[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cpr\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cpr":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,77,110],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100606394","phase-2-early-double-sequential-defibrillation-in-out-of-hospital-cardiac-arrest-100606394",false,"NCT07174986","Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest","\"A Randomized Trial Assessing the Effect of Early Double Sequential Defibrillation With Anterior-posterior and Anterior Lateral Pad Placement and Sequential Defibrillation Compared to Standard Pad Placement and Single Defibrillation in Patients With Out of Hospital Cardiac Arrest With Initial Shockable Rhythm and at Least One Failed Standard Defibrillation\"","DOUBLE D","Inclusion Criteria:\n\n* OHCA patients with VT\u002FVF at first rhythm analysis and at least one defibrillation performed in standard (A-L) position\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Obvious pregnancy\n* Known preexisting Do Not Attempt Resuscitation order","ALL","18 Years",{"count":20,"type":21},916,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE2","PHASE3","Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)\u002Fventricular tachycardia (VT) do not respond to initial defibrillation. The survival decreases with number of defibrillations required to terminate VF\u002FVT. In 2022, one prospective cluster randomized trial showed increased survival among (OHCA) patients in refractory VF using Double Sequential Defibrillation (DSD). If DSD can increase survival among all patients in VF that dont respond to one defibrillation, i.e. before it has become refractory is not known.\n\nThe aim of this trial is to assess survival with a double defibrillation strategy initiated as soon as possible among patients with Out of Hospital Cardiac Arrest with initial shockable rhythm and at least one failed standard defibrillation, compared with continued resuscitation using standard defibrillation.",[28,29,30,31,32,33],"Out of Hospital Cardiac Arrest","Ventricular Fibrillation","Defibrillation","CPR","ACLS","Sudden Death",[35,36,32],"Double sequential defibrillation","Double sequential external defibrillation","RECRUITING","2026-02-12",{"date":40,"type":41},"2026-02-17","ACTUAL",{"date":43,"type":41},"2025-09-08",{"date":45,"type":21},"2029-12",{"name":47,"class":48},"Gabriel Riva","OTHER",14,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100612841","the-effectiveness-of-continuous-compression-synchronous-ventilation-bio-cpr-100612841","NCT07258823","the Effectiveness of Continuous Compression-synchronous Ventilation (Bio-CPR)","Study on the Effectiveness of Continuous Compression-synchronous Ventilation (Bio-CPR) in the ACLS Stage of Cardiopulmonary Resuscitation (ACLS) Based on the Bionic Concept to Explore the Best Mechanical Ventilation Strategy","Bio-CPR","Inclusion Criteria:\n\n1. 18-65 years old; 2. Cardiac arrest with witnesses; 3. Onset - compression start time\\\u003C5 minutes; 4. Initial ventricular fibrillation rhythm; 5. Endotracheal intubation and use of a mechanical chest CPR device; Patients with OHCA who meet the above conditions\n\nExclusion Criteria:\n\n* 1\\. OHCA patients who are not suitable for mechanical compression ventilation; 2. The participant or his\u002Fher legally authorized representative (LAR) is unable or unwilling to provide written informed consent.","75 Years",{"count":60,"type":21},408,[62],"NA","Bio-CPR is an innovative new mechanical resuscitation model proposed by our research group. A multi-center RCT study was established to comprehensively evaluate the efficacy of this model and the current standard CPR protocol, verify its safety and efficacy, and provide high-quality clinical evidence support.",[65,66,31,32],"Out-of-hospital Cardiac Arrest (OHCA)","Cardiac Arrest (CA)","NOT_YET_RECRUITING","2025-11-21",{"date":70,"type":41},"2025-12-02",{"date":72,"type":21},"2026-02-01",{"date":74,"type":21},"2027-08-31",{"name":76,"class":48},"Guangdong Provincial People's Hospital",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":109},"100580402","peep-vs-zeep-in-out-of-hospital-cardiac-arrest-100580402","NCT06836830","PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest","Peri-Arrest Ventilation With Positive End-Expiratory-Pressure vs. Zero End-Expiratory-Pressure in Out-of-Hospital-Cardiac-Arrest","PerAVent","Inclusion Criteria:\n\n* Adults \\>= 18 years\n* non-traumatic OHCA\n* mechanical ventilation via airway device\n\nExclusion Criteria:\n\n* Patients \\\u003C 18 years,\n* traumatic cause of OHCA,\n* no cardiac arrest, withholding of resuscitation (e.g. Do-Not-Resuscitate orders)",{"count":86,"type":21},600,[62],"Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.",[90,91,31,66],"Ventilation Therapy","PEEP, Occult",[93,94,95,96,97,98,99,31],"Cardiac Arrest","Positive End-Expiratory Pressure","Zero End-Expiratory Pressure","Ventilation","Randomized Controlled Trial","Emergency Medicine","Resuscitation","2025-08-05",{"date":102,"type":41},"2025-08-06",{"date":104,"type":41},"2025-06-01",{"date":106,"type":21},"2026-10-31",{"name":108,"class":48},"Muehlenkreiskliniken, MKK",3,{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":117,"sex":17,"minAge":118,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":22,"phases":122,"briefSummary":123,"conditions":124,"keywords":125,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":140},"100587540","effect-of-an-educational-intervention-on-cpr-knowledge-and-skills-in-schoolchildren-100587540","NCT06929715","Effect of an Educational Intervention on CPR Knowledge and Skills in Schoolchildren","Effect of an Educational Intervention on CPR Knowledge and Skills in 7- and 8-Year-Old Schoolchildren: A Non-Randomized Controlled Trial","Inclusion Criteria:\n\n* Schoolchildren aged between 7 and 8 years.\n* Students enrolled in an educational institution that has authorized their participation in the study.\n* Not participating in any other intervention or educational program related to CPR during the study period.\n\nExclusion Criteria:\n\n* Students whose parents, legal guardians, teachers, or the students themselves report any health condition that prevents them from participating in the study.\n* Students who indicate having received prior training in CPR or related skills.\n* Students whose parents, legal guardians, or teachers report any cognitive condition that limits their ability to understand and follow the instructions necessary to learn and practice CPR in simulated scenarios.",true,"7 Years","8 Years",{"count":121,"type":21},388,[62],"This study aims to evaluate the effectiveness of a CPR intervention for children aged 7 and 8. Given the high prevalence of out-of-hospital cardiac arrests (OHCA) and the proven benefits of early CPR training, the study seeks to determine whether a structured intervention can improve young children's knowledge and skills in basic life support.\n\nWhat is the effect of a CPR training intervention on the knowledge and skills of 7- and 8-year-old schoolchildren?\n\nCardiac arrest is a leading cause of mortality worldwide. Research shows that survival rates increase significantly when CPR is performed promptly by a trained bystander. Countries with early CPR training programs in schools, such as Norway and Denmark, report better survival outcomes. However, in Latin America, CPR education in schools is still in its early stages. Evidence suggests that children can effectively learn and retain CPR knowledge, and they can serve as multipliers by passing their knowledge to family and peers.\n\nStudy Design:\n\nThis is a non-randomized, double-blind controlled trial with four phases:",[31,66],[126,127,128,129,130],"schoolchildren","learning","intervention","knowledge","skills","2025-04-08",{"date":133,"type":41},"2025-04-16",{"date":135,"type":21},"2025-05-01",{"date":137,"type":21},"2025-09-01",{"name":139,"class":48},"Universidad Nacional de Colombia",1]