[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"craniocerebral-trauma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:craniocerebral-trauma":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,82,118],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100641311","socio-cultural-level-health-literacy-and-parental-ct-demand-in-paediatric-minor-head-trauma-100641311",false,"NCT07655310","Socio-Cultural Level, Health Literacy, and Parental CT Demand in Paediatric Minor Head Trauma","The Relationship Between Family Socio-Cultural Level, Health Literacy, and Parental Demand for Computed Tomography in PECARN-Stratified Children Presenting With Minor Head Trauma: A Single-Centre Prospective Observational Cohort Study","Inclusion Criteria:\n\n1. Age less than 18 years at time of emergency department presentation\n2. Presenting complaint of head trauma sustained within the preceding 24 hours\n3. Classified as minor head trauma at triage, defined as a Glasgow Coma Scale (GCS) score of 14 or 15 at initial assessment\n4. Accompanied by a parent or legal guardian with capacity to provide written informed consent\n\nExclusion Criteria:\n\n1. GCS score 13 or less at presentation (moderate or severe head injury)\n2. Transfer from another medical facility\n3. Head trauma sustained more than 24 hours before emergency department presentation\n4. Known coagulopathy, anticoagulant therapy, or bleeding disorder\n5. Ventriculoperitoneal shunt in situ\n6. Previous intracranial neurosurgery\n7. Pre-existing neurological disorder affecting GCS interpretation (e.g., cerebral palsy, developmental delay)\n8. Clinical suspicion of abusive head trauma (non-accidental injury) identified by the treating physician\n9. Concurrent multi-system trauma\n10. No accompanying parent or guardian available for consent and socio-cultural assessment","ALL","17 Years",{"count":19,"type":20},200,"ESTIMATED","OBSERVATIONAL","Minor head trauma is one of the most frequent reasons for paediatric emergency department visits worldwide. The PECARN (Paediatric Emergency Care Applied Research Network) clinical decision rule stratifies children with minor head trauma into low-, intermediate-, and high-risk categories for clinically important traumatic brain injury (ciTBI) and provides evidence-based guidance on computed tomography (CT) ordering. Despite its high diagnostic accuracy, real-world CT utilisation frequently diverges from PECARN recommendations. Non-clinical family-level factors - including socio-cultural characteristics and health literacy - may drive part of this divergence, particularly through their influence on whether families explicitly request CT imaging.\n\nThis prospective observational cohort study will enrol 200 children with minor head trauma presenting to the emergency department of SBU Bursa Yuksek Ihtisas EAH, Bursa, Turkey. The primary aim is to determine whether family socio-cultural level (composite index incorporating education, occupation, income, and housing; scored 0-10) and health literacy (Newest Vital Sign-Turkish, NVS-TR) independently predict parental demand for CT imaging. Secondary aims include determining whether parental CT demand and family socio-cultural characteristics predict CT ordering by the treating physician, describing PECARN algorithm adherence patterns in this setting, and examining parental health-seeking behaviour at 7-day telephone follow-up.",[24,25,26],"Craniocerebral Trauma","Brain Injuries, Traumatic","Head Injuries, Closed",[28,29,30,31,32,33,34,35,36,37],"PECARN","paediatric head trauma","minor head trauma","computed tomography","health literacy","socio-cultural level","clinical decision rule","parental CT demand","emergency medicine","NVS-TR","RECRUITING","2026-06-17",{"date":41,"type":42},"2026-06-22","ACTUAL",{"date":44,"type":42},"2024-04-10",{"date":46,"type":20},"2027-08",{"name":48,"class":49},"Bursa Yuksek Ihtisas Training and Research Hospital","OTHER_GOV",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":50},"100633957","long-term-follow-up-of-pituitary-and-hypothalamic-dysfunction-in-children-who-have-suffered-moderate-to-severe-head-trauma-included-in-the-endoc-tc-cohort-100633957","NCT07533435","Long-term Follow-up of Pituitary and Hypothalamic Dysfunction in Children Who Have Suffered Moderate to Severe Head Trauma Included in the ENDOC TC Cohort","ENDOC TC 2","Inclusion Criteria:\n\n* Consent of the child if under 18 years of age and no objection from both parents, or no objection from the adult patient\n* Patients included in the Princeps Endoc TC study in Lyon\n\n  * Patients who have suffered a traumatic brain injury\n  * Children aged 2 months to 16 years inclusive\n  * Admitted to pediatric intensive care\n  * Initial Glasgow Coma Scale score between 3 and 12, regardless of the mechanism of head injury\n  * Informed consent signed by parents\n\nExclusion Criteria:\n\n* Patient deceased since the end of Endoc TC study",{"count":59,"type":20},90,"The annual incidence of traumatic brain injury (TBI), all causes combined, varies between 180 and 300 per 100,000. TBI increases the risk of death or serious sequelae by a factor of 8.\n\nStudies conducted in adults have shown an anterior pituitary deficit in 28% to 68% of patients with TBI. The variability of these studies does not currently allow for standardization of the management of these children in either the acute or late phases.\n\nSeveral studies, including a Lyon-based study called Endoc TC (Ref. Clinical Trials: NCT01250132), have aimed to investigate the association between anterior pituitary deficits in the acute phase and those identified a few months after the trauma.\n\nSince then, few studies have been conducted more than five years after the trauma to study its pituitary consequences.\n\nTo date, the investigators have sought to study the long-term prevalence of pituitary and hypothalamic dysfunction in patients who suffered moderate to severe head trauma during childhood, specifically patients included in the initial Endoc TC study in Lyon.\n\nTo this end, the main objective is to determine the current height of these patients and whether there are any associated growth delays or other clinical signs that may suggest the presence of a pituitary or hypothalamic hormone deficiency.\n\nThis study consists of a telephone questionnaire lasting approximately 15 minutes, with participants from Lyon who took part in ENDOC TC study, designed to determine the growth of these patients and the presence or absence of symptoms that may be related to post-traumatic damage to the hypothalamic-pituitary system linked to head trauma.",[24,62,63,64],"Hypothalamic-pituitary Disorders","Pediatric","Endocrinology",[66,67,68,69,70],"Traumatic brain injury","Anterior pituitary deficits","Growth delaus","Pituitary or hypothalamic hormone deficiency","Initial Endoc TC study (Ref. Clinical Trials : NCT01250132)","NOT_YET_RECRUITING","2026-05-20",{"date":74,"type":42},"2026-05-22",{"date":76,"type":20},"2026-04-22",{"date":78,"type":20},"2026-09-30",{"name":80,"class":81},"Hospices Civils de Lyon","OTHER",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":16,"minAge":91,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":101,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":50},"100564700","timing-impact-of-early-vs-late-cranioplasty-on-hemicraniectomy-outcomes-100564700","NCT06632587","Timing Impact of Early vs. Late Cranioplasty on Hemicraniectomy Outcomes","Comparing Outcomes Between Early and Standard-of-care Delayed Cranioplasty After Decompressive Hemicraniectomy","TIMELY","Inclusion Criteria:\n\n* Adults of age greater than or equal to 18 years at the time of acute traumatic injury or source of increased intracranial pressure secondary to stroke or intracranial hemorrhage necessitating decompressive hemicraniectomy (DHC)\n* Patient's cranial flap fulfills Craniectomy Contour Class A or B after 4 weeks postoperatively (doi:10.1227\u002Fons.0000000000000689)\n* Medically optimized for general anesthesia\u002Fsurgery\n\nExclusion Criteria:\n\n* Active systemic infection in weeks 6-8 post-DHC leading up to cranioplasty (e.g. pneumonia, urinary tract infection, soft tissue infection, bacteremia)\n* Cranial infection in the post-DHC period\n* Patient deemed not appropriate for early cranioplasty by attending neurosurgeon\n* Patient mortality prior to 8 weeks post-injury (\"injury\" defined as \"acute traumatic injury or source of increased intracranial pressure causing brain injury secondary to stroke or intracranial hemorrhage\")",true,"18 Years",{"count":93,"type":20},44,"INTERVENTIONAL",[96],"NA","This prospective, randomized study aims to comprehensively evaluate the impact of cranioplasty timing on postoperative complications and long-term functional outcomes following decompressive hemicraniectomy (DHC). The primary endpoint focuses on comparing the rates of various postoperative complications, including infection, seizures, return to the operating room, and the need for ventriculoperitoneal shunting, between patients undergoing standard of care cranioplasty (\\>3 months after DHC) and those receiving early cranioplasty (within 8 weeks).",[24,99,100],"Stroke","Intracranial Hemorrhages",[102,103,104,105,106,107,108],"Decompressive hemicraniectomy","cranioplasty","cranial trauma","stroke","intracranial hemorrhage","intracerebral hemorrhage","neurosurgery","2025-07-21",{"date":111,"type":42},"2025-07-23",{"date":113,"type":42},"2024-09-01",{"date":115,"type":20},"2027-09-01",{"name":117,"class":81},"Thomas Jefferson University",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":16,"minAge":91,"maxAge":125,"enrollmentInfo":126,"targetDuration":4,"studyType":94,"phases":128,"briefSummary":129,"conditions":130,"keywords":134,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":50},"100517277","exercise-in-postconcussion-symptoms-and-posttraumatic-headache-100517277","NCT06015451","Exercise in Postconcussion Symptoms and Posttraumatic Headache","Exercise Interventions in Patients With Postconcussion Symptoms and Posttraumatic Headache. A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Age 18-65 years\n* Having sustained a minimal head injury or mild traumatic brain injury at least 2 weeks ago.\n* At least one postconcussion symptoms, of at least moderate degree, occurring within the first week after the head injury.\n* Intolerance for physical activity (self-reported and measured; including symptom exacerbation later on the test day).\n* Capable of giving informed consent.\n\nExclusion Criteria:\n\n* More than 2 years since last injury.\n* The symptoms are better explained by other conditions.\n* Severe communication problems, typically due to poor knowledge of Norwegian.\n* Severe psychiatric, neurological, somatic, or substance abuse disorders that will make it problematic to function in a group and\u002For will complicate follow-up and outcome assessment.\n* Safety concerns according to the study medical checklist.","65 Years",{"count":127,"type":20},100,[96],"The goal of this clinical trial is to compare two models of delivery of guided exercise in patients with exercise intolerance after mild head injury.\n\nThe main question it aims to answer is:\n\n• Is a program that includes elements of in-house exercise and follow-up sessions, and repeated treadmill testing, superior to a program with telephone-based follow-up only?\n\nParticipants will undergo a treadmill test to determine eligibility for the study, and to determine at what intensity level their symptoms worsen (symptom threshold). Thereafter they will exercise 15-20 minutes, 3-5 times per week at 80-90% of the heart rate that was found to be the symptom threshold. One group will receive face-to-face folllow-up and repeated testing, one group will receive telephone-based follow-up only .\n\nResearchers will compare these two groups to see if closer follow-up is superior when it comes to recovery from exercise intolerance after 12 weeks of exercise.",[131,132,133,24],"Brain Concussion","Post-Concussion Syndrome","Post-Traumatic Headache",[135,136,137],"exercise intolerance","exercise","Thread mill test","2025-07-07",{"date":140,"type":42},"2025-07-08",{"date":142,"type":42},"2022-11-01",{"date":144,"type":20},"2026-09-01",{"name":146,"class":81},"St. Olavs Hospital"]