[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"critical-illness-recovery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:critical-illness-recovery":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,55,82,118,141],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":34,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100637070","virtual-reality-for-recovery-after-intensive-care-pics-100637070",false,"NCT07585500","Virtual Reality for Recovery After Intensive Care (PICS)","Virtual Reality Intervention for Post-Intensive Care Syndrome (PICS): A Protocol for a Pilot Randomized Controlled Trial for Cognitive, Physical and Psychological Outcomes","VR4ICU","Inclusion Criteria:\n\n* Adult patients, 18 years or older\n* Patients in the Intensive Care Unit\n* Ventilated patients must be in the post-extubation period\n* The patient has a projected remaining hospital stay of at least 4 days (assessed by the clinical team)\n* The patient has RASS score between -1 and +1\n* The patient has the ability to move both arms, even if with difficulties, as assessed by the clinical team, to be able to interact with the software\n* The patient can maintain a stable sitting position (30° to 60°)\n* The patient is able to communicate (speech, gesturing, or writing)\n* The patient can communicate and understand Portuguese\n* The patient or a legal representative provided informed consent\n\nExclusion Criteria:\n\n* Severe cognitive and neurodegenerative diseases: mental illness requiring institutionalization; acquired or congenital intellectual disability; known severe brain injuries (e.g., stroke with significant residual deficits); moderate to severe Traumatic Brain Injury (TBI) (defined by the duration of loss of consciousness\u002Fpost-traumatic amnesia or documented residual deficits); diagnosed neurodegenerative diseases (e.g., Parkinson's disease with severe movement impairment, Huntington's disease, severe Alzheimer's disease, or dementia of any etiology that prevents autonomy in daily life at baseline)\n* The patient uses neuromuscular blocking agents\n* The patient has a positive CAM-ICU result at the time of initial screening\n* The patient has active psychotic disorders or suicidal ideation\n* The patient has documented epilepsy or history of seizures\n* The patient has a \"Do Not Resuscitate\" (DNR) order, is on life support with exclusive focus on comfort, or has an unexpected survival predicted to be less than 24 hours\n* The patient has intoxication by an active substance or withdrawal syndrome requiring ongoing medical management that prevents safe and meaningful participation or accurate cognitive assessment\n* Patients with immobility or severe motor limitations in the upper limbs, fine motor skills, or cervical region\n* The patient has open wounds on the head or face that may affect the comfortable\u002Fsafe use of VR glasses, cause discomfort, or present a hygiene risk\n* The patient has uncorrected blindness or deafness that prevents the safe\u002Feffective use of VR\u002Ftablet devices.\n* Patients are participating in another rehabilitation study with interventions\n* Patients with a scheduled surgery where the ICU stay is expected to be less than 24 hours\n* Patients in need of respiratory support","ALL","18 Years",{"count":20,"type":21},51,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if virtual reality (VR) helps improve thinking and memory skills in adults who have stayed in the intensive care unit (ICU). The study focuses on people who needed a breathing machine or stayed in the ICU for several days and are at risk for memory or \"brain fog\" issues.\n\nThe main questions it aims to answer are:\n\n* Does using VR improve a participant's memory, attention, and thinking skills after an ICU stay?\n* Does the \"immersive\" feel of a VR headset work better to improve these skills than using a handheld tablet?\n\nResearchers will compare three groups to see how different types of care affect the brain:\n\n* VR-Rehab: Participants use a VR headset to play brain-training games.\n* Tablet-Rehab: Participants use a handheld tablet to play the same brain-training games.\n* Standard Care: Participants receive the usual hospital care without digital brain games.\n\nParticipants will:\n\n* Play brain-training games for 12 minutes every day for up to one week while in the hospital.\n* Complete memory and thinking tests with a researcher at the start of the study and again after two weeks.\n* Answer follow-up questions about their memory and thinking skills for 6 months after leaving the hospital.",[27,28,29,30,31,32,33],"Post-Intensive Care Syndrome (PICS)","Critical Illness Recovery","Rehabilitation After Critical Illness","Rehabilitation Exercise of ICU Patients","Cognitive Impairment","Critical Illness","Intensive Care Unit (ICU)",[27,31,32,35,36,37,33,38,39,40,41],"Virtual Reality (VR)","Digital Health","Rehabilitation","Critical Care","ICU Survivors","Pilot Study","Randomized Controlled Trial","RECRUITING","2026-05-08",{"date":45,"type":46},"2026-05-13","ACTUAL",{"date":48,"type":46},"2025-12-06",{"date":50,"type":21},"2026-06",{"name":52,"class":53},"University of Minho","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":54},"100633042","integrated-rehabilitation-in-hdu-for-post-intensive-care-syndromeliberation-in-patients-with-pics-100633042","NCT07521540","Integrated Rehabilitation in HDU for Post-Intensive Care SyndromeLiberation in Patients With PICS","Effect of Integrated Multidisciplinary Rehabilitation in a High-Dependency Unit on Outcomes of Patients With Post-Intensive Care Syndrome: A Prospective Interventional Study","Inclusion Criteria:\n\n* Age ≥18 years\n* Diagnosed with post-intensive care syndrome\n* Transferred from ICU to HDU\n* Available paired admission and discharge data\n\nExclusion Criteria:\n\n* Death within 24 hours after HDU admission\n* Missing primary outcome data",{"count":63,"type":21},250,[24],"Post-intensive care syndrome (PICS) is characterized by persistent physical, cognitive, and psychological impairments among survivors of critical illness. Although advances in intensive care medicine have reduced mortality, a large proportion of ICU survivors experience long-term functional impairments after discharge.\n\nHigh-dependency units (HDUs) serve as transitional care settings between intensive care units and general wards. Many critically ill survivors who cannot directly return home are transferred to HDU for continued treatment and rehabilitation. However, evidence regarding systematic multidisciplinary rehabilitation interventions in HDU settings remains limited.\n\nThis prospective single-center interventional study aims to evaluate the effects of an integrated multidisciplinary rehabilitation model implemented in the HDU on physical, cognitive, and psychological outcomes among patients with post-intensive care syndrome. All enrolled patients will receive standardized integrated medical, nursing, and rehabilitation interventions. Multidimensional functional assessments will be conducted at baseline, during hospitalization, and before discharge from the HDU.",[27,28,67],"Mechanical Ventilation",[69,70,71],"Ventilator liberation","High-dependency unit","Post-ICU rehabilitation","NOT_YET_RECRUITING","2026-04-08",{"date":75,"type":46},"2026-04-13",{"date":77,"type":21},"2026-04-01",{"date":79,"type":21},"2027-12-31",{"name":81,"class":53},"Hongying Jiang, MD",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":100,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":54},"100622989","behavioral-health-collaborative-care-model-in-post-icu-clinic-family-pilot-100622989","NCT07390786","Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot","Integration of a Behavioral Health Collaborative Care Model Into an ICU Recovery Clinic-Pilot for Families","Inclusion Criteria:\n\n\\- Family member of ICU Recovery Clinic patient enrolled in parent BH CoCM study\n\nExclusion Criteria:\n\n* Serious mental illness (e.g., schizophrenia, mania)\n* Late-stage dementia or cognitive impairment\n* Limited English proficiency\n* No internet-enabled device\n* Prisoners",{"count":90,"type":21},150,[24],"This pilot study evaluates the feasibility and acceptability of implementing a Behavioral Health Collaborative Care Model (BH CoCM) for family members of ICU survivors. The intervention includes telehealth-enabled behavioral health assessments and access to the NeuroFlow platform. A subset of participants will undergo qualitative interviews.",[28,94,95,96,97,98,99],"Behavioral Health Concerns","Anxiety","Depression - Major Depressive Disorder","PTSD","Critical Care, Intensive Care","PICS-F",[101,102,103,104,105,106,107,108,97,99],"Critical Ilness","critical care recovery","Post-Intensive Care Syndrome","Post-ICU care","behavioral health","mental health","anxiety","depression","2026-03-11",{"date":111,"type":46},"2026-03-12",{"date":113,"type":46},"2026-01-30",{"date":115,"type":21},"2028-06-30",{"name":117,"class":53},"Medical University of South Carolina",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":22,"phases":127,"briefSummary":128,"conditions":129,"keywords":133,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":137,"startDateStruct":138,"completionDateStruct":139,"leadSponsor":140,"locationsCount":54},"100621589","behavioral-health-collaborative-care-model-in-an-icu-recovery-clinic-100621589","NCT07372586","Behavioral Health Collaborative Care Model in an ICU Recovery Clinic","Integration of a Behavioral Health Collaborative Care Model Into an ICU Recovery Clinic","BeColM","Inclusion Criteria:\n\n\\- Attendance at the MUSC ICU Recovery Clinic within 180 days of discharge from the hospital\n\nExclusion Criteria:\n\n* ICU Admission was due to a primary addiction diagnosis (eg alcohol withdrawal or delirium tremens requiring ICU care)\n* Serious Mental Illness such as Schizophrenia, psychotic disorder, acute mania\n* Late Stage Dementia or Cognitive Impairment\n* Limited English or Spanish Proficiency\n* Lack of regular access to a computer, tablet or mobile device with internet access",{"count":90,"type":21},[24],"Survivors of critical illness are at high risk for mental health issues such as anxiety, depression, and PTSD. This single-site, randomized controlled trial at the Medical University of South Carolina will enroll 150 patients to compare outcomes between a behavioral health Collaborative Care Model (BH CoCM) and usual care (attention control). The intervention includes digital tools (Neuroflow), behavioral health coaching, and psychiatric support.",[130,95,96,131,97,28,32,132,94],"PICS","Post-Traumatic Stress","Collaborative Care",[134,135,130,107,108,97,136,105],"critical illness","post-ICU","collaborative care model",{"date":111,"type":46},{"date":113,"type":46},{"date":115,"type":21},{"name":117,"class":53},{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":22,"phases":152,"briefSummary":153,"conditions":154,"keywords":156,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":54},"100595642","i-wear-evaluating-wearables-and-health-summaries-in-icu-survivors-100595642","NCT07035106","I-WEAR: Evaluating Wearables and Health Summaries in ICU Survivors","I-WEAR: From ICU to Recovery - Evaluating the Feasibility and Usability of Bi-Weekly Health Summaries Using Wearables in Patients After Intensive Care Unit Treatment - A Pilot Study","I-WEAR","Inclusion Criteria:\n\n* Age 18-65 years at the time of ICU admission\n* ICU stay of at least 48 hours\n* ICU discharge within the last 2 years\n* Comorbidity of diabetes mellitus and\u002For chronic heart failure\u002Fcoronary artery disease\n* Written informed consent\n* Access to a home internet connection and smartphone with internet and Bluetooth\n\nExclusion Criteria:\n\n* Presence of a legal guardian\n* No smartphone or internet access\n* No cardiovascular disease\u002Fevent and\u002For diabetes\n* Implanted pacemaker or defibrillator\n* Allergies to materials in the wearable devices\n* Transfer from an ICU outside the Medical University of Vienna\n* Homelessness\n* Residence outside of Austria","65 Years",{"count":151,"type":21},60,[24],"This pilot study investigates the use of wearable health technology and bi-weekly digital health summaries in patients recovering from intensive care. Many patients experience physical, psychological, and cognitive challenges after an ICU stay, a condition known as Post-Intensive Care Syndrome (PICS). The study aims to evaluate the feasibility and usability of wearable devices-such as smartwatches, blood pressure monitors, and smart scales-for tracking recovery in real-world settings.\n\nParticipants will be randomly assigned to one of three groups: standard ICU follow-up care, wearable use only, or wearable use combined with bi-weekly health reports and optional lifestyle consultations. The study will assess participants' quality of life, experience using the technology, and adherence over a 6-month period. Results will inform the future use of digital tools in post-ICU care.",[27,28,155],"Coronary Artery Disease",[157,158,159,160,161,162,163,164,165,130,166,167],"Wearables","Health-related quality of life","ICU survivors","Digital health","Remote patient monitoring","System Usability Scale","SF-36","Bi-weekly health summary","Pilot study","Cardiovascular disease","Diabetes","2025-09-02",{"date":170,"type":46},"2025-09-09",{"date":172,"type":46},"2025-07-01",{"date":174,"type":21},"2026-05-30",{"name":176,"class":53},"Ludwig Boltzmann Gesellschaft"]