[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"critical-illness-requiring-intensive-care---polytrauma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:critical-illness-requiring-intensive-care---polytrauma":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":5},"100619480","immunorea---immunological-and-inflammatory-determinants-associated-with-the-prognosis-of-intensive-care-patients-100619480",false,"NCT07345169","IMMUNOREA - Immunological and Inflammatory Determinants Associated With the Prognosis of Intensive Care Patients","Studies on the Immunological and Inflammatory Determinants Associated With the Prognosis of Patients Admitted to Intensive Care","IMMUNOREA","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Admission to ICU within 24 hours\n\nExclusion Criteria:\n\n* Moribund patient (ECOG=4)\n* Legal protection (guardianship\u002Fcuratorship)\n* Uninsured patients\n* Pre-existing immunosuppression (active\u002Frecent cancer, hematologic disease, autoimmune disease, organ transplant, HIV)\n* Pregnant or breastfeeding women\n* Participation in another interventional trial\n* Patients under AME","ALL","18 Years",{"count":20,"type":21},540,"ESTIMATED","OBSERVATIONAL","This is a prospective observational physiopathological study aimed at evaluating the immunological and inflammatory determinants associated with the prognosis of patients admitted to intensive care units (ICU). The study will establish multidimensional models predicting one-year survival and the occurrence of nosocomial infections.\n\nPatients admitted to ICU undergo routine biological sampling. In addition to these, minimal supplementary samples will be collected for immunological and inflammatory biomarker analysis at admission, day 1, day 4, day 8, ICU discharge or day 28, and at 12 months. Additional samples may be taken during clinically significant events (nosocomial infections, complications).",[25,26,27,28,29,30],"Critical Illness","Intensive Care Patients","Critical Illness Requiring Intensive Care - Sepsis","Critical Illness Requiring Intensive Care - Acute Brain Injury","Critical Illness Requiring Intensive Care - Major Surgery","Critical Illness Requiring Intensive Care - Polytrauma",[32,33,34,35,36,37,38,39,40,41],"Sepsis","Critical illness","Intensive care","Immunology","Inflammation","Transcriptomics","scRNAseq","Flow cytometry","Nosocomial infections","Prognosis","RECRUITING","2026-01-06",{"date":45,"type":46},"2026-01-15","ACTUAL",{"date":48,"type":21},"2026-01",{"date":50,"type":21},"2031-02",{"name":52,"class":53},"Assistance Publique - Hôpitaux de Paris","OTHER"]