[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cranial-defect\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cranial-defect":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100620344","associations-of-cranial-outcomes-and-parental-expectations-and-satisfaction-100620344",false,"NCT07356401","Associations of Cranial Outcomes and Parental Expectations and Satisfaction","Association Between Cranial Morphological Changes, Parental Expectations, and Satisfaction Following Cranial Remolding Orthosis Treatment in Infants","Inclusion Criteria:\n\n* Infants diagnosed with positional cranial deformities (e.g., plagiocephaly, brachycephaly, or asymmetrical cranial shape)\n* Infants who received cranial remolding orthosis treatment\n* Use of a custom-made cranial remolding orthosis\n* Availability of pre-treatment and post-treatment cranial measurements\n* Parents or legal guardians who provided informed consent and were able to complete expectation and satisfaction questionnaires\n* Infants who completed the planned cranial remolding orthosis treatment and follow-up period\n\nExclusion Criteria:\n\n* Infants with neurological disorders, genetic syndromes, or congenital conditions affecting cranial growth\n* Infants who underwent previous cranial surgery or other cranial interventions\n* Infants who received non-custom-made or prefabricated cranial orthoses\n* Incomplete clinical records or missing pre- or post-treatment cranial measurements\n* Parents or caregivers unable to complete the questionnaires due to language or cognitive limitations\n* Infants with a diagnosis of microcephaly or macrocéphaly.","ALL","3 Months","18 Months",{"count":20,"type":21},20,"ESTIMATED","1 Month","OBSERVATIONAL","This study aims to investigate the association between objective cranial morphological changes and parental expectations and satisfaction in infants undergoing treatment with a cranial remolding orthosis (CRO). Infants diagnosed with positional cranial deformities and prescribed CRO treatment will be included. Cranial morphological outcomes will be assessed using standardized cranial measurements obtained before and after the treatment period.\n\nParental treatment expectations will be evaluated prior to the initiation of CRO therapy using the Treatment Expectation Questionnaire (TR.TEX-Q), while parental satisfaction with the device and treatment process will be assessed at the end of treatment using the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST).\n\nThe primary objective of the study is to examine the relationships between changes in cranial morphology and parental expectations and satisfaction scores. Secondary objectives include exploring the association between baseline expectations and post-treatment satisfaction. The findings are expected to provide insight into how objective treatment outcomes align with family-reported perceptions in cranial remolding orthosis therapy.",[26,27,28,29,30],"Plagiocephaly","Cranial Defect","Orthosis","Expectancy","Satisfaction","RECRUITING","2026-01-22",{"date":34,"type":35},"2026-01-26","ACTUAL",{"date":37,"type":35},"2025-11-25",{"date":39,"type":21},"2026-03-15",{"name":41,"class":42},"Gulhane School of Medicine","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100607052","study-on-the-effect-of-ultra-early-autologous-cranioplasty-on-neurological-function-recovery-100607052","NCT07183540","Study on the Effect of Ultra-early Autologous Cranioplasty on Neurological Function Recovery","Study on the Effect of Ultra-early Autologous Cranioplasty on Neurological Function Recovery: a Multicenter, Prospective, Open-label, Endpoint-blinded, Randomized Controlled Study","FAST-ECP","Inclusion Criteria:\n\n1. Decompressive craniectomy due to craniocerebral trauma, cerebral ischemia and cerebral hemorrhage.\n2. Age 18 - 80 years.\n3. The first time for cranial repair.\n4. unilateral skull defect.\n5. Compliant with recommended decompressive bone flap surgery and autogenous decompressive bone flap after bone flap collection\n6. signed the informed consent.\n\nExclusion Criteria:\n\n1. Poor healing of skin flap (active infection, non-healing, necrosis, sinus, thin or poor blood supply, etc.).\n2. Fracture of bone flap ≥2 pieces, partial open fracture\n3. Intracranial infection before operation.\n4. Severe bone metabolic diseases.\n5. Long-term use of immunosuppressants.\n6. Pregnant or lactating women.\n7. Coagulation disorders.\n8. Severe cardiopulmonary insufficiency.\n9. It is estimated that the CP process cannot be completed within 6 weeks after the bone plate decompression surgery.\n10. Skull defect size less than 25cm².\n11. Life expectancy less than 1 year.\n12. mRS greater than 1 before primary disease.\n13. Diabetic patients.\n14. Patients who are unable to cooperate with follow-up assessment (e.g. mental illness).","18 Years","80 Years",{"count":55,"type":21},582,"INTERVENTIONAL",[58],"NA","To compare the neurological recovery and complication rate of autogenous cranioplasty(CP) within 6 weeks after decompressive craniectomy (DC) with that of autogenous cranioplasty within 3\\~6 months after DC.",[27],[62,63,64,65],"Decompressive craniectomy and Cranioplasty","operation opportunity","ultra-early","Autologous skull","NOT_YET_RECRUITING","2025-09-17",{"date":69,"type":35},"2025-09-19",{"date":71,"type":21},"2025-10-01",{"date":73,"type":21},"2027-09-01",{"name":75,"class":42},"The Affiliated Hospital Of Guizhou Medical University",7,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":97},"100565465","a-prospective-observational-study-of-transcranial-doppler-ultrasound-in-the-assessment-of-cerebral-blood-flow-after-polyetheretherketone-cranioplasty-100565465","NCT06642532","A Prospective Observational Study of Transcranial Doppler Ultrasound in the Assessment of Cerebral Blood Flow After Polyetheretherketone Cranioplasty","Inclusion Criteria:\n\n1. Age of 18 years or older;\n2. Proposed polyetheretherketone cranioplasty;\n3. Incomplete cranial bone in the lateral temporal window;\n4. Signed informed consent for surgery and informed consent for research.\n\nExclusion Criteria:\n\n1)Although cranioplasty is proposed, the cranial bone in the temporal region is intact.",{"count":84,"type":21},10,"Polyetheretherketone has become one of the most important material choices for cranioplasty surgery. It has been shown that conventional ultrasound can be performed through the polyetheretherketone material for the examination of brain tissue and ventricular morphology. Transcranial doppler ultrasound can obtain good images of cerebral hemodynamic parameters in patients through polyetheretherketone-covered temporal window. This trial is a clinical prospective observational study in which cases treated with polyetheretherketone cranioplasty, and transcranial doppler ultrasonography is performed preoperatively and 10 days postoperatively, and data were collected mainly including bilateral hemodynamic parameters of middle cerebral artery(MCA), terminal internal carotid artery(TICA), (anterior communicating artery)ACA, and posterior cerebral artery(PCA) (Vs, Vd, Vm, PI index, RI index) from temporal window.",[27,87],"TCD","2024-11-13",{"date":90,"type":35},"2024-11-15",{"date":92,"type":35},"2024-06-01",{"date":94,"type":21},"2024-12-31",{"name":96,"class":42},"RenJi Hospital",2]