[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cyanotic-heart-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cyanotic-heart-disease":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100510499","phase-4-effect-of-methylprednisolone-on-systemic-inflammatory-response-during-pediatric-congenital-open-heart-surgery-100510499",false,"NCT05927233","Effect of Methylprednisolone on Systemic Inflammatory Response During Pediatric Congenital Open-Heart Surgery","Effect of Methylprednisolone on Systemic Inflammatory Response and Clinical Parameters During Pediatric Congenital Open-Heart Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Children 1 month- 18 years of age\n* Undergoing Cardiac surgery for the first time and requiring CPB\n* Surgeries for both cyatonic and acyanotic heart disease\n\nExclusion Criteria:\n\n* Pre-mature babies (\\\u003C 28 weeks at birth)\n* Neonates\n* Prior cardiac requiring CPB\n* Surgeries requiring CPB \\> 6 hours\n* Surgeries requiring second run of CPB\n* Patients requiring additional steroids during first 24 hours of CICU stay\n* Patient expires within the initial 24 hours CICU stay.\n* Compromised immune system - that is, known immunodeficiency or use of\n* immunomodulatory therapy.\n* Peri-operative presence of two or more clinical or laboratory signs of active infection that were not attributable to any other cause: fever more than 100°F, heart rate or respiratory rate more than the normal range for age, white blood cell count more than 15% of the upper limit of normal, and an elevated C-reactive protein level above baseline.\n* Preoperative mechanical ventilation, and preoperative need of inotropic agents or mechanical circulatory support.\n* Patient already receiving steroids","ALL","1 Month","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","The goal of this study is to evaluate the effects of steroids on the early postoperative inflammatory response in patients undergoing elective pediatric congenital cardiac surgery, requiring cardiopulmonary bypass (CPB).",[27,28],"Cyanotic Heart Disease","Cardiopulmonary Bypass",[30],"Paediatric population","RECRUITING","2024-07-30",{"date":34,"type":35},"2024-07-31","ACTUAL",{"date":37,"type":35},"2023-04-01",{"date":39,"type":21},"2025-06-30",{"name":41,"class":42},"Aga Khan University","OTHER"]