[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cough-hypersensitivity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cough-hypersensitivity":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":5},"100598392","cough-management-wellness-app-for-refractory-or-unexplained-chronic-cough-100598392",false,"NCT07070895","Cough Management Wellness App for Refractory or Unexplained Chronic Cough","A Prospective Decentralized Investigation of the Effect of a Cough Management Feature Inside a Wellness Application (CoughPro) in Refractory or Unexplained Chronic Cough (RCC\u002FUCC)","Inclusion Criteria:\n\n* Age 21 or older.\n* Currently suffering from a cough that started at least 8 weeks ago that is largely unproductive (i.e., at least 50% of the time the cough produces zero mucus that needs to be spit out or swallowed).\n* Normal chest X-ray or chest CT scan at some point that was prescribed specifically for their cough.\n* At least one physician visit for cough with standard-of-care therapy but inadequate symptom relief.\n* Stability of treatment: willing to avoid new cough treatments during study or report changes if they occur.\n* Ability to comply: willing\u002Fable to wear the watch daily for the required duration of study and to complete all required questionnaires.\n* Informed consent: understanding of the study procedures and agreement to comply with protocol.\n\nExclusion Criteria:\n\n* Recent upper respiratory infection (past 4 weeks).\n* History of hemoptysis (coughing up blood) since onset of the current cough.\n* Current smoker (incl. vaping) of any substance.\n* ≥10 consecutive pack-years smoking history within \\\u003C10 years prior to screening.\n* Diagnosed with a chronic lung condition (COPD, emphysema, lung cancer, IPF, chronic bronchitis, asthma). Note: Suspected asthma without confirmed diagnosis or benefit from asthma therapy is not an exclusion.\n* Current or past head\u002Fneck cancer.\n* Difficulty swallowing.\n* On ACE inhibitors, such as Benzapril (Lotensin), Captopril (Capoten), Enalapril\u002FEnalaprilat (Vasotec oral and injectable), Fosinopril (Monopril), Lisinopril (Zestril and Prinivil), Moexipril (Univasc), Perindopril (Aceon), Quinapril (Accupril), Ramipril (Altace), and Trandolapril (Mavik)\n* Prior treatment for cough by a speech-language pathologist.\n* Living with another individual with a frequent cough that would interfere with monitoring.\n* Participation in any cough intervention study within 30 days or 5 half-lives of the intervention.\n* Major scheduled surgery during the study period.","ALL","21 Years",{"count":19,"type":20},20,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this single-cohort clinical trial is to learn whether a smartphone-based Cough Management (CM) program can reduce cough frequency and burden in adults (21-80 years) who have refractory or unexplained chronic cough. \n\nThe main questions it aims to answer are:\n\n* Does four weeks of using the CM feature in the CoughPro app lower objective cough rate (coughs per hour) compared with each participant's one-week baseline? \n* Does the program also lessen cough intensity (bout metrics) and improve patient-reported quality-of-life scores on the Leicester Cough Questionnaire and PGI-S?\n\nParticipants will:\n\n* Wear a Hyfe CoughMonitor smartwatch continuously for 6 weeks (1-week baseline, 4-week intervention, 1-week follow-up), charging it nightly. \n* Complete science-based in-app CM lessons based on behavioral cough-suppression therapy and practice the techniques during the 4-week intervention.\n* Fill out online questionnaires (LCQ and PGI-S) at baseline and at the end of Week 4.\n* Join a brief exit interview, then return the smartwatch and receive a compensation voucher.",[26,27,28],"Refractory Chronic Cough","Unexplained Chronic Cough","Cough Hypersensitivity",[30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51],"chronic cough","hyfe","cough monitoring","coughpro","refractory chronic cough","unexplained chronic cough","digital therapeutic","DTx","software enhanced treatment","cough management","behavioural cough suppression techniques","BCST","digital health","CoughMonitor Suite","cough tracking","cough recording","cough bouts","coughing","cough hypersensitivity","urge to cough","cough-free time","Leicester Cough Questionnaire (LCQ)","RECRUITING","2025-09-10",{"date":55,"type":56},"2025-09-11","ACTUAL",{"date":58,"type":56},"2025-03-27",{"date":60,"type":20},"2025-09",{"name":62,"class":63},"Hyfe Inc","OTHER"]