[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"coughing-reflex\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:coughing-reflex":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100643496","the-effect-of-esketamine-on-cough-reflex-during-tracheal-extubation-in-patients-undergoing-non-inflatable-transoral-endoscopic-thyroid-surgery-100643496",false,"NCT07641673","The Effect of Esketamine on Cough Reflex During Tracheal Extubation in Patients Undergoing Non-inflatable Transoral Endoscopic Thyroid Surgery","The Effect of Esketamine on Cough Reflex During Tracheal Extubation in Patients Undergoing Non-inflatable Transoral Endoscopic Thyroid Surgery: A Randomized Controlled Study.","Inclusion Criteria:\n\n* Patients scheduled for endotracheal intubation-free thyroid surgery under oral endoscopy\n* ASA class I-II\n* Voluntarily participate in the study and sign the informed consent form\n\nExclusion Criteria:\n\n* Body Mass Index \\> 30 kg\u002Fm²\n* Patients with unstable ischemic cardiomyopathy, pulmonary hypertension, poorly controlled or untreated hypertension (arterial hypertension, resting systolic\u002Fdiastolic blood pressure \\>180\u002F100 mmHg)\n* Hepatic or renal dysfunction\n* History of oral, maxillofacial, neck, or airway surgery, or pathological structural alterations\n* Respiratory diseases (COPD, asthma, inflammation, chronic cough)\n* Patients with elevated intracranial pressure\n* Patients undergoing repeat surgery\n* History of allergy to the investigational drug used in the study\n* Patients with psychiatric disorders or alcohol abuse (daily ethanol intake ≥40 g, or having experienced alcohol withdrawal within the past 6 months, or unable to control alcohol consumption)","ALL","18 Years","65 Years",{"count":20,"type":21},186,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study intends to implement esketamine-assisted anesthesia in patients undergoing non-inflatable transoral endoscopic thyroidectomy through a prospective randomized controlled trial, in order to observe the effect of esketamine on coughing during extubation in thyroidectomy patients.",[27,28],"Thyroidectomy","Coughing Reflex","NOT_YET_RECRUITING","2026-06-07",{"date":32,"type":33},"2026-06-11","ACTUAL",{"date":35,"type":21},"2026-06",{"date":37,"type":21},"2027-09",{"name":39,"class":40},"The Second Hospital of Anhui Medical University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":58,"leadSponsor":59,"locationsCount":41},"100638116","the-effect-of-esketamine-on-cough-reflex-during-tracheal-extubation-in-patients-undergoing-open-thyroid-surgery-100638116","NCT07625826","The Effect of Esketamine on Cough Reflex During Tracheal Extubation in Patients Undergoing Open Thyroid Surgery","The Effect of Esketamine on Cough Reflex During Tracheal Extubation in Patients Undergoing Open Thyroid Surgery: A Randomized Controlled Study","Inclusion Criteria:\n\n* Patients scheduled for elective open thyroid surgery\n* ASA class I-II\n* Voluntarily participate in the study and sign the informed consent form\n\nExclusion Criteria:\n\n* Body Mass Index \\> 30 kg\u002Fm²\n* Patients with unstable ischemic cardiomyopathy, pulmonary hypertension, poorly controlled or untreated hypertension (arterial hypertension, resting systolic\u002Fdiastolic blood pressure \\>180\u002F100 mmHg)\n* Hepatic or renal dysfunction\n* History of oral, maxillofacial, neck, or airway surgery, or pathological structural alterations\n* Respiratory diseases (COPD, asthma, inflammation, chronic cough)\n* Patients with elevated intracranial pressure\n* Patients undergoing repeat surgery\n* History of allergy to the investigational drug used in the study\n* Patients with psychiatric disorders or alcohol abuse (daily ethanol intake ≥40 g, or having experienced alcohol withdrawal within the past 6 months, or unable to control alcohol consumption)",{"count":50,"type":21},136,[24],"This study intends to conduct a prospective randomized controlled trial to implement esketamine-assisted anesthesia in patients undergoing open thyroidectomy, in order to observe the effect of esketamine on coughing during extubation in thyroidectomy patients.",[27,28],"2026-06-03",{"date":56,"type":33},"2026-06-04",{"date":35,"type":21},{"date":37,"type":21},{"name":39,"class":40}]