[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cranial-neurosurgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cranial-neurosurgery":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,39],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100497296","feasibility-of-transcranial-focused-ultrasound-to-measure-brain-tumor-100497296",false,"NCT05755399","Feasibility of Transcranial Focused Ultrasound to Measure Brain Tumor","Inclusion Criteria:\n\n* Able to undergo informed consent\n* Scheduled and present for brain surgery\n* General Anesthesia planned\n* Neuronavigation used for surgery\n* Thin cut post-contrast imaging available for coregistration\n* At least 18 years of age\n\nExclusion Criteria:\n\n* Awake craniotomy planned\n* Unhealed wounds or infection of scalp\n* Diseases and conditions that would increase the morbidity and mortality of craniotomy and tumor resection (e.g. cardiopulmonary issues) in the opinion of the PI.\n* Pregnancy (also generally required for surgery)","ALL","18 Years",{"count":18,"type":19},15,"ESTIMATED","INTERVENTIONAL",[22],"NA","Transcranial focused ultrasound (tFUS) offers a platform for non-invasive imaging and treatment of the brain and pathology of the brain -- allowing high resolution imaging in both spatial and temporal dimensions. Compared with the gold- standard for brain imaging, magnetic resonance imaging (MRI), ultrasound offers reduced contrast while providing improved sampling in time through a significantly more cost-effective approach. In addition, while MRI is used to guide invasive treatments, only ultrasound can offer treatments through three primary mechanisms: 1) neuromodulation, 2) blood brain barrier modulation, and thermal\u002Fmechanical ablation through high intensity focused ultrasound (HIFU). All three treatment options require targeting therapy through the skull, which remains a barrier to clinical translation. This proposal is to test the feasibility of acquiring noninvasive targeting imaging intraoperatively prior to clinically indicated cranial neurosurgery. By acquiring volumetric ultrasound images while coregistered to previously obtained stereotactic magnetic resonance imaging, the study will be able to compare the ability of tFUS to identify and focus on brain pathology.",[25],"Cranial Neurosurgery","RECRUITING","2026-05-18",{"date":29,"type":30},"2026-05-19","ACTUAL",{"date":32,"type":30},"2023-10-19",{"date":34,"type":19},"2027-11-30",{"name":36,"class":37},"University of Minnesota","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":4,"briefSummary":50,"conditions":51,"keywords":52,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":38},"100627010","heart-rate-variability-and-processed-eeg-features-as-predictors-of-postoperative-outcomes-after-cranial-neurosurgery-100627010","NCT07443072","Heart Rate Variability and Processed EEG Features as Predictors of Postoperative Outcomes After Cranial Neurosurgery","Heart Rate Variability and Processed EEG Features as Predictors of Postoperative Outcomes After Cranial Neurosurgery - A Prospective Observational Study in the Post-Anesthesia Care Unit","HERO-PACU","Inclusion Criteria:\n\n* Adult patients (≥18 years) scheduled for elective cranial neurosurgery.\n* Planned extubation in the PACU after surgery.\n* Ability to obtain high-quality ECG and EEG recordings intra- and postoperatively (≥60 min expected PACU monitoring).\n* Written informed consent signed preoperatively.\n\nExclusion Criteria:\n\n* Pre-existing severe cardiac arrhythmias (e.g., atrial fibrillation, frequent ectopy) or pacemaker dependence.\n* Known severe autonomic neuropathy (e.g., advanced diabetes, Parkinson's disease with autonomic failure).\n* Preoperative conditions associated with abnormal EEG (status epilepticus, uncontrolled seizures, sedative\u002Fhypnotic overdose).\n* Intraoperative or immediate postoperative events necessitating continued mechanical ventilation or ICU admission (e.g., massive bleeding, intraoperative arrest).\n* Inability to provide informed consent (e.g., cognitive impairment, language barrier without interpreter).\n* Refusal of informed consent",{"count":48,"type":19},300,"OBSERVATIONAL","Patients undergoing cranial neurosurgery face a high-risk postoperative period, particularly during emergence from anesthesia and early recovery in the post-anesthesia care unit (PACU). Standard monitoring provides limited insight into brain and autonomic recovery processes. Heart rate variability (HRV) and processed electroencephalography (pEEG) may offer complementary markers of autonomic and cortical function, with potential to improve early detection of complications and guide individualized care.",[25],[53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74],"HRV","heart rate variability","EEG","electroencephalography","EEG patterns","EEG signatures","pEEG","processed EEG","Neurosurgery","Monitoring","PACU","Post Anesthesia Care Unit","Autonomous Nervous System","Cortical Function","Outcome after Neurosurgery","Post Operative Period","Post Operative Monitoring","Post Operative Outcome","Anesthesia","Emergence","Awakening","Recovery","2026-03-06",{"date":77,"type":30},"2026-03-10",{"date":79,"type":30},"2026-03-05",{"date":81,"type":19},"2027-02",{"name":83,"class":37},"Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta"]