[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"coronary-restenosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:coronary-restenosis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100611387","disease-characteristics-of-r-cad-100611387",false,"NCT07239921","Disease Characteristics of R-CAD","Disease Characteristics of Rapidly Progressive Coronary Artery Disease (R-CAD): A Case-control Study","Inclusion Criteria:\n\nCase Group (R-CAD patients):\n\n1. 18 years of age or older, male or female.\n2. Negative results of urine or blood pregnancy test for females with childbearing potential (not post-menopausal or surgically sterile).\n3. Prior history of coronary revascularization (PCI or CABG).\n4. Receiving standard treatment for secondary prevention of AS-CAD after the latest coronary revascularization.\n5. Rapidly progressive myocardial ischemia leading to hospitalization and\u002For coronary revascularization:\n\n   1. Typical symptoms of angina (Canadian Cardiovascular Society \\[CCS\\] classification III-IV) and non-invasive evidence of myocardial ischemia; and\n   2. Occurred within 6 months of the latest ischemia-driven hospitalization and\u002For coronary revascularization.\n6. Rapidly progressive coronary lesions leading to myocardial ischemia:\n\n   1. Angiographic evidence of new-onset or worsened coronary de novo or restenotic lesions relevant to myocardial ischemia, and\n   2. Occurred within 6 months of the latest ischemia-driven coronary angiography and\u002For revascularization.\n\nControl Group (NR-CAD patients):\n\n1. 35 to 75 years old\\*, male or female. (\\* Based on the age distribution characteristics of patients who have been diagnosed as R-CAD.)\n2. Negative results of urine or blood pregnancy test for females with childbearing potential (not post-menopausal or surgically sterile).\n3. Currently, at 12±6 months after the latest PCI.\n4. Receiving standard treatment for secondary prevention of AS-CAD after the latest PCI.\n5. Coronary angiography and\u002For optical coherence tomography (OCT) performed during the index hospitalization.\n6. No evidence of rapidly progressive myocardial ischemia and coronary lesions, i.e., not fulfilling items 5) and 6) of the inclusion criteria for R-CAD.\n\nExclusion Criteria:\n\n1. Receiving immunosuppressive therapy within 6 months.\n2. Coronary restenosis due to mechanical factors (stent under-expansion, stent mal-apposition, stent rupture, et al).\n3. Other moderate to severe heart diseases (congenital heart disease, valvular heart disease, myocarditis, cardiomyopathy, pericardial diseases, pulmonary hypertension, heart failure, arrhythmia, et al).\n4. Active malignancy (diagnosed within 12 months or with ongoing requirement for treatment).\n5. Vital organ failure.\n6. Life expectancy \\\u003C 1 year.\n7. In pregnancy or breast-feeding, or with intention to be pregnant during the study period.\n8. Risk of non-compliance (history of drug addiction or alcohol abuse, et al).\n9. Previous enrollment in this study.\n10. Participation in another study within 30 days.\n11. Involvement in the planning and conduct of this study (applying to investigators, contract research organization staffs, study site staffs, et al).\n12. Any condition, which in the opinion of the investigators, would make it unsuitable for the patient to participate in this study.","ALL","18 Years",{"count":19,"type":20},52,"ESTIMATED","OBSERVATIONAL","The present case-control study is designed to investigate the disease characteristics of rapidly progressive coronary artery disease (R-CAD) by comparing the demographics, clinical features, lab results, imaging findings, and prior treatment between patients in the case group (approximately 34 patients with R-CAD) and those in the control group (approximately 18 patients with non-rapidly progressive coronary artery disease \\[NR-CAD\\]).",[24,25,26,27,28,29,30],"Coronary Artery Disease","Coronary Artery Disease Progression","Coronary Stenosis","Coronary Restenosis","Coronary Stent Occlusion","Myocardial Revascularization","Percutaneous Coronary Intervention",[24,26,27,29,30,32,33],"Disease Progression","Disease Attributes","NOT_YET_RECRUITING","2025-11-21",{"date":37,"type":38},"2025-11-28","ACTUAL",{"date":40,"type":20},"2025-11",{"date":42,"type":20},"2026-10",{"name":44,"class":45},"Peking Union Medical College Hospital","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":55,"studyType":21,"phases":4,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100521900","complex-registry---a-prospective-cohort-study-to-describe-the-management-and-outcomes-of-patients-presenting-with-complex-and-calcified-coronary-artery-disease-100521900","NCT06075602","COMPLEX Registry - a Prospective COhort Study to Describe the Management and Outcomes of Patients Presenting with CompLEX and Calcified Coronary Artery Disease","COMPLEX","Inclusion Criteria:\n\n* Subject \\>18 years of age\n* Individuals presenting with chronic, complex and\u002For calcified CAD and requiring PCI or CABG\n* Complex coronary artery disease \u002F lesions must include at least one of the following attributes:\n* Long and\u002F or heavily calcified coronary lesions\n* In-stent restenosis\n* Chronic total occlusions (CTO)\n* Left main lesions\n* Bifurcation lesions\n* Bypass graft lesions\n* Small vessel disease \u002F coronary microvascular dysfunction (e.g. not amenable to PCI)\n* Subjects must be willing to sign a patient informed consent (PIC) or must have signed the General Consent (GK).\n\nExclusion Criteria:\n\nThe presence of any one of the following exclusion criteria will lead to exclusion of the patient.\n\n* Patient is \\\u003C18 years of age\n* Patient unwilling or unable to provide informed consent\n* Patients with no complex and calcified CAD",{"count":54,"type":20},5000,"10 Years","The purpose of the COMPLEX Registry is to prospectively and retrospectively collect baseline, clinical and procedural data of patients who have undergone PCI or CABG for complex and\u002F or calcified chronic CAD, irrespective of clinical presentation as well as to prospectively collect data about their clinical outcomes. The outcomes will be compared in different clinical subgroups (e.g. PCI vs. CABG). The impact of current PCI techniques\u002F devices, but also CABG strategies in different clinical settings and coronary artery lesions on cardiovascular outcomes will be assessed.",[58,24,27,59,60,61,62,63,64,65],"Coronary Disease","Coronary Arteriosclerosis","Coronary Artery Calcification","Stable Chronic Angina","Angina Pectoris","Angina, Stable","Angina, Unstable","Stent Thrombosis","RECRUITING","2024-10-27",{"date":69,"type":38},"2024-10-29",{"date":71,"type":38},"2021-11-01",{"date":73,"type":20},"2031-12-31",{"name":75,"class":45},"Luzerner Kantonsspital",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":84,"targetDuration":55,"studyType":21,"phases":4,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":88,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":92,"locationsCount":76},"100438392","siroop-registry---a-prospective-registry-study-to-evaluate-the-outcomes-of-coronary-artery-disease-patients-treated-with-sirolimus-or-paclitaxel-eluting-balloon-catheters-100438392","NCT04988685","SIROOP Registry - A Prospective Registry Study to Evaluate the Outcomes of Coronary Artery Disease Patients Treated With SIROlimus Or Paclitaxel Eluting Balloon Catheters","SIROOP","Inclusion Criteria:\n\n* Subject \\>18 years of age\n* Patients with significant acute or chronic coronary de-novo lesions or ISR lesions requiring treatment using PCI\n* Treatment with at least one DCB (device choice at the operator's discretion) In case of a patient with lesions treated at different procedural time, lesions will be separately collected and documented\n* Subjects must be willing to sign a patient informed consent (PIC) or must have signed the General Consent (GK).\n\nExclusion Criteria:\n\n* Patient is \\\u003C18 years of age\n* Patient unwilling or unable to provide informed consent\n* pregnancy and lactation\n* Indication for surgical revascularization",{"count":85,"type":20},2000,"The purpose of the SIROOP Registry is to retrospectively and prospectively collect baseline, clinical and procedural characteristics of patients who have undergone PCI and are treated with either currently available sirolimus or paclitaxel coated DCBs (see Table 1), irrespective of clinical presentation as well as to prospectively collect data about their clinical outcomes. Outcomes will be compared in different clinical subgroups. The impact of current DCBs in different clinical settings and coronary artery lesions on cardiovascular outcomes will be assessed.",[58,24,27,59,60,61,62,63,64,65],{"date":69,"type":38},{"date":90,"type":38},"2021-06-01",{"date":73,"type":20},{"name":75,"class":45}]