[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cortical-excitability\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cortical-excitability":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,53,81,109],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100643362","assessing-the-effects-of-hormones-on-noninvasive-transcranial-stimulation-100643362",false,"NCT07635017","Assessing the Effects of Hormones on Noninvasive Transcranial Stimulation","Inclusion Criteria:\n\n* Age between 18 and 40 years old\n* Female subjects must have regular menstrual cycles (defined as a cycle that occurs at predictable intervals, typically between 24 and 38-days length) via self-report\n\nExclusion Criteria:\n\n* Allergies to henna\n* Allergies to gel used for electrodes\n* History of seizures or epilepsy\n* Subjects must not have any serious disease, disorder, infection, or cognitive impairments that could affect their ability to participate in this study.\n* Female subjects of child-bearing potential must not be pregnant\n* Subjects must not have any implanted stimulators or pulse generators\n* Subjects must not have heart disease, including known arrhythmia\n* Subjects must not have any metal implants in their head",true,"ALL","18 Years","40 Years",{"count":20,"type":21},25,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is investigating how two types of non-invasive brain stimulation, transcranial electrical stimulation (TES) and transcranial magnetic stimulation (TMS), affect brain activity, and whether combining them produces stronger or more consistent effects than either one used alone. The motivation for this comes from the observation that TMS, which is FDA-approved for treating depression, tends to work less well in postmenopausal women because lower estrogen levels reduce the brain's ability to respond to stimulation. The research team believes that pairing TMS with TES, which targets a different set of brain cells, may be able to overcome this hormonal barrier and make stimulation more effective. Participants will come into the lab for up to 24 visits over 8 months, beginning with an initial visit to establish the right stimulation settings, followed by a series of stimulation sessions in which brain activity is measured before and after receiving either TES, TMS, or both together. For female participants, sessions will be scheduled at specific points in the menstrual cycle to capture the natural monthly rise and fall of estrogen, while male participants will be scheduled on a comparable fixed interval as a comparison group. The insights gained from this study could directly inform the development of better, more reliable brain stimulation treatments for women with depression.",[27,28,29,30,31],"Cortical Excitability","Healthy","TMS","Menstrual Cycle","Menopause",[33,34,35,36,37,38,27,39],"Transcranial Magnetic Stimulation","Transcranial Electrical Stimulation","Noninvasive Neuromodulation","Perimenopause","Electromyography","Hormones","Synaptic Plasticity","NOT_YET_RECRUITING","2026-06-04",{"date":43,"type":44},"2026-06-09","ACTUAL",{"date":46,"type":21},"2026-07-01",{"date":48,"type":21},"2028-07-01",{"name":50,"class":51},"Carnegie Mellon University","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":52},"100637576","rtms-induced-reduction-in-m1-excitability-100637576","NCT07588113","rTMS Induced Reduction in M1 Excitability","The Effects of rTMS Induced Reduction in M1 Excitability on Early-online Learning and Retention in Dexterous Video-game Task","Inclusion Criteria:\n\n* Between ages 18 and 45 years old (to avoid any changes in the developing brain, or with aging).\n* Answer 'no' to questions 2 through 17 on the brain stimulation questionnaire as these factors can increase likelihood of adverse events with brain stimulation.\n* No neurological damage, disease, or dysfunction (nerve damage, chronic pain disorders, diabetic neuropathy, epilepsy) that affect the upper limbs and limit the ability to complete the study, and\u002For compromise the objectives of the study\n* No significant visual impairment that would prevent them from playing a video game.\n\nExclusion Criteria:\n\n* Currently prescribed and taking stimulant medication (Adderall, Ritalin, Vyvanse, etc.)\n* Consumption of over-the-counter stimulants such as caffeine or nicotine (coffee, soda, supplements, energy drinks, tobacco products, or other nicotine containing products such as gum, vape pens, etc...) 12 hours prior to entering the lab on the day of testing as this can directly affect cortical excitability. If a subject takes any of these substances 12 hours prior to the study visit they will be asked to reschedule for a later date.\n* Have played a real stringed instrument in the last 12 months (e.g. guitar, bass, violin)\n* Have played the videogame \"Guitar Hero\" on a traditional guitar controller in the last 12 months.","45 Years",{"count":62,"type":21},32,[24],"When learning a new skill, much of the improvement comes from small alterations the brain makes with each repetition during practice, but this isn't the only time that improvements are made during the learning process. Individuals also get better at the motor skills during the time between practices, through a process called \"consolidation.\" It is known that an area of the brain called the primary motor cortex is involved in learning during active practice, but the investigators want to study if the primary motor cortex is important for consolidation. The investigators will examine how lowering the activity in this brain region affects your ability to consolidate learning to play a song on the videogame Guitar Hero.",[27,66,67],"Primary Motor Cortex","Motor Skills",[69,70],"Learning","Transcranial Magnetic Stimulation, Repetitive","RECRUITING","2026-05-28",{"date":74,"type":44},"2026-06-01",{"date":76,"type":44},"2026-04-23",{"date":78,"type":21},"2027-04-23",{"name":80,"class":51},"Indiana University",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":89,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":52},"100575237","dual-task-training-combined-with-tdcs-on-cognitive-motor-performance-and-brain-activity-in-stroke-patients-100575237","NCT06769672","Dual-task Training Combined With tDCS on Cognitive-motor Performance and Brain Activity in Stroke Patients","The Effect of Dual-task Training Combined With tDCS on Cognitive-motor Interference and Related Brain Activity in Stroke Patients","dual-task tDCS","Inclusion Criteria:\n\n* a diagnosis of stroke, stroke onset of more than 6 months,\n* aged 50 or more,\n* capable of following verbal and visual instructions,\n* having a Montreal Cognitive Assessment score ≥ 22,\n* able to walk for 10 meters with\u002Fwithout a mobility aid,\n* community-dwelling, unilateral stroke\n\nExclusion Criteria:\n\n* neurological disorders, gait-precluding pain or comorbidity,\n* receiving any formal rehabilitation training,\n* contraindications to exercise (e.g., unstable angina),\n* contraindications to fNIRS, MRI, and tDCS (e.g., brain skin injury, pacemaker, metal implants in the brain),\n* history of seizure or epilepsy,\n* color blindness.\n* unable to walk with\u002Fwithout a mobility aid while responsing stimulus by the remote control","50 Years",{"count":91,"type":21},72,[24],"The purpose of this study is to evaluate tDCS combined with cognitive-motor training on dual-task interference during dual-task walking, dual-task foot pedaling and the corresponding alterations of brain activity.",[95,27],"Stroke",[97,98,99],"Dual-task training","Cognitive-motor interference","tDCS","2026-02-06",{"date":102,"type":44},"2026-02-10",{"date":104,"type":44},"2025-01-01",{"date":106,"type":21},"2026-12-31",{"name":108,"class":51},"The Hong Kong Polytechnic University",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":15,"sex":16,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":22,"phases":120,"briefSummary":121,"conditions":122,"keywords":126,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":4},"100617176","cortical-excitability-and-role-of-non-invasive-brain-stimulation-in-adhd-and-autism-100617176","NCT07315217","Cortical Excitability and Role of Non Invasive Brain Stimulation in ADHD and AUTISM","Cortical Excitability and Role of Non Invasive Brain Stimulation in ADHD and AUTISM : Double Blind Randomized Clinical Trial","Inclusion Criteria:\n\n* Age 6-19 years.\n* ASD trial: DSM-5 diagnosis of ASD confirmed by CARS-2.\n* ADHD trial: DSM-5 diagnosis of ADHD confirmed by structured interview\u002FCONORS\n* IQ ≥ 70.\n* Stable medication for ≥4 weeks (if any).\n\nExclusion Criteria:\n\n* Epilepsy or seizure history.\n* Metallic implants or devices incompatible with TMS.\n* Severe psychiatric comorbidity (e.g., psychosis).\n* Inability to tolerate TMS procedures.","6 Years","19 Years",{"count":119,"type":21},80,[24],"This double-blind, randomized, sham-controlled clinical trial will evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on children and adolescents with attention-deficit\u002Fhyperactivity disorder (ADHD) or autism spectrum disorder (ASD) and matched healthy controls. Participants aged 6-19 years will be assigned to active or sham rTMS protocols targeting the dorsolateral prefrontal cortex over 3 weeks, with assessment of changes in disorder-specific symptoms and cortical excitability. The study aims to determine the safety, feasibility, and preliminary efficacy of rTMS as a non-invasive neuromodulation approach in pediatric neurodevelopmental disorders.",[27,123,124,125],"Brain Stimulation","ADHD","Autism",[127,128,124,125],"Cortical excitability","non invasive brain stimulation","2025-12-18",{"date":131,"type":44},"2026-01-02",{"date":133,"type":21},"2026-01",{"date":135,"type":21},"2027-02",{"name":137,"class":51},"Assiut University"]