[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cortical-blindness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cortical-blindness":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,44,81,120,149,169],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100641789","multisensory-rehabilitation-of-vision-loss-after-cortical-damage-100641789",false,"NCT07659691","Multisensory Rehabilitation of Vision Loss After Cortical Damage","Inclusion Criteria:\n\n* Patients will be recruited from the local subject population hospitalized\u002Fseen by Ophthalmology, Neurosurgery, and Neurology at Atrium Health Wake Forest Baptist\n* diagnosis of stable homonymous hemianopia (\\>4 weeks) with absence of hemineglect\n* a lesion encompassing at least primary visual cortex but sparing parietal cortex, to include lesions caused by an ischemic or hemorrhagic stroke or post-surgical changes due to an oncologic or non-oncologic tumor\n* normal or correctable auditory and cognitive function\n* willingness to participate in the three-month program\n* ability to perform visual discriminations in their intact field\n* life expectancy ≥12 months\n\nExclusion Criteria:\n\n* diagnosis of an unstable homonymous hemianopia and\u002For with hemineglect,\n* Abnormal or uncorrectable auditory and cognitive function\n* unwillingness to participate in the program\n* inability to perform the visual testing in their intact field\n* life expectancy \\\u003C 12 months\n* Any other condition that would compromise their ability to complete the study.","ALL","18 Years","85 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","Damage to visual cortex on one side of the brain frequently produces a profound and permanent blindness in contralesional space (hemianopia), a debilitating condition that causes enormous suffering for patients and their families.",[26],"Cortical Blindness",[28,29,30],"hemianopia","blindness","multisensory training","NOT_YET_RECRUITING","2026-06-15",{"date":34,"type":35},"2026-06-22","ACTUAL",{"date":37,"type":20},"2026-08",{"date":39,"type":20},"2027-12",{"name":41,"class":42},"Wake Forest University Health Sciences","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":65,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":43},"100642991","home-based-vision-rehabilitation-guided-by-brain-imaging-100642991","NCT07635329","Home-based Vision Rehabilitation Guided by Brain Imaging","Behavioral Rehabilitation Through Image-Guided Home-based Training","BRIGHT","Inclusion Criteria:\n\n1. At least 18 years of age.\n2. Capable of providing informed consent and complying with study procedures.\n3. Unilateral or bilateral focal brain damage causing visual field loss.\n4. At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.\n5. Eligible for MRI based on standard safety screening.\n\nExclusion Criteria:\n\n1. Severe neurological or psychiatric conditions unrelated to the focal lesion that may interfere with study participation or data interpretation.\n2. Current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.\n3. Ocular disease or disorder.",{"count":53,"type":20},100,[23],"The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss.\n\nUsing a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.",[57,58,59,60,26,61,62,63,64],"Visual Field Defect","Stroke","Hemianopia Homonymous","Quadrantanopia","Visual Field Defect, Peripheral","Visual Field Loss","Traumatic Brain Injury","Brain Tumor",[66,67,68,69,70],"neuroplasticity","stroke","vision","TBI","brain tumor","RECRUITING","2026-06-03",{"date":74,"type":35},"2026-06-09",{"date":76,"type":20},"2026-07-01",{"date":78,"type":20},"2030-03-31",{"name":80,"class":42},"Georgetown University",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":21,"phases":91,"briefSummary":92,"conditions":93,"keywords":99,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":43},"100445805","improving-visual-field-deficits-with-noninvasive-brain-stimulation-100445805","NCT05085210","Improving Visual Field Deficits With Noninvasive Brain Stimulation","Visual Restoration of Losses Caused by Cortical Damage: a New Protocol to Promote Fast Recovery","Inclusion Criteria:\n\n1. 18 years of age or older.\n2. Presence of some intact visual cortical areas (other than primary visual cortex) in the damaged brain hemisphere. This assessment will be made from MRI or CT scans of the subject's head, which will be obtained via standard release from their neurologist.\n3. First ever ischemic or hemorrhagic stroke with damage to primary visual cortex, and rendered blind over a portion of their visual field.\n\n   * Ischemic stroke patients will be either subacute (within 6 months of their stroke) or chronic (more than 6 months)\n   * Hemorrhagic stroke patients will be chronic only (greater than 6 months)\n4. Must demonstrate a clear deficit in either simple or complex visual perception in portions of their visual field as measured by visual perimetry.\n5. Imaging evidence that the stroke is primarily affecting the visual cortex.\n6. Willing and able to participate in the study protocol and to comply with study procedures.\n\nExclusion Criteria:\n\n1. No evidence of damage to the primary visual cortex.\n2. Visual cortex damage as a result of a subsequent stroke (not primary).\n3. Total cortical blindness, covering both left and right visual fields.\n4. Unable to fixate visual targets precisely or unable to perform the visual training exercises as directed.\n5. Complete loss of reading abilities.\n6. Current or prior history of any neurological disorder other than stroke, such as epilepsy, a progressive neurologic disease (e.g. multiple sclerosis) or intracranial brain lesions other than the qualifying stroke lesion.\n7. Current history of poorly controlled migraines including chronic medication for migraine prevention.\n8. History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or immediate (1st degree relative) family history of epilepsy; with the exception of a single seizure of benign etiology (e.g. febrile seizure) in the judgment of the investigator.\n9. History of fainting spells of unknown or undetermined etiology that might constitute seizures.\n10. Past or current history of major depression, bipolar disorder or psychotic disorders, or any other major psychiatric condition.\n11. Participants who are suffering from one-sided attentional neglect as determined by standard neuropsychological tests: figure cancellation and line bisection tasks.\n12. Contraindication for receiving tRNS.\n13. Chronic (particularly) uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.).\n14. Any complex, uncontrolled\u002Funstable or terminal medical illness.\n15. Substance abuse or dependence within the past six months.\n16. Medications will be reviewed by the responsible MD (Drs. Sandeep Kumar or Dan Press) and a decision about inclusion will be made based on the following: The patient's past medical history, drug dose, history of recent medication changes or duration of treatment, and combination of CNS active drugs.\n17. All female participants that are pre-menopausal will be required to have a pregnancy test; any participant who is pregnant or breastfeeding will not be enrolled in the study.\n18. Subjects who, in the investigator's opinion, might not be suitable for the study.\n19. A hair style or head dress that prevents electrode contact with the scalp or would interfere with the stimulation (for example: thick braids, hair weave, afro, wig).\n20. Additional criteria for Group 1b only: Contraindication for using VR technology, specifically an implanted medical device such as a pacemaker, implanted defibrillator, deep brain or vagal nerve stimulator. Participants with a history of seizures are already excluded per the above criteria.","80 Years",{"count":90,"type":20},24,[23],"This is a randomized, pilot interventional study in participants with visual field deficit (VFD) caused by cortical lesion. Damage to the primary visual cortex (V1) causes a contra-lesional, homonymous loss of conscious vision termed hemianopsia, the loss of one half of the visual field. The goal of this project is to elaborate and refine a rehabilitation protocol for VFD participants. It is hypothesized that visual restoration training using moving stimuli coupled with noninvasive current stimulation on the visual cortex will promote and speed up recovery of visual abilities within the blind field in VFD participants. Moreover, it is expected that visual recovery positively correlates with reduction of the blind field, as measured with traditional visual perimetry: the Humphrey visual field test or an eye-tracker based visual perimetry implemented in a virtual reality (VR) headset. Finally, although results will vary among participants depending on the extent and severity of the cortical lesion, it is expected that a bigger increase in neural response to moving stimuli in the blind visual field in cortical motion area, for those participants who will show the largest behavioral improvement after training. The overarching goals for the study are as follows: Group 1a will test the basic effects of transcranial random noise stimulation (tRNS) coupled with visual training in stroke cohorts, including (i) both chronic\u002Fsubacute ischemic and chronic hemorrhagic VFD stroke participants, and (ii) longitudinal testing up to 6 months post-treatment. Group 1b will test the effects of transcranial tRNS coupled with visual training on a Virtual Reality (VR) device in stroke cohorts, including both chronic\u002Fsubacute ischemic and chronic hemorrhagic VFD stroke participants. Group 2 will examine the effects of tRNS alone, without visual training, also including chronic and subacute VFD stroke participants and longitudinal testing.",[61,58,94,95,60,26,96,97,98],"Visual Impairment","Hemianopsia","Visual Field Defect Homonymous Bilateral","Occipital Lobe Infarct","Visual Fields Hemianopsia",[100,101,102,103,104,105,106,107,108,109,110],"Visual Field defects","Occipital Stroke","Ischemic Stroke","visual cortex","noninvasive brain stimulation","transcranial direct current stimulation","visual training","visual recovery","vision loss","quadrantanopia","Hemorrhagic stroke","2026-03-03",{"date":113,"type":35},"2026-03-04",{"date":115,"type":35},"2022-01-25",{"date":117,"type":20},"2026-06",{"name":119,"class":42},"Beth Israel Deaconess Medical Center",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":128,"sex":15,"minAge":129,"maxAge":88,"enrollmentInfo":130,"targetDuration":4,"studyType":131,"phases":4,"briefSummary":132,"conditions":133,"keywords":137,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":43},"100603304","mechanisms-of-visual-restoration-after-occipital-stroke-100603304","NCT07134777","Mechanisms of Visual Restoration After Occipital Stroke","Mechanisms of Visual Restoration After Occipital Stroke (MOVROS)","MOVROS","Cortically Blind Subjects (n=50)\n\nInclusion:\n\n* Subjects between 21 and 80 years of age\n* Subjects must be residents of the United States or Canada\n* Subjects must exhibit unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 80 years (verified by MRI and\u002For CT scans)\n* Subjects with reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey, MAIA, Goldmann, and\u002For equivalent perimetry. This deficit must be large enough to enclose a 5-deg diameter visual stimulus.\n* Subjects must be able to fixate on visual targets reliably for 1000ms, with jitter over less than 1-deg of visual angle.\n\n  o Note: This will be initially assessed by review of visual field reports as supplied by subjects during the screening process. However, we will be unable to fully assess their fixation ability until they start the psychophysics testing in our lab. If at that time we discover that they are unable to maintain adequate fixation, they will be withdrawn from the study.\n* Subjects must be willing, able, and competent to provide their own informed consent\n* Subjects must have their own home computer (desktop or laptop) and reliable internet access\n* All subjects must have normal cognitive abilities and memory, sufficient to be able to understand and follow written and oral instructions in English, as well as to remember how to complete visual training at home, on their own, as instructed, for several months.\n* Justification: We can only accept English-speaking subjects due to a lack of resources for supporting those who would require interpreter services. As all of our subjects are required to spend 3-5 days in lab with rigorous testing and training requirements, we must be able to communicate clearly and with minimal misunderstandings. This would require for up to 5-full days of in person interpreter services, for which we do not have funding. Additionally, ongoing communications take place by phone, email, and\u002For text as a part of home training (for routine check-ins and technical support for example) in the intervals between laboratory visits. This would require us to essentially have \"on demand\" access to interpreter services, which is simply not feasible.\n* Subjects must be safe and willing to undergo magnetic resonance imaging (MRI) scans\n\nExclusion:\n\n* Subjects who have past or present ocular disease interfering with visual acuity\n* Subjects with best-corrected visual acuity (BCVA) worse than 20\u002F40 in either eye\n* Subjects who have documented or suspected damage to the dorsal Lateral Geniculate Nucleus\n* Subjects who have diffuse whole-brain degenerative processes\n* Subjects who have experienced traumatic brain injury\n* Subjects who have any other brain damage deemed by study staff to potentially interfere with training ability or outcome measures\n* Subjects who have oculomotor defects deemed by study staff to potentially interfere with training ability or outcome measures (i.e., by impairing stable fixation during testing or training)\n* Subjects who have documented history of drug\u002Falcohol abuse\n* Subjects who are currently taking neuroactive medications which would impact training, as determined by PI\n* Subjects who have cognitive, memory or seizure disorders\n* Subjects with one-sided attentional neglect\n* Subjects who lack the competence or are otherwise unable to perform the visual training exercises as directed.\n* Subjects who have contradictions to MRI scanning will be excluded. These contraindications include: a) central nervous system aneurysm clips; b) implanted neural stimulator; c) implanted cardiac pacemaker or defibrillator; d) cochlear implant; e) ocular foreign body (e.g., metal shavings); f) insulin pump; g) metal shrapnel or bullet; h) any implanted device that is incompatible with MRI.\n* Subjects who have conditions that preclude MRI scanning, e.g., morbid obesity, claustrophobia.",true,"21 Years",{"count":53,"type":20},"OBSERVATIONAL","This project will collect brain imaging data to quantify the effects of early visual cortex damage and visual training interventions on the structure and function of the residual visual system. Our goal is to improve understanding of the consequences of permanent visual cortex damage in humans, and to understand how visual training impacts the function of the residual visual system to restore perception.",[26,134,135,98,136,59,97],"Stroke Ischemic","Vision Loss Partial","Hemianopia",[138,108,139],"occipital stroke","Homonymous quadranopsia","2025-11-26",{"date":142,"type":35},"2025-12-04",{"date":144,"type":35},"2025-10-17",{"date":146,"type":20},"2029-08-01",{"name":148,"class":42},"University of Rochester",{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":21,"phases":158,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":43},"100601043","visual-plasticity-following-brain-lesions-100601043","NCT07105358","Visual Plasticity Following Brain Lesions","Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training","VIBRANT","A. Stroke, brain tumor, or traumatic brain injury patients\n\nInclusion Criteria:\n\n1. At least 18 years of age.\n2. Capable of providing informed consent and complying with study procedures.\n3. Unilateral or bilateral focal brain damage causing loss of vision.\n4. At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.\n\nExclusion Criteria:\n\n1. Severe CNS diseases or disorders unrelated to the focal lesion, which could interfere with study results.\n2. Severe mental health challenges that could interfere with study results, or current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.\n3. Vision loss resulting from ocular disease or disorder.\n\nB. Healthy volunteers (age-matched controls):\n\nInclusion Criteria:\n\n1. At least 18 years of age.\n2. Capable of providing informed consent and complying with study procedures.\n\nExclusion Criteria:\n\n1. Any CNS diseases or psychiatric disorders (e.g., epilepsy, schizophrenia) that would interfere with study results.\n2. Previous head injury.\n3. Present or past (within past 6 months) drug or alcohol abuse or addiction based on DSM-5.",{"count":19,"type":20},[23],"The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual field loss resulting from damage to the post-chiasmatic visual pathways. It aims to investigate whether transcranial random noise stimulation (tRNS) combined with perceptual learning-based training has potential for improving visual impairments.",[57,58,136,60,26,64,63,61],"2025-07-29",{"date":163,"type":35},"2025-08-05",{"date":165,"type":35},"2025-07-17",{"date":167,"type":20},"2028-06-30",{"name":80,"class":42},{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":128,"sex":15,"minAge":129,"maxAge":88,"enrollmentInfo":177,"targetDuration":4,"studyType":21,"phases":178,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":43},"100525398","effect-of-visual-retraining-after-stroke-100525398","NCT06121219","Effect of Visual Retraining After Stroke","Effect of Visual Retraining on Visual Loss Following Cortical Damage","urochester","Cortically Blind Subjects\n\nInclusion:\n\n* Between 21 and 80 years of age\n* Residents of the United States or Canada\n* Unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range (21-75 years)\n* Reliable visual field defects in both eyes as measured by Humphrey, MAIA, Goldmann, and\u002For equivalent perimetry, large enough to enclose a 5-deg diameter visual stimulus.\n* Able to fixate on visual targets reliably for 1000ms\n* Must have a home computer (desktop or laptop) and reliable internet access\n* Willing, able, and competent to provide informed consent\n* Normal cognitive abilities, able to understand written and oral instructions in English, and competent and responsible adults in order to complete the visual training at home, independently, as instructed, for several months.\n\nExclusion:\n\n* Past or present eye disease interfering with visual acuity\n* BCVA worse than 20\u002F40 in either eye\n* Damage to the dorsal Lateral Geniculate Nucleus\n* Diffuse whole brain degenerative processes\n* History of traumatic brain injury\n* Any other brain damage deemed by study staff to potentially interfere with training ability or outcome measures\n* Documented history of drug\u002Falcohol abuse\n* Currently taking neuroactive medications which would impact training, as determined by PI\n* Presence of cognitive or seizure disorders\n* One-sided attentional neglect\n* Subjects who lack the competence or are otherwise unable to perform the visual training exercises as directed.\n\nControl Subjects (n = 50)\n\nInclusion:\n\n* Between 21 and 80 years of age\n* Report no history of neurological disorder.\n* Competent and responsible, as determined by the Principal Investigator.\n\nExclusion:\n\n* Presence of damage to the visual system\n* Presence of an active disease process involving their nervous system.\n* Cognitive or seizure disorders\n* Best corrected visual acuity worse than 20\u002F40 in either eye\n* Presence of vision field loss from ocular disease or disorder",{"count":53,"type":20},[23],"This project is intended to collect data using standard clinical tests and psychophysics to quantify the effect of visual cortical damage on the structure of the residual visual system, visual perception, spatial awareness, and brain function. The investigators will also assess the effect of intensive visual retraining on the residual visual system, processing of visual information and the use of such information in real-world situations following damage. This research is intended to improve our understanding of the consequences of permanent visual system damage in humans, of methods that can be used to reverse visual loss, and of brain mechanisms by which visual recovery is achieved.",[135,181,59,136,60,182,183,26],"Vision; Loss, Both Eyes","Stroke, Ischemic","Stroke - Occipital Infarction","2025-07-10",{"date":186,"type":35},"2025-07-16",{"date":188,"type":35},"2024-09-05",{"date":190,"type":20},"2032-01",{"name":148,"class":42}]