[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"critical-care-intensive-care\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:critical-care-intensive-care":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,24,0,[8,52,90,114,137,174,200,236,272,309,350,369,392,421,442,470,505,533,553,573,596,619,642,670],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":36,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100644682","burn-asv-trial-adaptive-support-ventilation-in-severe-burn-injury-100644682",false,"NCT07674563","BURN-ASV Trial: Adaptive Support Ventilation in Severe Burn Injury","Adaptive Support Ventilation Versus Conventional Lung-Protective Ventilation in Severe Burn Injury Including Thermobaric and Drone-Related Burns: The BURN-ASV Randomized Controlled Trial","BURN-ASV","Inclusion Criteria:\n\n* Age 18 years or older.\n* Thermal burn injury involving ≥20% total body surface area (TBSA).\n* Requirement for invasive mechanical ventilation expected to exceed 24 hours.\n* Admission to a participating intensive care unit within 48 hours of injury.\n* Burn injury resulting from conventional flame burns, explosion-related burns, drone-related burns, or thermobaric blast burns.\n* Written informed consent provided by the patient or a legally authorized representative.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Pregnancy or breastfeeding.\n* Pre-existing chronic respiratory failure requiring home oxygen therapy or long-term mechanical ventilation.\n* Severe chronic obstructive pulmonary disease (COPD GOLD IV) or other end-stage pulmonary disease.\n* Extracorporeal membrane oxygenation (ECMO) at the time of enrollment.\n* Severe traumatic brain injury requiring controlled hyperventilation.\n* Expected death within 24 hours of ICU admission.\n* Do-not-resuscitate (DNR) order or limitations of life-sustaining treatment.\n* Previous enrollment in the current study.\n* Participation in another interventional trial that may interfere with study outcomes.","ALL","18 Years","50 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","Severe burn injury frequently requires prolonged mechanical ventilation because of inhalation injury, respiratory failure, systemic inflammation, and repeated surgical procedures. Patients with extensive burns are at high risk of ventilator-associated complications, prolonged intensive care unit (ICU) stay, and death.\n\nAdaptive Support Ventilation (ASV) is an automated mode of mechanical ventilation that continuously adjusts breathing support according to the patient's respiratory needs and lung mechanics. Although ASV has shown potential benefits in general ICU populations, its effectiveness in patients with severe burn injuries has not been adequately studied.\n\nThe purpose of this randomized controlled trial is to compare Adaptive Support Ventilation with conventional lung-protective mechanical ventilation in critically ill adult burn patients, including those with inhalation injury, drone-related burns, and thermobaric blast burns. Participants will be randomly assigned to receive either ASV or conventional ventilation. The study will evaluate whether ASV improves ventilator-free days, reduces duration of mechanical ventilation, decreases ventilator-associated complications, and improves clinical outcomes.\n\nThe results of this study may help identify optimal ventilation strategies for patients with severe burn injuries and improve critical care management in both civilian and military burn centers.",[28,29,30,31,32,33,34,35],"Burn","Mechanical Ventilation","Mechanical Ventilation Complication","ICU","ICU Hospitalization","Critical Care, Intensive Care","Military Activity","Combat-Related Burn Injury",[37,35,38,39],"burn","adaptive support mechanical ventilation","mechanical ventilation","NOT_YET_RECRUITING","2026-06-24",{"date":43,"type":44},"2026-06-29","ACTUAL",{"date":46,"type":22},"2026-09-23",{"date":48,"type":22},"2026-11-23",{"name":50,"class":51},"Ukrainian Society of Regional Anesthesia and Pain Therapy","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":72,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":89},"100625308","mechanical-insufflation-exsufflation-in-critically-ill-patients-100625308","NCT07420946","Mechanical Insufflation-Exsufflation in Critically Ill Patients","Mechanical Insufflation-Exsufflation in Critically Ill Patients: An International DELphi Consensus (DELMI-E)","DELMI-E","Inclusion Criteria:\n\n* Healthcare professionals with documented clinical experience in critical care medicine, pulmonology, anesthesiology, respiratory therapy, or physiotherapy with involvement in airway clearance strategies.\n* Demonstrated experience or recognized expertise in the clinical use of MI-E, either in critically ill patients or in patients with complex respiratory conditions.\n* A minimum of 5 years of clinical experience in their respective field, or a proven academic or clinical contribution related to MI-E.\n* Willingness to participate in multiple Delphi rounds and to provide informed consent.\n* Ability to complete the questionnaires in English.\n\nExclusion Criteria:\n\n* Lack of direct clinical or academic experience related to MI-E or airway clearance techniques.\n* Inability or unwillingness to provide informed consent.\n* Failure to complete the first Delphi round after formal invitation and consent.\n* Withdrawal of consent at any stage of the Delphi process.",{"count":61,"type":22},30,"OBSERVATIONAL","Mechanical insufflation-exsufflation (MI-E) is an established airway clearance technique for patients with chronic conditions like neuromuscular diseases. However, its use in critically ill ICU patients remains inconsistent and lacks standardized guidelines. Despite growing research, current practices vary widely in patient selection, treatment protocols, and safety management, with limited high-quality evidence to support clear recommendations. To address this gap, an international, multidisciplinary Delphi consensus study is needed to establish expert-based best practices and feasible guidelines for the safe and effective implementation of MI-E in the intensive care setting.",[65,66,67,68,69,70,71,33],"Airway Clearance","Mechanical Insufflation-exsufflation","Mechanical Insufflation-exsufflation Session ( With Cough Assist)","Delphi Study","Consensus","Critical Illness","Critical Care",[73,74,75,69,76,77,78],"mechanical insufflation-exsufflation","Airway clearance","Delphi study","Cough assist","MI-E","critical care","RECRUITING","2026-06-15",{"date":82,"type":44},"2026-06-17",{"date":84,"type":44},"2026-06-10",{"date":86,"type":22},"2026-12-01",{"name":88,"class":51},"Medipol University",4,{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":98,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":109,"leadSponsor":111,"locationsCount":113},"100635584","clinical-practices-of-extubation-after-invasive-mechanical-ventilation-100635584","NCT07554586","Clinical Practices of Extubation After Invasive Mechanical Ventilation","Clinical Practices of Extubation After Invasive Mechanical Ventilation in Anesthesia and Intensive Care","EPP\u002FEPP = 1","Inclusion Criteria:\n\n* Physicians and students in anesthesiology and critical care,\n* Critical care physicians,\n* State-certified nurse anesthetists (IADE),\n* State-certified nurses (IDE) working in an anesthesia or intensive care team\n* Students (medical or nurse anesthetist) with at least 1 year of extubation experience.\n\nExclusion Criteria:\n\n* Healthcare professionals with no experience in extubation (less than one year of practice) Refusal to participate",true,{"count":100,"type":22},200,"Extubation is a delicate and complex phase of airway management in anesthesia and critical care. A variety of complications are of concern, ranging from transient hypoxemia to the need for reintubation, which can then become life-threatening for the patient.\n\nFor this procedure, it may be recommended to use the positive end-expiratory pressure (PEEP) extubation technique to reduce the risks of hypoxemia, atelectasis, and aspiration. However, no specific technique is preferred given the diversity of described procedures (spontaneous ventilation on an auxiliary circuit, PEEP-assisted spontaneous ventilation, adjustment of the APL valve). However, results may vary depending on the patient population (children, adults) and the setting (operating room, intensive care unit).\n\nGiven the lack of a preferred technique for performing extubation under positive end-expiratory pressure, the aim of this study is to describe the techniques used by healthcare professionals (physicians, nurse anesthetists, nurses) during the extubation of a surgical or intensive care patient.",[29,103,104,33],"Extubation","Anesthesia","2026-04-28",{"date":107,"type":44},"2026-05-04",{"date":105,"type":22},{"date":110,"type":22},"2026-10",{"name":112,"class":51},"Centre Hospitalier Universitaire de Nīmes",1,{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":124,"conditions":125,"keywords":126,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":129,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":136},"100612280","communication-enhancement-among-ventilated-patients-in-intensive-care-100612280","NCT07251530","Communication Enhancement Among Ventilated Patients in Intensive Care","Communication Enhancement Among Ventilated Patients in Intensive Care : Feasibility of Implementing \"JIB-TourS cARe\" High Technology Device With Eye Tracker","CESAR","Inclusion Criteria:\n\n* Intubated ventilated ICU patient\n* Hospitalized patient with an inflated cuff tracheostomy\n* conscious patient, able to open and close eyes on demand\n* of-age patient\n* French speaking\n\nExclusion Criteria:\n\n* Patient with uncorrected visual impairment or hearing deficiency\n* Known guardianship or trusteeship at the time of inclusion\n* Known pregnant women at the time of inclusion and lactating patients\n* opposed to the processing of personal data",{"count":123,"type":22},60,"Intensive care is a unit that admits ventilated patients. Hospitalization is extremely challenging for these patients. Their vital prognosis is at stake, and they often have difficulty moving due to pain, edema, neuromyopathy, or the presence of monitoring cables. They are also hindered in their communication: they cannot speak because of the presence of the intubation tube between their vocal cords or the tracheostomy cannula with the inflated cuff. Every day, in each intensive care unit, about 50% of ventilated patients are conscious and face communication difficulties. They describe this difficulty as a \"nightmare.\" This leads to challenges in care management and increases the anxiety caused by hospitalization in the intensive care unit. A large proportion of patients will develop post-intensive care syndrome. The tools currently used are not efficient. Moreover, many patients have comprehension difficulties due to the medications administered to them (sedatives) or due to the initial or secondary pathologies related to their hospitalization (confusional syndrome, ICU delirium).\n\nOur objective is to implement an adapted and personalized communication tool for ventilated patients in intensive care.",[33],[127,78,128],"communication","Augmentative and Alternative Communications Systems",{"date":107,"type":44},{"date":131,"type":44},"2026-03-19",{"date":133,"type":22},"2027-06-01",{"name":135,"class":51},"University Hospital, Tours",3,{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":145,"minAge":18,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":148,"conditions":149,"keywords":154,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":173},"100598171","organ-dysfunction-score-for-obstetric-patients-100598171","NCT07068022","Organ Dysfunction Score for Obstetric Patients","Development and Validation of an Obstetric Organ Dysfunction Score to Predict Mortality in Intensive Care Unit: A Multicenter, Prospective, Cohort Study","SOFA-OBS","Inclusion Criteria:\n\nAll of the following=\n\n* Pregnant (at any gestational age) or post-partum patients (at ≤3 days postpartum)\n* ≥ 18 years old\n* Requiring admission to ICU for any reason\n* Staying in the ICU for ≥ 24h\n* Giving her consent to participate. Patients will be recruited consecutively until reaching the sample size.\n\nExclusion Criteria:\n\nAny of the following=\n\n* Patients \\\u003C18 years old\n* Non-pregnant patients\n* ≥ 4 days postpartum\n* Patients or surrogates not giving consent to participate\n* ICU-LOS \\\u003C 24 h","FEMALE",{"count":147,"type":22},130,"The goal of this observational study is to develop and evaluate an organ dysfunction score adapted to pregnancy and early puerperium (SOFA-OBS) that also incorporates a non-invasive tool to evaluate respiratory function (pulse oximeter).\n\nThe main question it aims to answer is: Does an organ dysfunction score adapted to pregnant and postpartum patients have a higher capacity to predict mortality than a non-adjusted organ dysfunction score? Participants: Patients requiring ICU (Intensive Care Units) admission, who are either pregnant or postpartum (up to 3 days after giving birth). The investigators aimed to include 130 participants.\n\nThe investigators will only collect participants' data and laboratory results that ICU doctor usually need for clinical practice. No additional interventions are required. Moreover, the investigators will evaluate if measuring participants' oxygenation through a non-invasive tool (pulse oximeter) is equally effective as measuring oxygenation by an arterial puncture.\n\nBackground: When managing severely ill patients in ICU, the investigators often use what it is called scores. Scores refer to a numerical value assigned to a patient's condition, which often predict outcome. The Sequential Organ Failure Assessment (SOFA) score is a scoring system that assess severity of organ dysfunction (in liver, kidney, blood pressure, respiratory, neurologic and platelets). It also identifies patients with severe infections (sepsis) and patients with bad outcomes.\n\nPatients undergoing pregnancy or early postpartum develop physiological changes, such us a decrease in creatinine (a laboratory test measuring kidney function) and a decrease in blood pressure during the second trimester. These changes are not considered by the SOFA score. Actually, there is not an organ dysfunction score adapted to pregnant\u002Fpostpartum patients to be used in the ICU. Moreover, a blood sample taken by arterial puncture is required to evaluate respiratory function by the SOFA score, which is a painful procedure. Instead, the investigators could evaluate respiratory function using a pulse oximeter, which measures peripheral oxygen saturation without needing an arterial puncture.\n\nPotential benefits: A SOFA-OBS would hopefully become a more precise tool than general SOFA to evaluate organ dysfunction and to predict outcome among these patients. It would also help to detect sepsis earlier and treat it promptly, which might help reducing its mortality.",[150,151,152,33,153],"Pregnancy","Postpartum","Organ Dysfunction","Sepsis",[155,150,151,156,157,158,159,160,161,162,153,163,164],"Sequential Organ Failure Assessment score","Critical care","Intensive Care Unit","Creatinine","Peripheral oxygen saturation","Hypotension","Maternal mortality","Mortality","Septic shock","Multicenter study","2026-04-22",{"date":105,"type":44},{"date":168,"type":44},"2025-10-06",{"date":170,"type":22},"2027-02-28",{"name":172,"class":51},"Daniela Vasquez",18,{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":181,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":183,"conditions":184,"keywords":187,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":199},"100632214","up-study---decipher-persistent-critical-illness-through-in-deep-clinical-phenotyping-100632214","NCT07510776","UP STUDY - Decipher Persistent Critical Illness Through in Deep Clinical Phenotyping.","UPSt_UCI","Inclusion Criteria:\n\n* Adult patients aged 18 years or older;\n* ICU length of stay equal to or greater than 5 days.\n\nExclusion Criteria:\n\n* Patients with an ICU stay \\\u003C 5 days;\n* Patients discharged from the ICU early due to lack of ward availability, rather than clinical recovery;\n* Patients who do not survive the early phase of critical illness (i.e., early ICU deaths).",{"count":182,"type":22},7000,"Persistent Critical Illness (PCI) is a condition that affects some patients who remain in the Intensive Care Unit (ICU) for a long time, usually more than 10-14 days. It is estimated to occur in 5-20% of critically ill patients. A recent Portuguese study found that more than 14% of ICU patients stayed longer than 14 days. PCI is often associated with ongoing need for life support, such as mechanical ventilation or medications to maintain blood pressure. However, patients may also experience severe muscle weakness, repeated infections, or other complications, which makes this group very diverse.\n\nOne of the main risk factors for prolonged ICU stay is sepsis, a severe infection that affects the whole body. Other factors-such as prior health conditions, use of corticosteroids, sedation practices, early versus late mobilization, fluid and antibiotic management, and delirium treatment-may also influence the development and course of PCI.\n\nThis study aims to identify different clinical patterns (\"clusters\") among critically ill patients who remain in the ICU for more than 10 days. Patients will be followed until hospital discharge, and up to one year if data are available. Understanding these different patterns will help develop more personalized and effective care strategies for each patient profile.\n\nThe study is a multicenter retrospective cohort including adult patients (≥18 years) admitted to participating ICUs for more than 5 days between 2021 and 2023. Data collected will include demographic, clinical, and laboratory information, details of organ support (such as mechanical ventilation or vasopressors), medications, nutrition, and rehabilitation practices.\n\nStatistical and machine learning methods will be used to identify groups of patients with similar clinical trajectories and to assess how these groups are related to outcomes such as survival, recovery of organ function, or long-term disability.\n\nExpected results are the identification of distinct clinical clusters of PCI that combine clinical and laboratory data, and the development of tailored management strategies to improve recovery and outcomes for patients with PCI.",[70,185,33,71,186],"Recovery Outcomes","Critical Care Medicine",[188,156,70],"Persistant Critical Illness","2026-04-08",{"date":191,"type":44},"2026-04-13",{"date":193,"type":44},"2025-01-13",{"date":195,"type":22},"2027-12-31",{"name":197,"class":198},"Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa","NETWORK",7,{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":206,"eligibilityCriteria":207,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":208,"targetDuration":4,"studyType":23,"phases":210,"briefSummary":211,"conditions":212,"keywords":219,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":235},"100561160","the-family-icu-trial-100561160","NCT06586541","The Family-ICU Trial","Family Participation in Intensive Care Unit Rounds (The Family-ICU Trial)","Family-ICU","Inclusion Criteria:\n\n* Adult family members (age ≥ 18 years) of ICU patients\n* Expected ICU stay ≥ 48 hours\n* Family members wishing to participate in rounds virtually must have the technological capability and understanding to participate virtually (must have a phone or computer with internet and audio\u002Fvideo capabilities)\n\nExclusion Criteria:\n\n* Family members who do not wish to participate in care\n* Repeat admissions within the study period\n* Another family member has already participated in the study",{"count":209,"type":22},194,[25],"Family inclusion in adult intensive care unit (ICU) rounds is recommended by critical care professional societies, yet widespread uptake of this practice is limited. A key barrier cited by ICU clinicians is insufficient evidence to support this practice. There is a need for robust evidence to support family participation in adult ICU rounds and influence change to routine clinical care. The primary purpose of this study is to assess whether family participation in adult ICU rounds improves family engagement in care. The secondary objectives are to assess family satisfaction, and anxiety and depression, to explore user experiences of family participation in ICU rounds, and to evaluate strategies to improve family member recruitment and retention rates. This is a stepped-wedge cluster randomized trial (n=194) at 6 Canadian ICUs. The stepped wedge cluster randomized trial is a pragmatic study design that overcomes methodological limitations in evaluating a healthcare service delivery intervention. In the stepped-wedge cluster design, there is random and sequential crossover of clusters from control (phase 1) to intervention (phase 2) until all clusters are exposed. The stepped-wedge design also allows each site to function as its own control. The stepped-wedge design is more powerful than a parallel design when substantial cluster level effects are present.",[213,214,215,216,217,218,33],"Virtual Care","Family Engagement","Patient and Family Engagement","Health Care Delivery","Family-centered Care","Physician Rounds",[220,221,214,71,157,222,223,224,225,218],"Patient- and Family-Centered","Patient- and Family-Centered Care","Person-Centered Care","Delivery of Health Care","Virtual Rounds","Family Participation in Rounds","2026-03-25",{"date":228,"type":44},"2026-03-31",{"date":230,"type":44},"2024-11-18",{"date":232,"type":22},"2029-07",{"name":234,"class":51},"Lady Davis Institute",2,{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":243,"targetDuration":4,"studyType":23,"phases":245,"briefSummary":246,"conditions":247,"keywords":254,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":113},"100622989","behavioral-health-collaborative-care-model-in-post-icu-clinic-family-pilot-100622989","NCT07390786","Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot","Integration of a Behavioral Health Collaborative Care Model Into an ICU Recovery Clinic-Pilot for Families","Inclusion Criteria:\n\n\\- Family member of ICU Recovery Clinic patient enrolled in parent BH CoCM study\n\nExclusion Criteria:\n\n* Serious mental illness (e.g., schizophrenia, mania)\n* Late-stage dementia or cognitive impairment\n* Limited English proficiency\n* No internet-enabled device\n* Prisoners",{"count":244,"type":22},150,[25],"This pilot study evaluates the feasibility and acceptability of implementing a Behavioral Health Collaborative Care Model (BH CoCM) for family members of ICU survivors. The intervention includes telehealth-enabled behavioral health assessments and access to the NeuroFlow platform. A subset of participants will undergo qualitative interviews.",[248,249,250,251,252,33,253],"Critical Illness Recovery","Behavioral Health Concerns","Anxiety","Depression - Major Depressive Disorder","PTSD","PICS-F",[255,256,257,258,259,260,261,262,252,253],"Critical Ilness","critical care recovery","Post-Intensive Care Syndrome","Post-ICU care","behavioral health","mental health","anxiety","depression","2026-03-11",{"date":265,"type":44},"2026-03-12",{"date":267,"type":44},"2026-01-30",{"date":269,"type":22},"2028-06-30",{"name":271,"class":51},"Medical University of South Carolina",{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":278,"eligibilityCriteria":279,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":280,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":282,"conditions":283,"keywords":287,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":300,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":113},"100589917","dosage-of-early-rehabilitation-of-icu-patients-100589917","NCT06960642","Dosage of Early Rehabilitation of ICU Patients","Early Rehabilitation of Intensive Care Unit Patients - a Multinational Prospective Observational Study on Dosage and Outcome","ERUPT","Inclusion Criteria:\n\n* Adults (≥ 18 years old) within 48 hours of ICU admission\n* Expected to stay \\> 24 hours in the ICU\n\nExclusion Criteria:\n\n* Patients who receive end-of-life care at the time of screening\n* Patients whose treatment plans are still under discussion and\u002For not all team members are committed to full active treatment\n* Patients whose functional status is unlikely to be obtainable\n* Patients with language barriers",{"count":281,"type":22},6000,"Rehabilitation already begins in the intensive care unit (ICU) to maintain or restore the functional capacity of ICU patients and to counteract the long-term effects of intensive care treatment. Mobilisation is an important component.\n\nThe aim of this multinational observational study is to record and evaluate the different mobilisation practices for ICU patients worldwide. The investigators want to find out which forms of mobilisation in intensive care patients achieve the best results in terms of physical function, functional status and quality of life.\n\nThe goal is to recruit over 6,000 patients internationally. No interventions will be carried out, only routine clinical data will be documented and standardised and already established physical tests and questionnaires will be used.",[33,70,284,285,286],"Physiotherapy","Early Ambulation","Interprofessional Team Collaboration",[288,289,290,291,292,293,294,295,296,297,71,298,299],"early ambulation","early rehabilitation","early mobilisation","physiotherapy","Physical Therapy","ICUAW","PICS","Intensive Care Unit Acquired Weakness","Post Intensive Care Syndrom","Physical Function","Interprofessional","Nursing","2026-02-18",{"date":302,"type":44},"2026-02-20",{"date":304,"type":44},"2025-12-14",{"date":306,"type":22},"2027-06",{"name":308,"class":51},"Medical University of Vienna",{"id":310,"slug":311,"hasResults":11,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":315,"eligibilityCriteria":316,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":317,"targetDuration":4,"studyType":23,"phases":319,"briefSummary":321,"conditions":322,"keywords":326,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":342,"startDateStruct":344,"completionDateStruct":346,"leadSponsor":348,"locationsCount":89},"100607479","phase-4-creep-and-maintenance-fluid-sodium-chloride-administration-reduction-in-critically-ill-adults-100607479","NCT07189091","CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS","Effect of Reduced Sodium Chloride in Fluid Creep and Maintenance Fluids in Critically Ill Adults: A Randomized Controlled Trial","CRUSADERS","Inclusion criteria\n\n1. At least 18 years of age\n2. Patients who are admitted to the ICU for medical or surgical emergencies, including complications of elective surgery\n3. The treating physician expects the patient will still require ICU care in two days, indicating a severe or complex condition at enrollment\n4. The patient is expected to receive at least 300 mL of fluid creep or at least 1 liter of maintenance fluid according to study-arm during the first 24h after inclusion\n\nExclusion Criteria:\n\n1. A contraindication to hypotonic fluids due to risk of brain edema (including traumatic brain injury, major stroke, intracranial\u002Fsubarachnoid hemorrhage, meningoencephalitis, intracranial malignancies…), with the timing and clinical judgment left at the discretion of the treating physician.\n2. Hyponatremia below 131 mmol\u002FL at admission\n3. Admission solely for treatment of fluid accumulation due to cardiac decompensation, without other acute medical conditions requiring ICU-level care. Note: Patients with heart failure as a comorbidity, those on chronic diuretic therapy, or presenting with edema\u002Fbilateral lung infiltrates due to other conditions (e.g., sepsis, pneumonia) are not excluded.\n4. Patient's death is deemed imminent and inevitable, admission for palliative care or admission solely for organ donation\n5. Patient receiving chronic renal replacement therapy\n6. Patients referred after a stay of more than 24 hours in another ICU\n7. Patients randomized in CRUSADERS before\n8. Patient is co-enrolled in an unapproved concomitant ICU-trial or in any trial with an intervention that affects fluid administration or fluid balance\n\nAdditional exclusion criteria for the SALADIN nested substudy\n\n1. Patients expected to require renal replacement therapy within 24 hours\n2. Increased insensible fluid losses: burns, extensive wounds or skin defects or massive diarrhea,…\n3. Patients without a urine catheter\n4. Patients expected to require bladder irrigation within 24 hours\n5. Patients on chronic treatment with loop or thiazide diuretics (including combination preparations)",{"count":318,"type":22},640,[320],"PHASE4","This study is enrolling adult patients who require a prolonged stay in the intensive care unit (ICU). These patients often receive large amounts of intravenous fluids, which can contain more salt (sodium and chloride) than the body normally needs. Extra salt and water can build up in the body and may delay recovery.\n\nThe study will test two strategies:\n\nFluid creep: These are fluids used to dilute medications or keep intravenous lines open. Usually, the choice is based on habit. In the intervention group, a salt-free glucose 5% solution will be used (if the responsible pharmacist confirms it is compatible with the medication).\n\nMaintenance fluids: These fluids cover daily needs for water and electrolytes. In the intervention group, a lower-salt solution (NaCl 0.3% in glucose 3.3%) will be given, with volume decided by the treating physician.\n\nThe comparison group will receive usual care: NaCl 0.9% (commonly called \"normal saline\") for fluid creep, and an isotonic solution (PlasmaLyte) for maintenance fluids.\n\nThe main outcome is the number of days patients are alive and free of life support (such as ventilator or dialysis) during the first 90 days. Other outcomes include abnormal sodium, chloride, or glucose levels, fluid balance and need for diuretics, kidney injury, use of dialysis, time on the ventilator, survival, and length of ICU and hospital stay.\n\nA smaller substudy (SALADIN) will measure in detail how the body handles sodium, chloride, and water using additional calculation on blood tests, urine collections, body weight, and bioimpedance analysis",[33,323,324,70,325],"Fluid Accumulation","Fluid and Electrolyte Imbalance","Fluid Balance Outcomes",[157,327,70,328,329,330,331,332,333,334,335,336,337,338,339,340,341],"Critically Ill","Intravenous fluids","Maintenance fluids","Fluid Creep","Sodium chloride reduction","Salt reduction","Hypotonic fluids","Saline (NaCl 0.9%)","Fluid balance","Electrolyte disorders","Glycemic control","Acute kidney injury","Mechanical ventilation","Organ support","Hyponatremia",{"date":343,"type":44},"2026-02-03",{"date":345,"type":44},"2025-10-07",{"date":347,"type":22},"2028-07-30",{"name":349,"class":51},"University Hospital, Antwerp",{"id":351,"slug":352,"hasResults":11,"nctId":353,"briefTitle":354,"officialTitle":355,"acronym":4,"eligibilityCriteria":356,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":357,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":359,"conditions":360,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":367,"locationsCount":4},"100622420","validation-of-the-turkish-rdos-using-end-tidal-carbon-dioxide-100622420","NCT07383389","Validation of the Turkish RDOS Using End-Tidal Carbon Dioxide","Validation of the Turkish Respiratory Distress Observation Scale Using End-Tidal Carbon Dioxide in Critical Care Patients","Inclusion Criteria:\n\n* Being 18 years of age or older,\n* Having a diagnosis of lung or pleural cancer, chronic kidney failure, congestive heart failure, COPD, asthma, or pneumonia presenting with dyspnea,\n* Being specifically referred for treatment of dyspnea,\n* Having been in the intensive care unit for at least one day,\n* Participation in the study must be consented to by the individual or a family member.\n\nExclusion Criteria:\n\n* Being completely ventilator-dependent,\n* Having a diagnosis of central nervous system disease (quadriplegia, bulbar ALS).",{"count":358,"type":22},64,"Dyspnea is a complex and distressing symptom frequently observed in critically ill patients and is associated with increased morbidity, mortality, and prolonged intensive care unit (ICU) stay. Although dyspnea is inherently subjective, accurate assessment of its presence and severity is essential for appropriate clinical decision-making and treatment planning. In routine clinical practice, dyspnea is commonly assessed using patient self-report scales; however, this approach is not feasible in patients who are unable to communicate due to impaired consciousness, cognitive dysfunction, mechanical ventilation, sedation, or severe illness. Consequently, there is a critical need for valid and reliable observational tools that allow healthcare professionals to assess respiratory distress in non-communicative patients.\n\nThe Respiratory Distress Observation Scale (RDOS) is an eight-item observational instrument originally developed to assess respiratory distress in patients who cannot self-report dyspnea. The scale evaluates observable physiological and behavioral indicators, including respiratory rate, heart rate, use of accessory muscles, paradoxical breathing, nasal flaring, grunting, restlessness, and facial expression. RDOS has demonstrated acceptable reliability and validity in various patient populations and has been translated into multiple languages. A Turkish version of the RDOS has recently undergone linguistic and cultural adaptation; however, its validity has not yet been examined using an objective physiological reference standard.\n\nEnd-tidal carbon dioxide (ETCO₂), measured via capnography, provides a continuous, non-invasive indicator of ventilatory status and has been widely used in critically ill patients to monitor ventilation and respiratory adequacy. Alterations in ETCO₂ values may reflect changes in respiratory mechanics, ventilation-perfusion mismatch, and respiratory distress. Therefore, ETCO₂ represents a clinically relevant objective parameter for examining the concurrent validity of observational dyspnea assessment tools.\n\nThe primary objective of this study is to evaluate the validity of the Turkish version of the Respiratory Distress Observation Scale by examining its relationship with end-tidal carbon dioxide levels in critically ill adult patients hospitalized in the intensive care unit. This prospective observational study will be conducted over a six-month period in the ICU of a tertiary care hospital. A total of 64 adult patients aged 18 to 85 years who experience dyspnea and meet the inclusion criteria will be enrolled. Patients who are fully dependent on mechanical ventilation or have severe central nervous system disorders affecting respiratory control will be excluded.\n\nFollowing ethical approval and informed consent obtained from patients' legal representatives, demographic and clinical data will be collected from medical records. Physiological parameters including oxygen saturation, respiratory rate, heart rate, blood pressure, body temperature, arterial blood gas values, and ETCO₂ will be recorded simultaneously. Disease severity will be assessed using the Acute Physiology and Chronic Health Evaluation II (APACHE II) score. The Turkish RDOS will be administered by a trained evaluator, and capnography measurements will be performed concurrently using appropriate mainstream or sidestream techniques depending on the patient's airway status.\n\nStatistical analyses will include descriptive statistics and correlation analyses to examine the relationship between RDOS scores and ETCO₂ values. Concurrent and convergent validity will be evaluated using Pearson or Spearman correlation coefficients, depending on data distribution. It is hypothesized that higher RDOS scores, indicating more severe respiratory distress, will be associated with altered ETCO₂ levels, supporting the validity of the Turkish RDOS as an objective observational measure of dyspnea in critically ill patients.\n\nThe findings of this study are expected to provide important evidence supporting the clinical utility of the Turkish version of the Respiratory Distress Observation Scale for assessing respiratory distress in patients who are unable to self-report dyspnea. Establishing its validity against an objective physiological marker may facilitate more accurate monitoring of dyspnea, improve symptom management, and enhance the quality of care in intensive care settings.",[33,70],"2026-01-26",{"date":343,"type":44},{"date":364,"type":22},"2026-02-15",{"date":366,"type":22},"2026-10-01",{"name":368,"class":51},"Istinye University",{"id":370,"slug":371,"hasResults":11,"nctId":372,"briefTitle":373,"officialTitle":374,"acronym":375,"eligibilityCriteria":376,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":377,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":378,"conditions":379,"keywords":382,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":390,"locationsCount":235},"100614135","timing-and-dose-of-fluid-deresuscitation-in-critically-ill-patients-100614135","NCT07275658","Timing and Dose of Fluid Deresuscitation in Critically Ill Patients","Timing and Dose of Fluid Deresuscitation in Critically Ill Patients: a Prospective Observational Multicenter Study","TIDE","Inclusion Criteria:\n\n* Admission to one of the participating ICUs;\n* Clinical indication for deresuscitation using diuretics or ultrafiltration as set by the treating physician; first attempt during the ICU stay.\n\nExclusion Criteria:\n\n* Age below 18 years old;\n* Major cardiac shunts;\n* Moderate to severe aortic regurgitation;\n* Morbid Obesisty (BMI \\>40);\n* POCUS impossible or unreliable (i.e. pre-existing interstitial lung disease);\n* PLR or modified form of PLR impossible (i.e. ECMO);\n* Transfer from another ICU;\n* Previous inclusion in this study;\n* Patients who are moribund or facing the end of life;\n* Opt out.",{"count":244,"type":22},"Fluid deresuscitation is an important intervention in the Intensive Care Unit (ICU). This study aims to find (1) determinants of successful deresuscitation, (2) the optimal rate (dose) of deresuscitation based on these determinants, and (3) differences in metabolic profiles for a more personalized approach of deresuscitation.\n\nThis study is a multicenter, prospective, observational cohort study in critically ill patients. This study will include ICU patients who have a clinical indication for deresuscitation as set by the treating physician. Clinical, ultrasound and laboratory values will be collected and used for analysis.",[380,33,381],"Fluid Overload","Deresuscitation",[383],"ultrasound, RRT, furosemide","2026-01-19",{"date":386,"type":44},"2026-01-21",{"date":388,"type":44},"2025-10-15",{"date":170,"type":22},{"name":391,"class":51},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",{"id":393,"slug":394,"hasResults":11,"nctId":395,"briefTitle":396,"officialTitle":397,"acronym":398,"eligibilityCriteria":399,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":400,"targetDuration":4,"studyType":23,"phases":402,"briefSummary":403,"conditions":404,"keywords":408,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":411,"lastUpdatePostDateStruct":412,"startDateStruct":414,"completionDateStruct":416,"leadSponsor":418,"locationsCount":4},"100615156","protocolised-management-of-phosphate-replacement-trial-100615156","NCT07288944","Protocolised Management of Phosphate Replacement Trial","A Comparison of Two Phosphate Replacement Protocols for Critically Ill Patients Treated in an Intensive Care Unit: a Cluster, Crossover, Comparative Effectiveness, Randomised, Controlled Trial","PROMPT","Inclusion Criteria:\n\n* All adult patients admitted to participating intensive care units during the study period.\n\nExclusion Criteria:\n\n* There will be no specific exclusion criteria",{"count":401,"type":22},2400,[25],"The aim of this cluster, crossover, randomised controlled trial is to compare two standard arms of treatment for the replacement of phosphate in critically ill patients.\n\nWe hypothesise that protocolised restricted phosphate replacement, compared to protocolised liberal phosphate replacement, will result in reduced administration of phosphate with similar clinical outcomes.\n\nAll eligible Intensive Care Unit (ICU) patients will be included during their admission with the selected protocol for that period as per usual practice and treatment standards.",[405,406,407,33],"Phosphate Deficiency","Hypophosphatemia","Protocol Optimization",[409,71,410,406,405],"Phosphate Protocol","Intensive Care","2025-12-04",{"date":413,"type":44},"2025-12-17",{"date":415,"type":22},"2026-01",{"date":417,"type":22},"2027-12",{"name":419,"class":420},"Caboolture Hospital","OTHER_GOV",{"id":422,"slug":423,"hasResults":11,"nctId":424,"briefTitle":425,"officialTitle":425,"acronym":4,"eligibilityCriteria":426,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":427,"targetDuration":4,"studyType":23,"phases":429,"briefSummary":430,"conditions":431,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":437,"completionDateStruct":438,"leadSponsor":440,"locationsCount":113},"100603793","turnova-the-clinical-efficacy-manpower-reduction-and-cost-effectiveness-of-turn-assist-alternating-pressure-air-mattresses-for-pressure-injury-prevention-in-the-icu-100603793","NCT07141134","Turnova: The Clinical Efficacy, Manpower Reduction, and Cost-Effectiveness of Turn-Assist Alternating Pressure Air Mattresses for Pressure Injury Prevention in the ICU","Inclusion Criteria:\n\n* Adult patients (≥18 years old) admitted to medical or surgical intensive care units (ICUs).\n* Admission time between 08:00 and 23:00.\n* Clinical condition requires ICU-level care.\n\nExclusion Criteria:\n\n* Repeat ICU admission during the study period.\n* Unstable spinal fracture.\n* Receiving cervical or skeletal traction.\n* Body weight \\>180 kg (exceeds mattress weight limit).\n* Declines participation in the study.",{"count":428,"type":22},236,[25],"Pressure injuries are common in intensive care unit (ICU) patients who cannot reposition themselves. International guidelines recommend using support surfaces to redistribute pressure and regular turning to prevent these injuries. In Taiwan, high-specification foam mattresses (HSFM) with manual turning remain the standard, but frequent repositioning is labor-intensive and challenging in settings with limited nursing staff. The Turn-Assist Alternating Pressure Air Mattress (TAPAM) integrates pressure redistribution with automated lateral turning, potentially reducing nursing workload while maintaining preventive effectiveness. This study will compare TAPAM with HSFM plus manual turning in ICU patients, evaluating manpower requirements, time spent, perceived effort, and clinical outcomes. A cost-effectiveness and cost-benefit analysis will be conducted to assess the overall value of TAPAM for pressure injury prevention in high-risk ICU populations.",[33,432,433],"Nursing Workload","Cost Analysis","2025-09-02",{"date":436,"type":44},"2025-09-08",{"date":436,"type":22},{"date":439,"type":22},"2026-07-30",{"name":441,"class":51},"National Taiwan University Hospital",{"id":443,"slug":444,"hasResults":11,"nctId":445,"briefTitle":446,"officialTitle":446,"acronym":447,"eligibilityCriteria":448,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":449,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":450,"conditions":451,"keywords":455,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":466,"leadSponsor":468,"locationsCount":4},"100601401","the-role-of-simulation-based-training-in-resident-curriculum-in-anaesthesia-and-intensive-care-100601401","NCT07110012","The Role of Simulation-based Training in Resident Curriculum in Anaesthesia and Intensive Care","STRAIC","Inclusion Criteria:\n\n* ESAIC NASC representatives.\n\nExclusion Criteria:\n\n* not ESAIC NASC representatives.",{"count":100,"type":22},"This observational study aims to describe the situation in Europe regarding simulation training during residency in Anaesthesia and Intensive Care. The main questions it aims to answer are:\n\nHow many countries in Europe have obligatory simulation training during residency? How frequent is this training? What and how is trained during simulations? How is the situation regarding funding and participation in working hours in simulation training? What are the obstacles for the countries that do not have obligatory training? Participants will fill out an electronic survey.",[452,453,33,454],"Simulation Training","Education","Anaesthesia",[456,457,458,459,460,104],"simulation training","intensive care","European survey","education","physicians","2025-07-31",{"date":463,"type":44},"2025-08-07",{"date":465,"type":22},"2025-09-01",{"date":467,"type":22},"2025-12-30",{"name":469,"class":51},"Brno University Hospital",{"id":471,"slug":472,"hasResults":11,"nctId":473,"briefTitle":474,"officialTitle":474,"acronym":4,"eligibilityCriteria":475,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":476,"targetDuration":4,"studyType":23,"phases":478,"briefSummary":479,"conditions":480,"keywords":489,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":503,"locationsCount":113},"100597765","the-role-of-swan-ganz-catheter-in-hemodynamic-resuscitation-for-patients-with-cardiogenic-shock-100597765","NCT07062744","The Role of Swan-Ganz Catheter in Hemodynamic Resuscitation for Patients With Cardiogenic Shock","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Provided written informed consent to participate in the study.\n* Diagnosed with cardiogenic shock due to acute myocardial infarction according to IABP-SHOCK II (2012) criteria:\n\n  * Systolic blood pressure (SBP) \\\u003C 90 mmHg for at least 30 minutes, or requiring vasopressor agents to maintain SBP \\> 90 mmHg.\n  * Evidence of end-organ hypoperfusion, indicated by at least one of the following: Altered mental status, Urine output \\\u003C 30 mL\u002Fhour, Cold extremities with mottled skin, Serum lactate level \\> 2 mmol\u002FL.\n\nExclusion Criteria:\n\n* Presence of cervical cellulitis.\n* Inability to identify neck anatomy or history of cervical radiotherapy.\n* Coagulopathy (INR \\> 1.5 and\u002For platelet count \\\u003C 50 G\u002FL).\n* End-stage chronic diseases, including: Advanced malignancy, advanced-stage HIV, bedridden patients for more than 3 months, decompensated liver cirrhosis (Child-Pugh class C).\n* Patients with cardiac arrest or mechanical complications such as myocardial rupture prior to Swan-Ganz catheterization.\n* Congenital heart defects or intracardiac shunts. Refusal of participation by the patient or their legal representative.",{"count":477,"type":22},108,[25],"This clinical trial examines whether the use of the Swan-Ganz catheter, a specialized pulmonary artery catheter, can improve hemodynamic management and treatment outcomes in patients experiencing cardiogenic shock due to acute myocardial infarction (AMI).\n\nCardiogenic shock is a critical condition marked by the heart's inability to supply adequate blood to the organs, often resulting from a severe heart attack. Despite advancements in care, the condition remains associated with high mortality. Effective monitoring of cardiovascular status is crucial in guiding timely and tailored treatment decisions.\n\nParticipants in this study will undergo advanced hemodynamic monitoring using the Swan-Ganz catheter, which provides continuous data on cardiac output and other key parameters. This information enables physicians to better assess circulatory function and adjust therapies accordingly.\n\nThe research will evaluate clinical characteristics, response to treatment, and 30-day outcomes in patients managed with this technique. The study also aims to identify factors associated with successful hemodynamic stabilization and potential complications related to catheter use.\n\nA total of 108 adult patients meeting specific eligibility criteria will be enrolled at Bach Mai Hospital over 3 years. Participation is voluntary, and all patients will continue to receive standard-of-care treatment. All personal and medical data will be handled with strict confidentiality.",[481,482,483,484,485,486,33,487,488],"Cardiogenic Shock","Pulmonary Artery Catheter Waveform Interpretation","Hemodynamic Management","Hemodynamic Optimization","Hemodynamic Monitoring","Acute Myocardial Infarction (AMI)","Emergency","Cardio Vascular Disease",[490,491,492,493,494,495],"Swan-Ganz","Pulmonary Artery Catheter","Cardiogenic shock","Hemodynamic management","Invasive hemodynamic","Right Heart Catheter","2025-07-10",{"date":498,"type":44},"2025-07-14",{"date":500,"type":44},"2025-05-27",{"date":502,"type":22},"2027-12-30",{"name":504,"class":51},"Bach Mai Hospital",{"id":506,"slug":507,"hasResults":11,"nctId":508,"briefTitle":509,"officialTitle":510,"acronym":511,"eligibilityCriteria":512,"healthyVolunteers":98,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":513,"targetDuration":4,"studyType":23,"phases":514,"briefSummary":515,"conditions":516,"keywords":521,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":525,"lastUpdatePostDateStruct":526,"startDateStruct":528,"completionDateStruct":530,"leadSponsor":532,"locationsCount":235},"100591772","the-family-cares-trial-100591772","NCT06984770","The Family Cares Trial","Caring for the Caregiver: A Pilot Randomized Controlled Trial (The Family Cares Trial)","Family Cares","Inclusion Criteria:\n\n* (1) Family member of a person admitted to an ICU for \\>48 hours and survived to hospital discharge. \"Family\" is anyone with a biological, legal, or emotional relationship with the patient and whom the patient wants involved in their care\n* (2) Planned or current part or full-time caregiver of the ICU survivor\n* (3) Age ≥ 18 years\n* (4) Within 6 months of ICU survivor's hospital discharge.\n\nExclusion Criteria:\n\n* (1) Another family member participating in the study\n* (2) Inability to communicate in English or French.",{"count":123,"type":22},[25],"The goal of this pilot study is to learn if virtual peer support groups and strengths-based skills training can help family caregivers of ICU survivors providing ongoing support to ICU survivors after hospital discharge. The main question it aims to answer is:\n\n\\- Are virtual peer support groups and\u002For strengths-based skills support feasible and acceptable for family caregivers of ICU survivors? Researchers will compare the intervention group (virtual peer support groups or strengths-based skills training) to the control group (no intervention) to see if the interventions improve caregiver outcomes and assess feasibility and acceptability.\n\nParticipants will:\n\n* Participate in either virtual peer support groups or strengths-based skills training sessions (if assigned to the intervention arm).\n* Provide feedback on the feasibility and acceptability of the interventions (if assigned to the intervention arm).\n* Complete surveys and follow-up questionnaires (either online or by phone) to measure outcomes.",[214,33,215,216,217,517,518,519,520],"Pilot Study","Caregiver","Caregiver Burden","Family Caregivers",[221,214,71,157,222,223,522,523,524],"Post-ICU","Caregivers","Family Caregiver","2025-05-14",{"date":527,"type":44},"2025-05-22",{"date":529,"type":22},"2025-08",{"date":531,"type":22},"2027-08",{"name":234,"class":51},{"id":534,"slug":535,"hasResults":11,"nctId":536,"briefTitle":537,"officialTitle":538,"acronym":539,"eligibilityCriteria":540,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":541,"targetDuration":4,"studyType":23,"phases":542,"briefSummary":543,"conditions":544,"keywords":545,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":525,"lastUpdatePostDateStruct":546,"startDateStruct":548,"completionDateStruct":550,"leadSponsor":552,"locationsCount":235},"100561159","increasing-family-engagement-in-critical-care-100561159","NCT06586528","Increasing Family Engagement in Critical Care","Increasing Family Engagement in Critical Care: The NGAGE Trial (The NGAGE Trial)","NGAGE","Inclusion Criteria:\n\n* Adult family members (age ≥ 18 years) of ICU patients\n* Expected ICU stay ≥ 48 hours\n* Able to participate in English or French\n\nExclusion Criteria:\n\n* Family members who do not wish to participate in care\n* Repeat admissions within the study period\n* Another family member has already participated in the study",{"count":209,"type":22},[25],"The primary aim of this trial is to evaluate if the NGAGE tool improves care engagement in family members of ICU patients. The secondary objectives are to assess if the NGAGE tool improves communication, care satisfaction, psychological symptoms, and quality of life in family members of ICU patients.\n\nThe NGAGE trial is a stepped wedge cluster randomized trial of 6 Canadian adult ICUs, involving 194 family members. A family member will be considered anyone with a biological, emotional, or legal relationship with the patient and whom the patient wishes to be involved in their care. There will be random and sequential crossover of clusters from control (phase 1) to intervention (phase 2) until all clusters are exposed. The intervention group will have access to the NGAGE tool, which has modules to Learn, Engage, and Report. \"Engage\" allows the family member to indicate their desired engagement activity, which is then transmitted to the treating healthcare team to provide the requested activity. \"Learn\" contains educational capsules about the ICU environment and information about care participation. \"Report\" allows the family member to provide real-time feedback to the healthcare team. The primary endpoint is the FAMily Engagement (FAME) score within 1 week of ICU discharge. Secondary endpoints are family-centered outcomes, including communication quality, satisfaction, and mental health (anxiety and depression) scores within 1 week of ICU discharge, and quality of life and mental health (anxiety, depression, and post-traumatic distress symptoms) at 6 months. The mean difference of the validated FAME score, a continuous variable, will be compared between groups.",[214,33,215,216,217],[221,214,71,157,222,223],{"date":547,"type":44},"2025-05-18",{"date":549,"type":44},"2025-03-26",{"date":551,"type":22},"2027-09",{"name":234,"class":51},{"id":554,"slug":555,"hasResults":11,"nctId":556,"briefTitle":557,"officialTitle":557,"acronym":558,"eligibilityCriteria":559,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":560,"enrollmentInfo":561,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":563,"conditions":564,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":549,"lastUpdatePostDateStruct":565,"startDateStruct":567,"completionDateStruct":569,"leadSponsor":571,"locationsCount":113},"100585085","does-transcutaneous-phrenic-nerve-stimulation-prevent-diaphragm-atrophy-100585085","NCT06897774","Does Transcutaneous Phrenic Nerve Stimulation Prevent Diaphragm Atrophy?","NMES","Inclusion Criteria:Patients on invasive mechanical ventilation for 72 hours or more Patients older than 18 years\n\nExclusion Criteria: Patients under 18 years of age\n\n* Patients with less than 72 hours of mechanical ventilation\n* Pregnancy\n* Patients with a body mass index above 35kg\u002Fm²\n* Neuromuscular disease\n* Refractory epilepsy\n* Patients with pacemakers\n* ARDS\n* Unilateral or bilateral diaphragm paralysis\n* Presence of pneumothorax\n* Patients with large right pleural effusion\n* Tracheostomized patients\n* Patients undergoing upper abdominal surgery","80 Years",{"count":562,"type":22},80,"Dear participant Participants's patient, who is participants's first-degree relative, who is connected to a ventilator in the intensive care unit, unconscious and not authorized to give informed consent, has been invited to participate in the study titled 'Does transcutaneous phrenic nerve stimulation prevent diaphragm atrophy?\n\nIn order to strengthen this muscle and prevent loss of function, investigator provide electrical stimulation between the rib cage and abdomen through the skin with the tens device, causing the muscle to contract and enabling our patient to leave the respirator early.\n\nInvestigator aimed to investigate the protective effect of the tens device on the diaphragm by evaluating the diaphragm muscle with the ultrasonography device during the period when it is connected to the respirator. For this reason, the diaphragm will be contracted by giving electrical stimulation three times a day for 30 minutes with the tens device for 5 days during the period when participants's patient is connected to the respirator, and intermittent diaphragm ultrasound will be evaluated.\n\nParticipants or participants's legal guardian are asked to approve the use of participants's medical records during participants's treatment in the intensive care unit, provided that participants's personal information is kept confidential. Participants will not incur any financial burden by participating in the study and participants will not receive any additional payment.\n\nParticipants are free to leave the study at any time if deemed necessary, and the researcher can terminate the study if deemed necessary. The information obtained within the scope of the research can be used for scientific purposes and can be presented and published provided that the confidentiality record is respected.\n\nI have read (or orally listened to) the text above, which contains the information given to the participants before the research began. I agree to participate in the study as a Volunteer. I consent to the use of my medical information. I also understand that if I do not agree to participate in the study, my treatment will be carried out in full without interruption.\n\nParticipant name and surname:\n\nParticipant's relative's name and surname:\n\nDegree of closeness:\n\nSignature \u002F Date:",[33],{"date":566,"type":44},"2025-03-27",{"date":568,"type":44},"2024-01-22",{"date":570,"type":22},"2025-04-22",{"name":572,"class":420},"Bakirkoy Dr. Sadi Konuk Research and Training Hospital",{"id":574,"slug":575,"hasResults":11,"nctId":576,"briefTitle":577,"officialTitle":577,"acronym":578,"eligibilityCriteria":579,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":580,"enrollmentInfo":581,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":583,"conditions":584,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":588,"lastUpdatePostDateStruct":589,"startDateStruct":591,"completionDateStruct":593,"leadSponsor":595,"locationsCount":113},"100579214","n-care-project-enhancing-asian-pacific-collaboration-100579214","NCT06821386","N-Care Project: Enhancing Asian-Pacific Collaboration","N-Care project","Inclusion Criteria:\n\n1. Age: infant\u002Fnewborn less than 18 months\n2. Admitted to intensive care unit\n3. At least one of the following conditions A. Specific anomaly highly suggestive of a genetic etiology\n\n   * Multiple birth defects\n   * Single major malformation that required intervention (surgery or medication)\n   * Significantly abnormal EKG\n   * Significant hypotonia\n\nB. Children with high-risk stratification on assessment of a Brief Resolved Unexplained Event (BRUE) with any of the following:\n\n* Recurrent severe infection events\n* Recurrent or prolonged seizures\n* Unexplained cardiopulmonary resuscitation (CPR)\n* Suspect inborn error of metabolism\n\nExclusion Criteria:\n\n1. Infants with a definitive non-genetic diagnosis: ex as below A. An infection with normal response to therapy B. Isolated prematurity C. Transient hypoglycemia D. Isolated unconjugated hyperbilirubinemia E. Isolated Transient Neonatal Tachypnea F. Those where the clinical course can be explained without genetic testing\n2. Confirmed genetic diagnosis explains illness\n3. Lack of consent: Families who do not consent to genetic testing or data sharing.\n4. Infants without sufficient DNA sample quality\u002Fquantity: Where the quality or quantity of the DNA sample is inadequate for sequencing.","18 Months",{"count":582,"type":22},70,"Through Asian-Pacific multinational collaboration, we aim to utilize third-generation genome sequencing to rapidly diagnose genetic diseases in critically ill infants and young children, achieving the goal of early diagnosis for targeted treatment.",[585,586,33,587],"Whole Genome Sequencing","Genetic Disease","Nanopore Sequencing","2025-02-18",{"date":590,"type":44},"2025-02-20",{"date":592,"type":22},"2025-02-17",{"date":594,"type":22},"2032-12-31",{"name":441,"class":51},{"id":597,"slug":598,"hasResults":11,"nctId":599,"briefTitle":600,"officialTitle":600,"acronym":601,"eligibilityCriteria":602,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":603,"targetDuration":605,"studyType":62,"phases":4,"briefSummary":606,"conditions":607,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":611,"lastUpdatePostDateStruct":612,"startDateStruct":614,"completionDateStruct":616,"leadSponsor":617,"locationsCount":4},"100571715","the-critical-care-recovery-program-use-of-a-structured-clinic-visit-to-reduce-adverse-drug-events-in-icu-survivors-100571715","NCT06723860","The Critical Care Recovery Program: Use of a Structured Clinic Visit to Reduce Adverse Drug Events in ICU Survivors","CCRP","Inclusion Criteria:\n\n* Patient being discharged to ward, home or repatriated to local health centre AND ONE OR MORE OF\n\n  * Duration of mechanical ventilation \\>72 hours\n  * Length of stay in critical care \\>96 hours\n  * Out of hospital arrest\n  * Maternal critical illness\n  * Trauma\n  * Significant ICU delirium\n  * Unexpected adverse outcomes of planned treatment\n\nExclusion Criteria:\n\n* Patient discharged for palliative care or expected to die within the next two months",{"count":604,"type":22},3000,"1 Year","Background and Objective: Intensive Care Units (ICUs) save lives, but many ICU survivors face ongoing health issues, including adverse drug events (ADEs) from medications started during their hospital stay. These ADEs lead to emergency department visits and hospital admissions. Our project aims to improve the health of ICU survivors by creating a clinic that focuses on managing post-ICU health. The clinic will track and address medical issues that arise after ICU discharge and focus on deprescribing, or safely stopping, medications that may no longer be needed or could be harmful.\n\nProject Plan: The clinic will be set up within the CARES clinic at VGH. Patients will be enrolled when they leave the ICU and will have follow up visits after hospital discharge. During these visits, the team will review each patient's medications and develop a personalized plan to reduce or stop unnecessary medications. We will also monitor patients for any new health issues that arise and provide eduction to patients and caregivers about managing their health.\n\nResearch and Evaluation: We will collect and analyze data on patient health outcomes, including the incidence of ADEs, hospital reeadmissions, and emergency department visits. We hope to show that patients who receive follow up care have better health outcomes and use fewer healthcare resources than a historical cohort. This data will help us demonstrate the cost-effectiveness of the clinic and support the need for expanding ICU follow up programs in British Columbia.\n\nLong-term goals: We plan to establish a post-ICU care working group and expand the clinic model to other hospitals. Over the long term, we hope to standardize post-ICU care across BC, ensuring that all ICU survivors have access to comprehensive follow up care. This project will also lay the groundwork for future research on deprescribing medications for ICU related complications, which tend to improve or resolve once critical illness has resolved. The CCRP clinic will provide a setting to conduct clinical deprescription trials to establish whether long-term treatment of these complications is necessary.\n\nConclusion: Establishing a post-ICU discharge follow up clinic with a focus on deprescription has the potential to improve the long-term health and quality of life for ICU survivors. By reducing unnecessary medications, we can prevent complications, reduce hospital readmissions and demonstrate the value of comprehensive post-ICU follow up care.",[608,609,610,33],"Post Intensive Care Syndrome (PICS)","Polypharmacy","Adverse Drug Events","2024-12-04",{"date":613,"type":44},"2024-12-09",{"date":615,"type":22},"2025-01-30",{"date":502,"type":22},{"name":618,"class":51},"University of British Columbia",{"id":620,"slug":621,"hasResults":11,"nctId":622,"briefTitle":623,"officialTitle":624,"acronym":4,"eligibilityCriteria":625,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":626,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":628,"conditions":629,"keywords":632,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":634,"lastUpdatePostDateStruct":635,"startDateStruct":636,"completionDateStruct":638,"leadSponsor":640,"locationsCount":4},"100571643","definition-of-acute-kidney-injury-by-urine-output-in-critically-ill-patients-100571643","NCT06722924","Definition of Acute Kidney Injury by Urine Output in Critically Ill Patients","Definition of Acute Kidney Injury Based on Urine Output","Inclusion Criteria:\n\n* Admittance to intensive care units at Uppsala University Hospital between 2016-2024\n\nExclusion Criteria:\n\n* Minimum age 18 years",{"count":627,"type":22},15000,"The goal of this observational study is to explore the association between urine output and acute kidney injury in severely ill patients admitted to intensive care units. The main research questions are:\n\nWhat is the optimal threshold for defining reduced urine output in critically ill patients in intensive care? Is this threshold the same for different outcomes such as acute kidney injury, chronic kidney dysfunction, or mortality? Does this threshold change with treatment involving diuretics or dialysis? Does the patient's fluid balance or the amount of administered fluid affect the association between reduced urine output and the outcomes mentioned above? Is the optimal threshold for defining reduced urine output different for various patient categories and diagnoses, such as sepsis, burn injuries, or ARDS? Are there differences between surgical and non-surgical patients regarding the optimal threshold for defining reduced urine output in intensive care? Does the patient's comorbidity influence the level of reduced urine output that should be considered pathological?",[630,70,33,631],"Acute Kidney Injury","Critical Care, Fluid Resuscitation",[633],"observational study","2024-12-03",{"date":613,"type":44},{"date":637,"type":22},"2024-12",{"date":639,"type":22},"2025-03",{"name":641,"class":51},"Uppsala University",{"id":643,"slug":644,"hasResults":11,"nctId":645,"briefTitle":646,"officialTitle":647,"acronym":648,"eligibilityCriteria":649,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":650,"targetDuration":4,"studyType":23,"phases":651,"briefSummary":653,"conditions":654,"keywords":658,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":662,"startDateStruct":664,"completionDateStruct":666,"leadSponsor":668,"locationsCount":113},"100569603","phase-3-venous-excess-ultrasound-for-personalized-resuscitation-in-septic-shock-100569603","NCT06696391","Venous Excess Ultrasound for Personalized Resuscitation in Septic Shock","Venous Excess Ultrasound (VEXUS)-Guided Management Versus Usual Care in Patients with Septic Shock: a Pilot Randomized Controlled Trial","VESPER","Inclusion Criteria:\n\n1. Adult patients (≥18 years)\n2. Within 12 hours of meeting septic shock diagnosis based on following Sepsis-3 criteria: requirement for vasopressors to maintain organ perfusion, lactate \\> 2 mmol\u002FL, and suspected or confirmed infection)\n3. Within 48 hours of intensive care unit admission.\n\nExclusion Criteria:\n\n1. Already receiving renal replacement therapy\n2. Patients for whom a decision to initiate renal replacement therapy has been made prior to study enrolment\n3. Patients who have limitations on medical therapy or restrictions on goals of care\n4. Active bleeding causing hemodynamic instability\n5. Veno-venous or veno-arterial extracorporeal membrane oxygenation\n6. Previously enrolment in study\n7. 10% or more of body surface area acute burn injury\n8. Suspected or confirmed liver cirrhosis\n9. Established allergy to sulfa drugs;\n10. Patients receiving treatments that require continuous IV fluid infusions (e.g., diabetic ketoacidosis, diabetes insipidus)\n11. Unable to measure fluid balance accurately\n12. Contra-indication to study recommended interventions (e.g., diuretics, inotropes)\n13. Unable to perform VEXUS due to anatomical barriers (e.g., surgical dressings);\n14. Unable to complete VEXUS scan during the 6-hour resuscitation window\n15. Moderate to Severe Tricuspid Regurgitation\n16. Untreated Metabolic\u002Fbiochemical findings (Hypokalemia \\[K+\\]\\\u003C 3.0 mmol\u002FL; metabolic alkalosis \\[Bicarbonate \\> 40 mmol\u002FL and\u002For pH \\> 7.55\\], Hypomagnesemia \\[Mg2+\\] \\\u003C 0.6, and Hypernatremia \\[Na+\\] \\> 155 mmol\u002FL)",{"count":562,"type":22},[652],"PHASE3","The goal of this pilot clinical trial is to determine if conducting a larger study using venous excess ultrasound (VEXUS) to guide fluid management in patients with septic shock is feasible. Septic shock is a life-threatening condition where infection causes dangerously low blood pressure. While fluids are essential for treatment, too much fluid can harm the kidneys and result in the need for dialysis. The main questions it aims to answer are:\n\n1. Is it feasible to recruit patients, obtain consent, and follow the VEXUS-guided management protocol?\n2. Does VEXUS-guided management, compared with usual care, improve the health and well-being of patients with septic shock?\n\nResearchers will compare two groups: one receiving VEXUS-guided fluid management versus another receiving standard care, to assess the feasibility of a larger trial and explore whether VEXUS prevents fluid overload and kidney problems.\n\nParticipants in the VEXUS group will:\n\n1. Undergo VEXUS scans every 24 hours for 3 days\n2. Receive fluid management guided by VEXUS findings (including fluid restriction or removal if we identify venous congestion) and undergo cardiac ultrasound if we identify moderate to severe congestion\n3. Be monitored for 28 days to track kidney function, need for dialysis, and survival.",[655,153,656,33,657],"Septic Shock","Shock","Resuscitation",[659,660,661,655,517,657],"Randomized Controlled Trial","Ultrasound","Venous Congestion",{"date":663,"type":44},"2024-11-20",{"date":665,"type":22},"2024-12-01",{"date":667,"type":22},"2027-12-28",{"name":669,"class":51},"Western University, Canada",{"id":671,"slug":672,"hasResults":11,"nctId":673,"briefTitle":674,"officialTitle":675,"acronym":676,"eligibilityCriteria":677,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":678,"targetDuration":4,"studyType":23,"phases":679,"briefSummary":680,"conditions":681,"keywords":685,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":689,"lastUpdatePostDateStruct":690,"startDateStruct":692,"completionDateStruct":694,"leadSponsor":696,"locationsCount":235},"100525197","pilot-study-of-a-multidisciplinary-intervention-in-icu-survivors-at-risk-for-psychological-or-physical-morbidity-100525197","NCT06118606","Pilot Study of a Multidisciplinary Intervention in ICU Survivors At Risk for Psychological or Physical Morbidity","Interventional Multidisciplinary Rehabilitation and Special Support; a Pilot Study of a Case Manager-led Multidisciplinary Intervention in ICU Survivors At Risk for Psychological or Physical Morbidity -IMPRESS-ICU Pilot Study","IMPRESS","Inclusion Criteria:\n\n\\- Patients admitted ≥12 hours to the ICU with an increased risk for physical or psychological sequelae (assessed with the PROGRESS-ICU\u002FPREPICS instruments)\n\nExclusion Criteria:\n\n* Dementia or other major cognitive problems\n* Structural brain or spinal cord injury\n* Multiple limitations of medical treatment\n* Insufficient language skills (Swedish)",{"count":123,"type":22},[25],"Pilot study of the feasibility and utility of an early, in-hospital multidisciplinary intervention in ICU survivors at risk for psychological and physical problems post-ICU stay",[257,682,250,683,684,33],"Depressive Symptoms","Physical Disability","Posttraumatic Stress Symptom",[686,687,688],"Post-intensive care syndrome","Pilot study","Early follow-up intervention","2024-10-07",{"date":691,"type":44},"2024-10-09",{"date":693,"type":44},"2024-02-01",{"date":695,"type":22},"2025-04",{"name":697,"class":420},"Region Stockholm"]