[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"craniosynostosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:craniosynostosis":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100641476","pleth-variability-index-monitoring-in-pediatric-craniosynostosis-surgery-100641476",false,"NCT07657598","Pleth Variability Index Monitoring in Pediatric Craniosynostosis Surgery","Association of Pleth Variability Index Monitoring With Intraoperative Hemodynamic Control in Pediatric Craniosynostosis Surgery","PVI-CRANIO","Inclusion Criteria:\n\n* Pediatric patients aged 0 to 6 years\n* Patients scheduled to undergo craniosynostosis surgery\n* American Society of Anesthesiologists physical status I, II or III\n* Written informed consent obtained from the parent or legal guardian\n\nExclusion Criteria:\n\n* Patients older than 6 years\n* American Society of Anesthesiologists physical status IV\n* Inappropriate preoperative fasting status\n* History of significant cardiac, pulmonary or renal disease\n* Patients operated at another institution and subsequently transferred to the study center\n* Patients with peripheral circulatory impairment\n* Withdrawal of consent by the parent or legal guardian","ALL","6 Years",{"count":20,"type":21},30,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to evaluate the role of pleth variability index (PVI) and perfusion index (PI) monitoring in intraoperative hemodynamic control among pediatric patients undergoing craniosynostosis surgery. Patients aged 0-6 years will be monitored intraoperatively using standard anesthesia monitoring together with PVI and PI measurements. Hemodynamic parameters, including systolic, diastolic and mean arterial pressure, heart rate, central venous pressure, oxygen saturation, body temperature, urine output, blood loss, fluid replacement, blood product requirement, serum lactate level, blood gas parameters and intraoperative complications will be recorded. The study will assess the association between PVI\u002FPI changes and intraoperative hemodynamic status, bleeding and transfusion requirements.",[25],"Craniosynostosis",[27,28,29,30,31,32,33],"Pleth Variability Index","Perfusion Index","Craniosynostosis Surgery","Pediatric Anesthesia","Hemodynamic Monitoring","Intraoperative Hemodynamics","Fluid Management","RECRUITING","2026-06-13",{"date":37,"type":38},"2026-06-18","ACTUAL",{"date":40,"type":38},"2024-08-01",{"date":42,"type":21},"2028-02-01",{"name":44,"class":45},"Muzaffer GENCER","OTHER_GOV",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":46},"100587464","ocular-characteristics-in-patients-with-craniosynostosis-100587464","NCT06928727","Ocular Characteristics in Patients With Craniosynostosis","COPACA","Inclusion Criteria:\n\n* Diagnosis of craniostenosis\n\nExclusion Criteria:\n\n* Posterior plagiocephalia",{"count":55,"type":21},65,"Craniosynostosis are cranial deformations due to the premature closure of one or more cranial sutures. These deformations affect approximately one in 2.500 births. In most cases, craniosynostoses are isolated with unknown (non syndrome). On the other hand, 20% of these deformations are associated with other concentration (syndrome).\n\nCraniosynostosis has morphological (associated dysmorphism) and functional (growth conflict between the skull and the brain) repercussions. Ophthalmological disorders are frequent: refractive disorders, oculomotor disorders, optic nerve damage, sensory damage.\n\nThis retrospective study aims to describe the ocular clinical characteristics associated with craniosynostosis in patients followed at the Amiens University Hospital.",[25,58,59,60],"Strabismus","Intracranial Hypertension","Amblyopia",[25,62,63,64],"strabismus","amblyopia","intracranial hypertension","2026-02-10",{"date":67,"type":38},"2026-02-12",{"date":69,"type":38},"2025-04-04",{"date":71,"type":21},"2026-11",{"name":73,"class":74},"Centre Hospitalier Universitaire, Amiens","OTHER"]