[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cough-reflex-sensitivity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cough-reflex-sensitivity":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100633839","evaluating-the-feasibility-and-reliability-of-using-handheld-nebulizers-to-conduct-cough-sensitivity-testing-with-citric-acid-100633839",false,"NCT07531901","Evaluating the Feasibility and Reliability of Using Handheld Nebulizers to Conduct Cough Sensitivity Testing With Citric Acid","Inclusion Criteria:\n\n* Healthy adults at least 18 years of age\n* Consent to audio\u002Fvideo recording of the research sessions for research purposes\n* Spirometry testing results obtained by study team on same day of first testing session with FEV1\u002FFVC ratio and FEV1 percent predicted values of at least 0.70\n\nExclusion Criteria:\n\n* Pregnant or trying to become pregnant (if capable of becoming pregnant- a urine pregnancy test will be provided onsite and a negative result must be obtained prior to the first testing session)\n* Smoking of any substance in the last six months\n* Diagnosed or suspected pulmonary disease (e.g., asthma, COPD)\n* History of chronic cough\n* History of head or neck cancer\n* History of neurological disease (e.g., cerebrovascular accident)\n* History of dysphagia (swallowing difficulty)\n* Current complaint of a voice problem\n* Current upper respiratory infection",true,"ALL","18 Years","89 Years",{"count":20,"type":21},10,"ESTIMATED","INTERVENTIONAL",[24],"NA","Objective cough reflex sensitivity testing is typically restricted to specialized research laboratories due to reliance on expensive dosimeter-controlled aerosol delivery systems. This study evaluates the feasibility and reliability of a low-cost alternative method using a handheld nebulizer for citric acid cough challenge testing. Healthy adult participants will complete cough reflex sensitivity testing using both a standard dosimeter-controlled nebulizer system (Cosmed QuarkSpiro) and a handheld nebulizer (DeVilbiss 45). The study will compare cough threshold outcomes between methods to determine whether handheld nebulizer-based testing produces comparable and reproducible measurements.",[27],"Cough Reflex Sensitivity",[29,30],"cough challenge testing","cough reflex sensitivity testing","RECRUITING","2026-06-01",{"date":34,"type":35},"2026-06-03","ACTUAL",{"date":37,"type":21},"2026-06-05",{"date":39,"type":21},"2027-02-28",{"name":41,"class":42},"University of Montana","OTHER"]