[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"d-dimer\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:d-dimer":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,69,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100644557","superficial-vein-thrombosis-testing-in-the-emergency-department-100644557",false,"NCT07671300","Superficial Vein Thrombosis Testing in the Emergency Department","Evaluating Superficial Vein Thrombosis in the Emergency Department.","SVTest","Inclusion Criteria:\n\n* Aged ≥ 18\n* Tested for superficial vein thrombosis in the emergency department or urgent care centre\n* Patients tested for SVT at all sites, including arms, legs and torso\n\nExclusion Criteria:\n\n* Patient opted out of research at the participating site\n* Patient included in the study in the last 90 days","ALL","18 Years",{"count":20,"type":21},400,"ESTIMATED","OBSERVATIONAL","Superficial vein thrombosis (SVT) occurs when blood in a vein directly under the skin clots. SVT causes vein tenderness, pain, and skin discolouration. Over time, the vein hardens into a firm, nontender, easily palpable lump. SVT commonly occurs in the veins of the leg. Each year, 1 per 1000 people over the age of 18 have a superficial vein thrombosis (SVT). SVT is painful but usually gets better within a month. Four in 100 people with SVT develop progressively worse blood clotting involving the deep veins or lungs.\n\nIf a deep vein clot in the leg occurs it can cause permanent disability with post-thrombotic syndrome (long-term leg pain and swelling) and reduced quality of life. If a pulmonary embolism occurs it may causes chest pain, breathlessness, pulmonary hypertension, psychological distress, and potentially death.\n\nRisk factors for SVT include varicose veins, pregnancy, cancer, the use of intravenous catheters, a history of venous thromboembolism, age, and thrombophilia.\n\nGuidelines tell doctors to use ultrasound scanning to decide whether SVT needs treatment with a blood thinner or not. Blood thinners prevent the clot from worsening.\n\nMany people who have SVT go to the emergency department. Scanning is limited to the daytime so often people have multiple trips to the emergency department for their scan and they spend many hours waiting for a doctor to see them.\n\nOur research group developed simple ways to limit the need for scans for other types of blood clots, like blood clots in the lungs or in the deep veins. We use a simple blood test called D-dimer. We believe we may be able to use D-dimer to help limit the need for SVT scanning.\n\nThis is an exploratory study to document what happens to patients tested for SVT in the emergency department, and to see if the D-dimer blood test might be useful in reducing scans. We will review the emergency department charts for patients who came to the emergency department with SVT. Our results will tell us whether further studies would be helpful.",[25,26],"Superficial Vein Thrombosis","D-dimer",[26,28,29,30],"Superficial vein thrombosis","Emergency Medicine","diagnostic","NOT_YET_RECRUITING","2026-06-22",{"date":34,"type":35},"2026-06-26","ACTUAL",{"date":37,"type":21},"2026-07-15",{"date":39,"type":21},"2029-07",{"name":41,"class":42},"Dr. Kerstin de Wit","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":5},"100540699","emergency-medicine-pulmonary-embolism-testing-multicentre-study-100540699","NCT06320236","Emergency Medicine Pulmonary Embolism Testing Multicentre Study","EMPET","Inclusion Criteria:\n\n* Emergency department patient who is tested by an emergency physician for PE\n\nExclusion Criteria:\n\n* Patient is \\\u003C 18 years of age\n* No documentation of whether PE is the most likely diagnosis\n* D-dimer is not tested or else not resulted during the emergency visit\n* The D-dimer level is known before documentation of whether PE is the most likely diagnosis\n* The D-dimer is ordered prior to the physician assessing the patient\n* The patient has previously registered that they opt out of all research at the participating site\n* The patient leaves against medical advice\n* The patient has had PE or deep vein thrombosis imaging (CT pulmonary angiogram, ventilation-perfusion scan or lower limb ultrasound) within prior 30 days\n* There is a new (non-PE) indication for anticoagulation\n* The patient was initiated on treatment for presumed PE prior to PE testing\n* The patient has previously been enrolled into the study\n* The patient has a prior history of lower extremity deep vein thrombosis without availability of a baseline ultrasound scan\n* The patient was transferred from another hospital organization\n* The patient does not reside in Ontario\n* The patient has no valid Ontario Health Insurance Plan card",{"count":52,"type":21},4000,"It is important to diagnose pulmonary embolism in a timely manner to prevent death and long-term disability. More than half a million people (4-5% of emergency department patients) are tested for pulmonary embolism, although the positive rate is low. Imaging for PE testing exposes patients to radiation, is expensive, adds time to the emergency visit, and can lead to a false positive diagnoses. Existing protocols aimed at reducing unnecessary pulmonary embolism imaging are complex and seldom used by emergency physicians. Too many patients undergo unnecessary pulmonary embolism imaging.\n\nA new tool (called Adjust-Unlikely) could safely reduce pulmonary embolism imaging in Canada. A research group composed of researchers, emergency physicians, and patients developed the Adjust-Unlikely clinical decision rule: a rule which has been customized for emergency physicians and emergency patients. Adjust-Unlikely is highly sensitive at the bedside, meaning there are very few false negative results.\n\nThe study aim is to prospectively validate Adjust-Unlikely pulmonary embolism testing in emergency patients with suspected pulmonary embolism.",[55,26,56],"Pulmonary Embolism","Diagnosis",[26,55,58,59,29],"Adjust-Unlikely","Diagnostic","RECRUITING","2026-04-15",{"date":63,"type":35},"2026-04-20",{"date":65,"type":35},"2024-01-01",{"date":67,"type":21},"2027-09-30",{"name":41,"class":42},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":43},"100608282","association-between-plasma-d-dimer-in-adult-cap-and-severity-of-inflammatory-response-and-survival-100608282","NCT07199530","Association Between Plasma D Dimer in Adult CAP and Severity of Inflammatory Response and Survival","Association Between Elevated Plasma D-dimer in Adult Community-acquired Pneumonia Patients and Severity of Inflammatory Response and Survival","Inclusion Criteria:\n\n* Patients who will be admitted to the Chest department, or coming to the outpatient clinic at Ain-Shams University Hospitals with CAP, and have the following inclusions:\n\n  1. age ≥18 years\n  2. diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence.\n\nExclusion Criteria:\n\n* Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate.\n* patients who have any clinical or radiological signs suggesting COVID-19 pneumonia.",{"count":77,"type":21},50,"This observational study aims to investigate the association between elevated plasma D-dimer levels and the inflammatory response, as well as its impact on survival in adult patients with community-acquired pneumonia.\n\nthe study participants will be subjected to sampling for D-dimer and calculation of CURB-65 score. this aims to find the relation between them",[26],"2026-02-21",{"date":82,"type":35},"2026-02-24",{"date":84,"type":35},"2025-03-23",{"date":86,"type":21},"2026-04",{"name":88,"class":42},"Ain Shams University",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":98,"conditions":99,"keywords":105,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":119},"100523823","discovery-of-new-cancer-in-the-1-year-follow-up-after-ischemic-stroke-in-patients-at-risk-the-invisible-1-study-100523823","NCT06100718","Discovery of New Cancer in the 1-year Follow-up After Ischemic Stroke in Patients at Risk: The INVISIBLE-1 Study","INVISIBLE-1","Inclusion Criteria:\n\n* Informed consent as documented by signature from patient or next of kin\n* Age ≥ 18 years old\n* Acute ischemic stroke with symptom onset within 48 h before admission\n* Acute ischemic stroke with:\n\n  * persistent signs and symptoms of stroke lasting for ≥ 24 hours OR\n  * acute brain infarction documented by computer tomography (CT) or MRI\n* D-dimer ≥ 820 μg\u002FL measured after symptom-onset and within 24h after admission\n* Embolic stroke of unknown source (ESUS)\\* after initial work-up (acute cerebral imaging, 12-lead electrocardiogram, cardiac monitoring for at least 24h and echocardiography)\n\nExclusion Criteria:\n\n* Active cancer\\*\\* known at time of index-stroke\n* Intravenous Thrombolysis administrated prior to D-dimer measurement: Use of external laboratory value possible if available\n* New diagnosis of central nervous system cancer\n* Patient or next of kin (in case of lacking capacity) unlikely to be compliant or available for study follow-up interview\n\nESUS\\*: According to the definition from the NAVIGATE ESUS randomized trial: Non-lacunar ischemic stroke occurring in a patient in whom investigations did not show another specifically treatable underlying stroke etiology, primarily \\>50% stenosis in a proximal extracranial or intracranial artery, atrial fibrillation, other major-risk cardioembolic sources, or other determined etiology.\n\nActive Cancer\\*\\*: According to the definition from the International Society on Thrombosis and Haemostasis: Cancer diagnosed within the previous six months, recurrent, regionally advanced or metastatic cancer, cancer for which treatment had been administered within six months, or hematological malignancy that is not in complete remission for more than 5 years.\n\n► Patients with history of cancer not meeting these criteria anymore can be included in the study.",{"count":97,"type":21},370,"INVISIBLE-1 aims to prospectively follow patients up to one year after ischemic stroke to:\n\n1. Determine the cumulative incidence of occult cancer in patients with embolic stroke of undetermined source (ESUS) and elevated D-dimer\n2. Describe occult cancer characteristics and spontaneous course of occult cancer\n\nMethodology\n\nThe investigators will include 370 stroke patients with elevated D-dimer (≥ 820 μg\u002FL) at the time of stroke, suspicion of ESUS after initial workup and without known cancer. The investigators will perform a follow-up telephone interview at one year to assess the occurrence of a new cancer and characterize the course of the disease.\n\nSignificance\n\nDetermining the real incidence of occult cancer in high-risk patients will help support the implementation of screening trials in the future. Faster detection and treatment of occult cancers would significantly impact patient' outcomes by offering faster cancer treatment and optimal secondary stroke prevention.",[100,101,102,103,104,26],"Cancer-related Stroke","Paraneoplastic Coagulopathy","Occult Cancer","Ischemic Stroke","Embolic Stroke of Undetermined Source",[106,26,107,108,109],"Cancer-related stroke","ESUS","Occult cancer","Ischemic stroke","2024-12-09",{"date":112,"type":35},"2024-12-13",{"date":114,"type":35},"2022-01-01",{"date":116,"type":21},"2025-12-31",{"name":118,"class":42},"Insel Gruppe AG, University Hospital Bern",3]