[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"covert-brain-infarction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:covert-brain-infarction":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100593914","phase-3-a-european-randomized-study-on-blood-thinners-and-cholesterol-lowering-treatments-to-prevent-future-vascular-events-in-people-with-covert-brain-infarcts-cbi-100593914",false,"NCT07012629","A EUROpean Randomized Study on Blood-thinners and Cholesterol-lowering Treatments to Prevent Future Vascular Events in People With Covert Brain Infarcts (CBI)","A EUROpean Pragmatic Multicenter Randomized Trial on Platelet Inhibition and\u002For Lipid Lowering Treatment in Covert Brain Infarction (CBI)","EURO-CBI","Inclusion Criteria:\n\n* MRI demonstrating a lacunar infarct (acute\u002Fsubacute\u002Fchronic) without prior stroke\u002FTIA symptoms. (A round or ovoid, subcortical, fluid-filled cavity (signal similar to cerebrospinal fluid (CSF)) between 3 and 15 mm in diameter and demonstrating a peripheral T2\u002FFLAIR hyperintense rim of marginal gliosis. For infratentorial lesions the hyperintense rim may be less marked and a complete ring is not required) OR\n* MRI demonstrating a cortical infarct (acute\u002Fsubacute\u002Fchronic) without prior stroke\u002FTIA symptoms (A cortical infarct is defined as a fluid-filled cavity (signal similar to CSF) in the cortex, juxtacortical region or cerebellar cortex and with a ring of T2\u002FFLAIR hyperintense lesions or as cortical T2\u002FFLAIR lesions without a fluid-filled cavity with presumed vascular origin. Both supra- and infratentorial lesion will be included) AND Life expectancy \\> 12 months AND Predominantly independent in actives of daily living (mRS score ≤ 3) AND Age ≥ 50 years\n\nExclusion Criteria:\n\n* History of stroke\u002FTIA\n* High risk of bleeding (e.g., recent or recurrent gastrointestinal or genitourinary bleeding associated with a decrease in hemoglobin levels of at least 1 mmol\u002FL, active peptic ulcer disease, MRI with cortical siderosis and\u002For prior lobar hemorrhage)\n* Indication for long-term use of anticoagulants (e.g. deep vein thrombosis, pulmonary embolism, atrial fibrillation, and rarer indications; such as mechanical heart valve, antiphospholipid antibody syndrome etc.)\n* Concurrent indication for lipid-lowering treatment and\u002For platelet-inhibitors for secondary cardiovascular prevention (ischemic heart disease, recent stenting, ischemic stroke, revascularization surgeries, lower-extremity atherosclerotic arterial disease etc.)\n* Co-existing progressive neurodegenerative disease including dementia or Parkinson's disease.\n* Neoplastic condition that is uncontrolled or associated with an increased risk of bleeding\n* Patient already on antiplatelet or anticoagulation agent, regardless of indication\n* Women with a history of menopause below 12 months are only included after negative pregnancy test","ALL","50 Years",{"count":20,"type":21},1652,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","Magnetic resonance imaging (MRI) is commonly used in healthcare, and sometimes it shows small areas of brain damage called Covert Brain Infarcts (CBIs). These are usually found by chance when people have scans for things like headaches or dizziness. Although CBIs don't cause symptoms at the time, they are linked to a higher risk of future stroke and death.\n\nThere is currently no standard treatment for CBIs, and doctors have different approaches-some give stroke-preventing medication (like antiplatelets or statins), while others don't treat at all. This is mostly because there isn't enough research yet.\n\nThis study will test whether stroke-preventing treatments help people with CBIs. It will also look at whether having a CBI increases the risk of dementia, and whether treatment might lower that risk.",[27],"Covert Brain Infarction",[29,30,31,32],"CBI","Prevention","Asymptomatic brain infarction","Dementia","RECRUITING","2025-11-27",{"date":36,"type":37},"2025-12-04","ACTUAL",{"date":39,"type":37},"2025-11-26",{"date":41,"type":21},"2040-01-01",{"name":43,"class":44},"Aarhus University Hospital","OTHER",14,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":65,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":5},"100491894","prevalence-of-attributable-etiology-and-modifiable-stroke-risk-factors-in-patients-with-covert-brain-infarctions-100491894","NCT05685069","Prevalence of Attributable Etiology and Modifiable Stroke Risk Factors in Patients With Covert Brain Infarctions","Prevalence of Attributable Etiology and Modifiable Stroke Risk Factors in Patients With Covert Brain Infarctions (CBI-registry)","CBI-Registry","Inclusion Criteria:\n\n* Any clinically silent ischemic lesions of the brain parenchyma detected on neuroimaging defined according to established criteria as either:\n\n  * DWI positive lesions: Focus of restricted diffusion (high DWI signal and low ADC value) occurring in either white or gray matter, located in the cerebrum, cerebellum, or brain stem AND not satisfying the diagnostic criteria for MS OR\n  * Cavitatory Lesions: ≥ 3 mm in size that follow CSF on all sequences that are slit or wedge shaped with an irregular margin AND NOT longitudinally aligned with perforating vessels or with a multiple, bilateral symmetrical distribution OR\n  * T2W hyperintense\u002FT1W hypointense lesions: Focal lesion with high T2W signal and low T1W signal that have prior evidence of restricted diffusion; OR present within cortical gray matter or deep gray matter nuclei OR a lesion that is new, compared with an MRI performed within 3 months OR T2W hyper\u002FT1W hypointense lesions in the white matter, which are discontinuous but associated with the classic confluent periventricular T2 intense change of leukoaraiosis (Fazekas ≥2) AND NOT satisfying the diagnostic criteria for MS or with a significant patient history of severe trauma, radiation, drug toxicity, or carbon monoxide poisoning\n* Informed Consent as documented by signature by patient or legally authorized representative\n\nExclusion Criteria:\n\n* Projected life expectancy of less than 2 years,\n* Contraindication to MRI,\n* Patients with a history of symptoms compatible with an AIS\u002FTIA attributable to the lesion observed, covert neurological deficits are allowed,\n* Patient is already included in another clinical trial that will affect the objectives of this study,\n* Patient's lack of accountability, inability to appreciate the nature, meaning and consequences of the study and to formulate his\u002Fher own wishes correspondingly,\n* Women who are pregnant or breast feeding or intention to become pregnant during the course of the study,\n* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant,\n* Contraindications to any of the routine procedures, e.g. inability to obtain neurovascular ultrasound examination,\n* Known or suspected non-compliance, drug or alcohol abuse","16 Years",{"count":56,"type":21},230,"OBSERVATIONAL","The CBI registry is a prospective, interdisciplinary, multimodal observational registry of patients with covert brain infarction. Methods: A standardized workup in analogy to manifest ischemic stroke including cerebral MRI, long-term rhythm monitoring (3 x 7 days ECG), echocardiography, laboratory work-up and risk factor assessment as well as noninvasive angiography of the cervical and intracranial arteries will be performed.",[60,61,62,27,63,64],"Silent Stroke","Silent Cerebral Infarct","Covert Brain Infarct","Lacune","Silent Brain Infarction",[66,67,68],"Covert brain infarction","Covert cerebrovascular disease","Ischemic stroke","2024-11-12",{"date":71,"type":37},"2024-11-14",{"date":73,"type":37},"2019-03-01",{"date":75,"type":21},"2026-08-31",{"name":77,"class":44},"Insel Gruppe AG, University Hospital Bern"]