[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"craniofacial-abnormalities\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:craniofacial-abnormalities":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100629572","oral-health-dento-facial-condition-and-ohrqol-in-subjects-with-mowat-wilson-syndrome-an-epidemiologic-study-100629572",false,"NCT07476417","Oral Health, Dento-facial Condition and OHRQoL in Subjects With Mowat-Wilson Syndrome: an Epidemiologic Study.","ORALMOWAT26","Inclusion Criteria:\n\n* individuals affected by MWS with confirmed molecularly diagnosis of ZEB2 gene variation.\n* written informed consent statement signed by parents\u002Flegal guardians for participation in the study\n\nExclusion Criteria:\n\n* individuals not affected by MWS\n* refusal of parents\u002Flegal guardians to participate in the study","ALL",{"count":18,"type":19},25,"ESTIMATED","OBSERVATIONAL","Mowat-Wilson Syndrome (MWS) is a rare syndrome characterized by the presence of facial gestalt and delayed psychomotor development, variably associated with intellectual disability, epilepsy, Hirschsprung's disease (HSCR) and multiple congenital malformations.\n\nAlthough there is evidence of the presence of dental and craniofacial anomalies in MWS, little epidemiological data is available to date.\n\nThe goal of this observational study is to assess oral health and dento-facial phenotype of people affected by Mowat-Wilson Syndrome (MWS). In addition, the Oral Health Related Quality of Life (OHRQoL) will be investigated.",[23,24,25,26,27,28,29,30,31,32],"Mowat-Wilson Syndrome","Dental Caries","Periodontal Diseases","Sleep Related Breathing Disorder","Tooth Diseases","Malocclusion","Tooth Abnormalities","Oral Health Related Quality of Life (OHRQoL)","Craniofacial Abnormalities","Oral Mucosal Disease",[34,35,36,37,38,31],"Mowat-Wilson syndrome","dental caries","periodontal diseases","malocclusion","oral health","NOT_YET_RECRUITING","2026-03-19",{"date":42,"type":43},"2026-03-24","ACTUAL",{"date":45,"type":19},"2026-04-01",{"date":47,"type":19},"2026-08-30",{"name":49,"class":50},"University of Milan","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":51},"100625424","faces-4-kids--a-deep-phenotyping-database-of-craniofacial-anomalies-during-development-with-4-pilot-projects-100625424","NCT07422454","FACE.S-4-KIDS : A Deep Phenotyping Database of Craniofacial Anomalies During Development With 4 Pilot Projects","FACE.S-4-KIDS : FACE and SKULL for Key Innovative Data Science. Une Base de données de phénotypage Profond Des Anomalies Craniofaciales au Cours du développement","FACES-4-KIDS","Inclusion Criteria for patients:\n\n1. Patients suffering from one of the following pathologies:\n\n   craniostenosis linked to FGFR signaling, achondroplasia \u002F hypochondroplasia, osteogenesis imperfecta, Pierre Robin sequence (with or without anatomical markers).\n2. Patients who may or may not have benefited from genome sequencing as part of their care and who (or holders of parental authority where applicable) have consented to the conservation of the remains of their biological samples in one of these collections:\n\n   * Chondroplasia and craniostenosis,\n   * Constitutional Bone Diseases,\n   * Developmental anomalies.\n3. Patients who have undergone craniofacial imaging (CT or MRI) as part of their care.\n\nInclusion Criteria for controls:\n\n1. Patients who have consulted the Genetics, Pediatrics or Maxillofacial Surgery Departments at Necker, with none of these pathologies:\n\n   FGFR-related craniosynostoses Chondroplasia \u002F hypochondroplasia Osteogenesis imperfecta Pierre Robin sequence (with or without anatomical marker)\n2. Patients who have benefited from genome sequencing as part of their care and who have (or holders of parental authority where applicable) consented to the conservation of the remains of their biological samples in the \"Infectious Diseases\" collection .\n3. Patients who have undergone craniofacial imaging (CT or MRI) as part of their treatment.\n\nNon-inclusion Criteria:\n\nOpposition of the patient or his parents to the reuse of their data from care in this study",{"count":61,"type":19},3100,"FACE.S-4-KIDS is an ambitious database project addressing the scientific question of the variable expression of craniofacial disorders in humans, to reach a sound clinical management (diagnosis, prognosis), and the establishment of personalised treatment plans.",[31],[65,66,67,68,69,70],"Genetics","Rare disease","Craniofacial development","Dysmorphic syndromes","Deep phenotyping","Face and skull imaging","RECRUITING","2026-02-12",{"date":74,"type":43},"2026-02-20",{"date":76,"type":43},"2025-10-16",{"date":78,"type":19},"2033-10-31",{"name":80,"class":50},"Imagine Institute",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":109},"100616404","a-multicenter-retrospective-analysis-of-postoperative-respiratory-complications-in-children-with-obstructive-sleepapnea-100616404","NCT07305168","A Multicenter Retrospective Analysis of Postoperative Respiratory Complications in Children With Obstructive Sleepapnea","MRA PORC","Inclusion Criteria:\n\n* scheduled for (adeno)tonsillectomy as treatment for OSAS\n\nExclusion Criteria:\n\n* other surgery than (adeno)tonsillectomy performed as treatment for OSAS\n* Polysomnography not available within 1 year before surgery","1 Year","18 Years",{"count":91,"type":19},200,"This retrospective observational study aims to evaluate postoperative respiratory complications (PORC) after (adeno)tonsillectomy in children with OSA.\n\nIn order to increase the number of patients available for analysis, we will merge data collected at UZA with data collected at the the Department of Sleep Laboratory and Sleep Surgery at the Heim Pal National Pediatric Institute, Hungary. These colleagues performed an identical prospective data collection.",[94,95,96,97,31,98,99],"Obstructive Sleep Apnea","Postoperative Respiratory Complications","Adenotonsillectomy","Child Obesity","Children With Down Syndrome","Neurologic Disorder","2025-12-11",{"date":102,"type":43},"2025-12-26",{"date":104,"type":43},"2022-05-02",{"date":106,"type":19},"2027-03-01",{"name":108,"class":50},"University Hospital, Antwerp",2]