[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"deep-endometriosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:deep-endometriosis":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,45,72,94,123,148,174,200,227],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100622654","the-association-between-deep-endometriosis-and-the-occurrence-of-colorectal-carcinoma-100622654",false,"NCT07386431","The Association Between Deep Endometriosis and the Occurrence of Colorectal Carcinoma","Inclusion Criteria:\n\nFemale patients aged 18 and over, treated at the Department of Reproduction for diagnosed deep endometriosis, including bowel endometriosis, for whom surgical treatment is indicated.\n\nExclusion Criteria:\n\n* Patients with known inflammatory bowel disease (IBD), patients with a personal history of gynecological or gastrointestinal malignancy","FEMALE","18 Years",{"count":18,"type":19},30,"ESTIMATED","OBSERVATIONAL","The goal of this study is to identify the molecular or genetic mechanisms that may predispose patients with bowel endometriosis to an increased risk of colorectal carcinoma. The study will include patients for whom surgical treatment of bowel endometriosis is clinically indicated.\n\nThis research would represent a significant advancement in evaluating the necessity of surgical intervention in asymptomatic patients or those with mild symptoms. Furthermore, it would provide a broader insight into the systemic impact of endometriosis on other organ systems, ultimately improving risk assessment and preventive measures.",[23,24,25,26,27,28,29,30,31,32],"Endometriosis","Deep Endometriosis","Bowel Endometriosis","Colorectal Carcinoma","Colon Resection","Endometriosis Pelvic","Endometriosis Rectum","Carcinogenesis","Genetic Change","Infertility","NOT_YET_RECRUITING","2026-02-05",{"date":36,"type":37},"2026-02-06","ACTUAL",{"date":39,"type":19},"2026-02",{"date":41,"type":19},"2029-05",{"name":43,"class":44},"University Medical Centre Ljubljana","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":52,"targetDuration":54,"studyType":20,"phases":4,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100611669","cohort-of-the-franco-european-multidisciplinary-institute-of-endometriosis-100611669","NCT07243587","Cohort of the Franco-European Multidisciplinary Institute of Endometriosis","IFEMEndo","Inclusion Criteria:\n\n* Women aged \\>18 years\n* Women with histologically or radiologically confirmed deep endometriosis (and\u002For) infiltrating the colon and\u002For rectum\n* Women affiliated with the social security system\n\nExclusion Criteria:\n\n* Refusal to participate\n* Patients under guardianship or curatorship, or deprived of liberty",{"count":53,"type":19},15000,"10 Years","Endometriosis is a chronic benign gynecological condition affecting 5 to 10% of women of reproductive age, often responsible for pelvic pain, digestive symptoms, and infertility, leading to a significant reduction in quality of life. Despite its high prevalence, the long-term outcomes of different medical and surgical treatments remain poorly documented.\n\nThe IFEMENDO study is a prospective, observational, single-center, non-interventional cohort conducted at the Endometriosis Center of Clinique Tivoli-Ducos in Bordeaux, France. The objective is to evaluate the long-term efficacy of various therapeutic strategies-both medical and surgical-in terms of symptom improvement, quality of life, recurrence, and fertility outcomes.\n\nWomen with histologically or radiologically confirmed pelvic endometriosis are invited to participate. Data are collected through standardized questionnaires at baseline and at 1, 3, 5, 7, and 10 years after inclusion, either via the secure NO ENDO online platform or in paper form. The study will contribute to a better understanding of the natural history of endometriosis and the long-term effectiveness of different treatment approaches, ultimately supporting improvements in clinical management and patient care.",[23,24,57],"Pelvic Pain",[59,60],"cohort","prospective","RECRUITING","2025-11-17",{"date":64,"type":37},"2025-11-24",{"date":66,"type":37},"2021-02-01",{"date":68,"type":19},"2036-02",{"name":70,"class":44},"Clinique Tivoli Ducos",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":71},"100581587","ureteric-identification-using-indocyanine-green-dye-versus-conventional-ureteric-stenting-to-reduce-post-operative-pain-and-surgical-morbidity-during-endometriosis-surgery-100581587","NCT06852248","Ureteric Identification Using Indocyanine Green Dye Versus Conventional Ureteric Stenting to Reduce Post-operative Pain and Surgical Morbidity During Endometriosis Surgery","Ureteric Identification Using Indocyanine Green Dye Versus Conventional Ureteric Stenting to Reduce Post-operative Pain and Surgical Morbidity During Endometriosis Surgery: A Pilot Trial (ICE Trial)","ICE","Inclusion Criteria:\n\n* Women aged 18 to 50 years\n* Scheduled for laparoscopic or robotic-assisted surgical excision of deep endometriosis (DE) where ureteric stenting is planned.\n* Willing and able to provide consent for participation in the study\n\nExclusion Criteria:\n\n* Confirmed or suspected pregnancy at the time of enrolment.\n* Suspicion or confirmation of malignancy.\n* History of ureteric injury from prior surgery or trauma\n* Medically unfit for surgery due to the following conditions:\n\n  * Uncontrolled diabetes mellitus.\n  * Severe Chronic Obstructive Pulmonary Disease (COPD).\n  * Hypertrophic cardiomyopathy or significant cardiac conditions (e.g., recent myocardial infarction, aortic stenosis).\n  * History of stroke or severe kyphoscoliosis.\n  * Uncontrolled hypertension.\n* Body mass index (BMI): BMI greater than 45","50 Years",{"count":82,"type":19},70,"Endometriosis is a common (around 1 in 10 women), non-cancerous condition where tissue similar to the womb lining is found growing elsewhere, most commonly inside the pelvis. Symptoms vary but can include intense pelvic pain and infertility.\n\nEndometriosis that is very deep and painful may need surgery, which risks damage to the tubes that drain urine from the kidneys to the bladder (ureters). To reduce this risk, surgeons may put tiny plastic tubes called \"stents\" inside the ureters. These stents can stay for up-to 4 weeks following surgery but can cause severe pain and blood in the urine. Squirting a dye into the ureters, rather than using stents, may cause less pain for women after surgery whilst not making the removal of endometriosis worse, the operation take longer, or increasing the rates of complications (such as bleeding or damage to internal organs). Before a full clinical study can be run, the investigators need to understand whether this is possible, by doing a feasibility study",[23,24],"2025-08-26",{"date":87,"type":37},"2025-09-03",{"date":89,"type":37},"2025-07-29",{"date":91,"type":19},"2028-03",{"name":93,"class":44},"University Hospitals of North Midlands NHS Trust",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":103,"conditions":104,"keywords":109,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":71},"100592489","imaging-comparison-for-the-preoperative-planning-and-diagnosis-of-die-a-multicenter-retrospective-study-100592489","NCT06994091","Imaging Comparison for the Preoperative Planning and Diagnosis of DIE: a Multicenter Retrospective Study.","The Added Value of (Standard) Magnetic Resonance Imaging Compared to Transvaginal Ultrasound for the Preoperative Planning and Diagnosis of Deep Infiltrating Endometriosis: a Multicenter Retrospective Study.","Inclusion Criteria:\n\n* All patients who underwent preoperative imaging at AZ Sint-Jan AV and Ziekenhuis Oost-Limburg (ZOL) between October 2021 and December 2024, TVS with or without complementary MR followed by therapeutic surgery as part of DIE.\n\nExclusion Criteria:\n\n* Performing imaging, TVS with or without additional MR, by an operator without specific experience in the field.\n* Lack of a TVS report diagnosing DIE.\n* Preoperative diagnosis of only superficial endometriosis and\u002For endometriomas without DIE.\n* Performance of surgery by a surgeon without specific experience in the field.\n* Lack of a surgical report that correctly describes all DIE lesions.",{"count":102,"type":19},200,"Several centers in Belgium use both transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI) for the preoperative diagnosis of deep infiltrating endometriosis (DIE), while other centers rely almost exclusively on TVS. From the perspective of both the patient and the endometriosis care team, it is not primarily important that every individual lesion is mapped perfectly preoperatively, but rather that all lesions impacting clinical management and surgical planning are accurately detected. This is particularly crucial when a multidisciplinary approach is required, involving a urologist for bladder lesions and\u002For an abdominal surgeon for invasive rectosigmoid lesions. Moreover, providing the patient with thorough preoperative counseling is essential, and this is, of course, determined by the preoperative findings and the type of planned surgical procedure.\n\nIn this study, we first assess the diagnostic performance of TVS in the preoperative diagnosis of DIE. As a secondary objective, we evaluate the added value of MRI compared to TVS for preoperative surgical planning in patients who also underwent an MRI examination.",[24,105,106,107,108],"Surgery","Transvaginal Ultrasound","MRI","Preoperative Planning",[110,111,112,107,113],"deep endometriosis","surgery","tranvaginal ultrasound","preoperative planning","2025-05-20",{"date":116,"type":37},"2025-05-29",{"date":118,"type":19},"2025-06-01",{"date":120,"type":19},"2025-12-12",{"name":122,"class":44},"Ziekenhuis Oost-Limburg",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":130,"enrollmentInfo":131,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":133,"conditions":134,"keywords":135,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":71},"100579598","patients-undergoing-total-intracorporeal-or-extracorporeal-anastomosis-after-segmental-resection-for-deep-endometriosis-100579598","NCT06826378","Patients Undergoing Total Intracorporeal or Extracorporeal Anastomosis After Segmental Resection for Deep Endometriosis","Observational Study Between Patients Undergoing Total Intracorporeal Anastomosis Or Extracorporeal Anastomosis After Segmental Resection For Deep Endometriosis","Inclusion Criteria:\n\n* Women between 18 and 54 years of age\n* Diagnosis, by instrumental examination such as transvaginal ultrasound, of deep endometriosis with suspected intestinal involvement\n* Intraoperative indication for segmental resection for intestinal endometriosis\n* Obtaining informed consent for study participation and data processing\n\nExclusion Criteria:\n\n* Patients with a known concomitant inflammatory bowel syndrome (inflammatory bowel syndrome)\n* Patients undergoing emergency\u002Femergency surgery","54 Years",{"count":132,"type":19},60,"Impact on the quality of life (in terms of functional recovery and gastrointestinal symptoms) of segmental resection surgery in patients with intestinal endometriosis undergoing either a totally intracorporeal or extracorporeal procedure",[24],[23,136,105,137,138],"Gynaecology","Anastomosis","Segmental resection","2025-02-11",{"date":141,"type":37},"2025-02-14",{"date":143,"type":19},"2025-02",{"date":145,"type":19},"2026-05",{"name":147,"class":44},"IRCCS Azienda Ospedaliero-Universitaria di Bologna",{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":158,"conditions":159,"keywords":160,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":71},"100577551","radiological-diagnostics-in-patients-with-deep-endometriosis-100577551","NCT06799767","Radiological Diagnostics in Patients With Deep Endometriosis","Implementation Of Radiological Diagnostics In Patients With Deep Endometriosis","Inclusion Criteria:\n\n* Clinical and ultrasound diagnosis of deep endometriosis, with or without ovarian endometriosis, with indication for MRI for further diagnosis and subsequent candidate for laparoscopic surgical treatment of the pathology\n* Age between 18 and 40 years\n* Obtaining informed consent\n\nExclusion Criteria:\n\n* Previous abdominal surgery\n* Personal history of malignancy (current or previous)\n* Chronic inflammatory bowel disease (Crohn's disease, Ulcerative Rectocolitis, Indeterminate Colitis), interstitial cystitis\n* Personal history of Pelvic Inflammatory Disease (PID), active or previous\n* Previous radiotherapy\u002Fchemotherapy\n* Radiculopathy, herniated discs, spinal abnormalities and pathologies\n* Laparotomic conversion during surgery","40 Years",{"count":157,"type":19},94,"Endometriosis is a benign, chronic, recurrent disease characterised by the presence of endometrial glands and stroma outside the uterine cavity. A non-negligible proportion of patients, 2-37%, are affected by deep endometriosis (DIE), defined as the pathology's involvement of the muscular tunic propria of the abdomino-pelvic organs.\n\nFrom a therapeutic point of view, a medical or surgical approach is possible. The choice is influenced by several factors, such as the patient's age, reproductive desire, the extent of symptoms, the size and location of the endometriosis lesions, and the presence of organ damage. Although the surgical approach brings satisfactory results in terms of symptom reduction and improved fertility, the risk of complications can be very high, especially in the case of DIE, as bladder, rectal and sexual function can be compromised due to iatrogenic damage to the autonomic fibres that innervate the pelvic organs. Recently, the concept of 'nerve-sparing' surgery has been extended to gynaecology, and in particular to surgery for the treatment of endometriosis, showing encouraging results in terms of both symptom control and functional outcome.\n\nIn recent years, nuclear magnetic resonance imaging (NMR) has been increasingly helpful in the diagnosis of endometriosis and adenomyosis and is increasingly used in pre-operative planning.",[24],[110,161,162,163,164,165],"radiological diagnostics","tractography","augmented reality","3D-modelling","radiomics","2025-01-28",{"date":168,"type":37},"2025-01-29",{"date":170,"type":37},"2021-04-07",{"date":172,"type":19},"2025-04-30",{"name":147,"class":44},{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":184,"conditions":185,"keywords":186,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":199},"100576138","robotic-surgery-in-the-treatment-of-deep-endometriosis-da-vinci-vs-hugo-ras-comparison-100576138","NCT06781398","Robotic Surgery in the Treatment of Deep Endometriosis: Da Vinci Vs HUGO RAS Comparison","Robotic Surgery in the Treatment of Deep Endometriosis: Da Vinci Vs HUGO RAS Compared","Inclusion Criteria:\n\n* Age between 18 and 55 years;\n* Pelvic ultrasound and\u002For radiologic (MRI\u002FCT scan with rectal insufflation) diagnosis of endometriosis\n* Indication for surgery (symptomatic despite or refractory to medical therapy, and\u002For with critical bowel stenosis or urinary stenosis, and\u002For infertile awaiting medically assisted procreation (PMA) treatment or with previous failed assisted fertilization attempts);\n* ASA (American Society of Anesthesiologists physical status classification) class between 1 and 3;\n* Acquisition of consent to undergo surgical treatment;\n* Acquisition of consent for study participation and data processing\n\nExclusion Criteria:\n\n\\- Past or current diagnosis of gynecologic oncologic pathology.","55 Years",{"count":183,"type":19},86,"The aim is to clarify whether both surgical approaches represent, equivalently, a good treatment for the management of patients with deep endometriosis who are candidates for surgery, or whether there are any differences between the two methods, and, if so, how they differ",[24],[187,188,111,189,190],"endometriosis","gynaecology","Da Vinci","HUGO RAS","2025-01-13",{"date":193,"type":37},"2025-01-17",{"date":195,"type":19},"2025-01",{"date":197,"type":19},"2027-10",{"name":147,"class":44},2,{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":206,"eligibilityCriteria":207,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":80,"enrollmentInfo":208,"targetDuration":4,"studyType":209,"phases":210,"briefSummary":212,"conditions":213,"keywords":214,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":71},"100453022","robotic-versus-laparoscopic-surgery-for-deep-endometriosis-100453022","NCT05179109","Robotic Versus Laparoscopic Surgery for Deep Endometriosis","Robotic Versus Laparoscopic Surgery for Severe Deep Endometriosis: a Prospective, Randomized, Controlled Trial","ROBEndo","Inclusion Criteria:\n\n* ASA (American Society of Anesthesiologists physical status classification) 1-3\n* Diagnosed deep endometriosis (MRI)\n* Patient has symptoms\n* Operative treatment is indicated\n* Patient is able to give informed consent\n\nExclusion Criteria:\n\n* ASA \\> 3\n* Recurring rectosigmoid endometriosis",{"count":82,"type":19},"INTERVENTIONAL",[211],"NA","The objective of this study is to examine whether robot-assisted laparoscopy is superior compared to conventional laparoscopy as regards to patient outcome.",[23,24,105],[215,216,217],"Endometriosis surgery","Deep endometriosis surgery","Robotic surgery","2024-12-03",{"date":220,"type":37},"2024-12-06",{"date":222,"type":37},"2022-10-03",{"date":224,"type":19},"2026-12-31",{"name":226,"class":44},"University of Oulu",{"id":228,"slug":229,"hasResults":11,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":233,"eligibilityCriteria":234,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":181,"enrollmentInfo":235,"targetDuration":54,"studyType":20,"phases":4,"briefSummary":237,"conditions":238,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":71},"100545774","surgical-treatment-of-women-with-deep-endometriosis-100545774","NCT06386276","Surgical TReatment of Women With Deep ENDometriosis","Surgical TReatment of Women With Deep ENDometriosis Infiltrating the Sigmoid Colon and\u002For the Rectum. A Monocentric Archive","TrEnd","Inclusion Criteria:\n\n* age \\>\u002F= 18 years;\n* presence of deep endometriotic nodule(s) infiltrating the tunica muscularis of the sigmoid colon\u002Frectum.\n\nExclusion Criteria:\n\n* age \\\u003C18 years:\n* presence of coexisting inflammatory bowel disease;\n* patients who have received previous pelvic radiotherapy.",{"count":236,"type":19},250,"TrEnd trial is aimed to collect data from consecutive patients undergoing segmental sigmoid colon\u002Frectal resection for deep endometriosis. The main purpose of this project is to gather a large series of cases treated using standardized surgical procedures, allowing a precise evaluation of complications and long-term outcomes.",[24,105],"2024-04-23",{"date":241,"type":37},"2024-04-26",{"date":243,"type":37},"2023-10-11",{"date":245,"type":19},"2029-06-30",{"name":247,"class":44},"Casa di Cura Privata 'Malzoni - Villa dei Platani' S.P.A."]