[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"creatine-supplementation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:creatine-supplementation":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,56,87],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":35,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":4},"100637590","effects-of-creatine-and-heat-exposure-on-exercise-performance-and-body-water-distribution-100637590",false,"NCT07593014","Effects of Creatine and Heat Exposure on Exercise Performance and Body Water Distribution","Creatine Monohydrate Supplementation During Repeated Heat Exposure: Effects on Fluid Balance and Exercise Performance in a Randomized Double-Blind, Placebo-Controlled Trial","Inclusion Criteria:\n\n* Healthy biological males between 18 and 27 years of age\n* Recreationally active males and varsity athletes\n* Able to safely participate in moderate-intensity exercise and heat exposure\n* Willing to maintain habitual diet and physical activity throughout the study\n* Willing to refrain from additional dietary supplementation during study participation\n* Able to attend all required laboratory visits and heat exposure sessions\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* History of cardiovascular, metabolic, respiratory, renal, neurological, or heat-related illness\n* Contraindications to exercise testing or heat exposure identified during health screening\n* Current musculoskeletal injury limiting exercise participation\n* Current use of creatine supplementation or inability to complete the required washout period\n* Current use of medications or supplements known to affect hydration, thermoregulation, cardiovascular function, or exercise performance\n* Known allergy or intolerance to creatine monohydrate, maltodextrin, or orange juice\n* Inability to comply with study procedures or supplementation protocol\n* Resting tympanic temperature ≥38.0°C prior to a heat exposure session\n* Participation in another research study that may interfere with this protocol",true,"MALE","18 Years","27 Years",{"count":21,"type":22},25,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn whether creatine supplementation changes how the body adapts to repeated exercise in the heat in healthy recreationally active adults and varsity athletes. The study will also examine whether creatine affects fluid balance, blood volume changes and exercise performance.\n\nThe main questions it aims to answer are:\n\nDoes creatine supplementation increase plasma volume and total body water during repeated heat exposure more than placebo? Does creatine supplementation improve exercise performance after heat acclimation more than placebo? Does creatine supplementation influence cardiovascular responses to heat stress?\n\nResearchers will compare a creatine supplementation group to a placebo group to determine whether creatine changes the magnitude of heat acclimation adaptations.\n\nParticipants will:\n\nComplete baseline measurements of body composition, hydration, blood markers, and exercise performance.\n\nConsume either creatine monohydrate or a placebo supplement daily Complete repeated supervised exercise sessions in a controlled heated environment Undergo repeated assessments of body water, temperature, heart rate, and exercise performance throughout the study",[28,29,30,31,32,33,34],"Heat Exposure","Exercise Performance","Hydration","Body Fluid Compartments","Creatine Supplementation","Placebo - Control","Plasma Volume",[36,28,37,38,34,39,31,40,41,42,43],"Creatine Monohydrate","Heat Acclimation","Short Term Heat Acclimation","Fluid Balance","Wingate Test","VO2 Max","Cardiorespiratory Performance","Musculoskeletal Performance","NOT_YET_RECRUITING","2026-05-11",{"date":47,"type":48},"2026-05-18","ACTUAL",{"date":50,"type":22},"2026-07-30",{"date":52,"type":22},"2027-08-30",{"name":54,"class":55},"University of Windsor","OTHER",{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":64,"minAge":65,"maxAge":4,"enrollmentInfo":66,"targetDuration":4,"studyType":23,"phases":68,"briefSummary":69,"conditions":70,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":86},"100587245","effect-of-micronized-creatine-monohydrate-on-muscle-mass-strength-and-performance-in-older-adults-submitted-to-total-knee-arthroplasty-100587245","NCT06925880","Effect of Micronized Creatine Monohydrate on Muscle Mass, Strength and Performance in Older Adults Submitted to Total Knee Arthroplasty","Efficacy of Supplementation With Micronized Creatine Monohydrate in the Recovery of Muscle Mass, Muscle Strength and Functional Capacity in Older Adults Operated on for Total Knee Arthroplasty: Randomized Clinical Trial","CREAR","Inclusion Criteria:\n\n* Persons 65 years of age or older who have been operated on for the first time for total knee arthroplasty,\n* who are undergoing an outpatient rehabilitation program according to standard clinical practice,\n* who sign the informed consent form.\n\nExclusion Criteria:\n\n* Chronic renal disease at stage G3b or higher or glomerular filtration rate \\\u003C30 ml\u002Fmin\u002F1.73m2.\n* Hepatic insufficiency, cirrhosis.\n* Neuromuscular and neurodegenerative diseases (amyotrophic lateral sclerosis, multiple sclerosis, muscular dystrophy, myasthenia gravis, Parkinson's disease, etc.).\n* Severe or very severe chronic obstructive pulmonary disease (COPD) (GOLD III-IV).\n* Moderate or severe chronic heart failure (NYHA 3-4).\n* Central sensitivity syndrome (fibromyalgia and chronic fatigue syndrome).\n* Moderate or severe cognitive impairment (GDS≥4).\n* Moderate-severe dependence for basic activities of daily living (preintervention Barthel index \\\u003C60 points).\n* Hemiparesis, amputation or malformation of any limb.\n* Consumption of creatine monohydrate supplements in the last 6 months.","ALL","65 Years",{"count":67,"type":22},262,[25],"Double-blind randomized placebo-controlled clinical trial with two parallel arms. The main objective is to evaluate the efficacy and safety of creatine supplementation in older adults who have been operated on for total knee arthroplasty and undergoing a usual rehabilitation program. The intervention will consist of daily creatine monohydrate supplementation for 12 weeks. The intervention will start after surgery with a loading dose of 20g\u002Fday for 1 week and then continue with a maintenance dose of 5g\u002Fday for 11 weeks.\n\nMain outcome mesures included muscle mass, muscle strenght, sarcopenia, frailty, functional capacity and physical performance and will be assessed at baseline, 3 and 6 months follow-up.",[71,72,73,32,74,75],"Sarcopenia in Elderly","Frailty at Older Adults","Functional Capacity","Arthroplasties, Knee Replacement","Physical Performance","RECRUITING","2026-03-25",{"date":79,"type":48},"2026-03-30",{"date":81,"type":48},"2025-06-10",{"date":83,"type":22},"2027-10-31",{"name":85,"class":55},"Consorci Sanitari del Maresme",1,{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":16,"sex":94,"minAge":18,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":23,"phases":98,"briefSummary":99,"conditions":100,"keywords":107,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":86},"100588115","pre-sleep-creatine-enhances-anaerobic-power-in-recreationally-active-females-100588115","NCT06937190","Pre-Sleep Creatine Enhances Anaerobic Power in Recreationally Active Females","SleepCrM","Inclusion Criteria:\n\nFemale, aged 18 to 25 years\n\nRecreationally active (engaging in structured resistance training 3-4 times per week for the past 6 months)\n\nRegular menstrual cycles (used for scheduling purposes)\n\nAble and willing to provide informed consent\n\nAgreement to maintain normal diet and training routines throughout the study\n\nExclusion Criteria:\n\nHistory of musculoskeletal injury affecting lower or upper limbs within the past 6 months\n\nKnown allergy or intolerance to creatine or maltodextrin\n\nUse of performance-enhancing substances or supplements within the last 30 days\n\nUse of recovery modalities such as massage, cryotherapy, or compression garments during the study period\n\nCurrent use of anti-inflammatory medication\n\nPregnancy or breastfeeding\n\nInability to comply with study protocol or scheduled assessments","FEMALE","25 Years",{"count":97,"type":22},24,[25],"This study is a randomized, double-blind, placebo-controlled trial designed to examine the effects of pre-sleep creatine monohydrate supplementation on anaerobic performance and muscle damage markers in recreationally active females. Participants will be randomly assigned to receive either 5 grams of creatine monohydrate or a placebo 30 minutes before sleep for seven consecutive days. Anaerobic performance will be assessed using the Wingate Anaerobic Test, evaluating peak and average power output and fatigue index. Blood samples will be collected before and after the supplementation period to analyze markers of muscle damage, including creatine kinase and lactate dehydrogenase. This study aims to provide insight into the efficacy of short-term, time-specific creatine supplementation for enhancing performance and recovery.",[101,102,103,104,32,105,106],"Anaerobic Performance","Sports Nutrition","Exercise Recovery","Muscle Fatigue","Recreational Physical Activity","Female Athletes",[36,108,109,40,110,111,112,113,114,115,116],"Pre-Sleep Supplementation","Anaerobic Power","Muscle Damage Markers","Creatine Kinase (CK)","Lactate Dehydrogenase (LDH)","Female Exercise Performance","Nutritional Ergogenic Aid","Resistance Training","Recovery Enhancement","2025-04-15",{"date":119,"type":48},"2025-04-22",{"date":121,"type":48},"2025-04-01",{"date":123,"type":22},"2025-07-10",{"name":125,"class":55},"Ankara Yildirim Beyazıt University"]