[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cytomegalovirus-prophylaxis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cytomegalovirus-prophylaxis":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100053802","phase-1-a-clinical-study-of-letermovir-mk-8228-in-children-and-adolescents-who-receive-a-kidney-transplant-kt-mk-8228-077-100053802",false,"NCT07199465","A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)","A Phase 1, Open-label, Single-arm Study to Evaluate the Pharmacokinetics and Safety of Letermovir in Pediatric Kidney Transplant (KT) Recipients Less Than 18 Years of Age and Weighing Less Than 40 Kilograms","Inclusion Criteria:\n\nThe main inclusion criteria include but are not limited to the following:\n\n* Is a recipient of a primary or secondary allograft kidney\n* Is at least 4 weeks posttransplant and not more than 52 weeks posttransplant at the time of enrollment (Day 1) and is being managed per local standard of care\n* Has stable kidney function posttransplant\n* Has undetectable CMV deoxyribonucleic acid (DNA) from a plasma or whole blood sample collected within 14 days prior to enrollment\n* Must be able to take (as assessed by the investigator) letermovir tablets or oral pellets by mouth, or via gastrostomy or nasogastric tube (oral pellets only)\n* Does not have a condition that may interfere with the absorption of oral medication (e.g., vomiting, diarrhea, or a malabsorptive condition) from the day of enrollment (Day 1) until the intensive pharmacokinetics (IPK) sampling is completed\n* Weighs ≥2.5 and \\\u003C40 kg at enrollment (Day 1)\n\nExclusion Criteria:\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Has CMV disease or suspected CMV disease between screening and enrollment\n* Is on dialysis or plasmapheresis at the time of enrollment\n* Has evidence of CMV viremia at any time from screening until the time of enrollment\n* Has Child-Pugh B or C hepatic insufficiency within 14 days before enrollment\n* Is a multi-organ transplant recipient (e.g., kidney-pancreas)\n* Has any uncontrolled infection on the day of enrollment\n* Requires mechanical ventilation, or is hemodynamically unstable, at the time of enrollment\n* Has received or is receiving protocol-specified prohibited medications","ALL","17 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"PHASE1","Researchers are looking for a way to prevent cytomegalovirus (CMV) in children and adolescents who receive a kidney transplant (KT) and weigh less than 40 kilograms (88.2 pounds). The goals of the study are to:\n\n* Learn what happens to letermovir in the body over time\n* Learn about the safety of letermovir and if participants tolerate it",[26],"Cytomegalovirus Prophylaxis","RECRUITING","2026-07-10",{"date":30,"type":31},"2026-07-13","ACTUAL",{"date":33,"type":31},"2026-03-30",{"date":35,"type":20},"2028-05-19",{"name":37,"class":38},"Merck Sharp & Dohme LLC","INDUSTRY",18,{"id":41,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":42,"targetDuration":4,"studyType":21,"phases":43,"briefSummary":24,"conditions":44,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":48,"completionDateStruct":49,"leadSponsor":50,"locationsCount":51},"100608277",{"count":19,"type":20},[23],[26],"2026-06-10",{"date":47,"type":31},"2026-06-12",{"date":33,"type":31},{"date":35,"type":20},{"name":37,"class":38},17]