[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"couples\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:couples":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100548538","developing-and-testing-an-online-intervention-for-alcohol-and-cannabis-misuse-and-healthy-relationship-skills-among-young-adult-couples-100548538",false,"NCT06422299","Developing and Testing an Online Intervention for Alcohol and Cannabis Misuse and Healthy Relationship Skills Among Young Adult Couples","Developing and Testing an Online Intervention for Decreasing Alcohol and Cannabis Misuse and Increasing Healthy Relationship Skills Among Young Adult Couples: A Comprehensive Mixed-methods Approach","Inclusion Criteria:\n\n* Both partners in the couple are 18-29 years old\n* In a committed romantic relationship (e.g., dating seriously, cohabiting, married) with each other for at least 3 months\n* Face-to-face contact their partner at least 5 days per week\n* Live in Washington State\n* Have a valid email address and access to a cell phone\n* Report alcohol and cannabis co-use at least three times in the past month\n* Willingness to: complete online surveys during the allotted time frames, receive text messages and emails from the project, complete a baseline session, and participate during the same time period as their partner\n\nExclusion Criteria:\n\n* Couples who endorse any perpetration or receipt of severe interpersonal aggression during screening will be excluded and provided with resources",true,"ALL","18 Years","29 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to develop and test a brief online intervention to reduce alcohol and cannabis misuse and improve healthy relationship skills among young adult couples. The main questions it aims to answer are:\n\n* Will the intervention be feasible and acceptable to young adult couples?\n* Will the intervention demonstrate initial efficacy in reducing risky substance use and increasing relationship functioning?\n\nEligible couples will complete a virtual baseline session and be randomized to intervention condition (online intervention with 3-5 weeks of self-paced modules) or control condition (no intervention). Couples will complete two follow-up surveys (post-assessment - approximately 5 weeks after baseline, 3-month). Couples in the control condition will be offered the intervention after 3-month follow-up.\n\nResearchers will compare intervention and control groups to see if there there is a difference between the groups on substance misuse and relationship functioning at post-assessment and 3-month follow-up.",[28,29,30],"Alcohol Drinking","Cannabis Use","Couples",[32],"alcohol use, cannabis use, couples, healthy relationships, young adults","NOT_YET_RECRUITING","2026-05-04",{"date":36,"type":37},"2026-05-06","ACTUAL",{"date":39,"type":22},"2026-09-15",{"date":41,"type":22},"2027-08-01",{"name":43,"class":44},"University of Washington","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100499661","advancing-couple-and-family-alcohol-treatment-through-patient-oriented-research-and-mentorship-100499661","NCT05786157","Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship","Inclusion criteria\n\n1. Any gender identity; any race or ethnicity; ages 21 years or older.\n2. Must report ≥ 2 heavy drinking episodes in the past 30 days (i.e., 4 or more drinks for women, 5 or more for men in ≤ 2 hours) and consumed a quantity of alcohol that is equal to or greater than the standard dose administered for their weight in the laboratory (assessed via the TLFB).\n3. At least one instance of physical IPV in the current relationship reported by at least one partner within the couple (assessed by the CTS-2).\n4. Participants must agree not to drive or operate machinery for the remainder of the experimental visit day. Transportation will be provided if necessary.\n5. One or both partners in half the couples will be required to meet diagnostic criteria for PTSD or subthreshold PTSD (assessed by the CAPS-5).\n\nExclusion criteria:\n\n1. Possible drug use disorder (except caffeine or nicotine) as meeting DSM-5 diagnostic criteria via the QuickSCID; Recent recreational drug use (e.g., cannabis) is acceptable.\n2. Severe alcohol use disorder as meeting DSM-5 diagnostic criteria via the QuickSCID. Applies to those receiving alcohol administration only.\n3. Meeting DSM-5 criteria for a history of or current psychotic or bipolar disorders.\n4. Current suicidal or homicidal ideation and intent.\n5. History of or current psychiatric or medical condition for which alcohol administration is medically contraindicated.\n6. Body weight \\> 250 lbs (in order to rigorously control alcohol dosing). Applies to those receiving alcohol administration only.\n7. Use of medications such as lithium, methadone, alpha or beta blockers or cholinergic\u002F anticholinergic drugs likely to confound normative cardiovascular responding for the psychophysiological component of the project. Applies to those receiving alcohol administration only.\n8. Pregnancy or breastfeeding.\n9. Severe or unilateral partner violence in the past 6 months as measured by the CTS-2.","21 Years",{"count":53,"type":22},140,[25],"Intimate partner violence (IPV) is a serious public health problem that results in significant health and economic burdens including mortality, morbidity, and poor treatment outcomes. A well-developed field of research suggests that alcohol misuse and posttraumatic stress disorder (PTSD) can lead to IPV. Individuals with PTSD and\u002For problematic drinking behaviors are at risk for IPV because of several factors that are common symptoms of PTSD. Because individuals with PTSD often drink alcohol to \"self-medicate\" or cope with distressing PTSD symptoms, PTSD co-occurs with alcohol misuse and alcohol use disorder at extraordinarily high rates. However, few studies have examined the combined effects of alcohol misuse and PTSD on any form of violence.\n\nThis study will examine the effects of alcohol misuse and posttraumatic stress disorder (PTSD) on alcohol-related intimate partner violence (IPV). We will examine these associations among couples (N=70) in a controlled laboratory setting using validated, standardized methods in a 'real-world' settings using 28 days of ecological momentary assessment (EMA).",[57,58,30],"Alcohol Use Disorder","Posttraumatic Stress Disorder","RECRUITING","2026-04-02",{"date":62,"type":37},"2026-04-03",{"date":64,"type":37},"2024-03-01",{"date":66,"type":22},"2029-10-01",{"name":68,"class":44},"Medical University of South Carolina",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":23,"phases":81,"briefSummary":82,"conditions":83,"keywords":89,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100529371","a-dyadic-intervention-for-young-adult-patients-with-cancer-and-their-partner-caregivers-100529371","NCT06172907","A Dyadic Intervention for Young Adult Patients With Cancer and Their Partner Caregivers","YAD","Inclusion Criteria:\n\n* Either: (1) Currently receiving active cancer treatment (n=5) or are within two years of completing active treatment (n=5) at Massachusetts General Cancer Center (MGHCC), located in Boston, Massachusetts, United States, OR (2) are the partner of an individual between the ages of 25-39 who is currently receiving treatment at MGHCC (n=5) or who has completed cancer treatment at MGHCC within the past two years (n=5)\n* Either: (1) Indicates a score ≥4 on the National Comprehensive Cancer Network (NCCN) adapted distress thermometer study screening questions, OR (2) are the partner of a participant indicating a score ≥4 on the NCCN adapted distress thermometer study screening questions\n* English-speaking\n\nExclusion Criteria:\n\n• Uncontrolled psychosis, active suicidal ideation, or cognitive impairment","25 Years","39 Years",{"count":80,"type":22},20,[25],"The purpose of this pilot study is to examine the feasibility and acceptability of a brief psychotherapy intervention to improve psychosocial coping and maintain couple relationships among young adults (aged 25-39) with cancer and their caregiving partners.",[84,85,86,87,88,30],"Cancer","Survivorship","Caregiver Burden","Psychological Distress","Coping Skills",[90,91],"Young Adult Cancer","Cancer Caregiving","2026-01-08",{"date":94,"type":37},"2026-01-12",{"date":96,"type":37},"2024-04-19",{"date":98,"type":22},"2026-12",{"name":100,"class":44},"Massachusetts General Hospital",4]