[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"coronary\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:coronary":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100642777","phase-4-capra-evo-a-randomized-serial-pcct-trial-of-early-evolocumab-after-acs-100642777",false,"NCT07612774","CAPRA-EVO: a Randomized Serial PCCT Trial of Early Evolocumab After ACS","A Single-center, Randomized Controlled Comparison of Effect of Evolocumab Versus Standard Lipid Lowering Therapy on Plaque Progression in Patients With Acute Coronary Syndrome by Serial PCCT(CAPRA-EVO Trial)","CAPRA-EVO","Inclusion Criteria:\n\nEligible patients must meet the following criteria:\n\n* Age between 40 and 75 years.\n* Diagnosis of ACS, including ST-elevation myocardial infarction (STEMI) or non-ST-elevation myocardial infarction (NSTEMI) or unstable angina (UA).\n* Successful PCI treatment, with post-procedural TIMI grade 3 flow and residual stenosis \\\u003C30% and atherosclerotic plaque presence in non-culprit coronary vessels (not attributed to this target event).\n* Suboptimal LDL-C control: Patients must have received any statin treatment for at least 4 weeks, with an LDL-C level ≥1.8 mmol\u002FL; or Statin-naive patients must have an LDL-C level ≥3.2 mmol\u002FL.\n* Agreement to complete baseline CCTA and laboratory tests within 7 days of enrollment and signed informed consent.\n* Commitment to complete 52 weeks of follow-up.\n\nExclusion Criteria:\n\n* History of coronary artery bypass grafting (CABG).\n* History of valve surgery.\n* History of PCI treatment before the index ACS event\n* Complex bifurcation lesions (Medina 1,1,1).\n* Use of PCSK9 inhibitors (e.g., evolocumab, alirocumab) or potent CYP3A4 inhibitors (e.g., itraconazole) within the last 12 months.\n* Known intolerance to statins, evolocumab, or other investigational drugs related to the study.\n* Hepatic or renal insufficiency (eGFR \\\u003C60 mL\u002Fmin\u002F1.73m² or ALT\u002FAST \\>3 times the upper limit of normal).\n* Active autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus).\n* Uncontrolled heart failure (NYHA class III-IV) or malignant arrhythmias.\n* Known allergy or hypersensitivity to iodinated contrast media\n* Hyperthyroidism or active thyroid disease\n* Pregnancy or breastfeeding (or plans for pregnancy within the next year).\n* Life expectancy of less than 1 year (e.g., due to advanced malignancy).\n* Participation in another interventional clinical trial within the past 3 months.","ALL","40 Years","75 Years",{"count":21,"type":22},233,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","The CAPRA-EVO trial is a single-center, randomized, open-label study with blinded endpoint assessment comparing early evolocumab plus standard lipid-lowering therapy versus standard-of-care lipid-lowering therapy in patients with acute coronary syndrome after successful percutaneous coronary intervention. The study will use serial photon-counting coronary computed tomography angiography at baseline and 52 weeks to assess changes in non-culprit coronary plaque burden and stenosis severity. Secondary outcomes include changes in high-risk plaque features, lipid and inflammatory biomarkers, cardiovascular events, and safety outcomes. The trial aims to determine whether early intensive LDL-C lowering with evolocumab can reduce coronary plaque progression and support PCCT-CCTA as a noninvasive tool for monitoring atherosclerotic plaque dynamics.",[28,29],"Coronary","Coronary Artery Disease",[31,32,33,34],"acute coronary syndrome","coronary computed tomography angiography","proprotein convertase subtilisin\u002Fkexin type 9","randomized controlled trial","RECRUITING","2026-06-05",{"date":38,"type":39},"2026-06-09","ACTUAL",{"date":41,"type":22},"2026-05-19",{"date":43,"type":22},"2029-01-31",{"name":45,"class":46},"West China Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100268807","france-pci-registry--national-observatory-of-interventional-cardiology-100268807","NCT02778724","France PCI Registry : National Observatory of Interventional Cardiology","Inclusion Criteria:\n\n* Age =\\>18 years at enrollment\n* Patient who have had a coronary angiogram or angioplasty\n\nExclusion Criteria:\n\n* Patient who didn't want to participated","18 Years",{"count":56,"type":22},40000,"OBSERVATIONAL","Rigorous clinical practice assessment is a key factor to improve patient's care and prognosis in interventional cardiology (IC). A multicentric IC observational study (CRAC), fully integrated to usual coronary activity report software, started in Centre Val de Loire (CVL) region in 2014.\n\nCRAC observatory was conduced on five IC CathLab of CVL region. Quality of collected data is regularly evaluated and allowed building an exhaustive, and reliable database. This solution could easily be developed in other French regions.",[60,61,62,28,63,64],"Interventional","Cardiology","Angioplasty","STEMI","Database","2022-03-29",{"date":67,"type":39},"2022-04-07",{"date":69,"type":4},"2014-01",{"date":71,"type":22},"2030-12",{"name":73,"class":46},"Club Régional des Angioplasticiens de la région Centre",15]