[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"death-sudden-cardiac\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:death-sudden-cardiac":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,79,110],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100625380","pre-hospital-cooling-to-improve-cardiac-arrest-neurological-outcomes-precedence-100625380",false,"NCT07421882","PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)","PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE): a Pilot Feasibility Study","PRECEDENCE","Inclusion Criteria:\n\n1. Out-of-hospital cardiac arrest (OHCA) of any rhythm attended by Singapore Civil Defence Force (SCDF) paramedics.\n2. Return of spontaneous circulation (ROSC) achieved in the pre-hospital setting.\n3. Age ≥16 years and ≤80 years.\n4. Patient remains comatose after ROSC, with Glasgow Coma Scale (GCS) ≤8.\n\nExclusion Criteria:\n\n1. Age \\>80 years.\n2. Traumatic cause of cardiac arrest.\n3. Tympanic temperature \\\u003C34°C at time of assessment.\n4. Pregnant females.\n5. Termination of resuscitation in the Emergency Department.\n6. Withdrawal of life support within 24 hours of Coronary Care Unit (CCU) admission.","ALL","16 Years","80 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface cooling device (CarbonCool® vest) in adult out-of-hospital cardiac arrest (OHCA) patients with return of spontaneous circulation (ROSC). The study aims to assess feasibility, fidelity, acceptability, and safety of initiating cooling in the field by emergency medical services (EMS) prior to hospital arrival. Results will inform the design of a larger definitive trial to determine the clinical effectiveness of early pre-hospital TTM in improving neurological outcomes.",[28,29,30,31],"Out-Of-Hospital Cardiac Arrest","Cardiopulmonary Resuscitation","Death, Sudden, Cardiac","Therapeutic Hypothermia",[33],"Return of Spontaneous Circulation","RECRUITING","2026-04-23",{"date":37,"type":38},"2026-04-29","ACTUAL",{"date":40,"type":38},"2026-02-01",{"date":42,"type":22},"2027-03",{"name":44,"class":45},"Singapore General Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":59,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":46},"100633517","cardiac-magnetic-resonance-clinical-prediction-model-dilated-cardiomyopathy-100633517","NCT07527715","Cardiac Magnetic Resonance-Clinical Prediction Model-Dilated Cardiomyopathy","Study on Risk Early Warning of Clinical Prediction Model Based on Multi-Parameter Stress Perfusion Cardiac Magnetic Resonance in Adverse Prognosis of Dilated Cardiomyopathy","MPS-CMR-DCM","Inclusion Criteria\n\n1.An elevated left ventricular end-diastolic volume indexed to body surface area and reduced LVEF, compared with published age- and gender-specific reference values Exclusion Criteria\n\n1. significant coronary artery disease (CAD), defined as a stenosis of ˃50% in a major coronary artery\n2. infiltrative disease\n3. valvular cardiomyopathy\n4. arrhythmogenic cardiomyopathy\n5. congenital heart disease",true,"18 Years",{"count":58,"type":22},2000,"6 Months","OBSERVATIONAL","Dilated cardiomyopathy (DCM) is a common and serious heart disease characterized by left ventricular enlargement and impaired pumping function, with adverse prognosis (including heart failure, arrhythmia, heart-related hospitalization, and death) being a major concern for patients. Currently, a critical gap exists in accurately predicting which DCM patients are at high risk of these severe outcomes, limiting targeted clinical care.\n\nThis observational, non-invasive study aims to develop and validate a clinical prediction model for early risk warning of adverse prognosis in DCM patients. The model integrates multi-parameter stress perfusion cardiac magnetic resonance (MP stress perfusion CMR)-a safe, high-resolution imaging technique that assesses cardiac structure, function, blood perfusion, and tissue damage under mild stress-and standard clinical data (e.g., age, gender, blood pressure, and routine heart test results).\n\nThe model will be trained and tested using follow-up data from hundreds of DCM patients, with the analysis identifying patterns in CMR and clinical data associated with adverse outcomes. Once validated for accuracy, the model will provide doctors with personalized risk scores to prioritize care for high-risk patients (e.g., early intervention, close monitoring) and avoid over-treatment for lower-risk individuals.\n\nBeyond clinical application, the study will enhance understanding of DCM progression, laying the groundwork for improved diagnostic tools, more effective treatments, and better strategies to prevent DCM-related complications, ultimately improving patient quality of life and reducing mortality.",[63,64,65,30,66,67,68],"Cardiomyopathy, Dilated","Prognosis","Magnetic Resonance Imaging, Cardiac","Heart Failure","Risk Assessment","Stress Perfusion","2026-04-09",{"date":71,"type":38},"2026-04-14",{"date":73,"type":38},"2021-12-01",{"date":75,"type":22},"2038-12-01",{"name":77,"class":78},"Shandong Provincial Hospital","OTHER_GOV",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":90,"conditions":91,"keywords":95,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":5},"100112813","prospective-observational-study-of-the-icd-in-sudden-cardiac-death-prevention-100112813","NCT00733590","Prospective Observational Study of the ICD in Sudden Cardiac Death Prevention","Prospective Observational Study of the ICD in Sudden Cardiac Death Prevention (PROSe-ICD)","PROSe-ICD","Inclusion Criteria:\n\n* History of acute MI at least 4 weeks old\n* Non-ischemic LV dysfunction for at least 9 months\n* Who have an ejection fraction (EF) \\\u003C or = to 35%\n* Undergone elective replacement indicator (ERI) generator replacement of an FDA-approved ICD for primary prevention of SCD within 24 months of enrollment.\n* Who have primary prevention implants.\n\nExclusion Criteria:\n\n* ICD generator replacement for secondary prevention\n* Inability or unwillingness to provide valid informed consent\n* New York Heart Association Class IV heart failure\n* Patients with pre-existing Class 1 indications for pacemaker therapy.","85 Years",{"count":89,"type":22},1500,"The overall hypothesis of this study is that subtle interactions between structural (substrate) and functional (trigger) abnormalities of the heart, some of which are genetically-determined, can be used to identify patients at high risk of sudden cardiac death (SCD). Such information may be used to better define patients most likely to benefit from replacement of an internal defibrillator (ICD). The prospective, observational study to enroll, categorize and follow patients who receive an ICD pulse generator replacement for primary prevention of SCD (PROSe-ICD) was established to :\n\n1. to gain a better understanding of the biological mechanisms that predispose to SCD\n2. to develop readily determined clinical, electrocardiographic, genetic and blood protein markers identify patients with an increased risk of dying suddenly",[92,30,93,94],"Heart Failure, Congestive","Arrhythmia","Cardiomyopathies",[96,97,98,99,100],"defibrillator, implanted","genomics","electrocardiography","electrophysiological study","proteomics","2026-01-15",{"date":103,"type":38},"2026-01-20",{"date":105,"type":38},"2003-06",{"date":107,"type":22},"2029-03",{"name":109,"class":45},"Johns Hopkins University",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":121,"conditions":122,"keywords":126,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":46},"100555912","risk-of-sudden-cardiac-death-in-un-athletes-100555912","NCT06518252","Risk of Sudden Cardiac Death in UN Athletes","Detection of the Risk of Sudden Cardiac Death in Athletes From the Universidad Nacional de Colombia","Suddendeath","Inclusion Criteria:\n\n* Athletes belonging to the sports teams of the National University of Colombia, Bogotá campus.\n* Subject's sports history (practice time exceeding 2 years).\n* Individuals aged 18 to 35 years, without discrimination based on biological sex.\n* Training time exceeding 6 hours per week in their sports modality (weekly training record).\n* Personal history of cardiovascular disease (cardiac malformations or previously detected sudden death risk).\n* Athletes who attend at least 90% of the training sessions planned by the coach.\n\nExclusion Criteria:\n\n* Personal history of metabolic (type 1 and 2 diabetes mellitus), neurological (spinal cord injury), or renal disease.\n* Routine consumption of alcohol or psychoactive substances.\n* Use of antihypertensive medications, beta-blockers, or inotropes.\n* Cardiovascular disease diagnosed with previously established pharmacological management.","35 Years",{"count":120,"type":22},250,"The detection of sudden cardiac death risk in athletes is a topic of great relevance in the field of sports physiotherapy and physical activity. High-performance sports practice involves anatomical and physiological changes that can modify the mechanical and electrical properties of the heart, increasing the risk of potentially fatal cardiac events. Therefore, it is essential to implement early detection strategies to identify at-risk athletes and prevent tragedies during sports practice.\n\nMethodology: This study focuses on the prevalence of sudden cardiac death risk, using a 12-lead electrocardiogram as the primary detection tool. This examination will allow for the evaluation of the heart's electrical activity and the detection of potential anomalies that could predispose athletes to adverse cardiac events during sports practice. In addition to the electrocardiogram, cardiovascular screening questionnaires will be administered to collect information on personal and family health histories, as well as other relevant risk factors. In conjunction with the project's researchers, the sports medical team of the Universidad Nacional de Colombia will be responsible for conducting the evaluations, ensuring the precision and reliability of the obtained results. A detailed analysis of the collected data will be performed using statistical tools to identify possible correlations between the evaluated risk factors and the presence of sudden cardiac death risk in athletes. Logistic regression models will be employed to determine the strength of association between the studied variables and cardiovascular risk in this specific population.\n\nExpected Results: It is anticipated that implementing pre-participation evaluations, including the electrocardiogram and cardiovascular screening questionnaires, will enable the identification of athletes at higher risk of sudden cardiac death. These results will allow for the establishment of individualized risk profiles and the design of personalized prevention strategies for each athlete. Additionally, it is expected that the findings of this study will contribute to the development of early detection protocols for sudden cardiac death risk in athletes, which can be effectively implemented in sports settings. The information generated from this study will provide a solid foundation for clinical decision-making and the implementation of preventive measures to benefit the health and well-being of high-performance athletes.",[30,123,124,125],"Electrocardiogram QT Prolonged","Athlete Heart","Athletic Injuries",[127,128,129],"Sudden death of the athlete","Electrocardiogram","University sports.","2024-07-18",{"date":132,"type":38},"2024-07-24",{"date":134,"type":38},"2023-11-24",{"date":136,"type":22},"2025-06-25",{"name":138,"class":45},"Universidad Nacional de Colombia"]