[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"deep-caries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:deep-caries":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,45,82,109,133,155,178,207],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100501997","the-prognostic-impact-of-symptoms-and-lesion-depth-in-partial-removal-of-carious-tissue-100501997",false,"NCT05816525","The Prognostic Impact of Symptoms and Lesion Depth in Partial Removal of Carious Tissue","Inclusion Criteria:\n\n* the patient is communicating in the Finnish or English language\n* a deep primary or secondary carious lesion in 1st or 2nd premolar or molar on occlusal or proximal surface, extending to the deepest quarter of dentine assessed from the radiograph\n* asymptomatic or symptoms not more severe than reversible pulpitis (mild pulpitis according to the new pulpitis classification proposal)\n* pulp responding to the electric pulp testing and cold testing\n* the periodontal stage of the tooth should be I or II.\n\nIn case the patient has several teeth fulfilling the inclusion criteria, the one with the deepest lesion and\u002For most severe symptoms is chosen to the study.\n\nExclusion Criteria:\n\n* general medical condition which makes the patient more susceptible to odontogenic infection complications\n* pregnancy, breastfeeding\n* mental retardation, memory disorder\n* the carious lesion is extending to more than three surfaces or to both proximal surfaces\n* the tooth has previous other filling(s): i) extending deeper than to the outer third of dentine; or ii) the filling is larger than Class I or II; or iii) Class II filling is not restricted to enamel; or iv) the filling has secondary\u002Fresidual caries\n* the tooth is not restorable\n* periapical changes in the periapical radiograph\n* sensitivity to percussion; swelling; sinus tract; increased mobility; resorption\n* furcal lesion more severe than Class I\n* ongoing orthodontic treatment\n* declining to sign the written consent.",true,"ALL","18 Years","50 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","The goal of this prospective, observational clinical cohort study is to study the effect of the preoperative condition of the tooth on the outcome of partial removal of carious tissue in mature teeth in adults. The main questions the study aims to answer are:\n\n* Do preoperative symptoms affect the outcome?\n* Does the depth of the carious lesion affect the outcome?\n\nOne hundred participants will be recruited. Patients who meet the eligibility criteria will be asked to give their informed consent to participate in the study. Partial carious tissue removal will be performed regardless of participation in the study because selective carious tissue removal is the standard treatment of choice for a vital tooth with a deep carious lesion according to the Finnish national treatment guidelines. Participants will be asked to fill in a questionnaire regarding symptoms 7 days post-treatment. The teeth will then be followed up for 12-24 months.\n\nThe null hypothesis is that there is no difference in the success between i) deep and extremely deep carious lesions and ii) initial and mild pulpitis.",[25,26,27],"Deep Caries","Pulpitis Reversible","Pulp Hyperemia",[29,30,31],"vital pulp therapy","deep carious lesion","selective carious tissue removal","RECRUITING","2026-04-17",{"date":35,"type":36},"2026-04-22","ACTUAL",{"date":38,"type":36},"2023-04-21",{"date":40,"type":21},"2027-12-31",{"name":42,"class":43},"University of Helsinki","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":66,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":44},"100568638","phase-4-comparison-between-egyptian-mta-biodentine-versus-calcium-hydroxide-as-indirect-pulp-capping-materials-in-permanent-teeth-100568638","NCT06683833","Comparison Between Egyptian MTA, Biodentine Versus Calcium Hydroxide as Indirect Pulp Capping Materials In Permanent Teeth","Comparative Analysis of Egyptian MTA, Biodentine, and Calcium Hydroxide as Indirect Pulp Capping Materials in Permanent Teeth. (A 6m Randomized Clinical Trial)","Inclusion Criteria:\n\n* Adult patients aged 22: 45 years old.\n* Males or females.\n* Patients with vital teeth with deep carious lesions.\n* Patients in good general health.\n* Good oral hygiene.\n* Co-operative patients who show interest to participate in the study.\n\nExclusion Criteria:\n\n* Patients with systemic diseases.\n* Patients with known allergic or adverse reaction to the tested materials.\n* Patients with bad oral hygiene.\n* Patient who frequently use analgesic or any drugs that could mask the pain.","22 Years","45 Years",{"count":55,"type":21},35,"INTERVENTIONAL",[58],"PHASE4","Compare the clinical performance and patient satisfaction of Egyptian MTA, Biodentine versus Calcium Hydroxide as indirect pulp capping materials in permanent teeth",[25,61,62,63,64,65],"Indirect Pulp Capping","Mineral Trioxide Aggregate (MTA)","Calcium Hydroxide","Biodentine","Patient Reported Outcome Measures",[67,68,69,70,64,71,72],"Deep caries","Indirect pulp capping","Mineral trioxide aggregate (MTA)","Calcium hydroxide","Patient reported outcomes measures (PROMS)","Randomized clinical trial","2026-03-17",{"date":75,"type":36},"2026-03-18",{"date":77,"type":36},"2025-09-03",{"date":79,"type":21},"2026-07-03",{"name":81,"class":43},"Cairo University",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":15,"sex":16,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":56,"phases":93,"briefSummary":95,"conditions":96,"keywords":97,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":44},"100538644","phase-2-clinical-and-radiographic-success-rate-of-pulpotomy-versus-pulpectomy-for-management-of-primary-teeth-with-deep-caries-100538644","NCT06293521","Clinical and Radiographic Success Rate of Pulpotomy Versus Pulpectomy for Management of Primary Teeth With Deep Caries","Clinical and Radiographic Success Rate of Pulpotomy Versus Pulpectomy for Management of Primary Teeth With Deep Caries: A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Aged 4 to 6 years , in good general health\n2. The parents provided written informed consent.\n3. Clinical characteristics, defined as spontaneous pain and the presence of a deep carious lesion with pulp exposure and bleeding that did not halt within five minutes following removal of the coronal pulp tissue.\n4. Restorable teeth.\n\nExclusion Criteria:\n\n1. Physical or mental disability.\n2. Unable to attend follow-up visits.\n3. Previously accessed teeth.\n4. Swelling, tenderness to percussion or palpation, or pathological mobility.\n5. Pre-operative radiographic pathology such as resorption (internal or external), per-radicular or furcation radiolucency.","4 Years","6 Years",{"count":92,"type":21},40,[94],"PHASE2","This trial aims to compare treatment outcomes between Pulpotomy and Pulpectomy in treating vital primary teeth diagnosed with deep caries with symptoms of irreversible pulpits",[25],[98,99,100],"Irreversible pulpits","Pulpotomy","Pulpectomy","2025-12-18",{"date":103,"type":36},"2025-12-24",{"date":105,"type":21},"2026-01-01",{"date":107,"type":21},"2026-04-01",{"name":81,"class":43},{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":56,"phases":119,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":4},"100595165","deep-caries-in-mature-teeth-with-reversible-pulpitis-100595165","NCT07028905","Deep Caries in Mature Teeth With Reversible Pulpitis","Clinical, Radiographical, and Histological Evaluation of Treatment Outcomes Following Different Caries Removal Strategies in Mature Permanent Teeth With Reversible Pulpitis (A Randomized Clinical Trial and Ex-vivo Study)","Inclusion Criteria:\n\n1. The patient's age from 18 years to 40 years old\n2. Non -contributory medical history (ASA1)\n3. Mature permanent posterior teeth with primary or secondary deep caries extending ≥ 2\u002F3 of dentin\n4. The tooth should give a positive response to cold testing\n5. Clinical diagnosis of reversible pulpitis\n6. The tooth is restorable via direct restoration, probing pocket depth and mobility are within normal limits\n7. No signs of pulpal necrosis including sinus tract or swelling\n8. No radiographic evidence of periapical changes indicative of apical periodontitis\n\nExclusion Criteria:\n\n* Systemic medical conditions, pregnancy, alcoholic and smoker patients. 2- Teeth with spontaneous pain or percussion sensitivity in periodontal lesions, external or internal root resorption, sinus opening, mobility, or abscessed tooth. 3- Radiographic evidence of widened periodontal space, broken or interrupted lamina dura, and periapical radiolucency. 4- Intensified erosion damage or periodontitis. Patient reported clenching or bruxism, hopeless or non-restorable teeth. Immature teeth. 5- Patients with physical disabilities preventing tooth brushing. Patient had removable partial denture abutments, dental abscesses, pulp lesions, atypical facial pain, or pulpitis. 6- Patients had non-carious lesions like abrasion, erosion, attrition, or abfraction.\n\n  7- Patients with history of antibiotic or analgesics intake within few days of operative intervention. 8- Patients with previously root canal-treated teeth. 9- Periodontally compromised teeth. 10-Teeth that will be extracted for periodontal or orthodontic reasons as it will conduct for histological evaluation","40 Years",{"count":118,"type":21},144,[120],"NA","This clinical trial will be conducted to clinical, radiographical and histological evaluation of pulp condition with reversible pulpities after total and selective removal of primary and secondary caries (randomized clinical trial and exo-vivo study)",[25],"NOT_YET_RECRUITING","2025-09-22",{"date":126,"type":36},"2025-09-26",{"date":128,"type":21},"2025-10-20",{"date":130,"type":21},"2026-12-01",{"name":132,"class":43},"Minia University",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":16,"minAge":140,"maxAge":18,"enrollmentInfo":141,"targetDuration":4,"studyType":56,"phases":143,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":153,"locationsCount":4},"100583900","performance-of-bioactive-low-viscosity-composite-in-deep-marginal-elevation-restorations-100583900","NCT06882343","Performance of Bioactive Low Viscosity Composite in Deep Marginal Elevation Restorations","Performance of Bioactive Low Viscosity Composite in Deep Marginal Elevation Restorations: a Randomized Clinical Trial","Inclusion Criteria:\n\n* Adults patients (20-50)\n* Good oral hygiene (plaque index 0 or 1 )\n* Patient approving to participate in the study\n* Absence of parafunctional habits and\u002For bruxism\n\nExclusion Criteria:\n\n* Patients with known allergic or adverse reaction to the tested materials.\n* Systematic disease that may affect participation.\n* Xerostomic patients.\n* Bad oral hygiene (plaque index 2 or 3 )\n* Heavy smokers\n* Patients undergoing or will start orthodontic treatment\n* Patients with removable prothesis","20 Years",{"count":142,"type":21},50,[120],"The goal of this study is to evaluate the clinical, radiographic and periodontal performance of bioactive Giomer Shofu Flow Plus X F03 compared to nanohybrid resin composite restoration in deep subgingival proximal cavities over a period of 12 months.",[25,146],"Caries, Dental","2025-03-18",{"date":149,"type":36},"2025-03-21",{"date":151,"type":21},"2025-04-01",{"date":107,"type":21},{"name":154,"class":43},"Future University in Egypt",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":15,"sex":16,"minAge":140,"maxAge":18,"enrollmentInfo":162,"targetDuration":4,"studyType":56,"phases":163,"briefSummary":164,"conditions":165,"keywords":167,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":4},"100554295","evaluation-of-bioactive-giomer-material-versus-nanohybrid-resin-composite-in-deep-marginal-elevation-100554295","NCT06497231","Evaluation of Bioactive Giomer Material Versus Nanohybrid Resin Composite in Deep Marginal Elevation","Clinical and Periodontal Evaluation of Deep Marginal Elevation for Proximal Carious Lesions Restored with Bioactive Giomer Versus Nanohybrid Resin Composite: Two Years Randomized Trial","Inclusion Criteria:\n\n1. Young and middle aged patients (20-50)\n2. Good or moderate oral hygiene (plaque index 0 or 1 )\n3. Patient approval\n4. Absence of parafunctional habits and\u002For bruxism\n\nExclusion Criteria:\n\n1. Patients with known allergic or adverse reaction to the tested materials.\n2. Systematic disease that may affect participation.\n3. Xerostomic patients.\n4. Patients with active periodontal disease.\n5. Heavy smokers",{"count":142,"type":21},[120],"This study will be conducted to evaluate the clinical, radiographic and periodontal performance of bioactive Giomer compared to nanohybrid resin composite restoration in deep subgingival proximal cavities extending below the CEJ over a period of 24 months.",[25,166],"Dental Caries",[168,169],"Deep marginal elevation","Giomer","2024-11-24",{"date":172,"type":36},"2024-11-27",{"date":174,"type":21},"2024-12-01",{"date":176,"type":21},"2027-01-01",{"name":81,"class":43},{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":184,"eligibilityCriteria":185,"healthyVolunteers":15,"sex":16,"minAge":90,"maxAge":186,"enrollmentInfo":187,"targetDuration":4,"studyType":56,"phases":188,"briefSummary":190,"conditions":191,"keywords":192,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":44},"100532977","phase-3-clinical-and-radiographic-evaluation-of-bioceramic-putty-mta-versus-mta-in-pulpotomy-of-immature-permanent-molars-100532977","NCT06219824","Clinical and Radiographic Evaluation of Bioceramic Putty MTA Versus MTA in Pulpotomy of Immature Permanent Molars","Clinical and Radiographic Evaluation of Bioceramic Putty Mineral Trioxide Aggregate Versus Mineral Trioxide Aggregate in Pulpotomy of Immature Permanent Molars: A Randomized Clinical Trial","MTA","Inclusion Criteria:\n\n* Patients aged from 6-8 years of both sexes have immature permanent molars\n* with deep carious lesions indicated for pulpotomy.\n* Restorable young permanent molars with no clinical symptoms of irreversible pulpitis.\n* Permanent molars without any clinical sign of pulp necrosis including swelling, fistula, pain on percussion, and pathologic tooth mobility.\n* Permanent molars without any adverse radiographic findings including thickening of the periodontal ligament space, radiolucency at the interradicular or periapical regions\n* permanent molars without internal and external root resorption, or calcification in pulp tissue.\n\nExclusion Criteria:\n\n* Medically compromised patients who have systemic disease.\n* Uncooperative patients who refuse treatment.\n* Permanent molars that were previously restored.","8 Years",{"count":92,"type":21},[189],"PHASE3","The present study aims to evaluate the clinical and radiographic success of bioceramics putty MTA versus MTA in the pulpotomy of immature permanent molars\n\nThe main question it aims to answer is:\n\nWill the biocermaics putty MTA have higher clinical and radiographic success rates than MTA in pulpotomy of immature permanent molars?",[99,25],[193,194,195,29,196,197,198],"Immature permanent molars,","young permenent molars","pulpotomy","deep caries","Putty MTA","bioceramic MTA","2024-07-22",{"date":201,"type":36},"2024-07-23",{"date":203,"type":21},"2024-11-01",{"date":205,"type":21},"2025-11-30",{"name":81,"class":43},{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":215,"targetDuration":4,"studyType":56,"phases":217,"briefSummary":218,"conditions":219,"keywords":4,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":4},"100545201","outcome-of-selective--nonselective-caries-removal-in-permanent-teeth-100545201","NCT06378814","Outcome of Selective & Nonselective Caries Removal in Permanent Teeth","Randomized Clinical Trial of Treatment Outcomes of Selective Versus Nonselective Caries Removal in Deep Carious Lesions in Permanent Teeth.","RCT-SNCR","Inclusion Criteria:\n\n1. Dental patients from routine dental care at ADC (Acute Dental Care) clinics, both undergraduate and postgraduate dental clinics in Guy's Hospital.\n2. Both male and female individuals aged 18 years and older.\n3. Capable of providing informed consent.\n4. Generally, in good overall health from a medical standpoint.\n5. Possess at least one molar or premolar tooth exhibiting a clinically significant deep carious lesion, with or without carious pulp exposure.\n6. Displaying signs and symptoms indicative of a normal pulp or reversible pulpitis.\n7. positive response to the cold test (refrigerated gas).\n8. Absence of spontaneous pain.\n9. Absence of periapical lesions, as determined by routine radiographic examination\n\nExclusion Criteria:\n\n1. Presence of fistulas or swelling.\n2. Involvement of anterior teeth.\n3. Evidence of external or internal root resorption.\n4. Multiple teeth with carious lesions within the same quadrant.\n5. Pregnancy in women.\n6. Patients under the age of 18.\n7. Individuals unable to provide informed consent.\n8. Patients who have received antibiotics in the preceding month.\n9. Immunocompromised patients.\n10. Teeth with tooth surface loss resulting from traumatic parafunctional habits or teeth displaying craze lines.\n11. Caries located beneath the gingival margin .\n12. Teeth affected by periodontal issues, characterized by bone loss or severe gingival recession.\n13. Teeth with pulp exposure where operators cannot achieve hemostasis after applying a cotton pellet soaked with 2.5% sodium hypochlorite (NaOCl) for three cycles, with each cycle consisting of a 2-minute application of NaOCl.\n14. People with difficulty to understand the clinical trial concept, procedure and details including language barrier.\n15. participants who are involved in other research at the same period of our study.",{"count":216,"type":21},168,[120],"Patients presenting with deep decay within permanent teeth presents a common clinical challenge to dentists. The aim of this trial is to compare the success rate of the non-selective caries removal (NSCR) and selective caries removal (SCR) in managing deep caries, as both methods are commonly used in clinical practice.\n\nThis study will be a randomized controlled trial, with participants divided into two groups: NSCR group and SCR group. Participants of deep caries lesions (reaching more than two-thirds of dentin on periapical radiographs) Both groups will undergo either NSCR or SCR, followed by Partial Pulpotomy (PP) in cases with pulp exposure. Success rates will be assessed at follow-up visits scheduled 1, 3, and 5 years radiographs will be used to assess for pulp health(vitality).\n\nThe success rate of the two categories will be assessed using a scale that includes factors such as tooth vitality, caries recurrence, and clinical signs of pulpitis. The scale will be applied at follow-up visits. The trial will be conducted in post-graduate dental clinics at Guy's hospital.\n\nDeep caries in permanent teeth is a common clinical problem that can lead to pulp exposure and subsequent restorative challenges. The aim of this study is to provide evidence-based guidance for clinicians in managing deep caries lesions, as both NSCR and SCR are commonly used in clinical practice. The results of this study will help clinicians to make informed decisions when choosing the appropriate treatment approach for their patients.\n\nIn conclusion, this trial aims to compare the success rate of NSCR and SCR in managing deep caries lesions in permanent teeth, as both methods are commonly used in clinical practice. The results of this study will provide valuable insights into the effectiveness of these two treatment approaches and will help clinicians to make informed decisions when choosing the appropriate treatment approaches.",[25,220],"Carious Exposure of Pulp","2024-04-25",{"date":223,"type":36},"2024-04-29",{"date":225,"type":21},"2024-05-01",{"date":227,"type":21},"2030-04-30",{"name":229,"class":43},"King's College London"]