effect on the safety and\u002For effectiveness evaluation of this trial.\n\n2\\) Screening failed before any interventional factor is involved.\n\n3\\) Participated in academic trials like strategic comparison studies conducted under standard therapy provided that there is no additional risk or a specific procedure to a subject and no interference between this trial and other studies.","ALL","20 Years",{"count":20,"type":21},960,"ESTIMATED","INTERVENTIONAL",[24],"NA","The primary purpose of the study was to determine whether the 2-year probability of major adverse cardiac events (primary composite outcome) differed significantly between patients who underwent angiography-guided Percutaneous Coronary Intervention(PCI) and those who underwent Fractional Flow Reserve(FFR)-guided PCI in patients with Left Main Coronary Artery disease(LMCA).",[27,28],"Coronary Artery Disease Left Main","Coronary Artery Disease",[30,31],"Fractional Flow Reserve","Percutaneous Coronary Intervention","RECRUITING","2026-06-23",{"date":35,"type":36},"2026-06-24","ACTUAL",{"date":38,"type":36},"2024-04-25",{"date":40,"type":21},"2027-12",{"name":42,"class":43},"Seung-Jung Park","OTHER",49,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":55,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100601738","optimization-of-complex-percutaneous-coronary-intervention-with-liberal-use-of-intracoronary-imaging-versus-contemporary-practice-100601738","NCT07114393","Optimization of Complex Percutaneous Coronary Intervention With Liberal Use of Intracoronary Imaging Versus Contemporary Practice","OPTIMIZE-PCI 2","Inclusion Criteria:\n\n* All patients above the age of 18, included in the Netherlands Heart Registration (NHR) quality database after receiving PCI in complex coronary lesions, will be included in the analyses of this project.\n* Meeting one or more of the following complexity criteria:\n\n  * Left main: A stenosis of \\>50% and\u002For a FFR ≤ 0.80 and iFR ≤ 0.89 in the left main.\n  * Severely calcified lesion: Defined as use of calcium modification therapy (e.g. cutting balloon, scoring balloon, rotablation, orbital atherectomy, intravascular lithotripsy).\n  * Chronic total occlusion: Coronary CTO is defined as an obstruction of the coronary artery with the following classic lesion characteristics:\n\n    * TIMI flow 0\n    * Absence of contrast stasis at the site of the proximal capillaries\n    * Presence of collateral vessels\n    * Estimated occlusion duration of at least 3 months.\n  * Ostial lesion: Lesion at the origin (within 5 mm) of a major coronary vessel (LM, LAD, RCX and RCA).\n  * Long lesion: A vessel treated with one or multiple stents with a total stent length of ≥38 mm is considered a long lesion.\n  * Bifurcation (true): A coronary artery narrowing occurring adjacent to, and\u002For involving, the origin of a significant side branch ≥ 2.5mm. Only true bifurcation will be included, i.e. medina 1,1,1\u002F1,0,1\u002F0,1,1.\n  * In-stent restenosis: A reduction ≥50% of the luminal diameter within the previously stented segment or the vessel segments 5 mm proximal and distal to the stent (the \"stent edges\"), as assessed by coronary angiography.\n\nExclusion Criteria:\n\n\\- Non complex PCI","18 Years",{"count":54,"type":21},11092,"1 Year","OBSERVATIONAL","Coronary artery disease remains a leading cause of mortality worldwide and is commonly treated with percutaneous coronary intervention (PCI). Typically, PCI is guided by invasive coronary angiography (ICA). However, ICA has inherent limitations in accurately assessing vessel dimensions, calcium burden, circumferential tissue and whether a stent has achieved full expansion. Therefore ICA alone is insufficient for guiding stent optimization, especially in complex lesions which are most vulnerable to long-term stent failure. To overcome the limitations of ICA, intracoronary imaging can be used to guide and optimize PCI. The advantages of intracoronary imaging include obtaining larger lumen areas, better stent expansion and strut apposition, full lesion stent coverage and identifying stent complications. Multiple randomized studies have shown that these advantages translate into a reduction in major adverse cardiovascular events (MACE) in complex PCI. Consequently, the recommendation for intracoronary imaging has been upgraded in the most recent guidelines.\n\nDespite robust evidence supporting its benefits, intracoronary imaging remains relatively underused in real-world practice and in the Netherlands it is only used in 7% of complex PCI procedures. This underutilization may be attributed to several factors, including operator and hospital-dependent issues such as lack of experience, reluctance to spend additional time on intracoronary imaging and concerns about its cost-effectiveness. Therefore, initiating an implementation project to incorporate intracoronary imaging into routine use in the catheterization lab during complex PCI would be highly valuable. Such a project could make imaging-guided PCI the standard of care in complex PCI. Additionally, it could evaluate the cost-effectiveness of routine intracoronary imaging during complex PCI.\n\nFor this reason we designed the OPTIMIZE-PCI II, a national registry-based quality improvement project. This project is aimed at implementing a liberal intracoronary imaging-guided strategy for complex PCI across multiple centres in the Netherlands, with data extraction from the Netherlands Heart Registration (NHR) database. The objective of the OPTIMIZE-PCI II is to establish a routine use of intracoronary imaging in complex PCI, to determine if this approach reduces adverse cardiac events in real-world practice, and evaluate its cost-effectiveness.",[28,59,60,61],"Coronary Artery Disease (Left Main)","Chronic Total Occlusion (CTO)","Bifurcation Coronary Artery Disease",[63,64,65,66],"percutaneous coronary intervention","intracoronary imaging","stent optimization","complex coronary artery disease","2026-03-24",{"date":69,"type":36},"2026-03-27",{"date":71,"type":36},"2025-04-01",{"date":73,"type":21},"2027-05-01",{"name":75,"class":43},"Cathreine BV",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":76},"100601867","qfr-for-branch-stenosis-after-single-stent-in-bifurcation-lesions-100601867","NCT07116083","µQFR for Branch Stenosis After Single Stent in Bifurcation Lesions","Diagnostic Performance of µQFR for Residual Functional Stenosis in Bifurcation Lesions After Single-stenting Strategy","Inclusion Criteria:\n\n1. Age ≥ 18 years and provision of written informed consent for biospecimen donation upon hospital admission.\n2. Clinical suspicion or diagnosis of CAD requiring coronary angiography and physiological assessment.\n3. Angiographically confirmed true bifurcation lesions, including but not limited to: left main-left anterior descending-left circumflex (LM-LAD-LCx), left anterior descending-diagonal (LAD-Dg), left circumflex-obtuse marginal (LCx-OM), and right coronary artery-posterior left ventricular-posterior descending artery (RCA-PLV-PDA).\n4. Bifurcation lesion vessel diameter ≥ 2.5 mm with visually estimated angiographic diameter stenosis ≥ 50%.\n\nExclusion Criteria:\n\n1. Acute myocardial infarction.\n2. Cardiogenic shock or severe heart failure (Killip class IV).\n3. Serum creatinine \\> 150 μmol\u002FL or estimated glomerular filtration rate (eGFR) \\\u003C 45 mL\u002Fmin\u002F1.73 m² calculated using the CKD-EPI formula.\n4. Known allergy to iodinated contrast media.\n5. History of coronary artery bypass graft surgery.",{"count":85,"type":21},290,"Murray-law based single-view quantitative flow ratio (µQFR) has been recommended for guiding percutaneous coronary intervention (PCI) in selective patients. However, it's reliability has not been validated in bifurcation lesions which present complex anatomy and flluid conditions before and after PCI. The goal of this study is to investigate the diagnostic performance of µQFR in side branch after single-stent treatment for bifurcation lesions in patient with obstructive coronary artery diseases.",[28,59,88,89],"Obstructive Coronary Artery Disease","Stent Implantation",[91,92],"Functional Flow Reserve","Quantitative Flow Ratio","2026-01-28",{"date":95,"type":36},"2026-02-02",{"date":97,"type":36},"2025-08-13",{"date":99,"type":21},"2026-10-31",{"name":101,"class":43},"Shanghai Zhongshan Hospital"]