[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cost-benefit-analysis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cost-benefit-analysis":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,56,80,138],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":40,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100638424","ecardiacrehab---a-hybrid-patient-centered-ehealth-programme-100638424",false,"NCT07590635","eCardiacRehab - a Hybrid Patient-Centered eHealth Programme","eCardiacRehab - a Randomized Controlled Trial on a Hybrid Home-Based Patient-Centered eHealth Programme With Tailored Solutions","eCardiacRehab","Inclusion Criteria:\n\n* Adult Norwegian (or Scandinavian) speaking patients (≥ 18 years) who have a Norwegian national identification number\n* With coronary artery disease after percutaneous coronary intervention\n* Living at home\n* Have internet available\n* Provide signed informed consent\n\nExclusion Criteria:\n\n* Patients with cognitive impairment that may interfere with the ability to comply with the study protocol\n* Severe aortic stenosis\n* Severe arrhythmias\n* Expected lifetime less than one year as determined by study personnel\n* Otherwise clinically unstable\n* Not fully revascularized\n* Awaits percutaneous coronary intervention or coronary artery bypass graft surgery\n* Inability to comply with the study protocol due to any physical disability, somatic disease, or mental problems as determined by study personnel","ALL","18 Years",{"count":20,"type":21},1000,"ESTIMATED","INTERVENTIONAL",[24],"NA","The overall aim of eCardiacRehab trial is to meet rehabilitation needs of patients with coronary artery disease (CAD) regardless of their access to traditional place-based rehabilitation by developing and evaluating the efficacy and cost effectiveness of an interdisciplinary and comprehensive home-based hybrid programme. eCardiacRehab address patient- and system level challenges to increase access to cardiac rehabilitation (CR). We give particular attention to older patients, women, and those with comorbidities or mental health challenges. The vision of the hybrid home-based eCardiacRehab programme is to make CR available to all.\n\neCardiacRehab is a prospective, multicentre randomized open-label blinded end point evaluation (PROBE) trial. The primary endpoint is a hierarchical composite endpoint using a win-ratio framework combining cardiovascular (CV) death, unplanned contacts to the Emergency Department (ED) for observation or admission (\\>24 hours) for CV disease, and quality of life. Inclusion criteria are adult Scandinavian speaking patients (≥ 18 years) who have a Norwegian national identification number, with CAD treated with Percutaneous Coronary Intervention (PCI), are living at home, and have internet available to them and providing signed informed consent. Exclusion criteria are patients with severe aortic stenosis, severe arrhythmias, expected lifetime less than one year as determined by study personnel, otherwise clinically unstable, not fully revascularized, awaits PCI or coronary artery bypass graft operation (CABG) or inability to comply with the study protocol due to any physical disability, somatic disease, cognitive impairment or mental health challenges as determined by study personnel.",[27,28,29,30,31,32,33,34,35,36,37,38,39],"Comorbidities and Coexisting Conditions","Ethics","Continuity of Patient Care","Older Adults (65 Years and Older)","Cost-Benefit Analysis","Adherence, Medication","Secondary Prevention of Coronary Heart Disease","Health Literacy","eHealth Literacy","Mental Health","Cardiac Rehabilitation","Womens's Health","Coronary Artery Disease (CAD)",[37,41,42],"Coronary Artery Disease","Percutaneous Coronary Intervention","RECRUITING","2026-06-18",{"date":46,"type":47},"2026-06-23","ACTUAL",{"date":49,"type":47},"2026-05-21",{"date":51,"type":21},"2037-12-31",{"name":53,"class":54},"Haukeland University Hospital","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":22,"phases":66,"briefSummary":67,"conditions":68,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":55},"100481763","pragmatic-use-of-next-generation-sequencing-for-management-of-drug-resistant-tuberculosis-100481763","NCT05553236","Pragmatic Use of Next-generation Sequencing for Management of Drug-resistant Tuberculosis","Targeted Sequencing to Enhance, Liberate, and Optimize Treatment of Drug-resistant Tuberculosis","TSELiOT","Inclusion Criteria:\n\n1. Active RR-TB diagnosed at a study facility during the study period\n2. Positive Mtb culture, smear, or specimen derivative (e.g., GenoLyse remnant, Xpert cartridge extract)\n\nExclusion Criteria:\n\n1. Patient expects to relocate\u002Fmove residence outside of the study region\n2. Patient does not agree to participate in the study\n\nIn addition, participants later found to have isolates with rifamycin susceptibility on at least two additional tests (e.g., phenotypic DST, LPA, or sequencing) will be considered late exclusions.",{"count":65,"type":21},2500,[24],"TS ELiOT is a stepped-wedge, cluster randomized trial assessing the effect of a next-generation sequencing-based strategy on rifampin-resistant tuberculosis management and patient outcomes.",[69,70,31],"Drug-resistant Tuberculosis","HIV Coinfection","2026-01-22",{"date":73,"type":47},"2026-01-26",{"date":75,"type":47},"2024-08-01",{"date":77,"type":21},"2027-01",{"name":79,"class":54},"University of California, San Francisco",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":103,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":55},"100417487","health-enhancing-adapted-physical-activity-program-at-mon-stade-100417487","NCT04716322","Health-Enhancing Adapted Physical Activity Program at \"Mon Stade\"","Study of the Determinants Associated With Sustained Changes in Physical Activity Behaviors, and Their Effects on the Prevention and Treatment of Chronic Diseases, in Individuals Enrolled in an Adapted Physical Activity Program","SESAME","Inclusion Criteria:\n\n* Male or female\n* 18 years of age or older\n* Speaking and understanding French\n* Affected by a chronic pathology according to a predefined list (LTI, obesity, HTA, COPD, COVID-19 with persistent symptoms)\n* Carrier of a writing APA prescription\n* Able to come to \"Mon Stade\" twice a week for their APA sessions following the 16-week health-adapted PA program;\n* Signature of the information and consent form.\n\nExclusion Criteria:\n\n\\- Women whose pregnancy is known",true,{"count":90,"type":21},2024,[24],"Introduction: Regular practice of exercise or physical activity (PA) is a recognized intervention as a determinant of good health acquisition, maintenance, or recovery for a large number of chronic pathologies. Nevertheless, few studies have evaluated adherence to an initial health-adapted PA (APA) program, and persistence of active behavior over the time in individuals with a chronic disease.\n\nThe aim of the study is to determine the brakes and levers associated with motivation and long-term compliance. In addition, the investigators aim to evaluate the cost-effectiveness of such program in term of care consumption. Finally, the investigators complete their interest for APA prescription from practitioners agreeing to enroll their patients in the present study.\n\nMethod: The investigators perform a prospective monocentric cohort, of 2024 patients affected of a chronic disease or long-term illness (LTI), enrolled from 2021 to 2024 (4 years, 506 per year), for a 16-week APA program, and followed 5 years with an annual fitness and habits of life and care consumption evaluation.",[94,95,96,97,98,99,31,100,101,102],"Exercise Therapy","Behavior and Behavior Mechanisms","Adherence, Patient","Lifestyle, Sedentary","Life Style","Life Style, Healthy","Prescriptions","Physical Activity","Adapted Physical Activity",[102,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,101,122,123,124,125,126,127,128],"Active Live Habits","Adherence","Aerobic Capacity","Behavior","Body Composition","Budget Impact Analysis","Cardiorespiratory Fitness","Care Consumption","Chronic Disease","DEXA scan","Exercise","Health-Adapted Physical Activity","Health-Enhancing","Life-Style","Long-Term Illness","Medico-Economic","Motivation","Perceived Barriers","Physical Fitness","Prescription","Prevention","Psycho-social","Quality Of Life","Questionnaire","VO 2 measurement","2022-04-06",{"date":131,"type":47},"2022-04-07",{"date":133,"type":47},"2021-01-28",{"date":135,"type":21},"2030-12-31",{"name":137,"class":54},"Mon Stade Sports Medicine Centre",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":22,"phases":149,"briefSummary":150,"conditions":151,"keywords":155,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":55},"100432493","dysthymia-associated-costs-treatment-and-change-process-100432493","NCT04911829","Dysthymia: Associated Costs, Treatment and Change Process","DepressionForefront: Costs, Treatment and Change Process for Dysthymia","DFront","Inclusion Criteria:\n\n* Inclusion criteria will be liberal and similar to clinical practice criteria at the treatment site: Persistent depressive disorder as defined by the diagnostic and statistical manual of mental disorders (DSM5); which includes an International classification of disorders-10 (ICD-10) diagnosis of depression, dysthymia, recurrent depression. unsuccessful previous treatments. living within driving distance from the treatment facilities.\n\nExclusion Criteria:\n\n* current suicidal risk, current psychosis, marked emotional instability (i.e. issues with impulsivity), strong paranoid traits, current problems related to heavy substance abuse.","70 Years",{"count":148,"type":21},80,[24],"The study evaluates cost and effect of inpatient versus outpatient treatment of dysthymia, as well as investigates the processes through which psychotherapy works in treating dysthymia.",[152,153,154],"Depression","Cost Benefit Analysis","Psychotherapeutic Processes",[156,157,158,159],"Dysthymia","Persistent depressive disorder","Chronic depression","Recurrent depression","2021-05-31",{"date":162,"type":47},"2021-06-03",{"date":164,"type":47},"2016-01",{"date":166,"type":21},"2026-12",{"name":168,"class":54},"Modum Bad"]