[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cva-cerebrovascular-accident\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cva-cerebrovascular-accident":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,43,73,94,114,143],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100478842","constraint-induced-movement-therapy-plus-sensory-components-after-stroke-100478842",false,"NCT05515237","Constraint-Induced Movement Therapy Plus Sensory Components After Stroke","Constraint-Induced Movement Therapy Plus Sensory Components for Adults With Mild-to-Severe Arm and Hand Impairment After Stroke","Inclusion Criteria:\n\n* At least 6 months post stroke\n* The ability to demonstrate the minimum UE active movement criteria of shoulder ≥ 30 toward flexion or abduction, initiate movement at the elbow for flexion and extension, and initiate movement at the wrist, fingers, or thumb.\n* Mean score of \\\u003C2.5 on the Motor Activity Log\u002F G4\u002F5 Motor Activity Log indicating the participant's use of the more-affected UE.\n\nExclusion Criteria:\n\n* Score\\\u003C 24 on the Mini Mental State Exam\n* Inability to answer the MAL\u002F G4\u002F5 MAL questions and\u002For provide informed consent\n* The inability to come in to the laboratory setting for treatment.","ALL","18 Years","89 Years",{"count":20,"type":21},15,"ESTIMATED","INTERVENTIONAL",[24],"NA","Constraint-Induced Movement Therapy or CI Therapy is a form of treatment that systematically employs the application of selected behavioral techniques delivered in intensive treatment over consecutive day with the following strategies utilized: behavioral strategies are implemented to improve the use of the more- affected limb in life situation called a Transfer Package (TP), motor training using a technique called shaping to make progress in successive approximations, repetitive, task oriented training, and strategies to encourage or constrain participants to use the more-affected extremity including restraint of the less-affected arm in the upper extremity (UE) protocol. Numerous studies examining the application of CI therapy with UE rehabilitation after stroke have demonstrated strong evidence for improving the amount of use and the quality of the more-affected UE functional use in the participant's daily life situation.\n\nCI Therapy studies with adults, to date, have explored intensive treatment for participants with a range from mild-to-severe motor impairment following stroke with noted motor deficits and limited use of the more-affected arm and hand in everyday activities. Each CI Therapy protocol was designed for the level of impairment demonstrated by participants recruited for the study. However, often following stroke, patients not only have motor deficits but somatosensory impairments as well. The somatosensory issues have not, as yet, been systematically measured and trained in CI Therapy protocols with adults and represent an understudied area of stroke recovery. We hypothesize that participants with mild-to-severe motor impairment and UE functional use deficits can benefit from CI therapy protocols that include somatosensory measurement and training components substituted for portions of motor training without loss in outcome measure gains. Further, we hypothesize that adults can improve somatosensory outcomes as a result of a combined CI therapy plus somatosensory component protocol.",[27,28,29],"CVA (Cerebrovascular Accident)","Stroke","Upper Extremity Paresis","RECRUITING","2026-04-08",{"date":33,"type":34},"2026-04-13","ACTUAL",{"date":36,"type":34},"2023-03-30",{"date":38,"type":21},"2027-06",{"name":40,"class":41},"University of Alabama at Birmingham","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":42},"100626912","efficacy-and-safety-of-6degrees-mymove-interactive-virtual-reality-compared-to-passive-virtual-reality-in-subacute-stroke-and-traumatic-brain-injury-rehabilitation-a-randomized-controlled-trial-100626912","NCT07441798","Efficacy and Safety of 6Degrees MyMove Interactive Virtual Reality Compared to Passive Virtual Reality in Subacute Stroke and Traumatic Brain Injury Rehabilitation: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Time since neurological event: At least 2 weeks post-stroke or post-head injury.\n2. Motor impairment: Upper extremities: Presence of hemiparesis without complete paralysis. Participants receiving rehabilitation focused on functional transfer to the contralateral hand using compensatory or adaptive motor learning strategies will also be eligible. Lower extremities: Presence of partial voluntary movement sufficient to allow participation in rehabilitation training.\n3. Cognitive ability: Sufficient cognitive capacity to understand instructions and engage with VR-based training, as determined by the principal investigator and\u002For treating physician.\n4. Medical stability: Medically stable condition allowing participation in the training.\n5. Informed consent: Ability to provide written informed consent personally or via a legal guardian.\n6. Final eligibility will be determined by the principal investigator\u002F treating physician.\n\nExclusion Criteria:\n\n1. Severe cognitive or language impairment: Cognitive deficits or language comprehension impairments that prevent safe and meaningful participation.\n2. Neurological deficits interfering with VR: Severe hemispatial neglect or visual field deficits that interfere with VR use. Moderate neglect may be permitted at the investigator's discretion.\n3. Medical contraindications:\n\n   * Uncontrolled epilepsy\n   * Severe vestibular or vertigo disorders","40 Years",{"count":51,"type":21},60,[24],"Stroke and traumatic brain injury frequently result in persistent upper and lower limb motor impairment. While conventional rehabilitation improves outcomes, patient adherence and training intensity remain limiting factors. Immersive virtual reality (VR)-based therapy may enhance neuroplasticity by delivering high-intensity, task-oriented motor practice with enriched sensory feedback.\n\nThis randomized controlled trial evaluates the efficacy and safety of the 6Degrees MyMove interactive VR system compared to passive VR exposure in individuals undergoing subacute inpatient rehabilitation after stroke or traumatic brain injury. Sixty participants will be randomized 1:1 to receive either interactive VR-based motor training or passive VR viewing, in addition to standard rehabilitation care, three times weekly for eight weeks.\n\nThe primary objective is to determine whether interactive VR leads to greater improvement in motor function compared to passive VR. Secondary outcomes include dexterity, gait speed, functional independence, psychological status, adherence, usability, and safety.",[55,27],"TBI Traumatic Brain Injury",[57,58,59,60,61,62],"Virtual Reality Therapy","Upper Limb Rehabilitation","Stroke Rehabilitation","Fugl-Meyer Assessment","Neurorehabilitation","Wearable Motion Sensors","NOT_YET_RECRUITING","2026-02-24",{"date":66,"type":34},"2026-03-02",{"date":68,"type":21},"2026-03-18",{"date":70,"type":21},"2028-12-31",{"name":72,"class":41},"Reuth Rehabilitation Hospital",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":42},"100534657","intravenous-thrombolytic-therapy-in-acute-ischemic-stroke-patients-on-doac-100534657","NCT06241677","Intravenous Thrombolytic Therapy in Acute Ischemic Stroke Patients on DOAC","Intravenous Thrombolytic Therapy in Acute Ischemic Stroke Patients on Direct Oral Anticoagulants - A Prospective Multicenter Study","DOAC-IVT","Inclusion Criteria:\n\n1. Acute ischemic stroke patients with a last-known-well to presentation time within 4.5 hours\n2. Patients who took any doses of apixaban (2.5mg or 5mg twice daily), dabigatran (110mg or 150mg twice daily), edoxaban (30mg or 60mg daily) or rivaroxaban (15mg or 20mg daily) 12-48 hours before presentation\n3. National Institute of Health Stroke Scale (NIHSS) ≥ 3\n4. Alberta Stroke Programme Early CT (ASPECT) score ≥ 6\n5. Pre-morbid modified Rankin Scale (mRS) ≤ 3\n6. Patients aged ≥ 18 years old\n\nExclusion Criteria:\n\n1. Initial CT brain showing intracranial haemorrhage\n2. Contraindications to IVT according to current guideline recommendations \\[5\\], except for the use of DOAC within 12-48 hours\n3. Patients with an estimated glomerular filtration rate of ≤ 30ml\u002Fmin\u002F1.73m2\n4. Patients with bleeding propensities apart from the use of DOAC, e.g. platelet count of \\\u003C 100x109\u002FL\n5. Patients with significant head injury immediately prior to presentation",{"count":82,"type":21},260,[24],"Direct oral anticoagulants (DOAC) have emerged as safe and efficacious ischemic stroke prophylaxis for non-valvular atrial fibrillation (NVAF). All four DOACs - apixaban, dabigatran, edoxaban, rivaroxaban - were associated with lower risks of major bleeding compared to warfarin. Listed as core essential medicines by the World Health Organization, DOAC prescriptions have been surging worldwide. In Hong Kong, approximately 80,000 patients received DOACs from January 2009 through December 2022 according to the Hospital Authority registry.\n\nThe widespread DOAC usage had created DOAC-specific clinical dilemmas that lack evidence-based treatment despite twenty years of prescribing experience. Ischemic stroke despite DOAC (IS-DOAC), in particular, may occur in up to 6% of DOAC users annually. Due to the in vivo anticoagulation effect, there had been concerns of intracerebral bleeding (ICH) with intravenous thrombolytic therapy (IVT) for acute IS-DOAC. Under the current guideline recommendations, most acute IS-DOAC are contraindicated to IVT (see Intravenous thrombolytic therapy), which resulted in only a small proportion of acute ISDOAC patients being able to receive IVT even if presented early. Nonetheless, our group found that majority of patients had a DOAC level of \\\u003C50ng\u002FmL only 24 hours after DOAC cessation (see work done by us), a level deemed clinically negligible and safe for thrombolytic therapy. Together with evolving clinical evidence discussed below, IS-DOAC patients maybe unnecessarily barred from IVT, thus compromised functional recovery.\n\nWith robust pharmacokinetic and retrospective clinical evidence to support, it is hypothesized that IVT are safe in IS-DOAC patient. The investigators hereby propose a prospective multicenter study to determine the efficacy and safety of IVT in acute IS-DOAC.",[27],"2026-02-21",{"date":64,"type":34},{"date":89,"type":34},"2024-04-15",{"date":91,"type":21},"2029-03-31",{"name":93,"class":41},"Chinese University of Hong Kong",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":22,"phases":103,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":42},"100477096","constraint-induced-movement-therapy-for-adults-post-stroke-with-mild-upper-extremity-impairment-100477096","NCT05492513","Constraint-Induced Movement Therapy for Adults Post-Stroke With Mild Upper Extremity Impairment","Constraint-Induced Movement Therapy for Adults Post-Stroke With Mild Upper Extremity Impairment and Deficits in Desired Occupational Performance: A Pilot Study","Inclusion Criteria:\n\n* At least 6 months post stroke\n* The ability to demonstrate the minimum UE active movement criteria of 20 degrees of wrist extension from a fully flexed position, 10 degrees of thumb extension or abduction, and 10 degrees of extension of all finger joints.\n* Mean score of \\>2.5 on the Motor Activity Log indicating the participant's use of the more-affected UE.\n\nExclusion Criteria:\n\n* Score\\\u003C 24 on the Mini Mental State Exam\n* Inability to answer the MAL questions and\u002For provide informed consent\n* The inability to come in to the laboratory setting for treatment.",{"count":102,"type":21},12,[24],"Constraint-Induced Therapy (CI Therapy) is a behavioral approach to neurorehabilitation and consists of multi-components that have been applied in a systematic method to improve the use of the limb or function addressed in the intensive treatment. CI Therapy for the more-affected upper extremity (UE) post-stroke is administered in daily treatment sessions over consecutive weekdays. Sessions include motor training with repeated, timed trials using a technique called shaping, a set of behavioral strategies known as the Transfer Package (TP) to improve the use of the more-affected hand in the life situation, and strategies to remind participants to use the more-affected UE including restraint. Robust improvements in the amount and qualify of use have been realized with stroke participants from mild-to-severe UE impairment.",[27,28,29],"2026-02-18",{"date":108,"type":34},"2026-02-20",{"date":110,"type":34},"2022-12-08",{"date":112,"type":21},"2027-03",{"name":40,"class":41},{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":16,"minAge":121,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":22,"phases":125,"briefSummary":127,"conditions":128,"keywords":129,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":42},"100426136","early-phase-1-cognition-and-motor-learning-post-stroke-100426136","NCT04829071","Cognition and Motor Learning Post-stroke","Cognition as a Moderator of Motor Learning Post-stroke","Inclusion Criteria:\n\n* Unilateral stroke\n* Stroke occurred more than 6 months prior\n* Paresis confined to one side\n* Independently ambulatory (including the use of assistive devices)\n* Able to walk for 5 minutes without stopping\n* Answers no to all general health questions on the PAR-Q+\n* Willingness to complete study procedures\n\nExclusion Criteria:\n\n* Brainstem or cerebellar stroke\n* Aphasia (expressive, receptive, or global)\n* Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function\n* Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations\n* Uncontrolled hypertension (\\>160\u002F110mmHg)\n* Concurrent physical therapy\n* Claustrophobia\n* Significant cognitive deficit or dementia (\\\u003C20 on MoCA)\n* Inability to give informed consent","45 Years","85 Years",{"count":124,"type":21},65,[126],"EARLY_PHASE1","This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.",[28,27],[130,131,132,133],"stroke","walking","rehabilitation","cognition","2025-10-31",{"date":136,"type":34},"2025-11-04",{"date":138,"type":34},"2023-01-16",{"date":140,"type":21},"2026-12-14",{"name":142,"class":41},"University of Southern California",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":22,"phases":152,"briefSummary":153,"conditions":154,"keywords":161,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":42},"100567889","additional-effects-of-kinesio-taping-along-with-conservative-physical-therapy-on-upper-limb-function-range-of-motion-and-spasticity-in-the-patients-with-subacute-stroke-100567889","NCT06674057","Additional Effects of Kinesio-Taping Along with Conservative Physical Therapy on Upper Limb Function, Range of Motion and Spasticity in the Patients with Subacute Stroke","Inclusion Criteria:\n\n* Age group: 40-65 years onwards\n* Both males and females\n* Patients with history of diagnosed stroke and lie within subacute stage of stroke\n* MAS scale score of 1\\_2\n\nExclusion Criteria:\n\n* Any congenital deformities\n* cognitive deficits\n* Fractures\n* Upper limb surgery","65 Years",{"count":151,"type":21},40,[24],"A randomized control trial will be done on diagnosed stroke patients of subacute stage in Fauji Foundation Hospital Rawalpindi and leading edge physical therapy and rehabilitation clinic.The purpose of the study is to determine Additional Effects of Kinesio-Taping along with conservative Physical Therapy on upper limb function, Range of motion and Spasticity in the patients with Subacute Stroke. The conservational physical therapy includes Passive and active ROMs 25 repetitions each, 3 times per week. PNF stretching (hold relax) for spastic muscles for 20 repetitions with a 10 second hold and 10 second relaxation of the muscle group 3 times per week.\n\nD1 flexion and extension for 20 repetitions 3 times per week. Kinesio tape 3 times per week. (Anchor opposed to effected compartment to provide facilitation and sustained stretch). with srtrngth training included in week 3-6 with a resistance band of medium resistance.\n\ntreatment time will be 30 minutes on alternate days for six weeks.",[155,156,157,158,27,159,28,160],"Subacute Stroke","Upper Limb","Range of Motion","Spasticity","KINESIOTAPING","Function",[162,163,164,165,166,167],"Stroke.","subacute stroke","kinesio taping","proprioceptive neuromuscular facilitation","Upper limb function.","range of motion","2024-11-04",{"date":170,"type":34},"2024-11-05",{"date":172,"type":34},"2024-06-20",{"date":174,"type":21},"2025-01-20",{"name":176,"class":41},"Foundation University Islamabad"]