[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"crbsi---catheter-related-bloodstream-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:crbsi---catheter-related-bloodstream-infection":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100640493","neonatal-catheter-lock-for-infection-prevention-100640493",false,"NCT07585188","Neonatal Catheter Lock for Infection Prevention","Taurolidine Lock for Prevention of Central-Line Associated Bloodstream Infections in Neonates: A Triple-blind Randomized Controlled Trial","Neo-CLIP","Inclusion Criteria:\n\n* presence of a CVC (ECC, CICC, or FICC) for at least 48 hours\n* absence of systemic antibiotic therapy in the 48 hours preceding enrollment\n\nExclusion Criteria:\n\n* presence of an umbilical venous catheter\n* suspected thrombophilic disorder","ALL","1 Day","120 Days",{"count":21,"type":22},576,"ESTIMATED","INTERVENTIONAL",[25],"NA","For newborns admitted to Neonatal Intensive Care Units (NICUs), one of the main risk factors for late-onset sepsis is the presence of a central venous catheter (CVC), which is often essential for the administration of medications and parenteral nutrition in this patient population. From a nosological perspective, sepsis associated with the presence of a venous catheter is defined by two acronyms: CRBSI (Catheter-Related Bloodstream Infection - a microbiological definition) and CLABSI (Central Line-Associated Bloodstream Infection - an epidemiological definition).\n\nAmong preventive strategies for CRBSI\u002FCLABSI, antibiotic or antimicrobial catheter lock solutions - instilled in a volume equivalent to the catheter dead space and retained within the lumen until the next use - have demonstrated favorable efficacy in reducing infection risk.\n\nTaurolidine 2% is considered a preferred agent due to its broad-spectrum antibacterial and antifungal activity and its lack of association with the development of antimicrobial resistance.\n\nHowever, its prophylactic use in neonates remains largely investigational, with current evidence limited to small, retrospective observational studies involving catheters ≥3 Fr (e.g., femoral inserted central catheters - FICCs, centrally inserted central catheters - CICCs, and umbilical venous catheters).\n\nIn NICUs, epicutaneo-caval catheters (ECCs) are the most commonly used central venous access devices and represent a major source of catheter-related infections. Despite this, the use of antimicrobial lock prophylaxis in ECCs has been limited by concerns regarding catheter occlusion, given their smaller diameter (≤2 Fr). Nevertheless, available evidence indicates that short-duration locks, when combined with meticulous infusion line management, can be safely implemented without increasing the risk of catheter occlusion.\n\nThe aim of the study is to evaluate the efficacy of 2% taurolidine lock in the prevention of CLABSI\u002FCRBSI in neonates with CVC (ECC, FICC, or CICC).",[28,29,30],"CLABSI - Central Line Associated Bloodstream Infection","CRBSI - Catheter Related Bloodstream Infection","Neonatal Sepsis, Late-Onset",[32,33,34,35,36,37,38,39],"Taurolidine","Catheter lock therapy","Epicutaneo-caval catheter","Femoral inserted central catheters","Centrally inserted central catheters","Neonatal Intensive Care Unit","Newborn","Parenteral nutrition","NOT_YET_RECRUITING","2026-05-08",{"date":43,"type":44},"2026-05-13","ACTUAL",{"date":46,"type":22},"2026-10",{"date":48,"type":22},"2029-10",{"name":50,"class":51},"University of Turin, Italy","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":52},"100522674","multicenter-clinical-translational-study-of-icu-no-crbsi-based-on-improvement-science-100522674","NCT06085690","Multicenter Clinical Translational Study of \"ICU-NO CRBSI\" Based on Improvement Science","A Multicenter Clinical Translational Study of \"ICU-NO CRBSI\" Based on Improvement Science in China","Inclusion Criteria:\n\n* ICU stay over 48 hours\n* CVC was placed for more than 24 hours\n\nExclusion Criteria:\n\n* Pregnant patients\n* Patients with a history of CRBSI infection\n* Patients with central venous catheterization were brought in from other hospitals",true,{"count":62,"type":22},8050,[25],"The goal of this type of study is to construct the continuous quality promotion project \"ICU-NO CRBSI(Catheter-Related Bloodstream Infection , CRBSI)\" based on improvement science, and to verify its effect in the prevention of central venous catheter-related bloodstream infection and continuous quality improvement in ICU ( Intensive Care Unit , ICU) through multi-center implementation and two rounds of improvement.\n\nThe main question\\[s\\] it aims to answer are:\n\nWhat is the incidence of catheter-related bloodstream infection in the ICU of participating units? How compliant are health care providers in the ICU with evidence-based sensory control practices for the prevention of catheter-associated bloodstream infection?\n\nParticipants will be provided with the hospital's routine CVC (Central Venous Catheter ,CVC) care practices and CVC quality improvement measures based on evidence-based guidelines What technical and cultural support is needed to implement quality and safety improvement measures?",[29,66,67,68,69,28,70],"Evidence-based Nursing Practice","Central Venous Catheter Related Bloodstream Infection","Central Venous Catheter Associated Bloodstream Infection","Central Line Infection","Quality Improvement","RECRUITING","2025-11-14",{"date":74,"type":44},"2025-11-17",{"date":76,"type":44},"2023-09-04",{"date":78,"type":22},"2025-12-31",{"name":80,"class":51},"Fudan University"]