[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"crohn39s-disease-cd\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:crohn39s-disease-cd":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100575273","unraveling-the-blood-microbiome-in-postoperative-recurrence-of-crohns-disease-100575273",false,"NCT06770140","Unraveling the Blood Microbiome in Postoperative Recurrence of Crohn's Disease","IBDbloom","Inclusion Criteria:\n\n* Diagnosis of Crohn's Disease\n* Adult ≥ 16 years\n* Undergoing an ileocolonic resection or reresection\n* Written informed consent\n\nExclusion Criteria:\n\n* Use of antibiotics in the past 8 weeks at the timepoints when blood is withdrawn and feces is collected.\n* Use of probiotics in the past 8 weeks at the timepoints when blood is withdrawn and feces is collected.\n* Not willing to collect extra biosamples",true,"ALL","16 Years",{"count":20,"type":21},70,"ESTIMATED","OBSERVATIONAL","Crohn's disease, a chronic inflammation of the gastro-intestinal tract, is a disease with a complex pathogenetic background. Hereditary factors, environmental factors and the gut flora play a varying role in its onset, however, this role remains unclear to date. We hypothesize to detect tiny fragments of microbial DNA from the gut in the bloodstream, due to disruption in the natural defences of the gut lining. If this is true, it may hold the key to understanding why Crohn's disease recurs after surgery.\n\nOur objective in this study is to test retrospectively, if we can detect any difference in microbial DNA from the blood of ileocolonic resection (ICR) patients that do and do not show recurrence at the time of follow-up endoscopy at 6 months.",[25],"Crohn's Disease (CD)",[27,28,29],"Ileocolonic resection","Blood microbiome","Postoperative recurrence","NOT_YET_RECRUITING","2025-01-07",{"date":33,"type":34},"2025-01-13","ACTUAL",{"date":36,"type":21},"2025-02",{"date":38,"type":21},"2027-02",{"name":40,"class":41},"Erasmus Medical Center","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":5},"100193428","standardized-fecal-microbiota-transplantation-for-crohnaposs-diseases-100193428","NCT01793831","Standardized Fecal Microbiota Transplantation for Crohn&Apos;s Diseases","Efficacy and Safety of Standardized Fecal Microbiota Transplantation for Moderate to Severe Crohn&Apos;s Diseases","Inclusion Criteria:\n\nClinical diagnosis of Crohn's disease, with the diagnosis remaining unchanged after at least three months of follow-up.\n\nWillingness to undergo FMT (Fecal Microbiota Transplantation).\n\nExclusion Criteria:\n\nPresence of serious conditions that made them unsuitable for inclusion (e.g., malignant neoplasms, cardiopulmonary failure, serious liver or kidney disease).",{"count":51,"type":21},800,"INTERVENTIONAL",[54],"NA","The gut microbiota is considered to constitute a \"microbial organ\" which has pivotal roles in the intestinal diseases and body's metabolism. Evidence from animal and human studies strongly supports the link between intestinal bacteria and inflammatory bowel diseases (IBD). Dozens of studies reported its efficacy in treatment of severe Clostridium difficile colitis. Preliminary studies using fecal microbiota transplantation (FMT) for Ulcerative Colitis (UC), Crohn's diseases (CD), irritable bowel syndrome (IBS) and constipation have also met with some success. However, the results on CD is very limited. This marks the initial step in exploring the potential efficacy of fecal bacteriotherapy for CD. The investigators aim to evaluate the effectiveness, durability, and safety of FMT in a cohort of at least 500 patients with CD over a ten-year period",[57,25],"Inflammatory Bowel Disease",[59,60,61,62,63],"Inflammatory bowel disease","Fecal transplantation","Fecal bacteriotherapy","Fecal microbiota transplantation","Crohn's disease","RECRUITING","2024-11-26",{"date":67,"type":34},"2024-11-29",{"date":69,"type":34},"2013-02",{"date":71,"type":21},"2025-12",{"name":73,"class":41},"The Second Hospital of Nanjing Medical University"]