[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"deep-carious-lesions\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:deep-carious-lesions":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,80,119],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100616194","comparative-evaluation-of-calcium-silicate-doped-treated-dentin-matrix-and-mineral-trioxide-aggregate-as-miniature-pulpotomy-biomaterials-in-deep-carious-lesions-100616194",false,"NCT07302438","Comparative Evaluation of Calcium Silicate-doped Treated Dentin Matrix and Mineral Trioxide Aggregate as Miniature Pulpotomy Biomaterials in Deep Carious Lesions","Comparative Evaluation of Calcium Silicate-doped Treated Dentin Matrix and Mineral Trioxide Aggregate as Miniature Pulpotomy Biomaterials in Deep Carious Lesions: a Parallel, Double-blind, Randomised Clinical Trial","hTDM","Inclusion Criteria:\n\n* The healthy participants (ASA 1 and 2), between ages 14 - 35 years, reporting to AIIMS Nagpur from within a 100 kms radius with carious pulp exposure in mature permanent teeth and with the following clinical and radiographic features will be included in the study:\n\nI. Clinical features\n\n1. The clinical diagnosis of reversible pulpitis characterized by mild pain (on Numerical Rating Scale 11) that goes away within a couple of seconds following the removal of the stimulus (113)\n2. Positive response to pulp sensibility tests.\n\nII. Radiographic features\n\n1. Normal periapical tissues \\[Periapical index (PAI) score ≤2\\](114)\n2. The presence of carious lesion with radiolucency penetrating three-fourths (deep caries) or the entire (extremely deep caries) dentin thickness\n\nExclusion Criteria:\n\n* The patients with the following clinical and radiographic features will be excluded from the study:\n\nI. Clinical features\n\n1. A history of spontaneous unprovoked toothache, pain on percussion, a sinus tract, compromised periodontal status (periodontal pockets \\> 4mm), excessive mobility, crack\n2. Profuse hemorrhage from exposure site (\\>5 minutes)\n3. The presence of serous or purulent exudates from the exposure site.\n4. Teeth that have experienced traumatic occlusion, non-carious lesions, developmental defects etc.\n\nII. Radiographic features\n\n1. The evidence of internal or external resorption, or the calcification of the pulp chamber or canals or presence of condensing osteitis.\n2. The presence of radiolucency in the furcation or periapical regions.",true,"ALL","14 Years","35 Years",{"count":22,"type":23},56,"ESTIMATED","INTERVENTIONAL",[26],"NA","AIM:\n\nTo compare the efficacy of a Novel calcium silicate doped treated dentin matrix and Mineral Trioxide aggregate as biomaterials for miniature pulpotomy.\n\nOBJECTIVES:\n\nPrimary objective:\n\nTo evaluate the efficacy of calcium silicate-doped human-treated dentin matrix (CaSi+hTDM) compared to Mineral Trioxide Aggregate (MTA) in maintaining pulp vitality using cold testing following Miniature Pulpotomy (MP) in deep and extremely deep carious lesions with reversible pulpitis in 14- to 35-year-old patients reporting to Department of Dentistry, AIIMS Nagpur.\n\nSecondary objectives:\n\n1. To evaluate patient-reported outcomes such as pain, swelling, sinus tract etc. post-operatively.\n2. To determine the clinical success rates of both materials by assessing the Periapical index of healing over a 6 months follow-up period.\n\nNULL HYPOTHESIS:\n\nThe null hypothesis (H0) is that there is no difference between CaSi+hTDM and MTA in maintaining pulp vitality when used as a Miniature Pulpotomy (MP) biomaterial in carious lesions.",[29,30],"Reversible Pulpitis","Deep Carious Lesions",[32,33,34],"Human treated dentin matrix","Mineral Trioxide Aggregate","Calcium silicate","NOT_YET_RECRUITING","2026-03-08",{"date":38,"type":39},"2026-03-10","ACTUAL",{"date":41,"type":23},"2026-04-25",{"date":43,"type":23},"2027-04",{"name":45,"class":46},"All India Institute of Medical Sciences","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":18,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100606147","this-study-aims-to-clinically-assess-and-radiographically-measure-the-formed-dentin-bridge-over-the-pulp-utilizing-three-dimensional-imaging-following-the-application-of-a-bioactive-restorative-system-versus-a-conventional-restorative-system-after-selective-caries-removal-to-soft-dentin-over-2-100606147","NCT07171775","This Study Aims to Clinically Assess and Radiographically Measure the Formed Dentin Bridge Over the Pulp, Utilizing Three-dimensional Imaging Following the Application of a Bioactive Restorative System Versus a Conventional Restorative System After Selective Caries Removal to Soft Dentin Over 2","Clinical and Three-Dimensional Radiographic Assessment of Bioactive Restorative System Following Selective Caries Removal of Deep Lesions: A Two-Year Randomized Controlled Trial","Inclusion Criteria:\n\nPatient-related criteria:\n\n1. Adult patients (age: 18-40 years) of both genders.\n2. Good oral hygiene.\n3. Willing to sign the informed consent.\n4. Cooperative patients who accept the follow-up period.\n\nTooth-related criteria:\n\n1. Posterior permanent caries (ICDAS 5-6).\n2. Radiographically, caries is extending 50% of dentine with a radiopaque layer between the carious lesion and the pulp chamber.\n3. Sensitive teeth according to the cold pulp test.\n4. Negative response in percussion test.\n\nExclusion Criteria:\n\nPatient-related criteria:\n\n1. Allergy to any of the restorative materials.\n2. Patients undergoing orthodontic treatment with fixed appliances.\n3. Pregnant women.\n4. Patients with debilitating systemic diseases.\n5. Patient who frequently uses analgesics or any drugs that could mask the pain.\n\nTooth-related criteria:\n\n1. Teeth with previous restorations.\n2. Spontaneous pain or prolonged pain (more than 15 s) after the sensitivity test (cold test), which would indicate irreversible pulpitis.\n3. Negative sensibility tests, periapical radiolucency, and sensitivity to axial or lateral percussion.\n4. Mobile teeth, indicating periodontal disease or trauma.\n5. External or internal resorption.\n6. Chipped teeth or Cuspal loss","18 Years","40 Years",{"count":58,"type":23},66,[26],"This clinical trial aims to evaluate dentin bridge formation over the pulp following selective caries removal in permanent teeth with deep carious lesions (ICDAS scores 5-6). A total of 66 patients will be enrolled and randomly allocated to receive either a bioactive restorative system (bioactive universal adhesive combined with a bioactive bulk-fill resin composite) or a conventional non-bioactive restorative system. Clinical assessments, including pulp sensibility testing and patient-reported pain evaluation, together with three-dimensional radiographic analysis using cone beam computed tomography, will be conducted to assess the thickness and quality of reparative dentin bridge formation. Outcomes will be evaluated at baseline and during follow-up periods extending up to 24 months to compare the effectiveness of both restorative approaches in preserving pulp sensibility and promoting dentin-pulp complex repair.",[30,62,63],"Partial Caries Removal","Dentin Bridge",[65,66,67,68,69,70],"deep caries","partial caries removal","selective caries removal","dentin bridge","Bioactive","universal adhesive","2026-01-17",{"date":73,"type":39},"2026-01-21",{"date":75,"type":23},"2026-06-01",{"date":77,"type":23},"2028-06-01",{"name":79,"class":46},"Cairo University",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":18,"minAge":86,"maxAge":56,"enrollmentInfo":87,"targetDuration":4,"studyType":24,"phases":89,"briefSummary":91,"conditions":92,"keywords":102,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},"100584440","phase-2-clinical-and-radiographic-evaluation-of-indirect-pulp-capping-using-platelet-rich-fibrin-versus-mineral-trioxide-aggregate-in-deep-carious-molars-a-randomized-controlled-trial-100584440","NCT06889363","Clinical and Radiographic Evaluation of Indirect Pulp Capping Using Platelet Rich Fibrin Versus Mineral Trioxide Aggregate in Deep Carious Molars: a Randomized Controlled Trial","Inclusion Criteria:\n\n* o Patients with asymptomatic deep carious molars.\n\n  * Patients with clinically and radiographically confirmed deep carious lesions that do not exhibit spontaneous pain.\n  * Permanent molars only.\n  * Teeth with intact or minimally restored occlusal surfaces (i.e., no extensive restorations or fractures).\n  * No history of previous endodontic treatment or direct pulp capping on the study tooth.\n  * No signs of periapical pathology based on radiographic evaluation.\n  * Patients willing to participate and follow up for 12 months.\n  * Patients who agree to return for scheduled follow-ups at 3, 6, and 12 months.\n\nExclusion Criteria:\n\n* o Patients with systemic conditions affecting bone or tissue healing (e.g., uncontrolled diabetes, osteoporosis, immunosuppressed conditions).\n\n  * Pregnant or lactating women (if applicable to your study).\n  * Teeth with pulp exposure or necrotic pulp.\n  * Presence of symptomatic irreversible pulpitis (e.g., spontaneous pain, lingering pain).\n  * Periapical pathology or internal\u002Fexternal resorption detected radiographically.\n  * Severely broken down or non-restorable teeth.\n  * Calcified root canals or excessive sclerosis that could affect pulp testing reliability.\n  * Any pre-existing root canal treatment on the selected tooth.\n  * Patients who have undergone recent fluoride treatment, pulpotomy, or other pulp therapies in the past 6 months.\n  * Patients using medications affecting bone and tissue regeneration (e.g., bisphosphonates, corticosteroids).\n  * Patients unwilling or unable to commit to the 12-month follow-up schedule.\n  * Patients with poor oral hygiene or high caries risk that could compromise treatment outcomes.","20 Years",{"count":88,"type":23},50,[90],"PHASE2","The aim of this study is the clinical and radiographic evaluation of (Platelet-Rich Fibrin (PRF) versus Mineral Trioxide Aggregate (MTA) in indirect pulp capping when used with deep carious molars over 1 year follow up.",[93,94,95,96,97,98,99,30,100,101],"Dental Caries","Pulp Caping","Indirect Pulp Treatment","Indirect Pulp Cap","Indirect Pulp Capping","Indirect Pulp Therapy","Deep Carious Lesion","Molar Caries","Carious Molars",[103,104,105,106,107,108,109],"Molar caries","MTA","PRF","Indirect pulp capping","Deep carious lesion","carious molars","platelet rich fibrin","2025-03-17",{"date":112,"type":39},"2025-03-21",{"date":114,"type":23},"2025-06",{"date":116,"type":23},"2026-09",{"name":79,"class":46},1,{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":17,"sex":18,"minAge":127,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":24,"phases":131,"briefSummary":132,"conditions":133,"keywords":134,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":4},"100576072","clinical-performance-of-resin-composite-restoration-after-dentin-biomodification-by-grape-seed-extract-in-deep-carious-lesions-100576072","NCT06780527","Clinical Performance of Resin Composite Restoration After Dentin Biomodification by Grape Seed Extract in Deep Carious Lesions.","Clinical Performance and Radiographic Assessment of Resin Composite Restoration After Dentin Biomodification by Grape Seed Extract in Vital Teeth With Deep Occlusal Carious Lesions. \"18-M Randomized Clinical Trial\"","GSE","Inclusion Criteria:\n\n* Patient-related criteria:\n\n  1. Adult patients (age: 22-42 years) of both genders.\n  2. Good oral hygiene.\n  3. Willing to sign the informed consent.\n  4. Co-operative patients who accept the follow-up period.\n* Tooth-related criteria:\n\n  1. Posterior permanent caries (ICDAS 5\\&6).\n  2. Radiographically, caries is extending 50% of dentine with a radiopaque layer between the carious lesion and the pulp chamber.\n  3. Sensible teeth according to cold pulp test.\n  4. Negative response in percussion test.\n\nExclusion Criteria:\n\n* Patient-related criteria:\n\n  1. Allergy to any of the restorative materials.\n  2. Patients undergoing orthodontic treatment with fixed appliances.\n  3. Pregnant women.\n  4. Patients with debilitating systemic diseases.\n  5. Patient who frequently use analgesic or any drugs that could mask the pain.\n* Tooth-related criteria:\n\n  1. Teeth with previous restorations.\n  2. Spontaneous pain or prolonged pain (more than 15 s) after sensitivity test (cold test), which would indicate irreversible pulpitis.\n  3. Negative sensibility tests, periapical radiolucencies and sensitivity to axial or lateral percussion.\n  4. Mobile teeth, indicating periodontal disease or trauma.\n  5. External or internal resorption.\n  6. Chipped teeth or Cuspal loss","22 Years","42 Years",{"count":130,"type":23},60,[26],"This study will evaluate the clinical and radiographic performance of resin composite restoration after utilized a grape seed extract as dentin biomodification in vital teeth with deep occlusal carious lesions (ICDAS 5-6) after selective soft dentin removal technique.",[30],[135],"Deep caries, Partial caries removal, Grape seed extract,","2025-01-13",{"date":138,"type":39},"2025-01-17",{"date":140,"type":23},"2025-06-01",{"date":142,"type":23},"2027-03-01",{"name":79,"class":46}]