[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cortico-basal-degeneration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cortico-basal-degeneration":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100593008","imaging-studies-in-corticobasal-syndrome-100593008",false,"NCT07000851","Imaging Studies in Corticobasal Syndrome","Neuroinflammation, White Matter Integrity, AD Biomarkers and Pathology in Corticobasal Syndrome","I-CAN","Inclusion Criteria:\n\n* Age 18 years or older\n* Meet possible or probable CBS criteria\n\nExclusion Criteria:\n\n* Subjects will be excluded if MRI is contraindicated (due to implanted device, severe claustrophobia, etc)\n* Subjects will be excluded if they have a concurrent illnesses or structural abnormality that could account for the CBS syndrome\n* Subjects will be excluded if they have a mutation in the progranulin gene\n* Subjects will excluded if they have received anti-Aβ therapy\n* Women who are pregnant will be excluded\n* Subjects will be excluded if they are actively taking daily anti-inflammatory medications (NSAIDs, corticosteriods, etc)\n* Subjects will be excluded if they have generalized inflammatory condition and treatment with immunosuppressive, corticoid\u002Fglucocorticoid, steroidal or non-steroidal anti-inflammatory medication within 2 weeks of scanning",true,"ALL","18 Years",{"count":21,"type":22},80,"ESTIMATED","OBSERVATIONAL","The primary goal of this study is to investigate inflammation and white matter damage in corticobasal syndrome and determine whether these processes are related to each other. The investigator's will address our goal by using neuroimaging and blood plasma biomarkers, as well as molecular pathology.",[26,27,28,29,30,31],"Cortico Basal Degeneration","Corticobasal Syndrome","Corticobasal Syndrome(CBS)","Corticobasal Degeneration","Corticobasal Degeneration (CBD)","Corticobasal Syndrome (CBS)",[33,34,35,36,37,38],"neurodegeneration","neurodegenerative disease","cbs","cbd","corticobasal syndrome","corticobasal degeneration","RECRUITING","2025-07-03",{"date":42,"type":43},"2025-07-07","ACTUAL",{"date":45,"type":43},"2025-06-25",{"date":47,"type":22},"2031-03-30",{"name":49,"class":50},"Jennifer Whitwell","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":51},"100565703","utilisation-of-health-services-and-quality-of-life-in-patients-with-atypical-parkinsonian-syndromes-100565703","NCT06645626","Utilisation of Health Services and Quality of Life in Patients With Atypical Parkinsonian Syndromes","UHSQOLAPS","Inclusion Criteria:\n\nPatients and their carers must:\n\n* Be aged 18 or over\n* Have capacity to consent at the beginning of their involvement\n* Have a diagnosis of a neurodegenerative disease which includes progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy but may include other closely related diseases where the presentation is similar, such as Alzheimer's disease where they present with a corticobasal syndrome\n\nExclusion Criteria:\n\n* Patients or carers not meeting the inclusion criteria\n* Patients with static deficits only who do not have a neurodegenerative syndrome.\n* Patients who the principal investigator feels are not suitable to take part due to co-morbidities or participation in other trials.",{"count":60,"type":22},198,"The study will compare health care utilisation and quality of life for patients with progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy in different parts of the region that our specialist clinic operates in with different services as well as in other regions with no specialist clinics. This study aims to investigate which aspects of the service are most beneficial for the patients and to determine the influence of support services and specialty clinics on patients and their carers.",[63,26,64],"Progressive Supranuclear Palsy","Multiple System Atrophy",[66,67],"quality of life","health economics","2024-10-15",{"date":70,"type":43},"2024-10-17",{"date":72,"type":43},"2022-10-10",{"date":74,"type":22},"2027-07-15",{"name":76,"class":50},"University Hospital Southampton NHS Foundation Trust"]