[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"coronary-atheroscleroses\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:coronary-atheroscleroses":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,46,68,92,112,141],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100577090","risk-evaluation-by-coronary-imaging-and-artificial-intelligence-based-functional-analyzing-techniques---iii-100577090",false,"NCT06793774","Risk Evaluation by COronary Imaging and Artificial intelliGence Based fuNctIonal analyZing tEchniques - III","Risk Evaluation by Coronary Imaging and Artificial Intelligence-Based Functional Analyzing Techniques: Integrated Plaque Analysis by Coronary CT Angiography and Intracoronary Imaging.","RECOGNIZE-III","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patients with CCS or NSTE-ACS\n* Receive CCTA scan, with marginal lesions (DS between 40%-69%) or obstructive lesions (DS ≥70% or CT-FFR \\\u003C0.8) in major coronary arteries\n* Receive invasive coronary angiography and intracoronary imaging examination, including IVUS, OCT, NIRS, within 1 month after CCTA\n\nExclusion Criteria:\n\n* Unsuitable for CCTA (such as severe renal impairment, uncontrolled thyroid condition, allergic to iodine, etc.)\n* Receive percutaneous coronary intervention (PCI) within 6 months\n* Prior history of myocardial infarction or heart failure\n* Prior history of coronary artery bypass graft (CABG)\n* Abnormal liver function (serum alanine aminotransferase \\[ALT\\] level exceeding 3 times the upper limit of normal) or abnormal kidney function (eGFR ≤30%)\n* Familial hypercholesterolemia\n* Estimated survival ≤ 1 year\n* Malignant tumor\n* Pregnant or lactation, or have the intention to give birth within one year\n* Poor compliance, unable to follow-up","ALL","18 Years",{"count":20,"type":21},300,"ESTIMATED","2 Years","OBSERVATIONAL","This is a single-center, prospective cohort study. This study is designed to accurately analyze coronary artery plaque characteristics and local hemodynamic parameters in patients diagnosed with chronic coronary syndrome (CCS) or non-ST-segment elevation acute coronary syndrome (NSTE-ACS), with marginal lesions or obstructive lesions in major coronary arteries by multimodality imaging including noninvasive coronary CT angiography (CCTA) and intracoronary imaging techniques, such as intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near infrared spectroscopy (NIRS). The purpose of this study is to improve the accuracy and depth of plaque analysis by CCTA under the guidance of intracoronary imaging, therefore constructing a new CCTA-based high-risk plaque model.",[26,27,28],"Coronary Artery Disease","Coronary Atheroscleroses","Acute Coronary Syndromes (ACS)",[30,31,32],"coronary CT angiography","intracoronary imaging","coronary optical coherence tomography","RECRUITING","2025-01-21",{"date":36,"type":37},"2025-01-27","ACTUAL",{"date":39,"type":37},"2024-07-01",{"date":41,"type":21},"2027-12-31",{"name":43,"class":44},"Ruijin Hospital","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":56,"studyType":23,"phases":4,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":64,"startDateStruct":65,"completionDateStruct":66,"leadSponsor":67,"locationsCount":45},"100577091","risk-evaluation-by-coronary-imaging-and-artificial-intelligence-based-functional-analyzing-techniques---iv-100577091","NCT06793787","Risk Evaluation by COronary Imaging and Artificial intelliGence Based fuNctIonal analyZing tEchniques - IV","Risk Evaluation by Coronary Imaging and Artificial Intelligence-Based Functional Analyzing Techniques: Plasma Proteomic Profiles of Atheroma Classified by Intracoronary Imaging.","RECOGNIZE-IV","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patients with CCS or NSTE-ACS\n* Receive CCTA scan or ICA, with marginal lesions (DS between 40%-69%) or obstructive lesions (DS ≥70% or CT-FFR\u002FFFR \\\u003C0.8) in major coronary arteries\n* Receive invasive coronary angiography and OCT, with or without other intracoronary imaging techniques such as IVUS and NIRS\n\nExclusion Criteria:\n\n* Receive percutaneous coronary intervention (PCI) within 6 months\n* Prior history of myocardial infarction or heart failure\n* Prior history of coronary artery bypass graft (CABG)\n* Abnormal liver function (serum alanine aminotransferase \\[ALT\\] level exceeding 3 times the upper limit of normal) or abnormal kidney function (eGFR ≤30%)\n* Familial hypercholesterolemia\n* Estimated survival ≤ 1 year\n* Malignant tumor\n* Pregnant or lactation, or have the intention to give birth within one year\n* Poor compliance, unable to follow-up",{"count":55,"type":21},200,"24 Months","This study is a single-center, prospective cohort study. The study is designed to identify novel circulating biomarkers for early prediction of high-risk coronary plaques. Patients diagnosed with chronic coronary syndrome (CCS) or non-ST-segment elevation acute coronary syndrome (NSTE-ACS), with marginal lesions or obstructive lesions in major coronary arteries detected by noninvasive coronary CT angiography (CCTA) or invasive coronary angiography (ICA), will be consecutively enrolled. Optical coherence tomography (OCT), with or without other intracoronary imaging modalities such as intravascular ultrasound (IVUS) and near infrared spectroscopy (NIRS), will be performed. Liquid chromatography-mass spectrometry (LC-MS\u002FMS), bioinformatic analysis, and machine learning methods will be performed to characterize plasma proteomic profiles. The cohort will be followed-up every 3 months for 2 years. The association of novel biomarkers with the occurrence of major adverse cardiovascular events (MACEs) will be examined.",[26,27,28,59],"Chronic Coronary Syndrome",[61,62,63,31,30],"Acute coronary syndrome","Chronic coronary syndrome","Coronary vulnerable plaque",{"date":36,"type":37},{"date":39,"type":37},{"date":41,"type":21},{"name":43,"class":44},{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":74,"enrollmentInfo":75,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":77,"conditions":78,"keywords":79,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":45},"100557787","effect-of-pci-on-clinical-prognosis-of-chronic-coronary-artery-occlusion-100557787","NCT06542653","Effect of PCI on Clinical Prognosis of Chronic Coronary Artery Occlusion","Inclusion Criteria:\n\n* patients with at least one coronary CTO lesion at our hospital in between January 2011 and December 2017\n\nExclusion Criteria:\n\n* (1) patients with ST-segment elevation myocardial infarction (STEMI)\n* (2)a history of coronary artery bypass grafting (CABG)\n* (3) cardiogenic shock\n* (4) malignant tumor. Patients were referred for PCI based on CTO-related symptoms or evidence of viability, or corresponding ischemia in the area of the CTO artery.","75 Years",{"count":76,"type":21},258,"Coronary chronic total occlusions (CTOs) are considered to increase the risk of adverse clinical outcomes. The purpose of this study was to evaluate whether long-term clinical outcomes could be improved by successful percutaneous coronary intervention (PCI) over optimal medical therapy (OMT) in CTO patients.",[27],[80,81,82],"Chronic total occlusion","Percutaneous coronary intervention","Major adverse cardiovascular events","2024-12-23",{"date":85,"type":37},"2024-12-27",{"date":87,"type":37},"2023-09-17",{"date":89,"type":21},"2025-09-17",{"name":91,"class":44},"The First Affiliated Hospital with Nanjing Medical University",{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":45},"100554607","postprandial-triglyceride-impact-on-coronary-atherosclerosis-in-non-diabetic-patient-in-sohag-university-hospital-100554607","NCT06501287","Postprandial Triglyceride Impact on Coronary Atherosclerosis in Non-Diabetic Patient in Sohag University Hospital","Postprandial Triglyceride Impact on Coronary Atherosclerosis in Non-Diabetic Patient in Sohag University Hospital [NCT ID Not Yet Assigned]","Inclusion criteria includes CAD based on coronary angiography, laboratory and ECG evidence.\n\nExclusion criteria:\n\nPatients with other co-morbidities diseases, such as liver and kidney disorders and thyroid diseases. Diabetic patients.",{"count":100,"type":21},160,"INTRODUCTION Cardiovascular diseases, including coronary artery disease (CAD), are the leading cause of mortality worldwide. Despite remarkable advancements in diagnostic and therapeutic approaches, CAD continues to pose formidable challenges. Atherosclerosis, characterized by the deposition of lipids, inflammatory cells, and fibrous tissue within the arterial walls, is the fundamental pathology underpinning CAD. Atherosclerosis development and progression are closely intertwined with lipid metabolism, particularly elevated levels of low-density lipoprotein cholesterol (LDL-C) and reduced levels of high-density lipoprotein cholesterol (HDL-C) \\*1+. However, emerging evidence suggests that postprandial triglyceride levels, the transient increase in triglycerides following a meal, may play a pivotal role in atherosclerotic processes \\*2+. Postprandial hypertriglyceridemia has been linked to various cardiovascular risk factors, including inflammation, endothelial dysfunction, oxidative stress, and altered hemostasis \\*3+. cardiovascular disease (CVD) causes death for 4 million subjects in Europe every year. It causes death for women \\*2.2 million (55%)+ than men \\*1.8 million (45%)+, and cardiovascular (CV) deaths under 65 years more prevalent in men (490 000 versus 193 000) \\*4+. Endothelial dysfunction was the main cause of vascular atherosclerosis. The damage of Endothelium cause lipids and macrophages accumulation (mostly lowdensity lipoprotein) in vessel injury site \\*5+. Lipids considered the major cause of atherosclerosis \\*6+. The increase of blood cholesterol (especially LDL) considered the main cause of the disease. High levels of triglycerides could be independent risk factor for coronary artery disease (CAD), particularly in women. Although, it was suggested that high level of density lipoproteins (HDLs) can prohibit these risk factors. Extensive examinations showed that lipid decrease the prevention of CAD in primary and secondary cases \\*7+. The level \\> 90% of total glyceride and\u002For LDL and level \\> 10% of HDL confirm dyslipidemia \\*8+",[27],"2024-07-08",{"date":105,"type":37},"2024-07-15",{"date":107,"type":37},"2024-05-01",{"date":109,"type":21},"2024-12-25",{"name":111,"class":44},"Fatma Madhy Eissa",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":119,"sex":17,"minAge":18,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":123,"conditions":124,"keywords":125,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":45},"100549772","screening-coronary-artery-disease-using-artificial-intelligence-in-non-contrast-computed-tomography-100549772","NCT06438393","Screening Coronary Artery Disease Using artiFicial intelligencE in Non-contrast Computed Tomography","SAFE-CT","Inclusion Criteria:\n\n\\- Patient with stable chest pain who underwent a CTCA\n\nExclusion Criteria:\n\n* Missing non-contrast CT image (coronary calcium score image)\n* Known coronary artery disease\n* Prior myocardial infarction\n* Prior PCI or CABG",true,"100 Years",{"count":122,"type":21},1000,"This project aims to improve direct patient care by reducing the risks of futile exposure to ionizing radiation and iodinated contrast in patients referred for coronary computed tomography angiography",[26,27],[126,127,128,129,130],"Artificial intelligence","Radiomics","Deep learning","Coronary artery disease","Non-contrast computed tomography","NOT_YET_RECRUITING","2024-05-27",{"date":134,"type":37},"2024-05-31",{"date":136,"type":21},"2024-06",{"date":138,"type":21},"2027-12",{"name":140,"class":44},"Universidade do Porto",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":17,"minAge":148,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":151,"conditions":152,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":45},"100535602","carotid-atherosclerosis-in-predicting-coronary-artery-disease-100535602","NCT06253962","Carotid Atherosclerosis in Predicting Coronary Artery Disease","CACA","Inclusion Criteria:\n\n* patients receive carotid ultrasound and coronary angiography\n\nExclusion Criteria:\n\n* None","14 Years","90 Years",{"count":122,"type":21},"Carotid plaque burden and composition features, particularly lipid necrotic core, are significantly associated with severity of CAD stenosis. This study aims to explore the relationship between various phenotypic patterns of carotid atherosclerosis with the prevalence, phenotype, and severity of coronary atherosclerosis. The patients with chest tightness or chest pain will receive carotid artery ultrasonography before coronary angiography so as to explore the relationship between them.",[153,27],"Carotid Atherosclerosis","2024-02-04",{"date":156,"type":37},"2024-02-12",{"date":158,"type":21},"2024-02-10",{"date":160,"type":21},"2028-12-31",{"name":162,"class":44},"Shanghai Zhongshan Hospital"]