[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"craniotomy-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:craniotomy-surgery":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,77,98],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100578364","early-phase-1-pain-control-and-quality-of-recovery-after-intravenous-methadone-versus-intravenous-remifentanil-in-craniotomy-surgery-100578364",false,"NCT06810336","Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery","Inclusion Criteria:\n\n1. Adult Patients between ages 18 and 65 years old.\n2. Undergoing supratentorial intracranial surgery\n3. American Society of Anesthesiologists (ASA) physiological status I-III\n4. Body Mass Index (BMI) between 18.5 and 45\n5. Ability to understand and read English\n\nExclusion Criteria:\n\n1. Being unable or unwilling to sign a consent\n2. Anticipated discharge within 24 hours after surgery\n3. Patients requiring Emergent Surgery\n4. Preoperative usage of Methadone, or allergy to it.\n5. Patients with chronic pain, requiring daily opioid use at the time of surgery, MME \\>60 as FDA defines opioid tolerant as 60 MME, long-acting forms of opioids such as fentanyl patch, oxycontin\n6. Active or Prior Substance Use Disorder, undergoing active treatment with Medication of Opioid Use Disorder including methadone (once daily dosing), Buprenorphine (any formulation) and Naltrexone\n7. Preoperative chronic renal insufficiency or failure (defined as a serum creatinine more than 2 mg\u002Fdl),\n8. Pregnancy\n9. Significant liver disease (cirrhosis or hepatic failure)\n10. QTc \\>450 on preoperative electrocardiogram\n11. Pulmonary disease necessitating home oxygen therapy\n12. Inability to speak or read the English language","ALL","18 Years","65 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"EARLY_PHASE1","Postoperative pain is prevalent after intracranial surgery. Patients undergoing craniotomy are typically managed with short acting opioids to enable early and reliable post-operative neurological exam as well as avoid the risk of respiratory depression. However, a plethora of studies have shown that a majority of these patients experience moderate to severe pain in first 48 hours after surgery. Suboptimal pain control can lead to complications such as arterial hypertension and post-operative intracranial hemorrhage, and hence, increased morbidity and mortality.\n\nIntravenous (IV) methadone has a long analgesic half-life and has N-methyl-D-aspartate (NMDA) receptor antagonist and serotonin and norepinephrine reuptake inhibitor (SNRI) properties. It has previously been shown to reduce postoperative opioid requirements, postoperative nausea and vomiting (PONV), and postoperative pain scores in patients that underwent orthopedic, abdominal, complex spine, and cardiac surgery. Similar findings have been shown in obstetric patients that underwent caesarean delivery under general anesthesia as well as patients that underwent gynecologic surgery and received IV methadone intraoperatively.\n\nIn a recently published retrospective study, a single intraoperative dose of IV methadone was well tolerated with lower pain scores as well as MME (oral morphine milligram equivalents) requirements for up to 72 hours after elective intracranial surgery.\n\nIV methadone has, however, never been compared with conventional management via IV remifentanil for functional recovery in patients undergoing elective intercranial surgery.\n\nThe investigator's hypothesis is that intravenous (IV) methadone is non-inferior to IV remifentanil in patients who undergo elective intracranial surgery. It offers the advantage of being a single dose noninvasive analgesic modality that may contribute to decreasing MME consumption during the first 72 hours postoperatively, controlling postoperative pain, and improving quality of recovery after surgery.",[26,27,28,29,30,31],"Brain Injury","Brain Tumors","Craniotomy Surgery","Pain","Postoperative","Postoperative Care",[33],"craniotomy","RECRUITING","2026-04-27",{"date":37,"type":38},"2026-05-04","ACTUAL",{"date":40,"type":38},"2025-03-10",{"date":42,"type":20},"2027-09-10",{"name":44,"class":45},"University of Virginia","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":54,"targetDuration":56,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":46},"100634897","effects-of-ultrasound-guided-scalp-block-on-opioid-use-hemodynamics-and-postoperative-inflammation-in-craniotomy-100634897","NCT07545655","Effects of Ultrasound-Guided Scalp Block on Opioid Use, Hemodynamics, and Postoperative Inflammation in Craniotomy","Investigation of the Effects of Preoperative Ultrasound-Guided Scalp Block on Perioperative Opioid Consumption, Hemodynamic Stability, and Inflammatory Response in Patients Undergoing Craniotomy With a Skull Pin Head Holder","Inclusion Criteria:\n\n* Aged 18 years and older\n* Scheduled for elective intracranial surgery with skull pin head holder fixation\n* Classified as American Society of Anesthesiologists (ASA) physical status I-III\n* Provided written informed consent in the preoperative period\n\nExclusion Criteria:\n\n* Allergy to local anesthetics\n* Coagulopathy or anticoagulant use\n* Local infection at injection site\n* Pregnancy or breastfeeding\n* Chronic opioid use (\\>3 months) or chronic pain syndrome\n* Severe psychiatric disorders affecting pain assessment\n* Emergency surgery\n* Active infection or rheumatic disease\n* Hematological disease or malignancy (active or within 5 years)\n* Recent use of biological agents, chemotherapy, or corticosteroids (within 30 days)\n* NSAID use within 24 hours before surgery\n* Advanced organ failure (NYHA III-IV, Child-Pugh C, eGFR \\\u003C30 mL\u002Fmin)\n* Refusal to participate\n* Communication difficulties preventing pain assessment",{"count":55,"type":20},60,"1 Year","OBSERVATIONAL","This study shows that in craniotomy patients using a skull pin head holder, an ultrasound-guided scalp block reduces perioperative opioid consumption, improves hemodynamic stability, and decreases the inflammatory response.",[28],[61,62,63,64,65,66],"Craniotomy","Ultrasound-guided scalp block","Skull pin head holder","Perioperative opioid consumption","Hemodynamic stability","Inflammatory response","NOT_YET_RECRUITING","2026-04-21",{"date":70,"type":38},"2026-04-22",{"date":72,"type":20},"2026-04-10",{"date":74,"type":20},"2027-03-10",{"name":76,"class":45},"Fatih Sultan Mehmet Training and Research Hospital",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":84,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100608287","dexmedetomidine-versus-magnesium-sulfate-infusion-in-craniotomy-100608287","NCT07199595","Dexmedetomidine Versus Magnesium Sulfate Infusion in Craniotomy","Effect of Dexmedetomidine Versus Magnesium Sulfate Infusion on Intracranial Pressure and Cerebral Perfusion Pressure in Craniotomy Using Lumbar Drain Catheter","Inclusion Criteria:\n\n* Age 18-65 years\n* Elective craniotomy for supratentorial pathology\n* No contraindication to lumbar drain insertion\n* Baseline mental status is stable, allowing for a reliable postoperative neurological evaluation can be done\n* ASA physical status I-III\n\nExclusion Criteria:\n\n* Coagulopathy or current anticoagulation\n* Severe renal or hepatic dysfunction\n* Known allergy to study medications\n* traumatic brain injury",{"count":55,"type":20},[86],"NA","To compare the intraoperative effects of Dexmedetomidine and Magnesium Sulfate infusion on intracranial pressure and cerebral perfusion pressure in adult patients undergoing craniotomy",[28],"2025-09-22",{"date":91,"type":38},"2025-09-30",{"date":93,"type":20},"2025-10-20",{"date":95,"type":20},"2026-11-01",{"name":97,"class":45},"Assiut University",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":21,"phases":107,"briefSummary":108,"conditions":109,"keywords":113,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":46},"100596297","when-to-block-timing-of-scalp-block-in-craniotomy-100596297","NCT07043621","When to Block? Timing of Scalp Block in Craniotomy","Scalp Block Before Incision or Before Emergence in Craniotomy: A Randomized Controlled Evaluation of Effectiveness and Recovery Quality Via QoR-40","Inclusion Criteria:\n\n* Patients aged between 18 and 80 years.\n* Scheduled for craniotomy under general anesthesia.\n* ASA physical status classification I to III.\n* Glasgow Coma Scale (GCS) score of 15 at the time of emergence from anesthesia.\n* Provide informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Chronic use of analgesic medications prior to surgery.\n* Glasgow Coma Scale (GCS) score below 15 postoperatively.\n* Allergy or hypersensitivity to local anesthetics or opioids used in the study.\n* Contraindications for scalp block or patient-controlled analgesia.\n* Patients with severe hepatic, renal, or cardiac dysfunction.\n* Patients unable to comprehend or complete the QoR-40 questionnaire.","80 Years",{"count":55,"type":20},[86],"This study aims to evaluate the effect of scalp block timing-whether administered preoperatively or postoperatively-on postoperative recovery quality in patients undergoing craniotomy. The recovery quality will be assessed using the validated Quality of Recovery-40 (QoR-40) questionnaire. A total of 60 patients, aged 18-80 years, classified as ASA I-III and with a Glasgow Coma Scale (GCS) score of 15 upon admission to the recovery unit, will be enrolled. The primary outcome is the QoR-40 score. Secondary outcomes include hemodynamic changes and pain intensity measured by the Visual Analog Scale (VAS).",[110,111,28,112],"Scalp Block","Regional Anesthesia","QoR-40",[110,114,115,116],"Craniotomy surgery","analgesia","postoperative pain","2025-06-27",{"date":119,"type":38},"2025-06-29",{"date":121,"type":20},"2025-06",{"date":123,"type":20},"2025-12",{"name":125,"class":45},"Sakarya University"]