[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"decompression-sickness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:decompression-sickness":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,66],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100564282","epidemiological-assessment-of-technical-diving-accidents-in-mainland-france-and-factors-predictive-of-severity-tekcare-100564282",false,"NCT06627153","Epidemiological Assessment of Technical Diving Accidents in Mainland France and Factors Predictive of Severity (TEKCare)","Epidemiological Assessment of Technical Diving Accidents in Mainland France and Factors Predictive of Severity","TEKCare","Inclusion Criteria:\n\n* Civilian technical diver\n* Diving accident history (decompression sickness, biochemical accident or immersion pulmonary edema) following a technical dive in a trimix and\u002For rebreather dive\n* Treated in a hyperbaric center on the coast of mainland France\n\nExclusion Criteria:\n\n* Participation denied by the diver\n* Diving incident diagnosis not retained by the hyperbaric physician","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","This retrospective study aims at an epidemiological description of the clinical presentation of medical problems in technical diving. It assess anthropometric data, diving experience and dive planification, clinical presentation, treatment received and pronostic to understand specificity of this community.",[25,26,27,28,29],"Decompression Sickness","Pulmonary Edema - Acute","Oxygen Toxicity","Carbon Dioxide Poisoning","Nitrogen Narcosis","NOT_YET_RECRUITING","2024-10-02",{"date":33,"type":34},"2024-10-04","ACTUAL",{"date":36,"type":21},"2025-01-01",{"date":38,"type":21},"2025-12-31",{"name":40,"class":41},"University Hospital, Brest","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":53,"conditions":54,"keywords":55,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":4},"100544592","prediction--mechanisms-of-recovery-following-ieds-100544592","NCT06370897","Prediction & Mechanisms of Recovery Following IEDS","A Prospective and Retrospective Observational Study of Symptoms and Mechanisms of Recovery in People With Inner Ear Decompression Sickness (IEDS)","Prospective Study :\n\nInclusion\n\n• Divers admitted with suspected IEDS\n\nExclusion\n\n* Medically unstable\n* Unstable orthopaedic deficits\n\nRetrospective study :\n\nInclusion\n\n• Divers diagnosed with IEDS at DDRC within past 10 years\n\nExclusion\n\n• We will include all co-morbidities as these could affect prognosis and recovery following IEDS.\n\nHealthy control comparator group :\n\nNormative data will be gathered on an age matched group. There will be at least 10 participants for each decade (\\\u003C30yrs ,30-40yrs, 40-50 yrs,50-60yrs,60-70 yr.)\n\nInclusion criteria:\n\n• Adults over 18 years\n\nExclusion criteria:\n\n• Neurological, sensory or orthopaedic conditions that could affect balance.","85 Years",{"count":52,"type":21},41,"Inner Ear Decompression sickness (IEDS) accounts for 20% of all types of decompression sickness (the bends) in divers. The condition commonly affects the peripheral vestibular system (inner ear). IEDS results in acute symptoms of dizzyness (vertigo) and imbalance. Even with the recommended treatment of hyperbaric oxygen therapy some people do not recovery fully. However, even in the presence of a permanent vestibular deficit many people can show a behavioural recovery where symptoms improve over time. Recovery can be aided by vestibular rehabilitation (VR) which is now routine for acute IEDS but was not provided before 2021, and is not widespread across the UK (United Kingdom) or world, meaning people may have a suboptimal recovery.\n\nThis project will investigate if and how people recover after an acute episode of IEDS and whether people who had IEDS in the past show changes in the central (brain) processing of vestibular function and in symptoms of dizziness, balance and posture.\n\nThis project has two main parts. Part one is a prospective observational study where people with an acute onset of IEDS are serially monitored while they are receiving hyperbaric treatment and VR over 10-14 days. Part two is a retrospective observational study where who have had IEDS in the past 15 years are re-assessed in a one-off session. The tests in both parts involve clinical tests and specialist eye movement recordings that assess vestibular function. We will also determine the site of any vestibular pathology by using selective stimulation of the vestibular end organ or nerve and assess whether there are any changes in how the structure and function of central vestibular pathways in the brain. In people with chronic IEDS with vestibular symptoms we will offer participants a course of VR over 12 weeks and assess whether this is associated with any improvement in symptoms.",[25],[56],"vestibular, inner ear","2024-05-09",{"date":59,"type":34},"2024-05-13",{"date":61,"type":21},"2024-06",{"date":63,"type":21},"2028-09",{"name":65,"class":41},"University of Plymouth",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":74,"targetDuration":4,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":42},"100423256","impact-of-hyperoxia-and-involvement-of-the-immune-system-in-diving-accident-100423256","NCT04791488","Impact of Hyperoxia and Involvement of the Immune System in Diving Accident","OXYDIVE","Inclusion Criteria:\n\n* Healthy subject with no contraindications to diving OR patient admitted to the hospital for suspicion of a diving accident OR patient admitted to the hospital for hyperbaric oxygen therapy\n\nExclusion Criteria:\n\n* Contraindication to diving or contraindication to hyperbaric oxygen therapy",true,{"count":75,"type":21},265,"INTERVENTIONAL",[78],"NA","The impact of oxygen therapy in many pathologies has been subject of recent work, arguing both favourable and harmful effects. Consequently, one can wonder about the influence of hyperoxic gas mixture during diving on the genesis of decompression sickness, but also about the systematic application of normobaric and hyperbaric oxygen in case of proven decompression sickness.\n\nIn mammals, normoxic concentrations have been redefined at 20-100 mbars at the extracellular level and below 10 mbars in the mitochondria.\n\nUnder hyperbaric conditions, most of the oxygen being dissolved in blood plasma, a state of hyperoxia is established which escapes the usual delivery and regulation system represented by red blood cells.\n\nThe results of our team's previous work suggest a specific effect of diving on the levels of circulating mitochondrial DNA (mtDNA), suggesting cellular destruction linked to hyperoxia\u002Fhyperbaria. In fact, our studies, carried out on both animals and human divers, have shown that diving accident leads to an increase in mtDNA levels and an immune reaction through the mobilisation of leukocytes.\n\nThe main objective of this study is to compare the influence of oxygen partial pressure levels on the evolution of clinical and biological variables during hyperbaric oxygen therapy sessions in healthy versus injured divers.",[25],"RECRUITING","2023-04-27",{"date":84,"type":34},"2023-04-28",{"date":86,"type":34},"2022-03-30",{"date":88,"type":21},"2028-03-30",{"name":90,"class":41},"Direction Centrale du Service de Santé des Armées"]