[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"craniofacial-dystonia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:craniofacial-dystonia":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100289070","brain-networks-in-dystonia-100289070",false,"NCT03042962","Brain Networks in Dystonia","Inclusion Criteria:\n\n* Patients will have clinically documented focal dystonia\n* Unaffected relatives of patients with focal dystonia\n* Healthy controls will be healthy volunteers with a negative history of neurological, laryngeal or psychiatric problems\n* Age from 21 to 80 years.\n* Native English speakers.\n* Right-handedness (based on Edinburgh Handedness Inventory).\n\nExclusion Criteria:\n\n* Subjects who are incapable of giving an informed consent.\n* Pregnant or breastfeeding women until a time when they are no longer pregnant or breastfeeding. All women of childbearing potential will have a urine pregnancy test performed, which must be negative for participation in the imaging studies.\n* Subjects with past or present medical history of (a) neurological problems, such as stroke, movement disorders (other than dystonia in the patient groups), brain tumors, traumatic brain injury with loss of consciousness, ataxias, myopathies, myasthenia gravis, demyelinating diseases, alcoholism, drug depend-ence; (b) psychiatric problems, such as schizophrenia, major and\u002For bipolar depression, obsessive-compulsive disorder; (c) laryngeal problems, such as vocal fold paralysis, paresis, vocal fold nodules and polyps, carcinoma, chronic laryngitis.\n* Patients who are not symptomatic due to treatment with botulinum toxin injections into the laryngeal muscles. The duration of positive effects of botulinum toxin vary from patient to patient but lasts on average for 3-4 months. All patients will be evaluated to ensure that they are fully symptomatic prior to entering the study.\n* Patients with other forms of dystonia.\n* Patients who have dystonia symptoms at rest in order to avoid the potential confound of dystonic spasms occurring during the scanning.\n* To avoid the possibility of confounding effects of drugs acting upon the central nervous system, all study participants will be questioned about any prescribed or over-the-counter medications as part of their initial intake screening. Those patients who receive medication(s) affecting the central nervous system will be excluded from the study.\n* The patients will be asked whether they have undergone any head, neck, or hand surgeries, which resulted in changes in regional anatomy or innervation. Because brain, hand and laryngeal surgery may potentially lead to the brain structure and function re-organization, all patients with history of brain, hand and\u002For laryngeal surgery will be excluded from the study.\n* Subjects who have tattoos, ferromagnetic objects in their bodies (e.g., implanted stimulators, surgical clips, prosthesis, artificial heart valve, etc.) that cannot be removed for the purpose of study participation.",true,"ALL","21 Years","80 Years",{"count":20,"type":21},141,"ESTIMATED","OBSERVATIONAL","To date, there is only limited knowledge about the distinct neural abnormalities that lead to the development of different forms of focal dystonia. The goal of this study is to dissect the pathophysiological mechanisms underlying this clinical phenomenon using multi-level brain network analysis in patients with focal dystonia.",[25,26,27,28,29,30],"Spasmodic Dysphonia","Singer's Dystonia","Writer's Cramp","Musician's Focal Hand Dystonia","Craniofacial Dystonia","Blepharospasm Oromandibular Dystonia",[32,33,34],"dystonia","imaging","genetics","RECRUITING","2025-12-01",{"date":38,"type":39},"2025-12-08","ACTUAL",{"date":41,"type":39},"2015-08-01",{"date":43,"type":21},"2027-12-31",{"name":45,"class":46},"Massachusetts Eye and Ear Infirmary","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":47},"100471287","deep-brain-stimulation-for-idiopathic-craniofacial-dystonia-gpi-or-stn-100471287","NCT05416905","Deep Brain Stimulation for Idiopathic Craniofacial Dystonia: GPi or STN","Multicenter Evaluation of Deep Brain Stimulation for Idiopathic Craniofacial Dystonia: Globus Pallidus intErnus or Subthalamic Nucleus","MEIGES","Inclusion Criteria:\n\n1. Adult subject (male or female, 18-75 years);\n2. Diagnosed with idiopathic craniofacial dystonia for more than 1 year, including at least one of the eye and oromandibular region. Cervical dystonia may be present;\n3. Treated with oral drugs or botulinum toxin injections, but with no satisfactory curative effect;\n4. Normal cognitive function with MMSE score ≥ 24;\n5. Informed consent signed.\n\nExclusion Criteria:\n\n1. Only cervical dystonia, or combined with dystonia in other parts of the body other than the cervical region;\n2. Diagnosed with other neuropsychiatric diseases(Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, etc.);\n3. History of brain surgery;\n4. Severe depression with HRSD score ≥ 35;\n5. Contraindications to neurosurgery(cerebral infarction, hydrocephalus, cerebral atrophy, sequelae of cerebrovascular disease, etc);\n6. Contraindications to CT or MRI scanning(claustrophobia, etc);\n7. pregnant or breastfeeding female, or has positive pregnancy test prior to randomization;\n8. Contraindications to general anesthesia (severe arrhythmia, severe anemia, abnormal liver and kidney function, etc.);\n9. Expected lifetime \\\u003C 12 months;\n10. Currently receiving an investigational drug or device;\n11. Other circumstances that the investigator considers unsuitable to participate in this study or that may pose a significant risk to the patient (inability to understand or comply with research procedures and follow-up, etc.).","18 Years","75 Years",{"count":59,"type":21},110,"INTERVENTIONAL",[62],"NA","MEIGES is a prospective, multicenter, randomized controlled clinical trial with the primary hypothesis that, STN-DBS is non-inferior to GPi-DBS for motor symptoms improvements at 365 days postoperatively in patients with idiopathic craniofacial dystonia.",[29,65],"Deep Brain Stimulation",[29,65,67,68],"Globus pallidus internus","Subthalamic nucleus","2025-04-17",{"date":71,"type":39},"2025-04-22",{"date":73,"type":39},"2022-06-22",{"date":75,"type":21},"2025-05-30",{"name":77,"class":46},"Beijing Tiantan Hospital"]