[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ded\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ded":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100636872","upper-punctal-plug-occlusion-in-previous-lower-punctal-occlusion-100636872",false,"NCT07571330","Upper Punctal Plug Occlusion in Previous Lower Punctal Occlusion.","Effectiveness of Upper Punctal Plug Occlusion in Patients With Dry Eye Disease With Previous Lower Punctal Occlusion.","Inclusion Criteria:\n\n* Patients of both sexes\n* One or both eyes may be included\n* Inferior lacrimal punctum occluded (with a punctal plug or cauterization), clinically sealed under slit-lamp examination\n* Functional superior lacrimal punctum\n* Aqueous-deficient dry eye (such as Sjögren's disease, graft-versus-host disease, or primary dry eye disease.)\n* Age \\>18 years\n* OSDI score \\>13 and one of the following signs: Tear film markers (Fluorescein tear break up-time \\\u003C5, First non-invasive tear breakup time \\\u003C10, Schirmer test without anesthesia \\\u003C10 mm, Schirmer test with anesthesia \\\u003C10 mm), Ocular surface markers (corneal staining \\>5 spots or conjunctival staining \\>9 spots).\n\nExclusion Criteria:\n\n* Active ocular surface infection.\n* Patients who are unwilling to participate or to provide written informed consent.","ALL","18 Years",{"count":19,"type":20},36,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study evaluates the therapeutic effect of upper punctal plug occlusion in patients with dry eye disease with previous lower punctal occlusion.",[26,27],"DED","Aqueous-deficient Dry Eye Disease",[29,26,30,31],"Aqueous-deficient dry eye disease","Punctual plug","Superior punctual plug","RECRUITING","2026-05-04",{"date":35,"type":36},"2026-05-06","ACTUAL",{"date":38,"type":36},"2026-02-12",{"date":40,"type":20},"2026-11-01",{"name":42,"class":43},"Universidad Autonoma de Nuevo Leon","OTHER"]