[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"critical-care\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:critical-care":26},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,33,0,25,[9,43,79,109,138,173,199,227,257,284,321,354,377,409,432,452,481,506,529,555,582,612,633,654,680],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100644207","jugular-gating-for-upright-level-adjustment-and-targeted-enhancement-of-cerebral-perfusion-100644207",false,"NCT07665606","JUgular Gating for Upright Level Adjustment and Targeted Enhancement of Cerebral Perfusion","JUGULATE","Inclusion Criteria:\n\n* Patients ≥ 18 years old\n* Hospitalized in the neurocritical care unit or the trauma unit\n* Scheduled for nursing care requiring a supine position.\n* Arterial catheter allowing continuous measurement of mean arterial pressure.\n* Central venous catheter for continuous measurement of central venous pressure.\n* External ventricular drain or intracranial pressure sensor for intracranial pressure monitoring.\n* Bed with controlled inclination capability.\n* Clinically stable condition allowing transient positional changes (as judged by the clinician).\n* Not included, or planned to be included in another trial.\n\nExclusion Criteria:\n\n* Contraindication to trunk mobilization.\n* Being a minor or placed under supervision.\n* Hemodynamic or respiratory instability.\n* Uncontrolled intracranial hypertension, refractory arterial hypertension, or severe dysautonomia.\n* Pregnancy or breastfeeding.\n* Refusal to participate in the study.","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","OBSERVATIONAL","Investigators aim to demonstrate that the evolution of intracranial pressure (ICP) is nonlinear and may be influenced by jugular vein collapse. This collapse is estimated to occur at the angle where the hydrostatic pressure of the blood column matches the central venous pressure, and it can be assessed using ultrasonography. This approach allows for the determination of an individualized tilt angle, optimizing cerebral perfusion pressure without compromising venous drainage.",[25,26],"Intracranial Pressure","Critical Care",[25,28,29],"jugular vein collapse","Critical care","NOT_YET_RECRUITING","2026-06-18",{"date":33,"type":34},"2026-06-24","ACTUAL",{"date":36,"type":21},"2026-09-01",{"date":38,"type":21},"2027-03-31",{"name":40,"class":41},"University Hospital, Bordeaux","OTHER",1,{"id":44,"slug":45,"hasResults":12,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":52,"conditions":53,"keywords":61,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100625308","mechanical-insufflation-exsufflation-in-critically-ill-patients-100625308","NCT07420946","Mechanical Insufflation-Exsufflation in Critically Ill Patients","Mechanical Insufflation-Exsufflation in Critically Ill Patients: An International DELphi Consensus (DELMI-E)","DELMI-E","Inclusion Criteria:\n\n* Healthcare professionals with documented clinical experience in critical care medicine, pulmonology, anesthesiology, respiratory therapy, or physiotherapy with involvement in airway clearance strategies.\n* Demonstrated experience or recognized expertise in the clinical use of MI-E, either in critically ill patients or in patients with complex respiratory conditions.\n* A minimum of 5 years of clinical experience in their respective field, or a proven academic or clinical contribution related to MI-E.\n* Willingness to participate in multiple Delphi rounds and to provide informed consent.\n* Ability to complete the questionnaires in English.\n\nExclusion Criteria:\n\n* Lack of direct clinical or academic experience related to MI-E or airway clearance techniques.\n* Inability or unwillingness to provide informed consent.\n* Failure to complete the first Delphi round after formal invitation and consent.\n* Withdrawal of consent at any stage of the Delphi process.",{"count":20,"type":21},"Mechanical insufflation-exsufflation (MI-E) is an established airway clearance technique for patients with chronic conditions like neuromuscular diseases. However, its use in critically ill ICU patients remains inconsistent and lacks standardized guidelines. Despite growing research, current practices vary widely in patient selection, treatment protocols, and safety management, with limited high-quality evidence to support clear recommendations. To address this gap, an international, multidisciplinary Delphi consensus study is needed to establish expert-based best practices and feasible guidelines for the safe and effective implementation of MI-E in the intensive care setting.",[54,55,56,57,58,59,26,60],"Airway Clearance","Mechanical Insufflation-exsufflation","Mechanical Insufflation-exsufflation Session ( With Cough Assist)","Delphi Study","Consensus","Critical Illness","Critical Care, Intensive Care",[62,63,64,58,65,66,67],"mechanical insufflation-exsufflation","Airway clearance","Delphi study","Cough assist","MI-E","critical care","RECRUITING","2026-06-15",{"date":71,"type":34},"2026-06-17",{"date":73,"type":34},"2026-06-10",{"date":75,"type":21},"2026-12-01",{"name":77,"class":41},"Medipol University",4,{"id":80,"slug":81,"hasResults":12,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":42},"100638793","phase-2-electrophysiological-analysis-of-gamma-hydroxybutyrate-induced-sleep-in-intensive-care-patients-100638793","NCT07596342","Electrophysiological Analysis of Gamma-Hydroxybutyrate-induced Sleep in Intensive Care Patients","Electrophysiological Analysis of Gamma-Hydroxybutyrate-induced Sleep in Intensive Care Patients: A Pilot Double-Blind Randomized Controlled Trial","GAMMA-SLEEP","Inclusion Criteria:\n\n1. Aged 18 years or older\n2. Hospitalized in the ICU for more than 48 hours\n3. Informed consent obtained from the patient\n\nExclusion Criteria:\n\n1. Unstable patient\n2. Known allergy to Gamma-Hydroxybutyrate or any of the excipients\n3. Technical impossibility of performing polysomnography\n4. Childbearing or Positive pregnancy test for women of childbearing age or breastfeeding\n5. Patient who has already received the study treatment\n6. History of chronic alcoholism\n7. Uncontrolled epilepsy despite appropriate antiepileptic treatment\n8. Traumatic brain injury or neurological lesion at risk of epilepsy in the last month\n9. Severe hypertension: SBP \\> 180 mmHg despite antihypertensive treatment\n10. Hypokalemia \\\u003C 3.5 mmol\u002FL despite potassium supplementation\n11. Bradycardia due to intra-cardiac conduction disorders\n12. Obstructive sleep apnea syndrome\n13. Sodium restriction: Salt intake \\\u003C 3g\u002F24h\n14. Patients with known or suspected succinic semialdehyde dehydrogenase (SSADH) deficiency, given the risk of GHB accumulation due to impaired endogenous metabolism.\n15. Patients receiving barbiturates at inclusion\n16. Patients receiving opioids at inclusion for non-mechanically ventilated patient\n17. Patients presenting with hypernatraemia (sodium \\> 145 mmol\u002FL) or hyperchloraemia (chloride \\> 110 mmol\u002FL) at inclusion\n18. Patients with hepatic impairment (Child-Pugh B or C)\n19. Deep sedation defined by a RASS score \\\u003C -2\n20. Presence of mental confusion: Positive CAM-ICU\n21. Moribund patient or high likelihood of death within 48 hours\n22. Legal protection: guardianship, curatorship, or judicial protection\n23. Lack of social security or on AME (state medical aid)\n24. Participation in another interventional clinical trial related to the management of sleep disorders, delirium, or sedation in the ICU.",{"count":88,"type":21},24,"INTERVENTIONAL",[91],"PHASE2","In intensive care, sleep disturbances are extremely common and represent a major source of discomfort for patients. Restorative sleep is very limited. Beyond being the primary source of discomfort reported by patients, these sleep disturbances are associated with difficulties in weaning from mechanical ventilation, an increased risk of delirium, and potentially higher mortality. Traditional treatments artificially increase the total duration of sleep but lead to disrupted sleep architecture.\n\nGamma-hydroxybutyrate (GHB) is currently used for several sleep disorders, such as narcolepsy, due to its ability to increase restorative sleep. This medication has been used for years as a sedative in intensive care. Despite these potential benefits, the efficacy of GHB has never been evaluated for sleep disturbances in intensive care settings.\n\nThis study focuses on evaluating the effectiveness of intravenous Gamma-hydroxybutyrate (GHB) in the treatment of sleep disorders in intensive care.",[94,26],"Sleep Disorder (Disorder)",[96,97,98,99],"Gamma-hydroxybutyrate","Sleep disorder","ICU","Slow-wave sleep","2026-05-20",{"date":102,"type":34},"2026-05-22",{"date":104,"type":21},"2026-06",{"date":106,"type":21},"2027-10",{"name":108,"class":41},"Assistance Publique - Hôpitaux de Paris",{"id":110,"slug":111,"hasResults":12,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":89,"phases":118,"briefSummary":120,"conditions":121,"keywords":126,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":42},"100592197","focused-ultrasound-spleen-stimulation-and-inflammation-in-septic-shock-100592197","NCT06990295","Focused Ultrasound Spleen Stimulation and Inflammation in Septic Shock","Effects of Focused Ultrasound Spleen Neuromodulation on Inflammatory Cytokine Levels in Patients With Septic Shock: A Randomized Controlled Pilot Trial","Inclusion Criteria:\n\n* Age ≥ 18 years, regardless of sex\n* Diagnosed with septic shock according to Sepsis-3 criteria: Sequential Organ Failure Assessment (SOFA) score ≥ 2 and requiring vasopressor support to maintain a mean arterial pressure (MAP) ≥ 65 mmHg.\n* Admitted to the ICU within 24 hours of septic shock diagnosis\n* Expected to require intensive care for at least 72 hours\n* Informed consent obtained from the patient or legal representative\n\nExclusion Criteria:\n\n* Known pregnancy or breastfeeding\n* Participation in another interventional clinical trial within 30 days\n* Known immunodeficiency or ongoing immunosuppressive therapy\n* Malignancy with life expectancy \\\u003C 6 months\n* Contraindications to focused ultrasound (e.g., splenic trauma, splenectomy, local skin infection)\n* Do-not-resuscitate (DNR) order or expected death within 24 hours\n* Any other condition deemed unsuitable for participation by the investigators",{"count":117,"type":21},40,[119],"NA","This study evaluates the safety and effectiveness of focused ultrasound spleen neuromodulation in patients with septic shock, a life-threatening condition characterized by excessive inflammation and organ dysfunction. The primary objective is to determine whether non-invasive, focused ultrasound stimulation of the spleen can reduce circulating inflammatory cytokine levels in this patient population.\n\nEligibility Criteria:\n\nAdults aged 18 years or older Diagnosed with septic shock and admitted to the ICU within 24 hours Expected to require intensive care for at least 72 hours\n\nStudy Protocol:\n\nParticipants will be randomly assigned to one of two groups:\n\nIntervention Group: Will receive standard septic shock care plus twice-daily focused ultrasound stimulation over the spleen for five days, using a portable device.\n\nControl Group: Will receive standard septic shock care alone. Blood samples will be collected at baseline and Day 5 to measure inflammatory cytokine levels, including TNF-α, IL-1β, IL-6, and IL-10. Additional assessments will include lymphocyte subpopulations, organ function scores, ICU length of stay, 28-day mortality, and adverse events.\n\nOutcome Measures:\n\nPrimary: Change in levels of inflammatory cytokines on Day 5. Secondary: Changes in organ function (SOFA score), ICU length of stay, 28-day survival, and safety\u002Ftolerability of the intervention.",[122,123,124,125,26],"Septic Shock","Inflammatory Cytokines","Spleen Neuromodulation","Focused Ultrasound",[122,125,124,123,26,127,128],"Immune Modulation","Pilot Study","2026-05-15",{"date":131,"type":34},"2026-05-19",{"date":133,"type":34},"2025-07-25",{"date":135,"type":21},"2026-12-31",{"name":137,"class":41},"First Affiliated Hospital of Wannan Medical College",{"id":139,"slug":140,"hasResults":12,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":12,"sex":17,"minAge":146,"maxAge":147,"enrollmentInfo":148,"targetDuration":150,"studyType":22,"phases":4,"briefSummary":151,"conditions":152,"keywords":160,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":42},"100600102","rehabilitation-practices-in-critically-ill-patients-receiving-invasive-mechanical-ventilation-in-the-intensive-care-unit-100600102","NCT07093125","Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit.","An Observational Study on Rehabilitation Practices in the ICU for Critically Ill Patients Undergoing Invasive Mechanical Ventilation - Report (REPOrt)","REPOrt","Inclusion Criteria:\n\n* Patients admitted to a participating ICU\n* Adult patients (aged 16 years or older, depending on local regulations for the definition of \"adults\")\n* Patients who have received invasive ventilation for at least 48 hours\n* Patients who have obtained written informed consent from the patient or next of kin (if local legislation demands so)\n\nExclusion Criteria:\n\n• Patients admitted for withdrawn of life sustain therapy","16 Years","100 Years",{"count":149,"type":21},2400,"28 Days","This international, multicenter, observational study aims to describe rehabilitation practices in Intensive Care Units (ICUs) worldwide.\n\nThe primary objective is to provide an overview of current rehabilitation strategies used in ICUs globally.\n\nSecondary objectives include assessing the relationship between rehabilitation and key ICU outcomes such as ICU and hospital mortality, length of stay, duration of invasive ventilation, extubation failures, and long-term outcomes including quality of life and functional performance 28 days post-ICU discharge.\n\nThe study will also compare rehabilitation practices across different geographic and economic regions to identify potential disparities. The study is structured into three modules, with participation contingent on local resources and feasibility.\n\nThe BASIC Module (mandatory for all centers) gathers fundamental data on rehabilitation practices and their association with patient outcomes.\n\nThe EXTENDED Module (optional) collects more detailed information on the type, timing, duration, and safety of rehabilitation interventions, including passive exercises, active mobilization, respiratory therapies, dysphagia training, occupational therapy, and cognitive support.\n\nThe EXTENDED FOLLOW-UP Module (optional) evaluates the patient's quality of life and functional recovery 28 days after ICU discharge. By examining global rehabilitation practices and their impact on patient outcomes, this study aims to improve rehabilitation strategies in ICUs, contributing to better patient care, recovery, and long-term health outcomes.",[153,154,155,156,157,158,159,26],"Mechanical Ventilation","Pulmonary Rehabilitation","Intensive Care Units (ICUs)","Quality of Life (QOL)","Outcome Assessment","Extubation Failure","Mortality",[161,153,162,163],"Pulmonary rehabilitation","Intensive Care Unit (ICU)","Rehabilitation Outcomes","2026-04-27",{"date":166,"type":34},"2026-05-04",{"date":168,"type":34},"2025-10-01",{"date":170,"type":21},"2029-10-01",{"name":172,"class":41},"Universita degli Studi di Genova",{"id":174,"slug":175,"hasResults":12,"nctId":176,"briefTitle":177,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":180,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":182,"conditions":183,"keywords":186,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":198},"100632214","up-study---decipher-persistent-critical-illness-through-in-deep-clinical-phenotyping-100632214","NCT07510776","UP STUDY - Decipher Persistent Critical Illness Through in Deep Clinical Phenotyping.","UPSt_UCI","Inclusion Criteria:\n\n* Adult patients aged 18 years or older;\n* ICU length of stay equal to or greater than 5 days.\n\nExclusion Criteria:\n\n* Patients with an ICU stay \\\u003C 5 days;\n* Patients discharged from the ICU early due to lack of ward availability, rather than clinical recovery;\n* Patients who do not survive the early phase of critical illness (i.e., early ICU deaths).",{"count":181,"type":21},7000,"Persistent Critical Illness (PCI) is a condition that affects some patients who remain in the Intensive Care Unit (ICU) for a long time, usually more than 10-14 days. It is estimated to occur in 5-20% of critically ill patients. A recent Portuguese study found that more than 14% of ICU patients stayed longer than 14 days. PCI is often associated with ongoing need for life support, such as mechanical ventilation or medications to maintain blood pressure. However, patients may also experience severe muscle weakness, repeated infections, or other complications, which makes this group very diverse.\n\nOne of the main risk factors for prolonged ICU stay is sepsis, a severe infection that affects the whole body. Other factors-such as prior health conditions, use of corticosteroids, sedation practices, early versus late mobilization, fluid and antibiotic management, and delirium treatment-may also influence the development and course of PCI.\n\nThis study aims to identify different clinical patterns (\"clusters\") among critically ill patients who remain in the ICU for more than 10 days. Patients will be followed until hospital discharge, and up to one year if data are available. Understanding these different patterns will help develop more personalized and effective care strategies for each patient profile.\n\nThe study is a multicenter retrospective cohort including adult patients (≥18 years) admitted to participating ICUs for more than 5 days between 2021 and 2023. Data collected will include demographic, clinical, and laboratory information, details of organ support (such as mechanical ventilation or vasopressors), medications, nutrition, and rehabilitation practices.\n\nStatistical and machine learning methods will be used to identify groups of patients with similar clinical trajectories and to assess how these groups are related to outcomes such as survival, recovery of organ function, or long-term disability.\n\nExpected results are the identification of distinct clinical clusters of PCI that combine clinical and laboratory data, and the development of tailored management strategies to improve recovery and outcomes for patients with PCI.",[59,184,60,26,185],"Recovery Outcomes","Critical Care Medicine",[187,29,59],"Persistant Critical Illness","2026-04-08",{"date":190,"type":34},"2026-04-13",{"date":192,"type":34},"2025-01-13",{"date":194,"type":21},"2027-12-31",{"name":196,"class":197},"Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa","NETWORK",7,{"id":200,"slug":201,"hasResults":12,"nctId":202,"briefTitle":203,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":206,"targetDuration":4,"studyType":89,"phases":208,"briefSummary":209,"conditions":210,"keywords":213,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":42},"100631918","neuro---prognostication-using-late-somatosensory-evoked---potentials-100631918","NCT07506928","NEURO - Prognostication Using Late Somatosensory Evoked - Potentials","NEURO-PULSE","Inclusion Criteria:\n\n* Patients must be aged 18 years or over;\n* Patients must be admitted to the intensive care unit with a cerebrovascular pathology;\n* Patients must be in a comatose state with a Glasgow score strictly less than 8, 24 hours after stopping sedation.\n* Representative of the patient informed of the research and not objecting to it, information and collection of the participant's non-objection if recovery of the ability to understand the content of the information note,\n* The patient is a recipient of or affiliated with a social security scheme.\n\nExclusion Criteria:\n\n* Bilateral lesions of the motor cortex or cortico-spinal fasciculus,\n* Cutaneous infection of the scalp or any other lesion making surface electroencephalography impossible,\n* Patient whose short-term survival (48 - 72 hours) seems compromised,\n* Severe peripheral neuromyopathy,\n* Severe Acute Respiratory Distress Syndrome at the time of screening,\n* Hearing-impaired patients with hearing aids,\n* Pregnant or breastfeeding woman,\n* Patient under legal protection (persons deprived of their liberty or under guardianship).",{"count":207,"type":21},50,[119],"The main aim of this study is to develop a new technique for the passive diagnosis of cognitive-motor dissociation, with the detection of motor intention in a comatose patient by analysing the EEG signal and in particular the ERD\u002FERS amplitudes in the motor cortex after stimulation of the median nerve.",[211,212,26],"Comatose","Prognosis",[214,215,216,217,218],"Prognostication","Somatosensory evoked - potentials","Neurocritical care","Machine learning","Continuous EEG","2026-03-26",{"date":221,"type":34},"2026-04-02",{"date":223,"type":21},"2026-06-30",{"date":225,"type":21},"2028-06-30",{"name":40,"class":41},{"id":228,"slug":229,"hasResults":12,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":233,"eligibilityCriteria":234,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":235,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":237,"conditions":238,"keywords":244,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":254,"locationsCount":256},"100347976","metabolomics-study-on-postoperative-intensive-care-acquired-muscle-weakness-100347976","NCT03810768","Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness","Metabolomics Pilot Study on Postoperative Intensive Care Acquired Muscle Weakness (MIRACLE-I Study)","MIRACLE I","Inclusion Criteria:\n\n* invasive mechanically ventilated critically ill patient with expected intensive care unit stay \\> 3 days\n* postoperative patient\n* ≥ 18 years old\n* American Society of Anesthesiology (ASA) classification ≥ III\n\nExclusion Criteria:\n\n* moribund patient\n* non-curative care (comfort care)",{"count":236,"type":21},20,"In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation. We are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular testing.\n\nAim of the study is to investigate (1) changes of the blood metabolome in patients with ICUAW (intensive care unit acquired weakness) and (2) identify metabolic components who are responsible for ICUAW or can be used as marker for ICUAW.",[239,26,59,240,241,242,243],"Metabolomics","Critical Illness Myopathy","Critical Illness Polyneuropathy","Intensive Care (ICU) Myopathy","Muscle Weakness",[245,246,247],"pilot trial","muscle biopsy","blood metabolome","2026-02-28",{"date":250,"type":34},"2026-03-03",{"date":252,"type":34},"2022-09-02",{"date":135,"type":21},{"name":255,"class":41},"Technical University of Munich",3,{"id":258,"slug":259,"hasResults":12,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":263,"eligibilityCriteria":264,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":265,"targetDuration":4,"studyType":89,"phases":267,"briefSummary":268,"conditions":269,"keywords":272,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":280,"leadSponsor":282,"locationsCount":42},"100556553","inspiratory-effort-targeted-pressure-support-ventilation-it-psv-trial-100556553","NCT06526598","Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial","A Cluster Randomized Trial on Inspiratory Effort-Based Pressure Support Adjustment Strategy in Patients Undergoing Assisted Mechanical Ventilation","IT-PSV","Mechanically ventilated patients, who are admitted to the ICU with acute hypoxic respiratory failure, will be consecutively screened daily at 08:00-10:00 morning rounds.\n\nInclusion criteria:\n\n1. PSV initiated during the last 24 hours;\n2. Mechanical ventilation expected to be required for at least 24-48 h by responsible physicians;\n3. The partial pressure of oxygen in arterial blood (PaO2)\u002Finspired oxygen fraction (FiO2) ≤ 300 mmHg (measuring at clinical FiO2 and positive end-expiratory pressure PEEP);\n4. No sedation or stable sedation with Richmond Agitation Sedation Scale (RASS) of -2 to +1 or Riker's Sedation-Agitation Scale (SAS) of 3 to 4.\n\nExclusion criteria included:\n\n1. Age younger than 18 years old;\n2. Initiation of PSV before ICU admission;\n3. Duration of mechanical ventilation longer than 7 days before enrollment;\n4. History of neuromuscular diseases;\n5. Clinical suspicion of increased intracranial pressure;\n6. Extracorporeal support;\n7. Moribund conditions;\n8. Refusal by the ICU physicians or the patient.",{"count":266,"type":21},619,[119],"The Inspiratory effort-Targeted Pressure Support Ventilation (IT-PSV) is a cluster randomized controlled trial. Its main aim is to determine whether an inspiratory effort-targeted pressure support setting strategy, compared to the traditional tidal volume and respiratory rate target, can improve clinical outcomes in adult participants undergoing pressure support ventilation.\n\nThe investigators propose a physiological-oriented assisted ventilation management that, if found effective, could potentially change the clinical practice for mechanical ventilation.",[26,270,271],"Acute Hypoxic Respiratory Failure","Ventilator-Induced Lung Injury",[273,274,275],"pressure support ventilation","pressure muscle index","inspiratory effort","2026-01-19",{"date":278,"type":34},"2026-01-21",{"date":276,"type":34},{"date":281,"type":21},"2027-02-28",{"name":283,"class":41},"Capital Medical University",{"id":285,"slug":286,"hasResults":12,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":290,"eligibilityCriteria":291,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":292,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":294,"conditions":295,"keywords":302,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":313,"startDateStruct":315,"completionDateStruct":317,"leadSponsor":319,"locationsCount":42},"100580064","atrial-strain-in-septic-shock-100580064","NCT06832436","Atrial Strain in Septic Shock","Assessment of Left And Right Atrial Strain in Septic Shock","ALARMS","Inclusion Criteria:\n\n* Age: \\>18 years\n* Adult patients admitted to critical care for septic shock (SEPSIS-3 definition)\n* TTE performed as part of medical management\n* No objection to data usage\n\nExclusion Criteria:\n\n* Pregnancy\n* Moderate to severe valvular regurgitation\u002Fstenosis (\\>grade 2)\n* Ventricular or supraventricular tachyarrhythmia (HR \\>140 bpm) at the time of TTE\n* Poor echogenicity preventing LAS measurement\n* Mechanical circulatory support\n* Pacemaker dependence\n* Patients under guardianship",{"count":293,"type":21},60,"Septic shock is a critical condition associated with high mortality. Transthoracic echocardiography is widely used to evaluate cardiac function and guide treatment. Left and right atrial strain (LAS and RAS) measured via speckle tracking echocardiography have shown prognostic value in cardiovascular diseases. However, differences exist between echocardiographic software, leading to challenges in result comparability. This study aims to compare LAS and RAS measurements between ECHOPAC and UWS software, evaluate AutoStrain technology, and assess reproducibility across observers. The study is non-interventional and will use retrospective echocardiographic data from patients treated for septic shock. The findings will contribute to improving measurement standardization in critically ill patients.",[122,296,297,298,299,300,301,26],"Left Atrial Strain","Right Atrial Strain","Transthoracic Echocardiography","Speckle Tracking","Echocardiographic Software","Reproducibility",[303,304,305,306,307,308,309,310,311,67],"transthoracic echocardiography","septic shock","left atrial strain","right atrial strain","speckle tracking","echocardiographic software","AutoStrain","Bland-Altman analysis","reproducibility","2026-01-15",{"date":314,"type":34},"2026-01-16",{"date":316,"type":34},"2025-03-06",{"date":318,"type":21},"2026-09",{"name":320,"class":41},"Centre Hospitalier Universitaire, Amiens",{"id":322,"slug":323,"hasResults":12,"nctId":324,"briefTitle":325,"officialTitle":325,"acronym":326,"eligibilityCriteria":327,"healthyVolunteers":328,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":329,"targetDuration":4,"studyType":89,"phases":330,"briefSummary":331,"conditions":332,"keywords":337,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":42},"100620649","interprofessional-collaboration-in-the-cardiac-intensive-care-unit-cicu-an-action-research-training-project-100620649","NCT07360366","Interprofessional Collaboration in the Cardiac Intensive Care Unit (CICU): An Action-Research Training Project","COLLUTIC_25","Inclusion Criteria:\n\n* Healthcare professionals (physicians, nurses and healthcare assistants\u002FOSS) employed in the Cardiac Intensive Care Unit (UTIC) of the University Hospital of Parma.\n* Healthcare professionals who have completed the training pathway and are still working in the unit at the time of the six-month follow-up.\n* Medical and nursing students who have carried out or are carrying out a clinical placement within the UTIC.\n* Ability to use a computer or mobile device, essential for participating in the online training activities (e.g. Moodle, H5P).\n* Provision of written informed consent before initiation of any study procedure.\n\nExclusion Criteria:\n\n* Healthcare professionals who do not work in the cardiology setting or who are not employed in the UTIC of the AOU Parma.\n* Inability to participate in the training activities or assessment sessions for logistical, organisational or clinical reasons (e.g. planned prolonged absences during the study period).\n* Refusal or inability to provide informed consent.",true,{"count":293,"type":21},[119],"This study evaluates the impact of a structured interprofessional training program on daily collaboration within the Cardiac Intensive Care Unit (CICU\u002FUTIC) at the University Hospital of Parma. In high-intensity clinical settings, rapid and accurate coordination between physicians, nurses, and healthcare assistants is vital. Ineffective teamwork often leads to communication breakdowns, potentially compromising patient safety and care quality. This project investigates whether an interactive, scenario-based educational program can strengthen role clarity, communication, and shared decision-making.\n\nThe study seeks to determine if an active-learning program using interactive branching scenarios improves interprofessional collaboration more effectively than traditional methods. The researchers hypothesize that this simulation-based approach will significantly enhance professional outcomes, including self-efficacy, shared decision-making, and commitment to both the team and the profession.\n\nThe study utilizes a convenience sample (approx. 5 physicians, 30 nurses, 8 healthcare assistants, and 10 students). Eligible participants include staff and students currently or recently active in the Parma CICU who provide informed consent.\n\nThe intervention is delivered via a Moodle-based platform featuring case-based simulations. These scenarios replicate complex clinical pathways, such as:\n\nCath-lab and Electrophysiology procedures.\n\nHeart failure management.\n\nTAVI (Transcatheter Aortic Valve Implantation) preparation.\n\nAs participants navigate these scenarios, they must make critical decisions and receive immediate feedback designed to reinforce collaborative best practices.\n\nData Collection and Timeline\n\nData is gathered at three intervals: T0 (Baseline), T1 (Post-training), and T2 (6-month follow-up). Validated questionnaires measure:\n\nAttitudes toward physician-nurse collaboration.\n\nPerceived daily collaboration and decision-making satisfaction.\n\nProfessional commitment and work-related self-efficacy.\n\nThe training phase spans six months, with a subsequent six-month follow-up, totaling a 24-month project duration.\n\nEthics and Privacy Risks are minimal, primarily involving the time required for participation. The primary benefit is the development of skills that foster safer, more coordinated patient care. Privacy is strictly maintained through pseudo-anonymization, with data access restricted to the research team.",[333,334,335,336,26],"Interprofessional Relations","Interprofessional Education","Attitude of Health Personnel","Intensive Care Units",[333,338,339,340,336,341,26,342,343,344],"Interdisciplinary Communication","Health Personnel Attitudes","Nurse-Physician Relations","Coronary Care Units","Patient Care Team","Education, Interprofessional","Clinical Decision-Making","2026-01-14",{"date":347,"type":34},"2026-01-22",{"date":349,"type":21},"2026-02-15",{"date":351,"type":21},"2028-02-15",{"name":353,"class":41},"Azienda Ospedaliero-Universitaria di Parma",{"id":355,"slug":356,"hasResults":12,"nctId":357,"briefTitle":358,"officialTitle":358,"acronym":4,"eligibilityCriteria":359,"healthyVolunteers":328,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":360,"targetDuration":4,"studyType":89,"phases":362,"briefSummary":363,"conditions":364,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":368,"lastUpdatePostDateStruct":369,"startDateStruct":371,"completionDateStruct":373,"leadSponsor":375,"locationsCount":256},"100484398","phase-2-a-clinical-trial-of-interventions-to-support-family-surrogates-of-critically-ill-patients-100484398","NCT05587517","A Clinical Trial of Interventions to Support Family Surrogates of Critically Ill Patients","Inclusion Criteria:\n\n* Patients who, during their hospital stay, have been admitted to the ICU and are near EoL, as indicated by a modified \"surprise question\" whereby physicians are asked to identify patients whom they do not expect to survive the next 12 months.\n* Surrogate decision-makers of patients who were admitted to the ICU or step-down unit during their current admission\u002Fstay, or within 1 month of discharge from their last admission\u002Fstay.\n* Surrogate decision-makers are 18 years or older.\n* Surrogate decision-makers whom physicians or advance practice providers (i.e. physician assistants, nurse practitioners) indicate as the designated health care proxy or decision-making patient surrogates, or who are listed as such in the patient's medical charts or by self-report of the surrogate.\n* Surrogate decision-makers must speak English.\n* Surrogate decision-makers must report \"syndromal\" levels of pre-loss grief (PG-12 score ≥ 25) or peritraumatic distress (PDI ≥ 23).\n* Surrogate decision makers will need to reside in a state in which an interventionist is licensed or otherwise be able to comply with current telehealth regulations.\n* Surrogate decision-makers will need to be willing to utilize a device (computer, tablet, phone) with internet.\n* Surrogate decision-makers who are able and willing to provide an emergency contact.\n\nExclusion Criteria:\n\n* Patients and surrogate decision-makers who do not meet the eligibility criteria.\n* Surrogate decision-makers who indicate the presence of cognitive impairment based on responses to the Ultra-Brief Confusion Assessment Method and\u002For significant psychiatric or cognitive disturbance sufficient, in the investigator\u002Fstudy staff's judgment, to preclude completion of the assessment measures, interview or informed consent.\n* Surrogate-decision makers who endorse suicidal ideation in the past month based on responses to the Columbia Suicide Severity Rating Scale.\n* Surrogate-decision makers who are unable to access a functional device for videoconferencing and decline the offer to use a study loner device.",{"count":361,"type":21},172,[91],"Hypotheses 1a and 1b: Compared to Supportive Conversation arm, the EMPOWER intervention will significantly decrease surrogate decision makers' symptoms of grief and Post Traumatic Stress Disorder (PTSD) (primary outcomes); and H1b. experiential avoidance, depression, regrets, and increases in patients' value-concordant care (secondary outcomes) at T1-T4.\n\nHypothesis 2. Qualitative data will provide insights not captured by quantitative data.\n\nHypothesis 3. Reductions in experiential avoidance will mediate reductions in grief and Post Traumatic Stress Disorder (PTSD) symptoms, highlighting it as important to target in future implementation.",[365,366,367,26],"Grief","Trauma","Psychotherapy","2025-10-27",{"date":370,"type":34},"2025-10-29",{"date":372,"type":34},"2022-10-11",{"date":374,"type":21},"2027-12-11",{"name":376,"class":41},"Weill Medical College of Cornell University",{"id":378,"slug":379,"hasResults":12,"nctId":380,"briefTitle":381,"officialTitle":382,"acronym":383,"eligibilityCriteria":384,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":385,"targetDuration":4,"studyType":89,"phases":387,"briefSummary":388,"conditions":389,"keywords":395,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":42},"100606160","effects-of-artificial-intelligence-nurse-orientation-program-on-psychological-outcomes-and-length-of-hospital-stay-in-intensive-care-unit-100606160","NCT07171944","Effects of Artificial Intelligence Nurse Orientation Program on Psychological Outcomes and Length of Hospital Stay in Intensive Care Unit","Effects of AINurse Orientation Program on Psychological Outcomes and Length of Hospital Stay: A Randomized Controlled Trial","AINURSE-OP","Inclusion Criteria:\n\n* Intensive care unit confusion assessment scale (CAM-ICU scale) score of 0-2\n* Age 18 years or older\n* Hospitalized in the intensive care unit for at least 24 hours\n* Glasgow coma scale score of 13-14-15 points\n* Richmond Agitation Sedation Scale (RASS) score between -1 and +1\n* No hearing problems\n\nExclusion Criteria:\n\n* Intensive care unit confusion assessment scale (CAM-ICU scale) score of 6-7\n* Any psychiatric illness or impaired brain function\n* Defined hearing loss\n* Advanced dementia\n* Younger than 18 years of age\n* Richmond Agitation Sedation Scale (RASS) score outside the range of -1 to +1\n* Who use sedative medication\n* History of surgery or disease around the ear",{"count":386,"type":21},10,[119],"Artificial intelligence (AI), now an integral part of healthcare services and presents numerous opportunities. Customized treatment plans, clinical decision support systems, predictive analysis for disease prevention, patient engagement and education, quality improvement, and error reduction are some of these opportunities. In the context of delirium prevention, risk assessment, and treatment planning, the AI-supported system AI-AntiDelirium is designed to standardize the approach to delirium management in alignment with the PADIS guidelines. A randomized controlled trial evaluating the effectiveness of this system found that the workload of nurses decreased, facilitated early diagnosis and prevention of delirium, and recommended evidence-based and individualized delirium interventions. A systematic review concluded that AI applications did not significantly impact the length of hospital stay and emphasized the need for further research. Also, AI platforms contributed to positive results in reducing anxiety and depression in patients. Furthermore, systematic reviews have demonstrated that AI-based chatbots are effective in alleviating symptoms of depression and anxiety. However, the literature includes a limited number of patient education programs specifically designed to prevent or manage delirium through AI-based approaches. Notably, there is a lack of studies comparing the effectiveness of AI-supported educational interventions with those delivered directly by nurses.\n\nThe goal of this clinical trial is to develop a structured AINurse and Human Nurse orientation training program for intensive care unit (ICU) patients and compare the effects of these training programs on ICU patients' delirium-free days, level of anxiety and depression, and length of stay in the ICU. Hypotheses of the study:\n\nH1: Patients who receive the structured AINurse patient orientation training program will have longer delirium-free days than patients who receive Human Nurse orientation training.\n\nH2: Patients who receive the structured AINurse patient orientation training program will have lower levels of anxiety and depression than patients who receive the Human Nurse orientation training.\n\nH3: Patients who receive the structured AINurse patient orientation training program will have shorter lengths of stay in the intensive care unit than patients who receive the Human Nurse orientation training.\n\nResearchers will compare the AINurse patient orientation training program and the orientation training program provided by human nurses in terms of patients' delirium-free days, level of anxiety and depression, and length of stay in the ICU.\n\n* Those in the intervention group will receive the AINurse orientation training program twice daily for 3 days.\n* Participants in the control group will receive face-to-face structured orientation training from researchers twice daily for 3 days.\n* Delirium-free day assessment, anxiety and depression will be evaluated for patients in both groups over 3 days.\n* The length of stay in the intensive care unit will be monitored for patients in both groups.",[390,391,155,392,393,26,394],"Delirium","Anxiety and Depression","Artificial Intelligence (AI)","Nurse","Orientation",[390,396,397,398,67,399,393],"Artificial intelligence","Anxiety and depression","Intensive care unit","Orientation Training","2025-09-10",{"date":402,"type":34},"2025-09-15",{"date":404,"type":21},"2025-11-01",{"date":406,"type":21},"2026-11-01",{"name":408,"class":41},"Koç University",{"id":410,"slug":411,"hasResults":12,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":415,"eligibilityCriteria":416,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":417,"targetDuration":419,"studyType":22,"phases":4,"briefSummary":420,"conditions":421,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":423,"lastUpdatePostDateStruct":424,"startDateStruct":426,"completionDateStruct":428,"leadSponsor":430,"locationsCount":42},"100518658","anesthesia-and-critical-care-registry-100518658","NCT06033404","Anesthesia and Critical Care Registry","Registry of Patients Undergoing Anesthesia or Intensive Care Maneuvers","ARIA","Inclusion Criteria:\n\n* Patients undergoing Anesthesia or Critical care\n* Signed informed consent.\n\nExclusion Criteria:\n\nRefused informed consent",{"count":418,"type":21},30000,"1 Year","In recent decades, knowledge in the anesthesiology field has increasingly expanded, allowing for the refinement of monitoring techniques, therapies, and local-regional anesthesia maneuvers, and for the extension of care to a larger number of patients, including those previously excluded due to advanced age or comorbidities. Similarly, Intensive care management has continuously evolved, following innovations in the field of drugs and with the great diffusion of extracorporeal supports. The fundamental importance of registry studies has been recognized in this context to rapidly generate reliable data and improve the quality of care.\n\nThis prospective observational study is aimed at collecting data of all patients (expected 300,000) undergoing anesthesia or intensive care maneuvers at our institution. This registry aims to assist in carrying out registry-based clinical studies focused on improving current therapeutic and patient management standards.",[422,26],"Anesthesia","2025-08-05",{"date":425,"type":34},"2025-08-06",{"date":427,"type":34},"2023-07-12",{"date":429,"type":21},"2033-12",{"name":431,"class":41},"Università Vita-Salute San Raffaele",{"id":433,"slug":434,"hasResults":12,"nctId":435,"briefTitle":436,"officialTitle":437,"acronym":4,"eligibilityCriteria":438,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":147,"enrollmentInfo":439,"targetDuration":4,"studyType":89,"phases":441,"briefSummary":442,"conditions":443,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":444,"lastUpdatePostDateStruct":445,"startDateStruct":447,"completionDateStruct":449,"leadSponsor":450,"locationsCount":4},"100526343","early-multimodal-therapy-and-mechanical-ventilation-100526343","NCT06133504","Early Multimodal Therapy and Mechanical Ventilation","Association Between Early Multimodal Therapy and Mechanical Ventilation Days in the Intensive Care Unit at Fundación Santa Fe de Bogotá: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\nThe inclusion criteria are as follows:\n\nPatients hospitalized in the adult intensive care unit of the Fundación Santa Fe de Bogotá.\n\nRequirement of invasive mechanical ventilation through an endotracheal tube for a period exceeding 72 hours with an expected continuation of at least 24 hours.\n\nBarthel Index equal to or greater than 70\n\nExclusion Criteria:\n\n* Invasive mechanical ventilation through tracheostomy or a nasotracheal tube.\n* History of head and neck surgery at any time prior to ICU admission.\n* Patients directly admitted to the ICU due to cardiac arrest by any cause.\n* Airway burn.\n* Burns involving ≥ 50% of the body surface area.\n* Chronic obstructive pulmonary disease (these patients usually require prolonged mechanical ventilation due to the underlying respiratory dysfunction)\n* Patients referred from another institution.\n* Demyelinating diseases or neuromuscular junction disorders at ICU admission.\n* Patients requiring neuromuscular blockade.\n* Patients with a life expectancy of ≤180 days will be excluded based on their primary diagnosis (e.g., advanced cancer, end-stage heart failure), comorbidities, recent clinical course, medical judgment by the ICU team, and functional status as assessed by the Barthel index.\n* ICU readmissions.\n* Participation in other rehabilitation clinical trials.\n* Liver or kidney transplant.\n* Patients with an active cancer diagnosis undergoing oncological treatment (chemotherapy\u002Fsurgery) at the time of eligibil- ity assessment.",{"count":440,"type":21},74,[119],"To assess the association between early multimodal therapy and the duration of invasive mechanical ventilation in the Intensive Care Unit at Fundación Santa Fe de Bogotá.",[26,59],"2025-07-03",{"date":446,"type":34},"2025-07-09",{"date":448,"type":21},"2025-07",{"date":104,"type":21},{"name":451,"class":41},"Fundación Santa Fe de Bogota",{"id":453,"slug":454,"hasResults":12,"nctId":455,"briefTitle":456,"officialTitle":457,"acronym":458,"eligibilityCriteria":459,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":460,"enrollmentInfo":461,"targetDuration":4,"studyType":89,"phases":463,"briefSummary":464,"conditions":465,"keywords":466,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":472,"lastUpdatePostDateStruct":473,"startDateStruct":475,"completionDateStruct":477,"leadSponsor":479,"locationsCount":42},"100594440","bed-bath-with-auditory-hypnosis-on-icu-patients-100594440","NCT07019467","Bed Bath With Auditory Hypnosis on ICU Patients","The Effect of Bed Bath Given to Intensive Care Unit Patients With Auditory Hypnosis on Physiological and Comfort Parameters: a Randomized Controlled Experimental Study","RCS","Inclusion Criteria:\n\n* Over 18 years of age\n* Glasgow Coma Scale score: 8 and above\n* Richmond Agitation-Sedation Scale (RASS) score between +2 and -3\n* APACHE II score \\\u003C10 points\n* Stayed in the ICU for at least 24 hours\n* Continues breathing with invasive mechanical ventilation support device\n* Not receiving antihypertensive treatment\n* Not taking inotropic drugs that directly affect vital signs (esmolol, noradrenaline, dopamine, adrenaline, dopamine, nitrate, etc.)\n* No wounds\u002Finjuries that would prevent bed bathing\n* There is no harm in moving it\n* Routine blood gas values (no extra blood gas sample will be taken for this study)\n\nExclusion Criteria:\n\n* Glasgow Coma Scale score: Under 8\n* Richmond Agitation-Sedation Scale (RASS) score of +3 and above, -4 and below\n* APACHE II score \\>10 points\n* Stayed in ICU for less than 24 hours\n* Referred to another ICU or clinic during the collection of research data\n* Intubated in less than 24 hours\n* Treatment protocol changed (hypertension and inotrope etc. drugs started)\n* Disturbed physiological parameters during bed bathing\n* Restricted mobility\n* No request for blood gas collection\u002Fno blood gas value\n* Patients who exit during the study period will be excluded from the study.","75 Years",{"count":462,"type":21},66,[119],"Intensive care units (ICUs) are specialized units where complex life-saving treatment and care activities are performed. Due to the treatment procedures performed in these specialized units, a large number of tools\u002Fequipment\u002Fdevices\u002Fcables (endotracheal tubes, monitor cables, hemodialysis machines, mechanical ventilation, etc.) are placed on critically ill patients. These treatment devices restrict the movement of patients, creating obstacles to the independent performance of basic human needs such as personal hygiene. One of the individual hygiene practices frequently applied in ICUs is bed bathing. The application of bed bathing in ICUs varies according to institutional and clinical policies. In addition to its beneficial effects such as preventing infection, accelerating blood circulation, providing comfort and relaxation, etc., bed bathing also carries the risk of having a negative effect on physiological parameters. Eliminating or minimizing this risk is one of the primary care objectives of intensive care nurses. In this regard, it is crucial that bed baths, which are considered a routine nursing activity in ICUs, are performed in accordance with specific standards and protocols. In recent years, there has been an increase in the use of certain non-pharmacological care interventions in ICUs. One such intervention is auditory suggestion. Auditory suggestion refers to messages delivered through hearing to facilitate the adoption of specific thoughts, feelings, or behaviors. This method includes music, verbal suggestion, nature sounds, and other auditory stimuli that are believed to have the potential to influence the subconscious. In recent years, auditory suggestion has been integrated into the treatment processes of critically ill patients, particularly in intensive care units. This method is applied to reduce patients' stress, control pain, and support hemodynamic stability. Research has provided strong evidence supporting the physiological and psychological effects of auditory suggestion on both adult and pediatric patients. On the other hand, maintaining the patient's physiological parameters under control and increasing their comfort level while administering bed baths in the ICU are desired outcomes of nursing care. Based on this, the study was designed as a randomized controlled trial to investigate the effects of bed baths administered with auditory suggestion on physiological and comfort parameters in intensive care patients. The study, which will be conducted with a total of 66 ICU patients meeting the sample selection criteria, will apply the \"bed bath protocol with auditory suggestion\" to the study group and routine bed baths to the control group (only once). The study data will be collected using the \"Patient Information Form\" and the \"Physiological and Comfort Parameters Monitoring Form\" (data from the form will be collected and recorded before the bath, immediately after the bath, and 30 minutes after the bath). The study data will be analyzed using appropriate statistical methods.",[26],[467,468,469,470,98,471],"auditory hypnosis","bed bath","comfort","critical ill patients","physiological parameters","2025-06-11",{"date":474,"type":34},"2025-06-13",{"date":476,"type":21},"2025-06-15",{"date":478,"type":21},"2025-12-31",{"name":480,"class":41},"Banu Terzi",{"id":482,"slug":483,"hasResults":12,"nctId":484,"briefTitle":485,"officialTitle":486,"acronym":4,"eligibilityCriteria":487,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":488,"targetDuration":4,"studyType":89,"phases":490,"briefSummary":491,"conditions":492,"keywords":494,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":501,"completionDateStruct":502,"leadSponsor":504,"locationsCount":42},"100590712","use-of-nasal-pressure-to-assess-inspiratory-effort-under-different-oxygen-treatments-100590712","NCT06970990","Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments","Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments: a Prospective Physiological Study","Inclusion Criteria:\n\n1. No mechanical ventilation required,Able to tolerate oxygen therapy via nasal cannula, standard face mask, or nasal high-flow oxygen therapy;\n2. Respiratory stability:Capable of spontaneous breathing with effective cough for secretion clearance.Oxygen saturation (SpO₂) \\> 90% or PaO₂\u002FFiO₂ ≥ 150 mmHg when receiving nasal cannula oxygen at 3 L\u002Fmin;\n3. Hemodynamic stability:Heart rate (HR) ≤ 120 bpm;Systolic blood pressure (SBP) 90-150 mmHg;No vasoactive medications OR norepinephrine dosage \\\u003C 0.1-0.2 μg\u002Fkg·min (or equivalent doses of other vasoactive agents);\n4. Metabolic stability;\n5. Compliance with medical instructions.Able to follow prescribed tasks.Esophageal pressure monitoring catheter already in place;\n6. Patient or legal guardian agrees to participate and has signed the informed consent form.\n\nExclusion Criteria:\n\n1. Age \\\u003C 18 years;\n2. Pregnancy;\n3. Hemodynamic instability:Mean arterial pressure (MAP) \\\u003C 60 mmHg.Heart rate (HR) \\> 120 bpm or \\\u003C 60 bpm;\n4. Respiratory instability:Respiratory rate (RR) \\> 35 bpm.Oxygen saturation (SpO₂) \\\u003C 90%;\n5. Neuromuscular diseases or phrenic nerve injury;\n6. Recent trauma or surgery involving the trachea, esophagus, neck, or chest.Contraindications to esophageal catheter placement or inability to monitor esophageal pressure;\n7. Nasal obstruction or anatomical abnormalities:Complete nasal obstruction.Severe anatomical abnormalities (e.g., severe septal deviation, nasal polyps, or tumors) preventing catheter placement or compromising ventilation;\n8. High-risk craniofacial conditions:Severe facial trauma or skull base fracture with risk of catheter misplacement into the intracranial space.Active epistaxis or incomplete healing after nasal surgery;\n9. Bleeding risk:Severe coagulopathy.Esophageal\u002Fgastric varices or other conditions predisposing to hemorrhage.",{"count":489,"type":21},26,[119],"The aim of this study was to investigate the effects of different oxygen therapy modalities (including nasal cannula oxygen, mask oxygen and high-flow nasal cannula oxygen) on the correlation between Nasal Pressure and Esophageal Pressure by means of a prospective physiological study, to assess the dynamic changes of nasal pressure and esophageal pressure and their underlying mechanisms under different conditions of oxygen therapy, to analyse the effects of oxygen therapy parameters on the relationship between the two, and to explore the feasibility of nasal pressure as a non-invasive monitoring indicator, in order to replaceor supplement esophageal manometry in clinical practice, especially in patients with respiratory distress and instability.Meanwhile, this study will also evaluate the effects of different oxygen therapy modalities on patients' respiratory mechanics and comfort, provide a scientific basis for the clinical selection of individualised oxygen therapy regimens, and ultimately provide new physiological evidence for the management of oxygen therapy in patients with acute respiratory failure in the intensive care unit (ICU) and outside the ICU, promote the development of non-invasive monitoring technology, and improve the clinical prognosis and therapeutic experience of patients.",[26,493],"Inspiratory Effort",[495,275,496,497],"Esophageal pressure","oxygen treatments","Nasal Pressure","2025-05-20",{"date":500,"type":34},"2025-05-22",{"date":498,"type":34},{"date":503,"type":21},"2025-12-30",{"name":505,"class":41},"Jian-Xin Zhou",{"id":507,"slug":508,"hasResults":12,"nctId":509,"briefTitle":510,"officialTitle":511,"acronym":4,"eligibilityCriteria":512,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":513,"targetDuration":4,"studyType":89,"phases":514,"briefSummary":515,"conditions":516,"keywords":518,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":522,"lastUpdatePostDateStruct":523,"startDateStruct":525,"completionDateStruct":527,"leadSponsor":528,"locationsCount":42},"100578854","comparison-of-physiological-effects-of-two-high-flow-tracheal-oxygen-versus-t-piece-during-spontaneous-breathing-trials-100578854","NCT06816706","Comparison of Physiological Effects of Two High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials","Comparison of Physiological Effects of Two Types of High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials in Mechanically Ventilated Patients","Inclusion Criteria:\n\n1. Mechanical ventilation for more than 24 hours\n2. Considered by the physicians for the readiness to wean and ready for spontaneous breathing trials\n\nExclusion Criteria:\n\n1. Age younger than 18 years old\n2. Pregnancy\n3. Hemodynamic instability (mean arterial pressure \\\u003C60 mmHg, heart rate \\>140 or \\\u003C60 bpm)\n4. Respiratory and oxygenation instability (respiratory rate \\> 35bpm or oxygen saturation measured by pulse oximetry \\\u003C90%)\n5. Neuromuscular diseases or phrenic nerve injury\n6. Recent trauma or surgery to the trachea, esophagus, neck, chest, or stomach\n7. Pneumothorax or placement of a chest drainage\n8. Contraindication to electrical impedance tomography (EIT) (implantable defibrillator)\n9. Anticipating withdrawal of life support",{"count":236,"type":21},[119],"Spontaneous breathing trials (SBT) are essential for assessing extubation tolerance, yet optimal approaches are debated. High-flow nasal oxygen offers benefits like precise oxygen delivery, flow-related positive end-expiratory pressure generation and improved lung function. While high-flow tracheal oxygen can also be used as an SBT method, it has reduced physiological effects due to bypassing the upper airway with a more open circuit. To enhance this limitation, investigators developed a modified high-flow tracheal oxygen tube with a smaller expiratory end diameter to increase expiratory resistance and airway pressure. This is a prospective randomized crossover study that aims to compare the physiological effects of standard and modified high-flow tracheal oxygen versus T-piece during SBT.",[26,517,153],"Oxygen Therapy",[519,520,521],"high-flow tracheal oxygen","T piece","spontaneous breathing trial","2025-03-20",{"date":524,"type":34},"2025-03-21",{"date":526,"type":34},"2025-03-01",{"date":503,"type":21},{"name":505,"class":41},{"id":530,"slug":531,"hasResults":12,"nctId":532,"briefTitle":533,"officialTitle":534,"acronym":535,"eligibilityCriteria":536,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":537,"targetDuration":539,"studyType":22,"phases":4,"briefSummary":540,"conditions":541,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":547,"lastUpdatePostDateStruct":548,"startDateStruct":549,"completionDateStruct":551,"leadSponsor":553,"locationsCount":42},"100582391","effect-of-reduced-vasopressors-on-mortality-in-ecmo-supported-cardiogenic-shock-patients-100582391","NCT06862700","Effect of Reduced Vasopressors on Mortality in ECMO-supported Cardiogenic Shock Patients","Association Between Vasopressor Exposure Levels and 30-Day Mortality in Patients Receiving ECMO Support for Cardiogenic Shock: A Prospective Multicenter Cohort Study","VREM-CS","Inclusion Criteria:\n\n* Adults (≥18 years) with cardiogenic shock requiring VA-ECMO support.\n* First-time ECMO initiation.\n* Venoarterial ECMO (VA-ECMO) as the initial mode.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years.\n* Severe pulmonary hypertension.\n* Vasopressor use for non-shock indications (e.g., bleeding, post-cardiopulmonary bypass vasoplegia).\n* Severe missing data.",{"count":538,"type":21},534,"30 Days","The goal of this observational study is to learn about the association between vasopressor exposure levels and outcomes in adults with cardiogenic shock receiving VA-ECMO. The main question it aims to answer is:\n\nDoes reduced exposure to vasopressors lower the 30-day mortality in patients with cardiogenic shock when receiving ECMO support? Participants who are receiving ECMO support for cardiogenic shock as part of their regular medical care will have their data collected, including information about their vasopressor use and mortality outcomes, over the course of the study.",[542,543,544,545,26,546],"Cardiogenic Shock","Extracorporeal Membrane Oxygenation","Vasopressors","Hemodynamic Management","Heart Failure","2025-03-04",{"date":316,"type":34},{"date":550,"type":34},"2025-02-26",{"date":552,"type":21},"2028-01-01",{"name":554,"class":41},"Xiaotong Hou",{"id":556,"slug":557,"hasResults":12,"nctId":558,"briefTitle":559,"officialTitle":560,"acronym":4,"eligibilityCriteria":561,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":562,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":563,"conditions":564,"keywords":566,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":572,"lastUpdatePostDateStruct":573,"startDateStruct":575,"completionDateStruct":577,"leadSponsor":579,"locationsCount":581},"100574227","evaluating-the-use-of-artificial-intelligence-to-improve-family-conversations-for-intensive-care-patients-and-their-families-100574227","NCT06756542","Evaluating the Use of Artificial Intelligence to Improve Family Conversations for Intensive Care Patients and Their Families","Utilizing Large Language Models to Augment Family Conversations in the Intensive Care Unit","Inclusion Criteria:\n\n* Informed-consent is signed by all participating family members during the conversation.\n* Informed-consent is signed by the ICU healthcare professionals.\n* The patient of the family must be admitted to the adult ICU.\n* All participating family members must be 18 years or older.\n* The family conversation must be in Dutch.\n\nExclusion Criteria:\n\n* Trained to interpret medical jargon and\u002For intensive care terminology specifically\n* Difficulty reading and\u002For writing in the Dutch language",{"count":117,"type":21},"This study looks at how artificial intelligence (AI), like generative pre-trained transformer (GPT-4), can help doctors in the intensive care unit (ICU) save time and improve communication with families. Right now, doctors spend a lot of time writing notes after family conversations, which takes time away from patient care. The investigators are testing whether AI can create accurate and easy-to-understand summaries of these conversations, making it quicker for doctors to document and clearer for families to understand. ICU doctors and adult family members of patients will take part in this study, with their full consent. The goal is to see if this new technology can make life easier for doctors while helping families better understand medical information.",[565,26],"Intensive Care Medicine",[567,568,569,570,571],"intensive care","artificial intelligence","large language models","administration reduction","patient satisfaction","2025-02-24",{"date":574,"type":34},"2025-02-25",{"date":576,"type":34},"2025-01-14",{"date":578,"type":21},"2025-12",{"name":580,"class":41},"Davy van de Sande",2,{"id":583,"slug":584,"hasResults":12,"nctId":585,"briefTitle":586,"officialTitle":586,"acronym":587,"eligibilityCriteria":588,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":589,"targetDuration":591,"studyType":22,"phases":4,"briefSummary":592,"conditions":593,"keywords":596,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":603,"lastUpdatePostDateStruct":604,"startDateStruct":606,"completionDateStruct":608,"leadSponsor":609,"locationsCount":611},"100489927","measuring-family-engagement-in-care-the-fame-study-100489927","NCT05659485","Measuring Family Engagement in Care (The FAME Study)","FAME","Inclusion Criteria:\n\n* Family member of patient admitted to the intensive care units\n* Able to participate in English or French\n* Age 18 years old or older\n\nExclusion Criteria:\n\n* ICU stays less than 24 hours\n* Another family member has already participated in the study",{"count":590,"type":21},198,"2 Weeks","There are currently no validated tools to specifically measure family engagement in the intensive care unit (ICU). To address this gap, an interdisciplinary team developed a novel instrument to measure family engagement in the ICU. This will be a prospective observational cohort with an embedded qualitative study to validate the FAMily Engagement (FAME) instrument in the ICU setting. This study will also evaluate the association between family activation, engagement, and family-centred outcomes, and exploring factors (age, relationship, sex, gender, race\u002Fethnicity) that may influence family engagement in the ICU.",[594,595,26],"Family Engagement","Patient-centered Care",[597,598,599,600,601,602,398],"Family","Engagement","Family engagement","Family-centered care","Measures","Instruments","2025-02-11",{"date":605,"type":34},"2025-02-13",{"date":607,"type":34},"2023-01-31",{"date":503,"type":21},{"name":610,"class":41},"Lady Davis Institute",6,{"id":613,"slug":614,"hasResults":12,"nctId":615,"briefTitle":616,"officialTitle":617,"acronym":4,"eligibilityCriteria":618,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":619,"targetDuration":4,"studyType":89,"phases":620,"briefSummary":621,"conditions":622,"keywords":624,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":626,"lastUpdatePostDateStruct":627,"startDateStruct":629,"completionDateStruct":631,"leadSponsor":632,"locationsCount":42},"100578857","comparison-of-physiological-effects-of-two-types-of-high-flow-oxygen-therapy-in-tracheostomized-patients-100578857","NCT06816745","Comparison of Physiological Effects of Two Types of High-Flow Oxygen Therapy in Tracheostomized Patients","Comparison of Physiological Effects of Standard and Modified High-Flow Oxygen Therapy in Tracheostomized Patients","Inclusion Criteria:\n\nTracheostomy with stable spontaneous breathing.\n\nExclusion Criteria:\n\n1. Age younger than 18 years old\n2. Pregnancy\n3. Hemodynamic instability (mean arterial pressure \\\u003C60 mmHg, heart rate \\>140 or \\\u003C60 bpm)\n4. Respiratory and oxygenation instability (respiratory rate \\> 35bpm or oxygen saturation measured by pulse oximetry \\\u003C90%)\n5. Neuromuscular diseases or phrenic nerve injury\n6. Recent trauma or surgery to the trachea, esophagus, neck, chest, or stomach\n7. Pneumothorax or placement of a chest drainage\n8. Contraindication to electrical impedance tomography (EIT) (implantable defibrillator)\n9. Anticipating withdrawal of life support",{"count":236,"type":21},[119],"High-flow nasal oxygen therapy offers benefits like precise oxygen delivery, flow-related positive end-expiratory pressure generation and improved lung function. High-flow oxygen therapy can be applied via tracheostomy as high-flow tracheal oxygen. While high-flow tracheal oxygen has been used to facilitate weaning, it has diminished physiological effects due to bypassing upper airways. To enhance its effectiveness, researchers developed a modified high-flow tracheal oxygen tube with a smaller expiratory end diameter to increase airway resistance and pressure. This is a prospective randomized crossover study that aims to compare the physiological effects of standard and modified high-flow oxygen therapy in tracheostomized patients.",[26,517,623],"Tracheostomy",[519,625],"tracheostomy","2025-02-06",{"date":628,"type":34},"2025-02-10",{"date":630,"type":21},"2025-02-20",{"date":503,"type":21},{"name":505,"class":41},{"id":634,"slug":635,"hasResults":12,"nctId":636,"briefTitle":637,"officialTitle":638,"acronym":4,"eligibilityCriteria":639,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":640,"targetDuration":4,"studyType":89,"phases":641,"briefSummary":642,"conditions":643,"keywords":645,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":646,"lastUpdatePostDateStruct":647,"startDateStruct":649,"completionDateStruct":651,"leadSponsor":653,"locationsCount":42},"100575213","a-pilot-trial-of-pressure-muscle-index-targeted-psv-trial-100575213","NCT06769360","A Pilot Trial of Pressure Muscle Index-Targeted PSV Trial","A Pragmatic Pilot Trial Evaluating Inspiratory Pressure Adjustment Based on Pressure Muscle Index in Patients Undergoing Pressure Support Ventilation","Inclusion Criteria:\n\n1. PSV initiated during the last 24 hours, whether transition from controlled modes or primary initiation;\n2. Mechanical ventilation expected to be required for at least 24-48 hours by responsible physicians;\n3. The partial pressure of oxygen in arterial blood (PaO2)\u002Finspired oxygen fraction (FiO2) ≤ 300 mmHg (measuring at clinical FiO2 and positive end-expiratory pressure \\[PEEP\\]);\n4. No sedation or stable sedation with Richmond Agitation Sedation Scale (RASS) of -2 to +1 or Riker's Sedation-Agitation Scale (SAS) of 3 to 4.\n\nExclusion Criteria:\n\n1. Age younger than 18 years old;\n2. Initiation of PSV before ICU admission;\n3. Duration of mechanical ventilation longer than 7 days before enrollment;\n4. History of neuromuscular diseases;\n5. Clinical suspicion of increased intracranial pressure;\n6. Presentation with pneumothorax and\u002For bronchopleural fistula;\n7. Extracorporeal support;\n8. Moribund conditions;\n9. Refusal by the ICU physicians or the patient.",{"count":293,"type":21},[119],"Pressure support ventilation (PSV) is one of the most frequently used ventilator modes in the intensive care unit (ICU). The successful implementation of PSV depends on matching the patient's inspiratory effort with the ventilator support. In clinical practice, the pressure support level is usually set and adjusted according to tidal volume (VT) and respiratory rate (RR). However, these parameters may not fully represent the patient's effort. Previous studies have shown that pressure muscle index (PMI), which is measured as the difference between the peak and plateau airway pressure during an end-inspiratory airway occlusion, could reliably determine the low and high inspiratory effort during PSV.\n\nHowever, the comparative effectiveness of these two pressure support level setting strategies remains uncertain. Our aim is to explore clinical and implementation factors relevant to a future definitive randomized controlled trial to evaluate PMI - and VT\u002FRR - pressure support level setting strategies. The Inspiratory effort-targeted pressure support ventilation pragmatic pilot trial will test clinician adherence and to explore clinical outcomes.\n\nTwo centers are included in a pragmatic sequential cluster crossover pilot trial. We enrolled all eligible adults with acute respiratory failure requiring mechanical ventilation admitted to ICU. The pressure support level setting strategy was assigned according to the epoch. The first trial epoch will be assigned to VTRR - pressure support level setting strategy for 4 weeks. The washout week between the two epochs will be 4 weeks. Then sequentially, it will be crossed over to PMI - pressure support level setting strategy for 4 weeks.\n\n* In the VT\u002FRR-targeted group, the pressure support is adjusted to obtain a VT between 6 and 8 ml\u002Fkg PBW and RR between 20 and 35 breaths\u002Fmin until day 28 or death or performance of spontaneous breathing trial (SBT).\n* In the PMI-targeted group, the pressure support is adjusted according to PMI between 0 and 2 cmH2O until day 28 or death or performance of SBT.\n\nWe will also survey clinicians to understand potential facilitators and barriers to conducting a definitive randomized trial.",[26,270,644],"Ventilator Lung",[273,274,275],"2025-02-05",{"date":648,"type":34},"2025-02-07",{"date":650,"type":34},"2025-01-20",{"date":652,"type":21},"2025-04",{"name":283,"class":41},{"id":655,"slug":656,"hasResults":12,"nctId":657,"briefTitle":658,"officialTitle":659,"acronym":4,"eligibilityCriteria":660,"healthyVolunteers":12,"sex":17,"minAge":661,"maxAge":4,"enrollmentInfo":662,"targetDuration":4,"studyType":89,"phases":664,"briefSummary":665,"conditions":666,"keywords":669,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":672,"lastUpdatePostDateStruct":673,"startDateStruct":674,"completionDateStruct":676,"leadSponsor":678,"locationsCount":42},"100578384","comparing-efficacy-between-two-protocols-of-intravenous-insulin-infusion-for-diabetic-adults-in-icu-100578384","NCT06810596","Comparing Efficacy Between Two Protocols of Intravenous Insulin Infusion for Diabetic Adults in ICU","Comparing Glycemic Control Efficacy Between The National Health System and Suez Canal University Protocols of Intravenous Insulin Infusion for Diabetic Adults in ICU","Inclusion Criteria:\n\n* Patients who admitted to the hospital with a potentially life-threatening condition (Critically ill patients) with HbA1C \\>6.0.\n\nExclusion Criteria:\n\n* DKA patients.\n* Pregnant or breast-feeding patients.\n* Hyperosmolar Non-Ketotic Coma.","19 Years",{"count":663,"type":21},100,[119],"The goal of clinical trial is to improve the adequacy of blood sugar control in diabetic critically ill adult patients who admitted to the intensive care unit(ICU) in Suez Canal University (SCU) hospitals by comparing glycemic control efficacy between the NHS in the UK and suggested SCU Protocols of Intravenous Insulin Infusion.\n\nThe main questions it aims to answer are:\n\nIs SCU protocol of Intravenous Insulin Infusion more effective than NHS protocol in achieving blood glucose control targets in critically ill adult patients?\n\nResearchers will compare glycemic control efficacy between the NHS in UK and suggested SCU Protocols of Intravenous Insulin Infusion for critically ill Adults in ICU to determine the best protocol in achieving good blood glucose control in diabetic critically ill adult patients in SCU Hospitals.",[667,26,668],"Glycemic Control","Diabetes Mellitus",[667,670,671],"Insulin Infusion Protocol","Critically ill","2025-01-31",{"date":646,"type":34},{"date":675,"type":34},"2024-12-15",{"date":677,"type":21},"2025-04-15",{"name":679,"class":41},"Suez Canal University",{"id":681,"slug":682,"hasResults":12,"nctId":683,"briefTitle":684,"officialTitle":685,"acronym":686,"eligibilityCriteria":687,"healthyVolunteers":328,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":688,"targetDuration":4,"studyType":89,"phases":690,"briefSummary":691,"conditions":692,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":696,"lastUpdatePostDateStruct":697,"startDateStruct":698,"completionDateStruct":700,"leadSponsor":702,"locationsCount":4},"100575616","effects-of-nonpharmacological-interventions-in-sleep-quality-anxiety-and-delirium-for-patients-of-adult-intensive-care-units-100575616","NCT06774599","Effects of Nonpharmacological Interventions in Sleep Quality, Anxiety, and Delirium for Patients of Adult Intensive Care Units","Effects of Nonpharmacological Interventions in Sleep Quality, Anxiety, and Delirium for Patients of Adult Intensive Care Units: a Randomized Controlled Trial","Sleep","Inclusion Criteria:\n\n* Conscious and able to speak or write (GCS ≥ 11)\n* Hemodynamically stable\n* Normal hearing and able to communicate in a low voice\n* Stay in ICU for more than 24 hours\n* Aged over 18 years.\n\nExclusion Criteria:\n\n* Pre-existing insomnia diagnosis with long-term reliance on sleep medication,\n* Sleep-related medical history such as sleep apnea\n* Shift work prior to hospitalization\n* Diagnosis of alcohol abuse or schizophrenia\n* End-of-life or terminal conditions\n* Allergy to essential oils\n* Exclusion of dementia",{"count":689,"type":21},154,[119],"This study will investigate the effect of nonpharmacological intervention in sleep quality, anxiety and delirium among adult ICU patients.",[693,26,694,695,390],"Intensive Care Unit","Sleep Quality","Anxiety","2025-01-12",{"date":576,"type":34},{"date":699,"type":21},"2025-03-14",{"date":701,"type":21},"2025-10-09",{"name":703,"class":41},"Chiayi Christian Hospital"]