[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cough-variant-asthma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cough-variant-asthma":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100293896","phase-4-sensory-mechanical-responses-to-eucapneic-voluntary-hyperventilation-and-mannitol-100293896",false,"NCT03105843","Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol","Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol in Individuals With Cough Variant Asthma and Chronic Cough","Inclusion Criteria:\n\n* Individuals aged 18-65 years of age with CVA and individuals with methacholine-induced cough but normal airway sensitivity. The following definitions will be used:\n\n  1. CVA: chronic cough (≥8 weeks) is the sole or predominant symptom and positive methacholine challenge (PC20 ≤ 16 mg\u002FmL) and history of cough responding to specific asthma treatment (such as inhaled steroid or 1 week trial of bronchodilator);\n  2. Methacholine-induced cough but normal airway sensitivity: chronic cough (≥8 weeks) is the sole or predominant symptom and negative methacholine challenges (PC20 \\> 16 mg\u002FmL).\n* Individuals aged 18-65 years of age with no history of asthma or chronic cough.\n\nExclusion Criteria:\n\n* an exacerbation necessitating a change in medication, emergency department visit or hospitalizations within the previous 4 weeks\n* inability to perform acceptable spirometry\n* medical contraindications to methacholine challenge testing\n* smoking history in excess of 10 pack years Note: Previous treatment with inhaled or systemic corticosteroids is not an exclusion criterion; medication use will be recorded and examined in the analysis.",true,"ALL","18 Years","65 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Mannitol in individuals with cough variant asthma (CVA) and methacholine-induced cough with normal airway sensitivity (COUGH) and compare these responses to a control group of healthy individuals without asthma or chronic cough.\n\nWe hypothesize:\n\n1. EVH and Mannitol cause dyspnea, cough, small airway obstruction with resultant dynamic hyperinflation, gas trapping and autoPEEP in individuals with CVA and COUGH, but not healthy controls.\n2. The sensory-mechanical responses to both hyperosmolar challenges (EVH and Mannitol) are comparable within groups (CVA, COUGH and healthy controls).",[28,29,30],"Asthma","Cough","Cough Variant Asthma",[28,29,32,33],"Eucapneic Voluntary Hyperventilation","Hypertonic Saline","RECRUITING","2025-03-17",{"date":37,"type":38},"2025-03-20","ACTUAL",{"date":40,"type":38},"2022-03-01",{"date":42,"type":22},"2026-06-30",{"name":44,"class":45},"Dr. Diane Lougheed","OTHER"]