[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cortisol\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cortisol":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,87,128,169,215],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100633046","effect-of-video-based-versus-verbal-preoperative-information-on-anxiety-and-cortisol-levels-in-elective-cesarean-section-100633046",false,"NCT07521592","Effect of Video-Based Versus Verbal Preoperative Information on Anxiety and Cortisol Levels in Elective Cesarean Section","The Effect of Video-Based Versus Verbal Preoperative Information on Anxiety and Serum Cortisol Levels in Elective Cesarean Section: A Prospective Randomized Controlled Study","Inclusion Criteria:\n\n* Pregnant women aged 18 years or older\n* Scheduled for elective cesarean delivery\n* Planned to receive spinal anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Emergency cesarean delivery\n* History of psychiatric disorders\n* Current use of anxiolytic or antidepressant medications\n* Endocrine disorders, particularly adrenal or thyroid disease\n* Current corticosteroid therapy\n* History of previous surgery under spinal anesthesia\n* Cognitive impairment preventing effective communication or completion of the assessment scales\n* American Society of Anesthesiologists (ASA) physical status III-V","FEMALE","18 Years",{"count":19,"type":20},140,"ESTIMATED","INTERVENTIONAL",[23],"NA","Preoperative anxiety is a common problem in patients undergoing elective cesarean section and may negatively affect perioperative outcomes through activation of the stress response, including increased cortisol levels. Effective preoperative information is considered a key non-pharmacological strategy to reduce anxiety; however, the optimal method of information delivery remains unclear. This prospective randomized controlled trial aims to compare the effects of video-based versus verbal preoperative information on anxiety levels and serum cortisol response in patients scheduled for elective cesarean delivery under spinal anesthesia. Anxiety will be assessed using the State-Trait Anxiety Inventory (STAI), and serum cortisol levels will be measured before and after the intervention. The findings of this study are expected to provide evidence for improving patient-centered preoperative education strategies in obstetric anesthesia.\"",[26,27,28,29],"Preoperative Anxiety","Cesarean Section","Surgical Stress Response","Cortisol",[26,31,32],"Cesarean Delivery","Cortisol Biomarker","NOT_YET_RECRUITING","2026-04-08",{"date":36,"type":37},"2026-04-13","ACTUAL",{"date":39,"type":20},"2026-04-02",{"date":41,"type":20},"2026-07",{"name":43,"class":44},"Elazıg Fethi Sekin Sehir Hastanesi","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":71,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":86},"100632191","effects-of-breastfeeding-virtual-reality-and-stress-ball-on-pain-anxiety-cortisol-levels-and-comfort-during-episiotomy-repair-100632191","NCT07510477","Effects of Breastfeeding, Virtual Reality, and Stress Ball on Pain, Anxiety, Cortisol Levels, and Comfort During Episiotomy Repair","Effects of Breastfeeding, Virtual Reality, and Stress Ball on Pain, Anxiety, Cortisol Levels, and Comfort During Episiotomy Repair in Primiparous Women: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Pregnant women between 18 and 45 years of age.\n* Primiparous women (first-time mothers).\n* Gestational age between 37 and 42 weeks (term pregnancy).\n* Singleton pregnancy with a vertex presentation.\n* Spontaneous vaginal delivery requiring a mediolateral episiotomy.\n* Newborn birth weight between 2500 and 4500 grams.\n* Newborn Apgar scores of 7 or higher at the 1st and 5th minutes.\n* Ability to read, understand, and speak Turkish fluently.\n* Voluntary participation with signed informed consent.\n\nExclusion and Withdrawal Criteria:\n\n* Requesting to withdraw from the research at any stage.\n* Presence of any congenital anomalies in the newborn.\n* Presence of maternal visual or hearing impairments.\n* Occurrence of fetal mortality or morbidity.\n* Occurrence of anal sphincter injury or 3rd\u002F4th-degree lacerations in addition to the episiotomy.\n* Performance of the episiotomy repair in an operating room.\n* Use of assisted delivery methods (e.g., vacuum extraction).\n* Administration of sedative drugs or extra anesthetic agents (excluding routine local perineal infiltration).\n* Development of maternal complications (e.g., postpartum hemorrhage) preventing data collection.",true,"45 Years",{"count":55,"type":20},120,[23],"The goal of this clinical trial is to learn about the effects of three different interventions-breastfeeding, using a stress ball, or wearing virtual reality (VR) goggles-on pain, anxiety, and stress during episiotomy repair (stitching) after childbirth. It also aims to examine how these methods affect a mother's comfort after the procedure.\n\nThe main questions it aims to answer are:\n\nDoes breastfeeding, using a stress ball, or using VR goggles lower the mother's pain and anxiety during the repair? Do these interventions reduce the mother's biological stress levels, measured by saliva cortisol tests? Do these methods lead to higher postpartum comfort levels for the mother in the first 24 hours after birth?\n\nResearcher will compare these three intervention groups to a \"control group\" (mothers receiving standard hospital care) to see which approach is most effective.\n\nParticipants will:\n\nBe randomly assigned to one of four groups: Breastfeeding, VR Goggles, Stress Ball, or Standard Care.\n\nUse their assigned intervention throughout the entire episiotomy repair process.\n\nProvide saliva samples before and after the procedure to measure stress hormones (cortisol).\n\nRate their pain and anxiety levels using clinical scales twice: once before the procedure begins and once immediately after it is finished.\n\nComplete a survey about their comfort levels between 6 and 24 hours after the delivery.",[59,60,61,62,63,29,64,65,66,67,68,69,70],"Episiotomy","Breastfeeding","Virtual Reality","Virtual Goggles","Anxiety","Postpartum Comfort","Postpartum Comfort Scale","Stress Physiological","PAIN, ANXIETY, AND COMFORT","Acute Pain","Stress Ball","Midwifery",[60,61,69,72,73,74,75,59,76],"Midwifery Care","Primiparous Women","Randomized Controlled Trial","Salivary Cortisol","Episiotomy Repair","2026-03-30",{"date":79,"type":37},"2026-04-03",{"date":81,"type":20},"2026-04",{"date":83,"type":20},"2027-09",{"name":85,"class":44},"Aydin Adnan Menderes University",1,{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":52,"sex":94,"minAge":95,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":21,"phases":98,"briefSummary":99,"conditions":100,"keywords":112,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":4},"100628685","feasibility-of-breathwork-intervention-with-older-adults-after-knee-surgery-100628685","NCT07464860","Feasibility of Breathwork Intervention With Older Adults After Knee Surgery","A Box Breathing Intervention and the Surgical Stress Response in Older Adults Undergoing Total Knee Arthroplasty: A Randomized Controlled Feasibility Trial","Adults aged 65 years or older of any sex, gender and ethnic background who meet the following criteria will be eligible to enroll in the present study:\n\nInclusion Criteria:\n\n* scheduled for elective TKA within the next week to two months (can be second knee, but cannot be a revision of the original knee)\n* self-reported good health, including denial of debilitating illness that may affect participation in or be potentially exacerbated by deep, controlled breathing (i.e., chronic obstructive pulmonary disorder \\[COPD\\], symptomatic or advanced heart failure, complete heart block, glaucoma, epilepsy)\n* denial of conditions that alter cortisol release or that require corticosteroid therapy (i.e., Cushing's syndrome, Addison's disease, pituitary tumors, adrenal gland tumors, asthma)\n* denial of severe psychiatric or cognitive conditions that warrant the need for a durable power of attorney (DPOA)\n* able to understand written and verbal English.\n\nExclusion Criteria:\n\n* currently taking oral, injectable, intranasal, topical, or inhaled corticosteroid medications (i.e., prednisone, hydrocortisone, dexamethasone, methylprednisolone, methylprednisolone acetate, triamcinolone, betamethasone, mometasone, fluticasone, budesonide, clobetasol)\n* do not have the technology requirements to complete data collection (i.e., participant does not have a smartphone, tablet, laptop, or desktop computer; lack of reliable internet)\n\nThe following exclusion criteria may affect participants' ability to remain in the study following enrollment:\n\n• Development of complications during surgery that require prolonged hospitalization into Postoperative Day (POD) 2 (e.g., postoperative intubation and ventilation requirements, intractable pain, intractable nausea\u002Fvomiting, signs of infection or sepsis)","ALL","65 Years",{"count":97,"type":20},32,[23],"Postoperative complications after surgical procedures, including following total knee arthroplasty (TKA), have a negative impact on the health and well-being of surgical patients. Older adults (≥65 years) are particularly vulnerable to postoperative complications and their associated morbidities due to the biological aging process. Older adults comprise nearly half of surgical patients worldwide, and this number is expected to increase in the next 10-20 years as the aging population continues to grow. TKA is the most common procedure undergone by older adults, and the rate of TKA procedures is also expected to rise. Despite perioperative guidelines and protocols to prevent postoperative complications, the prevalence of postoperative complications following TKA is approximately 12%. Given these statistics, millions of older adults undergoing TKA may be at risk for postoperative complications and their associated morbidities in the coming decades. Therefore, additional interventions are needed to combat postoperative complications in this population.\n\nThe body's natural response to surgery, also known as the surgical stress response (SSR), contributes to postoperative complications through complex mechanisms involving the autonomic nervous system (ANS). Increased sympathetic nervous system (SNS) activity, or the body's fight-or-flight response, causes dysregulation in feedback systems that regulate the stress response, potentially leading to poorer outcomes. Interventions, such as breathwork, that induce the parasympathetic nervous system (PNS), or the body's rest-and-digest response, have been shown to balance the ANS, regulate stress biology, and improve outcomes. This study will examine the feasibility of adding a breathwork intervention (Box Breathing), compared to an attention control, to standard perioperative care for older adults undergoing TKA. This study will also examine the proof of concept that Box Breathing, compared to an attention control, may help regulate the SSR by assessing an objective measure of stress-related biology, diurnal cortisol rhythm, and gathering self-report information on pain, anxiety, depression, and quality of recovery following TKA.",[28,66,101,102,103,104,105,106,107,29,108,109,110,111],"Stress Physiology","Stress Psychological","Breathing Techniques","Breathing Exercises","Hypothalamic Pituitary Adrenal","Relaxation","Relaxation Therapy","Postoperative Pain","Postoperative Anxiety","Postoperative Depression","Quality of Recovery (QoR-15)",[28,113,114,115,104,103,116,108,109,110,117,118],"Total Knee Arthroplasty","Hypothalamic-Pituitary-Adrenal Axis","Breathwork","Postoperative Complications","Quality of Recovery","Diurnal Cortisol Rhythm","2026-03-06",{"date":121,"type":37},"2026-03-11",{"date":123,"type":20},"2026-04-06",{"date":125,"type":20},"2026-09-30",{"name":127,"class":44},"University of Arizona",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":52,"sex":16,"minAge":135,"maxAge":4,"enrollmentInfo":136,"targetDuration":4,"studyType":21,"phases":138,"briefSummary":139,"conditions":140,"keywords":150,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":86},"100619990","mindfulness-and-meditation-based-lactation-education-on-maternal-breastmilk-in-the-neonatal-icu-100619990","NCT07351799","Mindfulness and Meditation Based Lactation Education on Maternal Breastmilk in the Neonatal ICU","The Impact of Mindfulness and Meditation Based Lactation Education on Maternal Breastmilk in the Neonatal ICU: Intervention Study","Inclusion Criteria:\n\n* Maternal age \\> 20 years of age\n* Read, write and understand English\n* Infant NICU admit\n* Infant birthplace of Rochester, MN (Mayo Clinic)\n* Maternal adherence to pumping ≥ 8 times in 24 hours\n* Mother enrolled within 72 hours of birth\n* Gestational age of neonate at birth of \\\u003C 34 0\u002F7 weeks\n\nExclusion Criteria:\n\n* Maternal extensive existing mindfulness practice\n* Maternal breast\u002Fchest surgery\n* Maternal polycystic ovarian syndrome (PCOS)\n* Maternal current illicit substance abuse\n* Diagnosis of maternal current severe mental health concerns\n* Maternal multiple gestation (twins or higher order) pregnancy and delivery","20 Years",{"count":137,"type":20},40,[23],"The purpose of this research is to investigate associations between mindfulness and meditation techniques and changes in maternal breastmilk in the mother pumping for her NICU infant.",[141,142,143,144,145,146,147,29,148,63,149],"Lactation","Mindfulness","NICU","Breastmilk","Neonatal","Meditation","Pumping, Breast","Oxytocin","Depression",[151,152,143,153,145,154,155,156,157,158,149],"lactation","mindfulness","breastmilk","meditation","pumping, breast","cortisol","oxytocin","anxiety","RECRUITING","2026-01-12",{"date":162,"type":37},"2026-01-20",{"date":164,"type":37},"2025-09-22",{"date":166,"type":20},"2026-11-02",{"name":168,"class":44},"Mayo Clinic",{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":52,"sex":16,"minAge":176,"maxAge":177,"enrollmentInfo":178,"targetDuration":4,"studyType":21,"phases":179,"briefSummary":180,"conditions":181,"keywords":196,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":86},"100617476","evaluation-of-the-impact-of-a-nutritional-formulation-on-cognitive-performance-following-stress-exposure-100617476","NCT07319117","Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.","A Double-blind, Placebo-controlled, Randomised, Acute, Repeated Measures Cross-over Study to Evaluate the Impact of Skoshify 'Think Tank' Nutritional Formulation on Cognitive Performance Following Stress Exposure.","Inclusion Criteria:\n\n1. Willing and able to provide written informed consent (in English)\n2. Aged 40-60\n3. Female\n4. Daily caffeine drinkers\n5. Healthy and free from significant physical and psychiatric disorders\n\nExclusion Criteria:\n\n1. Current cigarette smokers\u002Fvapers.\n2. Known food allergy or intolerance to the investigational products or control products.\n3. Not willing to consume coffee.\n4. Individuals diagnosed with psychiatric\u002Fmental health conditions.\n5. Individuals engaging in recreational drug use.\n6. Individuals with diagnosed cardiovascular conditions (e.g. heart disease, high blood pressure)\n7. Individuals taking prescribed medication except contraceptives\u002Fhormone replacement therapy\n8. Individuals suffering from Raynaud's or circulatory issues\n9. Individuals who have suffered an injury or infection in their hand\u002Farm in the last month\n10. Individuals who have suffered from chronic pain conditions or experience extreme numbness or pain in response to cold temperatures.\n11. Previous brain injury\u002Fbrain surgery\n12. Individuals who work night shifts.\n13. Currently pregnant or breastfeeding.\n14. Previous participants in a laboratory stress protocol.","40 Years","60 Years",{"count":137,"type":20},[23],"The proposed project will evaluate the synergistic effects of a nutritional formulation, 'Think Tank' on cognitive performance following exposure to a psychological and physical stressor. Adopting a double-blind repeated measures cross-over design, middle-aged females (40-60 years) will be recruited to take part in a two-stage research study that will examine whether the formulation enhances cognitive performance and subjective well-being following the challenge of a stressor, compared to placebo. Cognitive assessments will examine the impact of the nutritional formulation on working memory, sustained attention, cognitive flexibility and inhibitory control. The study will also assess physiological (heart rate, blood pressure and cortisol) and subjective (well-being, anxiety, positive and negative mood, stress) markers of stress reactivity. The study will also explore levels sleep quality, mental and physical fatigue, effort, productivity, and perceived impact of the intervention.",[182,183,184,185,186,187,29,188,63,149,189,190,191,192,193,194,195],"Cognitive Assessment","Working Memory","Executive Function (Cognition)","Sustained Attention","Inhibitory Control","Cognitive Flexibility","Stress","Sleep Quality","Blood Pressure","Heart Rate","Mental Fatigue","Physical Fatigue","Productivity","Effort",[197,198,199,200,201,202,203,204,205],"Cognitive Performance","Stress Response","Creatine","Magnesium","L-Tyrosine","L-Theanine","Rhodiola","Phosphatidylserine","Citicoline","2025-12-19",{"date":208,"type":37},"2026-01-06",{"date":210,"type":20},"2025-12-15",{"date":212,"type":20},"2026-08-31",{"name":214,"class":44},"Leeds Beckett University",{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":221,"eligibilityCriteria":222,"healthyVolunteers":52,"sex":94,"minAge":223,"maxAge":4,"enrollmentInfo":224,"targetDuration":4,"studyType":21,"phases":226,"briefSummary":227,"conditions":228,"keywords":232,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":247},"100568905","light-in-healthcare-environment-ljus-i-sjukhusmilj-100568905","NCT06687304","Light in Healthcare Environment (Ljus i sjukhusmiljö)","Benefits of Light in the Radiographic Environment","LIS","Inclusion Criteria:\n\nRadiographer\n\nExclusion Criteria:\n\n\\-","21 Years",{"count":225,"type":20},18,[23],"The goal of this clinical trial is to learn if light can enhance the feeling of well-being and sleep quality in Radiographers. It will also find out if there is an optimal recipe for light. The main questions it aims to answer are:\n\n* Will alertness, energy levels, and sleep quality increase in radiographers when the lighting is differed?\n* What light recipe is the most beneficial for the personnel? Researchers will compare no enhanced light environment to different enhanced light environment to see if the enhanced light is beneficial for radiographers.\n\nParticipants will:\n\n* Will work in an enhanced light environment or a non-enhanced light environment\n* Answer surveys\n* Take saliva sample",[189,229,230,29,231],"Well-being","Melatonin","Energy Levels",[233,234,235,236,237],"Light","Radiography","Light environment","Circadian rhythm","Personnel at radiology departments","2025-11-24",{"date":240,"type":37},"2025-12-02",{"date":242,"type":37},"2024-11-15",{"date":244,"type":20},"2027-03-31",{"name":246,"class":44},"Lund University",3]